Alleviation of metabolic bottleneck by combinatorial engineering enhanced astaxanthin synthesis in Saccharomyces cerevisiae

Enzyme and Microbial Technology

Volumn 100, Issue , 2017, Pages 28-36

  Zhou, Pingping ^a   Xie, Wenping ^a   Li, Aipeng ^a   Wang, Fan ^a   Yao, Zhen ^a   Bian, Qi ^a   Zhu, Yongqiang ^a   Yu, Hongwei ^a   Ye, Lidan ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Astaxanthin; Directed evolution; Metabolic engineering; Saccharomyces cerevisiae; carotene ketolase

Indexed keywords

BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; BIOSYNTHESIS; ENZYMES; METABOLISM; YEAST;

ASTAXANTHIN; COMBINATORIAL ENGINEERING; COMBINATORIAL STRATEGIES; DIRECTED EVOLUTION; PROTEIN ENGINEERING; RATE-LIMITING ENZYMES; SHAKE-FLASK CULTURES; VALUE ADDED PRODUCTS;

METABOLIC ENGINEERING;

ASTAXANTHIN; BETA CAROTENE; BETA CAROTENE KETOLASE; CANTHAXANTHIN; RESTRICTION ENDONUCLEASE; TRANSFERASE; UNCLASSIFIED DRUG; BETA-CAROTENE KETOLASE; FARNESYL TRANS TRANSFERASE; MUTANT PROTEIN; OXYGENASE; RECOMBINANT PROTEIN; XANTHOPHYLL;

ARTICLE; BIOMASS PRODUCTION; BIOSYNTHESIS; EXTRACTION; GENE OVEREXPRESSION; METABOLIC ENGINEERING; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN ENGINEERING; RECOMBINANT PLASMID; SACCHAROMYCES CEREVISIAE; BIOMASS; CHLAMYDOMONADALES; DIPLOIDY; DIRECTED MOLECULAR EVOLUTION; ENZYMOLOGY; FERMENTATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MICROBIOLOGY; PROCEDURES;

BETA CAROTENE; BIOMASS; BIOSYNTHETIC PATHWAYS; DIPLOIDY; DIRECTED MOLECULAR EVOLUTION; FARNESYLTRANSTRANSFERASE; FERMENTATION; INDUSTRIAL MICROBIOLOGY; METABOLIC ENGINEERING; MUTANT PROTEINS; OXYGENASES; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; VOLVOCIDA; XANTHOPHYLLS;

EID: 85013224868     PISSN: 01410229     EISSN: 18790909     Source Type: Journal    
DOI: 10.1016/j.enzmictec.2017.02.006     Document Type: Article

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