Toxic PRn poly-dipeptides encoded by the C9orf72 repeat expansion block nuclear import and export

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 7, 2017, Pages E1111-E1117

  Shi, Kevin Y ^a   Mori, Eiichiro ^a   Nizami, Zehra F ^b   Lin, Yi ^a   Kato, Masato ^a   Xiang, Siheng ^a   Wu, Leeju C ^a   Ding, Ming ^a   Yu, Yonghao ^a   Gall, Joseph G ^b   McKnight, Steven L ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b GEOPHYSICAL LABORATORY   (United States)

Author keywords

C9orf72 repeat expansion; FG domain; Labile cross polymers; Nuclear pore; PRn poly dipeptide

Indexed keywords

1,6 HEXANEDIOL; ALKANOL; DIPEPTIDE; GLYCINE; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; PHENYLALANINE; PROLINE ARGININE POLY DIPEPTIDE; UNCLASSIFIED DRUG; WHEAT GERM AGGLUTININ; BIOPOLYMER; C9ORF72 PROTEIN, HUMAN; GLYCOL; GUANINE NUCLEOTIDE EXCHANGE C9ORF72; NUCLEOPORIN; NUP98 PROTEIN, HUMAN; PROTEIN BINDING; REPETITIVE DNA;

AGAR GEL ELECTROPHORESIS; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS MEMBRANE; ESCHERICHIA COLI; HUMAN; IN SITU HYBRIDIZATION; IN VITRO STUDY; MACROMOLECULE; NONHUMAN; NUCLEAR EXPORT SIGNAL; NUCLEAR IMPORT; NUCLEAR PORE; NUCLEAR PORE COMPLEX; OOCYTE; PEPTIDE SYNTHESIS; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FOOTPRINTING; PROTEIN PURIFICATION; TRANSMISSION ELECTRON MICROSCOPY; X RAY DIFFRACTION; XENOPUS LAEVIS; ANIMAL; CHEMISTRY; CONFOCAL MICROSCOPY; DRUG EFFECTS; FEMALE; GENETICS; METABOLISM; NUCLEOCYTOPLASMIC TRANSPORT; PERMEABILITY; PROTEIN DOMAIN; ULTRASTRUCTURE;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; BIOPOLYMERS; C9ORF72 PROTEIN; DIPEPTIDES; DNA REPEAT EXPANSION; FEMALE; GLYCOLS; HUMANS; MICROSCOPY, CONFOCAL; NUCLEAR PORE; NUCLEAR PORE COMPLEX PROTEINS; OOCYTES; PERMEABILITY; PROTEIN BINDING; PROTEIN DOMAINS; WHEAT GERM AGGLUTININS; XENOPUS LAEVIS;

EID: 85012982029     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1620293114     Document Type: Article

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