Assessment of dietary intake of 10 intense sweeteners by the Italian population

Food and Chemical Toxicology

Volumn 102, Issue , 2017, Pages 186-197

  Le Donne, Cinzia ^a   Mistura, Lorenza ^a   Goscinny, Séverine ^b   Janvier, Steven ^b   Cuypers, Koenraad ^b   D'Addezio, Laura ^a   Sette, Stefania ^a   Catasta, Giovina ^a   Ferrari, Marika ^a   Piccinelli, Raffaela ^a   Van Loco, Joris ^b   Turrini, Aida ^a  

^a Center of Food and Nutrition   (Italy)

^b SCIENTIFIC INSTITUTE OF PUBLIC HEALTH   (Belgium)

Author keywords

Consumers in Italy; Dietary exposure; Food label survey; Intense sweeteners; Occurrence

Indexed keywords

ACESULFAME; ASPARTAME; CYCLAMATE SODIUM; NEOHESPERIDIN; NEOTAME; SACCHARIN; STEVIOL; SUCRALOSE; SWEETENING AGENT; THAUMATIN;

ADOLESCENT; ADULT; AGED; ARTICLE; BEVERAGE; CHILD; CONCENTRATION (PARAMETERS); DIETARY INTAKE; DIETARY SUPPLEMENT; FEMALE; FOOD ANALYSIS; FOOD PACKAGING; HEALTH SURVEY; HUMAN; ITALIAN (CITIZEN); ITALY; MALE; MARKET; MEASUREMENT ACCURACY; MIDDLE AGED; NORMAL HUMAN; NUTRITIONAL REQUIREMENT; PRESCHOOL CHILD; QUANTITATIVE ANALYSIS; RISK ASSESSMENT; SCHOOL CHILD; YOUNG ADULT; ANALYSIS; DIET; STATISTICS AND NUMERICAL DATA;

ASPARTAME; BEVERAGES; DIET SURVEYS; DIETARY SUPPLEMENTS; FOOD LABELING; HUMANS; ITALY; SWEETENING AGENTS;

EID: 85013391709     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2017.02.014     Document Type: Article

References (37)

