IGF-1-Mediated Survival from Induced Death of Human Primary Cultured Retinal Pigment Epithelial Cells Is Mediated by an Akt-Dependent Signaling Pathway

Molecular Neurobiology

Volumn 55, Issue 3, 2018, Pages 1915-1927

  Zheng, Wenhua ^a,b   Meng, Qian ^a   Wang, Haitao ^a,c   Yan, Fengxia ^a   Little, Peter J ^d   Deng, Xinguo ^b   Lin, Shaofen ^b  

^a University of Macau   (Macao)

^b SUN YAT SEN UNIVERSITY   (China)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Apoptosis; Cell signaling; Growth factors; Retinopathy; Serum deprivation

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; FIRTECAN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RPE65 PROTEIN; SMALL INTERFERING RNA; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG; VISUAL PIGMENT; IGF1 PROTEIN, HUMAN;

A WAVE; ADULT; AGE RELATED MACULAR DEGENERATION; AKT SIGNALING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; B WAVE; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ELECTRORETINOGRAM; EPITHELIUM CELL; EYE PROTECTION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LIGHT EXPOSURE; MALE; NONHUMAN; PRIMARY CULTURE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RETINAL PIGMENT EPITHELIUM; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CELL DEATH; DOSE RESPONSE; INTRAVITREAL DRUG ADMINISTRATION; METABOLISM; PATHOLOGY; PHOTOSTIMULATION; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INTRAVITREAL INJECTIONS; PHOTIC STIMULATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RETINAL PIGMENT EPITHELIUM; SIGNAL TRANSDUCTION;

EID: 85013776511     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-017-0447-0     Document Type: Article

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