메뉴 건너뛰기




Volumn 34, Issue , 2012, Pages 24-33

Poly(Ethylene Glycol) in Drug Delivery, Why Does it Work, and Can We do Better? All Atom Molecular Dynamics Simulation Provides Some Answers

Author keywords

nanomedicine; PEGylated liposomes; PEGylation; poly(ethylene glycol); rational drug design; targeted drug delivery

Indexed keywords


EID: 85013071209     PISSN: 18753884     EISSN: 18753892     Source Type: Conference Proceeding    
DOI: 10.1016/j.phpro.2012.05.004     Document Type: Conference Paper
Times cited : (74)

References (52)
  • 2
    • 61549130569 scopus 로고    scopus 로고
    • Targeted drugs and nanomedicine: Present and future
    • P. Debbage Targeted drugs and nanomedicine: present and future Curr. Pharm. Des. 15 2009 153 172
    • (2009) Curr. Pharm. Des. , vol.15 , pp. 153-172
    • Debbage, P.1
  • 4
    • 77956434412 scopus 로고    scopus 로고
    • Nanotechnology in drug delivery and tissue engineering: From discovery to applications
    • J. Shi, A.R. Votruba, O.C. Farokhzad, and R. Langer Nanotechnology in drug delivery and tissue engineering: from discovery to applications Nano Lett. 10 2010 3223 3230
    • (2010) Nano Lett. , vol.10 , pp. 3223-3230
    • Shi, J.1    Votruba, A.R.2    Farokhzad, O.C.3    Langer, R.4
  • 5
    • 77957677097 scopus 로고    scopus 로고
    • Cancer nanotechnology: Application of nanotechnology in cancer therapy
    • R. Misra, S. Acharya, and S.K. Sahoo Cancer nanotechnology: application of nanotechnology in cancer therapy Drug Discovery Today 15 2010 842 850
    • (2010) Drug Discovery Today , vol.15 , pp. 842-850
    • Misra, R.1    Acharya, S.2    Sahoo, S.K.3
  • 6
    • 79251501645 scopus 로고    scopus 로고
    • Nanoparticles with targeting, triggered release, aid imaging functionality for cancer applications
    • K. Loomis, K. McNeeley, and R.V. Bellamkonda Nanoparticles with targeting, triggered release, aid imaging functionality for cancer applications Soft Matt. 7 2011 839 856
    • (2011) Soft Matt. , vol.7 , pp. 839-856
    • Loomis, K.1    McNeeley, K.2    Bellamkonda, R.V.3
  • 7
    • 0036222748 scopus 로고    scopus 로고
    • Long-circulating sterically stabilized liposomes as carriers of agents for treatment of infection or for imaging infectious foci
    • I.A.J.M Bakker-Woudenberg Long-circulating sterically stabilized liposomes as carriers of agents for treatment of infection or for imaging infectious foci Int. J Antimicrob. Agents 19 2 2002 299 311
    • (2002) Int. J Antimicrob. Agents , vol.19 , Issue.2 , pp. 299-311
    • Bakker-Woudenberg, I.A.J.M.1
  • 8
    • 0024978864 scopus 로고
    • Cationic liposome-mediated transfection
    • P.L. Felgner, and G.M. Ringold Cationic liposome-mediated transfection Nature 337 1989 387 388
    • (1989) Nature , vol.337 , pp. 387-388
    • Felgner, P.L.1    Ringold, G.M.2
  • 9
    • 0030161222 scopus 로고    scopus 로고
    • Liposomes as delivery agents for medical imaging
    • V.P. Torchilin Liposomes as delivery agents for medical imaging Mol. Med. Today 2 6 1996 242 249
    • (1996) Mol. Med. Today , vol.2 , Issue.6 , pp. 242-249
    • Torchilin, V.P.1
  • 11
    • 72749093756 scopus 로고    scopus 로고
