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Volumn 35, Issue 3, 2017, Pages 545-550

Concise review: Induced pluripotent stem cell research in the era of precision medicine

Author keywords

Experimental models; Genomics; Induced pluripotent stem cells

Indexed keywords

GENOME-WIDE ASSOCIATION STUDY; HUMAN; HUMAN GENOME; INDUCED PLURIPOTENT STEM CELL; MONOGENIC DISORDER; PERSONALIZED MEDICINE; PHENOTYPIC VARIATION; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; ANIMAL; CYTOLOGY; GENETICS; METABOLISM; PHENOTYPE; STEM CELL RESEARCH; ARTICLE; CELL DIFFERENTIATION; GENE EDITING; GENOMICS; NONHUMAN;

EID: 85012988624     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.2570     Document Type: Review
Times cited : (69)

References (55)
  • 1
    • 2042437650 scopus 로고    scopus 로고
    • Initial sequencing and analysis of the human genome
    • Lander ES, Linton LM, Birren B et al. Initial sequencing and analysis of the human genome. Nature 2001;409:860–921.
    • (2001) Nature , vol.409 , pp. 860-921
    • Lander, E.S.1    Linton, L.M.2    Birren, B.3
  • 2
    • 0035895505 scopus 로고    scopus 로고
    • The sequence of the human genome
    • Venter JC, Adams MD, Myers EW et al. The sequence of the human genome. Science 2001;291:1304–1351.
    • (2001) Science , vol.291 , pp. 1304-1351
    • Venter, J.C.1    Adams, M.D.2    Myers, E.W.3
  • 3
    • 79959503826 scopus 로고    scopus 로고
    • The international HapMap project
    • International HapMap Consortium. The international HapMap project. Nature 2003; 426:789–796.
    • (2003) Nature , vol.426 , pp. 789-796
  • 4
    • 35348983887 scopus 로고    scopus 로고
    • A second generation human haplotype map of over 3.1 million SNPs
    • International HapMap Consortium, Frazer KA, Ballinger DG et al. A second generation human haplotype map of over 3.1 million SNPs. Nature 2007;449:851–861.
    • (2007) Nature , vol.449 , pp. 851-861
    • Frazer, K.A.1    Ballinger, D.G.2
  • 5
    • 84943171338 scopus 로고    scopus 로고
    • A global reference for human genetic variation
    • 1000 Genomes Project Consortium, Auton A, Brooks LD et al. A global reference for human genetic variation. Nature 2015; 526:68–74.
    • (2015) Nature , vol.526 , pp. 68-74
    • Auton, A.1    Brooks, L.D.2
  • 6
    • 84891790401 scopus 로고    scopus 로고
    • The NHGRI GWAS Catalog, a curated resource of SNP-trait associations
    • Welter D, MacArthur J, Morales J et al. The NHGRI GWAS Catalog, a curated resource of SNP-trait associations. Nucleic Acids Res 2014;42:D1001–D1006.
    • (2014) Nucleic Acids Res , vol.42 , pp. D1001-D1006
    • Welter, D.1    Macarthur, J.2    Morales, J.3
  • 7
    • 84923762812 scopus 로고    scopus 로고
    • A new initiative on precision medicine
    • Collins FS, Varmus H. A new initiative on precision medicine. N Engl J Med 2015;372: 793–795.
    • (2015) N Engl J Med , vol.372 , pp. 793-795
    • Collins, F.S.1    Varmus, H.2
  • 8
    • 84925581553 scopus 로고    scopus 로고
    • Obama seeks $213m to fund “precision medicine”
    • McCarthy M. Obama seeks $213m to fund “precision medicine". BMJ 2015; 350:h587.
    • (2015) BMJ , vol.350
    • McCarthy, M.1
  • 9
    • 84862528505 scopus 로고    scopus 로고
    • Induced pluripotent stem cells: Past, present, and future
    • Yamanaka S. Induced pluripotent stem cells: Past, present, and future. Cell Stem Cell 2012;10:678–684.