1. ANSES, French Agency for Food, Environmental and Occupational Health & Safety, Intense Sweeteners. Definitions and Presentation of the Agency's Work. Available at:, 2015 https://www.anses.fr/en/content/intense-sweeteners Updated on 13/01/2015 (Last accessed on June 2016).
2. Anton, S.D., Martin, C.K., Han, H., Coulon, S., Cefalu, W.T., Geiselman, P., Williamson, D.A., Effects of stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levels. Appetite 55 (2010), 37–43.
3. Arcella, D., Le Donne, C., Piccinelli, R., Leclercq, C., Dietary estimated intake of intense sweeteners by Italian teenagers. Present levels and projections derived from the INRAN-RM-2001 food survey. Food Chem. Toxicol. 42:4 (2004), 677–685.
4. Brown, R.J., De Banate, M.A., Rother, K.I., Artificial sweeteners: a systematic review of metabolic effects in youth. Int. J. Pediatr. Obes. 5 (2010), 305–312.
5. Bruyère, O., Ahmed, H.S., Atlan, C., Belegaud, J., Bortolotti, M., Canivenc-Lavier, M.C., Charrière, S., Girardet, J.P., Houdart, S., Kalonji, E., Nadaud, P., Rajas, F., Slama, G., Margaritis, I., Review of the nutritional benefits and risks related to intense sweeteners. Arch. Public. Health, 7, 2015, 41.
6. Connolly, A., Boylan, E., Nugent, A., Hearty, A., Gibney, M.J., The development of a food-packaging database based on intakes of packaged foods in Irish teens (13–17 years). Proc. Nutr. Soc., 67, 2009, E273.
7. EFSA, European Food Safety Authority, Guidance of the scientific committee on a request from EFSA related to uncertainties in dietary exposure assessment. EFSA J. 438 (2006), 1–54.
8. EFSA, European Food Safety Authority, Panel on Food Additives and Nutrient Sources (ANS); Scientific Opinion on safety of steviol glycosides for the proposed uses as a food additive. EFSA J., 8(4), 2010, 1537 2010.
9. EFSA, European Food Safety Authority, Panel on Dietetic Products, Nutrition and Allergies (NDA). Scientific Opinion on the substantiation of health claims related to intense sweeteners and contribution to the maintenance or achievement of a normal body weight (ID 1136, 1444, 4299), reduction of post-prandial glycaemic responses (ID 4298), maintenance of normal blood glucose concentrations (ID 1221, 4298), and maintenance of tooth mineralisation by decreasing tooth demineralisation (ID 1134, 1167, 1283) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA J., 9(6), 2011, 2229.
10. EFSA, European Food Safety Authority, Overview of the procedures currently used at EFSA for the assessment of dietary exposure to different chemical substances. EFSA J., 9(12), 2011, 2490 2011.
11. EFSA, European Food Safety Authority, Chemicals in Food. Available at:, 2013 http://www.efsa.europa.eu/en/faqs/faqchemicalsinfood (Last accessed on November 2015).
12. European Commission, Development of Methodologies for the Monitoring of Food Additive Intake across the European Union, Task 4.2-Final Report Submitted by the Task Coordinator 16 January 1998. Volume European Commission., 1998, Belgium, Brussels, 1–45 (Annex AJ).
13. European Commission, Regulation (EC) No 1333/2008 of the European parliament and of the Council of 16 December 2008 on food additives. Off. J. Eur. Union L295 (2008), 205–211.
14. European Commission, Regulation (EU) No 1129/2011 of 11 November 2011 amending Annex II to regulation (EC) No 1333/2008 of the European parliament and of the Council by establishing a union list of food additives. Off. J. Eur. Union L 295/1, 2011, 1–177.
15. European Commission, Regulation (EU) No 1131/2011 of 11 November 2011 amending Annex II to regulation (EC) No 1333/2008 of the European parliament and of the Council with regard to steviol glycosides. Off. J. Eur. Union L 295/205, 2011, 205–211.
16. Federdistribuzione, Mappa del sistema distributivo italiano - Dati 2012. Available at:, 2012 http://www.federdistribuzione.it/studi_e_ricerche.php.
17. Food Drink Europe, Data & Trends of the European Food and Drink Industry 2013-2014 Report. FoodDrink Europe. available at:, 2012 http://www.fooddrinkeurope.eu/S=0/publication/data-trends-of-the-european-food-and-drink-industry/.
18. FSA, Food Standard Agency, Diary Survey of the Intake of Intense Sweeteners by Young Children from Soft Drinks. 2003, Food Standard Agency, London, United Kingdom, 1–24.
19. Huvaere, K., Vandevijvere, S., Hasni, M., Vinkx, C., van Loco, J., Dietary intake of artificial sweeteners by the Belgian population. Food Addit. Contam. Part A 29:1 (2012), 54–65.
20. Janvier, S., Goscinny, S., Le Donne, C., Van Loco, J., Low calorie sweeteners in food and food supplements on the Italian market. Food Addit. Contam. Part B Surveill. 8:4 (2015), 298–308.