    • Recent developments in liposomes, microparticles and nanoparticles for protein and peptide drug delivery
    • M.L. Tan, P.F.M. Choong, and C.R. Dass Recent developments in liposomes, microparticles and nanoparticles for protein and peptide drug delivery Peptides 31 2010 184 193
    • (2010) Peptides , vol.31 , pp. 184-193
    • Tan, M.L.1    Choong, P.F.M.2    Dass, C.R.3
  • 12
    • 14144250911 scopus 로고    scopus 로고
    • Recent advances with liposomes as pharmaceutical carriers
    • V.P. Torchilin Recent advances with liposomes as pharmaceutical carriers Nat. Rev. Drug. Discov. 4 2 2005 145 160
    • (2005) Nat. Rev. Drug. Discov. , vol.4 , Issue.2 , pp. 145-160
    • Torchilin, V.P.1
  • 13
    • 12344307628 scopus 로고    scopus 로고
    • Drug transport to brain with targeted nanoparticles
    • J.C. Olivier Drug transport to brain with targeted nanoparticles NeuroRx 2 1 2005 108 119
    • (2005) NeuroRx , vol.2 , Issue.1 , pp. 108-119
    • Olivier, J.C.1
  • 14
    • 75749158573 scopus 로고    scopus 로고
    • PEGylation for improving the effectiveness of therapeutic biomolecules
    • F.M. Veronese, and G. Pasut PEGylation for improving the effectiveness of therapeutic biomolecules Drugs Today 45 9 2009 687 695
    • (2009) Drugs Today , vol.45 , Issue.9 , pp. 687-695
    • Veronese, F.M.1    Pasut, G.2
  • 15
    • 54249146140 scopus 로고    scopus 로고
    • Properties of polyethylene glycol supported tetraaryporphyrin in aqueous solution and its interaction with liposomal membranes
    • K. Nawalany, B. Kozik, M. Kepczynski, S. Zapotoczny, M. Kumorek, M. Nowakowska, and B. Jachimska Properties of polyethylene glycol supported tetraaryporphyrin in aqueous solution and its interaction with liposomal membranes J. Phys. Chem. B 112 2008 12231 12239
    • (2008) J. Phys. Chem. B , vol.112 , pp. 12231-12239
    • Nawalany, K.1    Kozik, B.2    Kepczynski, M.3    Zapotoczny, S.4    Kumorek, M.5    Nowakowska, M.6    Jachimska, B.7
  • 16
    • 77951245382 scopus 로고    scopus 로고
    • A. Guśner, Solubility profiles of poly(ethylene glycol)/solvent systems. II. Comparison of thermodynamic parameters from viscosity measurements
    • C.O. Dinç, and G. Kibarer A. Guśner, Solubility profiles of poly(ethylene glycol)/solvent systems. II. comparison of thermodynamic parameters from viscosity measurements J. Appl. Polym. Sci 117 2010 1100 1119
    • (2010) J. Appl. Polym. Sci , vol.117 , pp. 1100-1119
    • Dinç, C.O.1    Kibarer, G.2
  • 17
    • 0015124656 scopus 로고
    • Pharmaceutical applications of solid dispersion systems
    • W.L. Chiou, and S. Riegelman Pharmaceutical applications of solid dispersion systems J. Pharm. Sci. 60 9 1971 1281 1302
    • (1971) J. Pharm. Sci. , vol.60 , Issue.9 , pp. 1281-1302
    • Chiou, W.L.1    Riegelman, S.2
  • 18
    • 0032885450 scopus 로고    scopus 로고
    • Solid dispersion of poorly water-soluble drugs: Early promises, subsequent problems, and recent breakthroughs
    • A.T.M. Serajuddin Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughs J Pharm. Sci. 88 10 1999 1058 1066
    • (1999) J Pharm. Sci. , vol.88 , Issue.10 , pp. 1058-1066
    • Serajuddin, A.T.M.1
  • 19