    • (2012) Cell Stem Cell , vol.10 , pp. 678-684
    • Yamanaka, S.1
  • 10
    • 84928727557 scopus 로고    scopus 로고
    • Induced pluripotent stem cells
    • Wilson KD, Wu JC. Induced pluripotent stem cells. JAMA 2015;313:1613–1614.
    • (2015) JAMA , vol.313 , pp. 1613-1614
    • Wilson, K.D.1    Wu, J.C.2
  • 11
    • 84902096048 scopus 로고    scopus 로고
    • Development and applications of CRISPR-Cas9 for genome engineering
    • Hsu PD, Lander ES, Zhang F. Development and applications of CRISPR-Cas9 for genome engineering. Cell 2014;157:1262–1278.
    • (2014) Cell , vol.157 , pp. 1262-1278
    • Hsu, P.D.1    Lander, E.S.2    Zhang, F.3
  • 12
    • 84898778301 scopus 로고    scopus 로고
    • A guide to genome engineering with programmable nucleases
    • Kim H, Kim J-S. A guide to genome engineering with programmable nucleases. Nat Rev Genet 2014;15:321–334.
    • (2014) Nat Rev Genet , vol.15 , pp. 321-334
    • Kim, H.1    Kim, J.-S.2
  • 13
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K, Tanabe K, Ohnuki M et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007;131:861–872.
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3
  • 14
    • 36749043230 scopus 로고    scopus 로고
    • Induced pluripotent stem cell lines derived from human somatic cells
    • Yu J, Vodyanik MA, Smuga-Otto K et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007;318: 1917–1920.
    • (2007) Science , vol.318 , pp. 1917-1920
    • Yu, J.1    Vodyanik, M.A.2    Smuga-Otto, K.3
  • 15
    • 79959770204 scopus 로고    scopus 로고
    • Induced pluripotent stem cells as a next-generation biomedical interface
    • Hankowski KE, Hamazaki T, Umezawa A et al. Induced pluripotent stem cells as a next-generation biomedical interface. Lab Invest 2011;91:972–977.
    • (2011) Lab Invest , vol.91 , pp. 972-977
    • Hankowski, K.E.1    Hamazaki, T.2    Umezawa, A.3
  • 16
    • 84856007232 scopus 로고    scopus 로고
    • The promise of induced pluripotent stem cells in research and therapy
    • Robinton DA, Daley GQ. The promise of induced pluripotent stem cells in research and therapy. Nature 2012;481:295–305.
    • (2012) Nature , vol.481 , pp. 295-305
    • Robinton, D.A.1    Daley, G.Q.2
  • 17
    • 58249110796 scopus 로고    scopus 로고
    • Induced pluripotent stem cells from a spinal muscular atrophy patient
    • Ebert AD, Yu J, Rose FF et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 2009;457:277–280.
    • (2009) Nature , vol.457 , pp. 277-280
    • Ebert, A.D.1    Yu, J.2    Rose, F.F.3
  • 18
    • 79952446402 scopus 로고    scopus 로고
    • Modelling the long QT syndrome with induced pluripotent stem cells
    • Itzhaki I, Maizels L, Huber I et al. Modelling the long QT syndrome with induced pluripotent stem cells. Nature 2011;471:225–229.
    • (2011) Nature , vol.471 , pp. 225-229
    • Itzhaki, I.1    Maizels, L.2    Huber, I.3
  • 19
    • 84861203696 scopus 로고    scopus 로고
    • Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington’s disease patient cells
    • Juopperi TA, Kim WR, Chiang C-H et al. Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington’s disease patient cells. Mol Brain 2012;5:17.
    • (2012) Mol Brain , vol.5 , pp. 17
    • Juopperi, T.A.1    Kim, W.R.2    Chiang, C.-H.3
  • 20
    • 84888772136 scopus 로고    scopus 로고
    • Length-dependent CTG.CAG triplet-repeat expansion in myotonic dystrophy patient-derived induced pluripotent stem cells
    • Du J, Campau E, Soragni E et al. Length-dependent CTG.CAG triplet-repeat expansion in myotonic dystrophy patient-derived induced pluripotent stem cells. Hum Mol Genet 2013;22:5276–5287.
