Ophiobolin A, a sesterpenoid fungal phytotoxin, displays different mechanisms of cell death in mammalian cells depending upon the cancer cell origin

International Journal of Oncology

Volumn 50, Issue 3, 2017, Pages 773-786

  Morrison, Rachel ^a   Lodge, Tiffany ^a   Evidente, Antonio ^b   Kiss, Robert ^c   Townley, Helen ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

Apoptosis; Cancer; Mitochondria; Necrosis; Ophiobolin

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE; OPHIOBOLIN A; UNCLASSIFIED DRUG; CALCIUM; MYCOTOXIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE; SESTERTERPENE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG RESPONSE; DRUG STRUCTURE; ENDOPLASMIC RETICULUM STRESS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LD50; MAMMAL CELL; MITOCHONDRION; MOLECULAR DYNAMICS; NONHUMAN; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; APOPTOSIS; DRUG EFFECTS; ENDOPLASMIC RETICULUM; HELA CELL LINE; MCF-7 CELL LINE; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; TUMOR CELL LINE; UNFOLDED PROTEIN RESPONSE;

APOPTOSIS; CALCIUM; CASPASES; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; FLOW CYTOMETRY; HELA CELLS; HUMANS; MCF-7 CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MYCOTOXINS; POLY(ADP-RIBOSE) POLYMERASES; REACTIVE OXYGEN SPECIES; SESTERTERPENES; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE;

EID: 85013057099     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2017.3858     Document Type: Article

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