Analysis of cause of failure of new targeting peptide in PEGylated liposome: Molecular modeling as rational design tool for nanomedicine

European Journal of Pharmaceutical Sciences

Volumn 46, Issue 3, 2012, Pages 121-130

  Lehtinen, Julia ^a   Magarkar, Aniket ^a   Stepniewski, Michał ^a   Hakola, Satu ^b   Bergman, Mathias ^b   Róg, Tomasz ^c   Yliperttula, Marjo ^a   Urtti, Arto ^a   Bunker, Alex ^a,d  

^a UNIVERSITY OF HELSINKI   (Finland)

^b Karyon Ltd   (Finland)

^c TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^d AALTO UNIVERSITY   (Finland)

Author keywords

molecular dynamics; nanomedicine; PEGylated liposome; rational design; targeted delivery

Indexed keywords

ACTIVATED ENDOTHELIUM TARGETING PEPTIDE; ARGINYLGLYCYLASPARTIC ACID; HUMAN SERUM ALBUMIN; LIPOSOME; MACROGOL; MALEIMIDE; PEPTIDE; RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN CELL; HYDROPHILICITY; HYDROPHOBICITY; MALE; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOUSE; NANOMEDICINE; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PROTEIN TARGETING; VASCULAR ENDOTHELIUM;

AMINO ACID MOTIFS; ANIMALS; CELLS, CULTURED; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIGANDS; LIPOSOMES; MALEIMIDES; MICE; MICE, NUDE; MODELS, CHEMICAL; MOLECULAR DYNAMICS SIMULATION; MOLECULAR TARGETED THERAPY; NANOMEDICINE; PEPTIDES; POLYETHYLENE GLYCOLS; PROTEIN BINDING; RECEPTORS, CELL SURFACE; TISSUE DISTRIBUTION;

EID: 84859428482     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2012.02.009     Document Type: Article

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