    • (2013) Hum Mol Genet , vol.22 , pp. 5276-5287
    • Du, J.1    Campau, E.2    Soragni, E.3
  • 21
    • 84870495669 scopus 로고    scopus 로고
    • JD induced pluripotent stem cell-derived hepa-tocytes faithfully recapitulate the pathophysiology of familial hypercholesterolemia
    • Cayo MA, Cai J, DeLaForest A et al. JD induced pluripotent stem cell-derived hepa-tocytes faithfully recapitulate the pathophysiology of familial hypercholesterolemia. Hepatology 2012;56:2163–2171.
    • (2012) Hepatology , vol.56 , pp. 2163-2171
    • Cayo, M.A.1    Cai, J.2    Delaforest, A.3
  • 22
    • 84864305346 scopus 로고    scopus 로고
    • Generation of human b-thalassemia induced pluripotent stem cells from amniotic fluid cells using a single excisable lentiviral stem cell cassette
    • Fan Y, Luo Y, Chen X et al. Generation of human b-thalassemia induced pluripotent stem cells from amniotic fluid cells using a single excisable lentiviral stem cell cassette. J Reprod Dev 2012;58:404–409.
    • (2012) J Reprod Dev , vol.58 , pp. 404-409
    • Fan, Y.1    Luo, Y.2    Chen, X.3
  • 23
    • 84920103442 scopus 로고    scopus 로고
    • A practical guide to induced pluripotent stem cell research using patient samples
    • Santostefano KE, Hamazaki T, Biel NM et al. A practical guide to induced pluripotent stem cell research using patient samples. Lab Invest 2015;95:4–13.
    • (2015) Lab Invest , vol.95 , pp. 4-13
    • Santostefano, K.E.1    Hamazaki, T.2    Biel, N.M.3
  • 24
    • 84908571755 scopus 로고    scopus 로고
    • Statin treatment rescues FGFR3 skeletal dys-plasia phenotypes
    • Yamashita A, Morioka M, Kishi H et al. Statin treatment rescues FGFR3 skeletal dys-plasia phenotypes. Nature 2014;513:507–511.
    • (2014) Nature , vol.513 , pp. 507-511
    • Yamashita, A.1    Morioka, M.2    Kishi, H.3
  • 25
    • 84884414984 scopus 로고    scopus 로고
    • Cerebral organoids model human brain development and microcephaly
    • Lancaster M, A Renner M, Martin C-A et al. Cerebral organoids model human brain development and microcephaly. Nature 2013; 501:373–379.
    • (2013) Nature , vol.501 , pp. 373-379
    • Lancaster, M.1    A Renner, M.2    Martin, C.-A.3
  • 26
    • 84862526635 scopus 로고    scopus 로고
    • Self-formation of optic cups and storable stratified neural retina from human ESCs
    • Nakano T, Ando S, Takata N et al. Self-formation of optic cups and storable stratified neural retina from human ESCs. Cell Stem Cell 2012;10:771–785.
    • (2012) Cell Stem Cell , vol.10 , pp. 771-785
    • Nakano, T.1    Ando, S.2    Takata, N.3
  • 27
    • 84954138949 scopus 로고    scopus 로고
    • Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells
    • Ozone C, Suga H, Eiraku M et al. Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells. Nat Commun 2016;7:10351.
    • (2016) Nat Commun , vol.7
    • Ozone, C.1    Suga, H.2    Eiraku, M.3
  • 28
    • 4244206245 scopus 로고
    • Accessed August 18, 2016
    • Pastores GM, Hughes DA. Gaucher disease. 1993. Available at http://www.ncbi.nlm.nih.gov/pubmed/20301446. Accessed August 18, 2016.