21. JECFA - Joint FAO/WHO Expert Committee on Food Additives (Food and Agriculture Organization of the United Nations/World Health Organization [FAO/WHO]), Safety Evaluation of Certain Food Additives. Prepared by the Sixty-ninth Meeting of the Joint FAO/WHO Expert Committee on Food Additives(JECFA). WHO FOOD ADDITIVES SERIES, vol. 60, 2009, World Health Organization, Geneva 2009.
22. JECFA - Joint FAO/WHO Expert Committee on Food Additives (Food and Agriculture Organization of the United Nations/World Health Organization [FAO/WHO]), Dietary Exposure Assessment of Chemicals in Food (Chapter 6), in: Principles and Methods for the Risk Assessment of Chemicals in Food. Environmental Health Criteria 240. FAO/WHO. International Programme on Chemical Safety (IPCS). 2009, World Health Organization, Geneva, Switzerland 2009.
23. Le Donne, C., Catasta, G., Ferrari, M., Hearty, A., Connolly, A., Leclercq, C., on behalf of the Flavours, Additives and Food Contact Material Exposure Task (FACET) Consortium. Use of market share data to select food products for an occurrence survey on flavourings in eight EU countries within the FACET project. Int. J. Food Sci. Nutr. 64:6 (2013), 768–779.
24. Leclercq, C., Berardi, D., Sorbillo, M.R., Lambe, J., Intake of saccharin, aspartame, acesulfame K and cyclamate in Italian teenagers: present levels and projections. Food Addit. Contam. 16 (1999), 99–109.
25. Leclercq, C., Arcella, D., Piccinelli, R., Sette, S., Le Donne, C., Turrini, A., on behalf of the INRAN-SCAI 2005–06 Study Group. The Italian National Food Consumption Survey INRAN-SCAI 2005–06: main results in terms of food consumption. Publ. Health Nutr. 12 (2009), 2504–2532.
26. Mattes, R.D., Popkin, B.M., Nonnutritive sweetener consumption in humans: effects on appetite and food intake and their putative mechanisms. Am. J. Clin. Nutr. 89 (2009), 1–14.
27. Mistura, L., Sette, S., O'Mahony, C., Engel, K.H., Mehegan, J., Leclercq, C., On behalf of the Flavours, Additives, and Food Contact Material Exposure Task (FACET) Consortium. Modelling framework for assessment of dietary exposure to added flavouring substances within the FACET (Flavours, Additives, and Food Contact Material Exposure Task) project. Food Chem. Toxicol. 58C (2013 Apr 29), 236–241, 10.1016/j.fct.2013.04.041.
28. Nusser, S.M., Carriquiry, A.L., Dodd, K.W., Fuller, W.A., A semiparametric transformation approach to estimating usual daily intake distributions. J. Am. Stat. Assoc. 91 (1996), 1440–1449.
29. Pepino, M.Y., Bourne, C., Non-nutritive sweeteners, energy balance, and glucose homeostasis. Curr. Opin. Clin. Nutr. Metab. Care 14 (2011), 391–395.
30. Pereira, M.A., Diet beverages and the risk of obesity, diabetes, and cardiovascular disease: a review of the evidence. Nut. Rev. 71:7 (2013), 433–440.
31. Piccinelli, R., Pandelova, M., Le Donne, C., Ferrari, M., Schramm, K.-W., Leclercq, C., Design and preparation of market baskets of EU Union commercial baby foods for the assessment of infant exposure to food chemicals and to their effects. Food Addit. Contam. 27 (2010), 1337–1351.
32. Rogers, P.J., Hogenkamp, P.S., de Graaf, C., Higgs, S., Lluch, A., Ness, A.R., Penfold, C., Perry, R., Putz, P., Yeomans, M.R., Mela, D.J., Does low-energy sweetener consumption affect energy intake and body weight? A systematic review, including meta-analyses, of the evidence from human and animal studies. Int. J. Obes., 2015, 1–14, 10.1038/ijo.2015.177.
33. Shankar, P., Ahuja, S., Sriram, K., Non-nutritive sweeteners: review and update. Nutrition 29 (2013), 1293–1299.
34. Tate, D.F., Turner-McGrievy, G., Lyons, E., Stevens, J., Erickson, K., Polzien, K., Diamond, M., Wang, X., Popkin, B., Replacing caloric beverages with water or diet beverages for weight loss in adults: main results of the Choose Healthy Options Consciously Everyday (CHOICE) randomized clinical trial. Am. J. Clin. Nutr. 95 (2012), 555–563.
35. Vin, K., Connolly, A., McCaffrey, T., McKevitt, A., O'Mahony, C., Prieto, M., Tennant, D., Hearty, A., Volatier, J.L., Estimation of the dietary intake of 13 priority additives in France, Italy, the UK and Ireland as part of the FACET project. Food Addit. Contam. 30:12 (2013), 2050–2080.
36. Wiebe, N., Padwal, R., Field, C., Marks, S., Jacobs, R., Tonelli, M.A., A systematic review on the effect of sweeteners on glycemic response and clinically relevant outcomes. BMC Med. 9:123 (2011), 1–18.
37. Yang, Q., Gain weight by ‘‘going diet?’’ Artificial sweeteners and the neurobiology of sugar cravings: neuroscience 2010. Yale J. Biol. Med. 83 (2010), 101–108.