    • 0034601240 scopus 로고    scopus 로고
    • Improving drug solubility for oral delivery using solid dispersions
    • C. Leuner, and J. Dressman Improving drug solubility for oral delivery using solid dispersions Eur. J. Pharm. Biopharm. 50 2000 47 60
    • (2000) Eur. J. Pharm. Biopharm. , vol.50 , pp. 47-60
    • Leuner, C.1    Dressman, J.2
  • 20
    • 0031800381 scopus 로고    scopus 로고
    • Novel applications of liposomes
    • D.D. Lasic Novel applications of liposomes Trends Biotechnol. 16 7 1998 307 321
    • (1998) Trends Biotechnol. , vol.16 , Issue.7 , pp. 307-321
    • Lasic, D.D.1
  • 21
    • 36849051517 scopus 로고    scopus 로고
    • Temperature-sensitive poly(N-(2- hydroxypropyl)methacrylamide mono/dilactate)-coated liposomes for triggered contents release
    • L. Paasonen, B. Romberg, G. Storm, M. Yliperttula, A. Urtti, and W.E. Hennink Temperature-sensitive poly(N-(2- hydroxypropyl)methacrylamide mono/dilactate)-coated liposomes for triggered contents release Bioconj. Chem. 18 2007 2131 2136
    • (2007) Bioconj. Chem. , vol.18 , pp. 2131-2136
    • Paasonen, L.1    Romberg, B.2    Storm, G.3    Yliperttula, M.4    Urtti, A.5    Hennink, W.E.6
  • 22
    • 0141927263 scopus 로고    scopus 로고
    • Stealth liposomes and long circulating nanoparticles: Critical issues in pharmacokinetics, opsonization and protein-binding properties, Prog
    • S.M. Moghimi, and J. Szebeni Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties, Prog Lipid Res. 42 6 2003 463 478
    • (2003) Lipid Res. , vol.42 , Issue.6 , pp. 463-478
    • Moghimi, S.M.1    Szebeni, J.2
  • 23
    • 77956036859 scopus 로고    scopus 로고
    • Poly(ethylene glycol) in drug delivery: Pros and cons as well as potential alternatives
    • K. Knop, R. Hoogenboom, D. Fischer, and U. Schubert Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives Angew. Chem. Int. Ed. 49 2010 6288 6308
    • (2010) Angew. Chem. Int. Ed. , vol.49 , pp. 6288-6308
    • Knop, K.1    Hoogenboom, R.2    Fischer, D.3    Schubert, U.4
  • 25
    • 0030980974 scopus 로고    scopus 로고
    • Grafted poly-(ethylene glycol) on lipid surfaces inhibits protein adsorption and cell adhesion
    • H. Du, P. Chandaroy, and S.W. Hui Grafted poly-(ethylene glycol) on lipid surfaces inhibits protein adsorption and cell adhesion Biochim. Biophys. Acta 1326 1997 236 248
    • (1997) Biochim. Biophys. Acta , vol.1326 , pp. 236-248
    • Du, H.1    Chandaroy, P.2    Hui, S.W.3
  • 26
    • 0035815979 scopus 로고    scopus 로고
    • Protein adsorption to polyethylene glycol modified liposomes from fibrinogen solution and from plasma
    • M.E. Price, R.M. Cornelius, and J.L. Brash Protein adsorption to polyethylene glycol modified liposomes from fibrinogen solution and from plasma Biochim. Biophys. Acta 1512 2001 191 205
    • (2001) Biochim. Biophys. Acta , vol.1512 , pp. 191-205
    • Price, M.E.1    Cornelius, R.M.2    Brash, J.L.3
  • 27
    • 77956519357 scopus 로고    scopus 로고
    • T. Rog, Effects of the lipid bilayer phase state on the water membrane interface
    • M. Stepniewski, A. Bunker, M. Pasenkiewicz-Gierula, and M. Karttunen T. Rog, Effects of the lipid bilayer phase state on the water membrane interface J. Phys. Chem. B 114 2010 11784 11792