    • (1993) Gaucher Disease
    • Pastores, G.M.1    Hughes, D.A.2
  • 29
    • 0037371235 scopus 로고    scopus 로고
    • Reciprocal and nonreciprocal recombination at the glucocerebrosidase gene region: Implications for complexity in Gaucher disease
    • Tayebi N, Stubblefield BK, Park JK et al. Reciprocal and nonreciprocal recombination at the glucocerebrosidase gene region: Implications for complexity in Gaucher disease. Am J Hum Genet 2003;72:519–534.
    • (2003) Am J Hum Genet , vol.72 , pp. 519-534
    • Tayebi, N.1    Stubblefield, B.K.2    Park, J.K.3
  • 30
    • 1842834057 scopus 로고    scopus 로고
    • Twin pairs showing discordance of phenotype in adult Gaucher’s disease
    • Lachmann RH, Grant IR, Halsall D et al. Twin pairs showing discordance of phenotype in adult Gaucher’s disease. QJM 2004;97:199–204.
    • (2004) QJM , vol.97 , pp. 199-204
    • Lachmann, R.H.1    Grant, I.R.2    Halsall, D.3
  • 31
    • 84897520098 scopus 로고    scopus 로고
    • Glucocerebrosidase 2 gene deletion rescues type 1 Gaucher disease
    • Mistry PK, Liu J, Sun L et al. Glucocerebrosidase 2 gene deletion rescues type 1 Gaucher disease. Proc Natl Acad Sci USA 2014;111:4934–4939.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 4934-4939
    • Mistry, P.K.1    Liu, J.2    Sun, L.3
  • 32
    • 84943773762 scopus 로고    scopus 로고
    • Altered TFEB-mediated lysosomal biogenesis in Gaucher disease iPSC-derived neuronal cells
    • Awad O, Sarkar C, Panicker LM et al. Altered TFEB-mediated lysosomal biogenesis in Gaucher disease iPSC-derived neuronal cells. Hum Mol Genet 2015;24:5775–5788.
    • (2015) Hum Mol Genet , vol.24 , pp. 5775-5788
    • Awad, O.1    Sarkar, C.2    Panicker, L.M.3
  • 33
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • WTCCC. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007;447: 661–678.
    • (2007) Nature , vol.447 , pp. 661-678
  • 35
    • 84921845885 scopus 로고    scopus 로고
    • Cost-effectiveness of hypertension therapy according to 2014 guidelines
    • Moran AE, Odden MC, Thanataveerat A et al. Cost-effectiveness of hypertension therapy according to 2014 guidelines. N Engl J Med 2015;372:447–455.
    • (2015) N Engl J Med , vol.372 , pp. 447-455
    • Moran, A.E.1    Odden, M.C.2    Thanataveerat, A.3
  • 36
    • 84901808693 scopus 로고    scopus 로고
    • Blood pressure and incidence of twelve cardiovascular diseases: Lifetime risks, healthy life-years lost, and age-specific associations in 1.25 million people
    • Rapsomaniki E, Timmis A, George J et al. Blood pressure and incidence of twelve cardiovascular diseases: Lifetime risks, healthy life-years lost, and age-specific associations in 1.25 million people. Lancet 2014;383:1899–1911.
    • (2014) Lancet , vol.383 , pp. 1899-1911
    • Rapsomaniki, E.1    Timmis, A.2    George, J.3
  • 37
    • 21644466324 scopus 로고    scopus 로고
    • Pharmacogenomics of blood pressure response to antihypertensive treatment
    • Mellen PB, Herrington DM. Pharmacogenomics of blood pressure response to antihypertensive treatment. J Hypertens 2005;23: 1311–1325.
    • (2005) J Hypertens , vol.23 , pp. 1311-1325
    • Mellen, P.B.1    Herrington, D.M.2
  • 38
    • 84949655013 scopus 로고    scopus 로고
    • Vascular smooth muscle cells from hypertensive patient-derived induced pluripotent stem cells to advance hypertension pharmacogenomics
    • Biel NM, Santostefano KE, DiVita BB et al. Vascular smooth muscle cells from hypertensive patient-derived induced pluripotent stem cells to advance hypertension pharmacogenomics. Stem Cells Transl Med 2015;4:1380–1390.
