Production of IgG autoantibody requires expression of activation-induced deaminase in early-developing B cells in a mouse model of SLE

European Journal of Immunology

Volumn 44, Issue 10, 2014, Pages 3093-3108

  Umiker, Benjamin R ^a   Mcdonald, Gabrielle ^a   Larbi, Amma ^a   Medina, Carlos O ^a   Hobeika, Elias ^b,c   Reth, Michael ^b,c   Imanishi Kari, Thereza ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

AID; Pathogenic autoantibodies; Receptor editing; Systemic lupus erythemathosus

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; CRE RECOMBINASE; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M; AICDA (ACTIVATION-INDUCED CYTIDINE DEAMINASE); ANTINUCLEAR ANTIBODY; AUTOANTIBODY; AUTOANTIGEN; CYTIDINE DEAMINASE; IMMUNOGLOBULIN G;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY BLOOD LEVEL; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE ACTIVATION; CELL FUNCTION; CELL LINEAGE; CELL LOSS; CELL MATURATION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENETIC CODE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MALE; MISSENSE MUTATION; MONONUCLEAR CELL; MOUSE; MUTATION RATE; NONHUMAN; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; RNA BINDING; SEQUENCE ANALYSIS; SOMATIC HYPERMUTATION; SYSTEMIC LUPUS ERYTHEMATOSUS; ANIMAL; B LYMPHOCYTE; BAGG ALBINO MOUSE; BIOSYNTHESIS; C57BL MOUSE; DISEASE MODEL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GENE REARRANGEMENT; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY;

ANIMALS; ANTIBODIES, ANTINUCLEAR; ANTIBODY FORMATION; AUTOANTIBODIES; AUTOANTIGENS; B-LYMPHOCYTES; CYTIDINE DEAMINASE; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNE TOLERANCE; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE, INBRED BALB C; MICE, INBRED C57BL; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84912560975     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201344282     Document Type: Article

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