    • (2010) J. Phys. Chem. B , vol.114 , pp. 11784-11792
    • Stepniewski, M.1    Bunker, A.2    Pasenkiewicz-Gierula, M.3    Karttunen, M.4
  • 29
    • 84859428482 scopus 로고    scopus 로고
    • Analysis of cause of failure of new targeting peptide in PEGylated liposome: Molecular modeling as rational design tool for nanomedicine
    • J. Lehtinen, A. Magarkar, M. Stepniewski, S. Hakola, M. Bergman, T. Rog, M. Yliperttula, A. Urtti, and A. Bunker Analysis of cause of failure of new targeting peptide in PEGylated liposome: molecular modeling as rational design tool for nanomedicine Eur. J. Pharm. Sci. 46 3 2012 121 130
    • (2012) Eur. J. Pharm. Sci. , vol.46 , Issue.3 , pp. 121-130
    • Lehtinen, J.1    Magarkar, A.2    Stepniewski, M.3    Hakola, S.4    Bergman, M.5    Rog, T.6    Yliperttula, M.7    Urtti, A.8    Bunker, A.9
  • 30
    • 84859771128 scopus 로고    scopus 로고
    • Molecular dynamics simulation of pegylated bilayer interacting with salt ions: A model of the liposome surface in the bloodstream
    • A. Magarkar, E. Karakas, M. Stepniewski, T. Rog, and A. Bunker Molecular dynamics simulation of pegylated bilayer interacting with salt ions: a model of the liposome surface in the bloodstream J. Phys. Chem. B 116 14 2012 4212 4219
    • (2012) J. Phys. Chem. B , vol.116 , Issue.14 , pp. 4212-4219
    • Magarkar, A.1    Karakas, E.2    Stepniewski, M.3    Rog, T.4    Bunker, A.5
  • 32
    • 33645941402 scopus 로고
    • The OPLS potential functions for proteins. Energy minimizations for crystals of cyclic peptides and crambin
    • W.L. Jorgensen, and J. Tirado-Rives The OPLS potential functions for proteins. energy minimizations for crystals of cyclic peptides and crambin J. Am. Chem. Soc. 110 1988 1657 1666
    • (1988) J. Am. Chem. Soc. , vol.110 , pp. 1657-1666
    • Jorgensen, W.L.1    Tirado-Rives, J.2
  • 33
    • 0000388705 scopus 로고    scopus 로고
    • LINCS: A linear constraint solver for molecular simulations
    • B. Hess, H. Bekker, H.J.C. Berendsen, and J.G.E.M. Fraaije LINCS: A linear constraint solver for molecular simulations J. Comp. Chem. 18 12 1997 1463 1472
    • (1997) J. Comp. Chem. , vol.18 , Issue.12 , pp. 1463-1472
    • Hess, B.1    Bekker, H.2    Berendsen, H.J.C.3    Fraaije, J.G.E.M.4
  • 34
    • 34547809547 scopus 로고
    • A unified formulation of the constant temperature molecular dynamics methods
    • S. Nose A unified formulation of the constant temperature molecular dynamics methods J. Chem. Phys. 81 1 1984 511 519
    • (1984) J. Chem. Phys. , vol.81 , Issue.1 , pp. 511-519
    • Nose, S.1
  • 35
    • 0001538909 scopus 로고
    • Canonical dynamics: Equilibrium phase-space distributions
    • W.G. Hoover Canonical dynamics: Equilibrium phase-space distributions Phys. Rev. A 31 3 1985 1695 1697
    • (1985) Phys. Rev. A , vol.31 , Issue.3 , pp. 1695-1697
    • Hoover, W.G.1
  • 36
    • 0019707626 scopus 로고
    • Polymorphic transitions in single crystals: A new molecular dynamics method
    • M. Parrinello, and A. Rahman Polymorphic transitions in single crystals: A new molecular dynamics method J. Appl. Phys. 52 12 1981 7182 7190