    • (2015) Stem Cells Transl Med , vol.4 , pp. 1380-1390
    • Biel, N.M.1    Santostefano, K.E.2    Divita, B.B.3
  • 39
    • 60649094697 scopus 로고    scopus 로고
    • Pharmacogenomics of antihypertensive drugs: Rationale and design of the Pharma-cogenomic Evaluation of Antihypertensive Responses (PEAR) study
    • Johnson JA, Boerwinkle E, Zineh I et al. Pharmacogenomics of antihypertensive drugs: Rationale and design of the Pharma-cogenomic Evaluation of Antihypertensive Responses (PEAR) study. Am Heart J 2009; 157:442–449.
    • (2009) Am Heart J , vol.157 , pp. 442-449
    • Johnson, J.A.1    Boerwinkle, E.2    Zineh, I.3
  • 40
    • 84908377652 scopus 로고    scopus 로고
    • Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymor-phism using a human induced pluripotent stem cell model system
    • Ebert AD, Kodo K, Liang P et al. Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymor-phism using a human induced pluripotent stem cell model system. Sci Transl Med 2014;6:255ra130.
    • (2014) Sci Transl Med , vol.6
    • Ebert, A.D.1    Kodo, K.2    Liang, P.3
  • 41
    • 84944769086 scopus 로고    scopus 로고
    • Derivation of ethnically diverse human induced pluripotent stem cell lines
    • Chang EA, Tomov ML, Suhr ST et al. Derivation of ethnically diverse human induced pluripotent stem cell lines. Sci Rep 2015;5: 15234.
    • (2015) Sci Rep , vol.5
    • Chang, E.A.1    Tomov, M.L.2    Suhr, S.T.3
  • 42
    • 84966930890 scopus 로고    scopus 로고
    • Induced pluripotent stem cells meet genome editing
    • Hockemeyer D, Jaenisch R. Induced pluripotent stem cells meet genome editing. Cell Stem Cell 2016;18:573–586.
    • (2016) Cell Stem Cell , vol.18 , pp. 573-586
    • Hockemeyer, D.1    Jaenisch, R.2
  • 43
    • 84960971321 scopus 로고    scopus 로고
    • Genome editing in pluripotent stem cells: Research and therapeutic applications
    • Deleidi M, Yu C. Genome editing in pluripotent stem cells: Research and therapeutic applications. Biochem Biophys Res Commun 2016;473:665–674.
    • (2016) Biochem Biophys Res Commun , vol.473 , pp. 665-674
    • Deleidi, M.1    Yu, C.2
  • 44
    • 84971238775 scopus 로고    scopus 로고
    • Parkinson-associated risk variant in distal enhancer of a-synuclein modulates target gene expression
    • Soldner F, Stelzer Y, Shivalila CS et al. Parkinson-associated risk variant in distal enhancer of a-synuclein modulates target gene expression. Nature 2016;533:95–99.
    • (2016) Nature , vol.533 , pp. 95-99
    • Soldner, F.1    Stelzer, Y.2    Shivalila, C.S.3
  • 45
    • 84945401367 scopus 로고    scopus 로고
    • Standardized phenotyping enhances Mendelian disease gene identification
    • Vissers LELM, Veltman JA. Standardized phenotyping enhances Mendelian disease gene identification. Nat Genet 2015;47:1222–1224.
    • (2015) Nat Genet , vol.47 , pp. 1222-1224
    • Vissers, L.1    Veltman, J.A.2
  • 46
    • 84945319215 scopus 로고    scopus 로고
    • Discovery of four recessive developmental disorders using probabilistic genotype and phenotype matching among 4,125 families
    • Akawi N, McRae J, Ansari M et al. Discovery of four recessive developmental disorders using probabilistic genotype and phenotype matching among 4,125 families. Nat Genet 2015;47:1363–1369.
    • (2015) Nat Genet , vol.47 , pp. 1363-1369
    • Akawi, N.1    McRae, J.2    Ansari, M.3
  • 47
    • 84976597028 scopus 로고    scopus 로고
    • Prodromal clinical markers of Parkinson disease in Gaucher disease individuals
    • Gatto EM, Etcheverry JL, Sanguinetti A et al. Prodromal clinical markers of Parkinson disease in Gaucher disease individuals. Eur Neurol 2016;76:19–21.
    • (2016) Eur Neurol , vol.76 , pp. 19-21
    • Gatto, E.M.1    Etcheverry, J.L.2    Sanguinetti, A.3
  • 48
    • 84975110901 scopus 로고    scopus 로고
    • Strong association between glucocerebrosidase mutations and Parkinson’s disease in Sweden
    • Ran C, Brodin L, Forsgren L et al. Strong association between glucocerebrosidase mutations and Parkinson’s disease in Sweden. Neurobiol Aging 2016;45:212.e5-212.e11.
    • (2016) Neurobiol Aging , vol.45 , pp. 212.e5-212.e11
    • Ran, C.1    Brodin, L.2    Forsgren, L.3
  • 49
    • 70350319531 scopus 로고    scopus 로고
    • Multicenter analysis of glucocerebrosidase mutations in Parkinson’s disease
    • Sidransky E, Nalls MA, Aasly JO et al. Multicenter analysis of glucocerebrosidase mutations in Parkinson’s disease. N Engl J Med 2009;361:1651–1661.
    • (2009) N Engl J Med , vol.361 , pp. 1651-1661
    • Sidransky, E.1    Nalls, M.A.2    Aasly, J.O.3
  • 50
    • 33751183948 scopus 로고    scopus 로고
    • In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion
    • Chimienti F, Devergnas S, Pattou F et al. In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion. J Cell Sci 2006;119:4199–4206.
    • (2006) J Cell Sci , vol.119 , pp. 4199-4206
    • Chimienti, F.1    Devergnas, S.2    Pattou, F.3
  • 51
    • 75749086085 scopus 로고    scopus 로고
    • New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    • Dupuis J, Langenberg C, Prokopenko I et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010;42:105–116.
    • (2010) Nat Genet , vol.42 , pp. 105-116
    • Dupuis, J.1    Langenberg, C.2    Prokopenko, I.3
  • 52
    • 80053405321 scopus 로고    scopus 로고
    • Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes
    • Strawbridge RJ, Dupuis J, Prokopenko I et al. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes 2011;60:2624–2634.
    • (2011) Diabetes , vol.60 , pp. 2624-2634
    • Strawbridge, R.J.1    Dupuis, J.2    Prokopenko, I.3
  • 53
    • 84868337361 scopus 로고    scopus 로고
    • Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
    • Morris AP, Voight BF, Teslovich TM et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet 2012;44:981–990.
    • (2012) Nat Genet , vol.44 , pp. 981-990
    • Morris, A.P.1    Voight, B.F.2    Teslovich, T.M.3
  • 54
    • 84897407583 scopus 로고    scopus 로고
    • Loss-of-function mutations in SLC30A8 protect against type 2 diabetes
    • Flannick J, Thorleifsson G, Beer NL et al. Loss-of-function mutations in SLC30A8 protect against type 2 diabetes. Nat Genet 2014;46:357–363.
    • (2014) Nat Genet , vol.46 , pp. 357-363
    • Flannick, J.1    Thorleifsson, G.2    Beer, N.L.3
  • 55
    • 84969941163 scopus 로고    scopus 로고
    • Analysis of 589,306 genomes identifies individuals resilient to severe Mendelian childhood diseases
    • Chen R, Shi L, Hakenberg J et al. Analysis of 589,306 genomes identifies individuals resilient to severe Mendelian childhood diseases. Nat Biotechnol 2016;34:531–538.
    • (2016) Nat Biotechnol , vol.34 , pp. 531-538
    • Chen, R.1    Shi, L.2    Hakenberg, J.3


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