    • (1981) J. Appl. Phys. , vol.52 , Issue.12 , pp. 7182-7190
    • Parrinello, M.1    Rahman, A.2
  • 38
    • 77249154557 scopus 로고    scopus 로고
    • Understanding the lithium transport within a rouse-based model for a PEO/LiTFSI polymer electrolyte
    • D. Diddens, A. Heuer, and O. Borodin Understanding the lithium transport within a rouse-based model for a PEO/LiTFSI polymer electrolyte Macromolecules 43 2010 2028 2036
    • (2010) Macromolecules , vol.43 , pp. 2028-2036
    • Diddens, D.1    Heuer, A.2    Borodin, O.3
  • 39
    • 0030182459 scopus 로고    scopus 로고
    • Local coordination and conformation in polyether electrolytes: Geometries of M-triglyme complexes (A4 = Li, Na, K, Mg and Ca) from ab-initio molecular orbital calculations
    • P. Johansson, S.P. Gejji, J. Tegenfeldt, and J. Lindgren Local coordination and conformation in polyether electrolytes: geometries of M-triglyme complexes (A4 = Li, Na, K, Mg and Ca) from ab-initio molecular orbital calculations Solid State Ionics 86-88 1996 297 302
    • (1996) Solid State Ionics , vol.86-88 , pp. 297-302
    • Johansson, P.1    Gejji, S.P.2    Tegenfeldt, J.3    Lindgren, J.4
  • 40
    • 50849102610 scopus 로고    scopus 로고
    • Self-assembly of poly(ethylene oxide)-block-poly(acrylic acid) induced by CaCl2: Mechanistic study
    • H.R. Sondjaja, T.A. Hatton, and K.C. Tam Self-assembly of poly(ethylene oxide)-block-poly(acrylic acid) induced by CaCl2: mechanistic study Lamgmuir 24 2008 8501 8506
    • (2008) Lamgmuir , vol.24 , pp. 8501-8506
    • Sondjaja, H.R.1    Hatton, T.A.2    Tam, K.C.3
  • 41
    • 80052091167 scopus 로고    scopus 로고
    • Structure and dynamics of highly PEG-ylated sterically stabilized micelles in aqueous media
    • L. Vukovic, F.A. Katib, S.P. Drake, A. Madriga, K.S. Brandenburg, P. Kral, and H. Onyuksel Structure and dynamics of highly PEG-ylated sterically stabilized micelles in aqueous media JACS 133 2011 13481 13488
    • (2011) JACS , vol.133 , pp. 13481-13488
    • Vukovic, L.1    Katib, F.A.2    Drake, S.P.3    Madriga, A.4    Brandenburg, K.S.5    Kral, P.6    Onyuksel, H.7
  • 42
    • 0033980919 scopus 로고    scopus 로고
    • Effect of grafted polyethylene glycol (PEG) on the size, encapsulation e-ciency and permeability of vesicles
    • A.R. Nicholas, M.J. Scott, N.I. Kennedy, and M.N. Jones Effect of grafted polyethylene glycol (PEG) on the size, encapsulation e-ciency and permeability of vesicles Biochim Biophys. Acta 1463 2000 167 178
    • (2000) Biochim Biophys. Acta , vol.1463 , pp. 167-178
    • Nicholas, A.R.1    Scott, M.J.2    Kennedy, N.I.3    Jones, M.N.4
  • 44
    • 71549166641 scopus 로고    scopus 로고
    • Mitochondrial membranes with mono- and divalent salt: Changes induced by salt ions on structure and dynamics
    • S. Pśoyry, T. Rog, M. Karttunen, and I. Vattulainen Mitochondrial membranes with mono- and divalent salt: Changes induced by salt ions on structure and dynamics J. Phys. Chem. B 113 2009 15513 15521
    • (2009) J. Phys. Chem. B , vol.113 , pp. 15513-15521
    • Pśoyry, S.1    Rog, T.2    Karttunen, M.3    Vattulainen, I.4
  • 46
    • 74149083683 scopus 로고    scopus 로고
    • Ca+ adsorption to lipid membranes and the effect of cholesterol in their composition
    • X.L.R. Iraolagoitia, and M.F. Martini Ca+ adsorption to lipid membranes and the effect of cholesterol in their composition Colloids Surf., B 76 2010 215 220
    • (2010) Colloids Surf., B , vol.76 , pp. 215-220
    • Iraolagoitia, X.L.R.1    Martini, M.F.2
  • 47
    • 0029877551 scopus 로고    scopus 로고
    • Poly(ethylene glycol)-lipid conjugates regulate the calcium-induced fusion of liposomes composed of phosphatidylethanolamine and phosphatidylserine
    • J.W. Holland, C. Hui, P.R. Cullis, and T.D. Madden Poly(ethylene glycol)-lipid conjugates regulate the calcium-induced fusion of liposomes composed of phosphatidylethanolamine and phosphatidylserine Biochemistry 35 1996 2618 2624
    • (1996) Biochemistry , vol.35 , pp. 2618-2624
    • Holland, J.W.1    Hui, C.2    Cullis, P.R.3    Madden, T.D.4
  • 48
    • 79953186583 scopus 로고    scopus 로고
    • How PEGylation enhances the stability and potency of insulin: A molecular dynamics simulation
    • C. Yang, D. Lu, and Z. Liu How PEGylation enhances the stability and potency of insulin: a molecular dynamics simulation Biochemistry 50 2011 2585 2593
    • (2011) Biochemistry , vol.50 , pp. 2585-2593
    • Yang, C.1    Lu, D.2    Liu, Z.3
  • 49
    • 84863011559 scopus 로고    scopus 로고
    • Pressure and surface tension control self-assembled structures in mixtures of pegylated and non-pegylated lipids
    • S.-C. Yang, and R. Faller Pressure and surface tension control self-assembled structures in mixtures of pegylated and non-pegylated lipids Langmuir 28 2012 2275 2280
    • (2012) Langmuir , vol.28 , pp. 2275-2280
    • Yang, S.-C.1    Faller, R.2
  • 50
    • 77749279958 scopus 로고    scopus 로고
    • Effect of polymer grafting on the bilayer gel to liquid-crystalline transition
    • F.M. Thakkar, and K.G. Ayappa Effect of polymer grafting on the bilayer gel to liquid-crystalline transition J. Phys. Chem. B 114 2010 2738 2748
    • (2010) J. Phys. Chem. B , vol.114 , pp. 2738-2748
    • Thakkar, F.M.1    Ayappa, K.G.2
  • 51
    • 79953880810 scopus 로고    scopus 로고
    • Effects of PEGylation on the size and internal structure of dendrimers: Self-penetration of long PEG chains into the dendrimer core
    • H. Lee, and R.G. Larson Effects of PEGylation on the size and internal structure of dendrimers: self-penetration of long PEG chains into the dendrimer core Macromolecules 44 7 2011 2291 2298
    • (2011) Macromolecules , vol.44 , Issue.7 , pp. 2291-2298
    • Lee, H.1    Larson, R.G.2
  • 52
    • 84855322653 scopus 로고    scopus 로고
    • Computational approaches to the rational design of nanoemulsions, polymeric micelles, and dendrimers for drug delivery, Nanomed
    • L. Huynh, C. Neale, R. Pom'es, and C. Allen Computational approaches to the rational design of nanoemulsions, polymeric micelles, and dendrimers for drug delivery, Nanomed Nanotechnol. Biol. Med. 8 2012 20 36
    • (2012) Nanotechnol. Biol. Med. , vol.8 , pp. 20-36
    • Huynh, L.1    Neale, C.2    Pom'Es, R.3    Allen, C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.