Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110δ-Akt-Mediated Signals

Cell Metabolism

Volumn 25, Issue 3, 2017, Pages 593-609

  Mauro, Claudio ^a   Smith, Joanne ^a   Cucchi, Danilo ^a,b   Coe, David ^a   Fu, Hongmei ^a   Bonacina, Fabrizia ^c   Baragetti, Andrea ^c   Cermenati, Gaia ^c   Caruso, Donatella ^c   Mitro, Nico ^c   Catapano, Alberico L ^c,d   Ammirati, Enrico ^e   Longhi, Maria P ^a   Okkenhaug, Klaus ^f   Norata, Giuseppe D ^c,g   Marelli Berg, Federica M ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b Pasteur Institute   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d IRCCS MULTIMEDICA   (Italy)

^e OSPEDALE NIGUARDA CA GRANDA   (Italy)

^f BABRAHAM INSTITUTE   (United Kingdom)

^g CURTIN UNIVERSITY   (Australia)

Author keywords

Akt; CD4; differentiation; effector memory; high fat diet; inflammation; obesity; palmitate; saturated fatty acid; T lymphocyte

Indexed keywords

CHEMOKINE RECEPTOR CXCR3; GAMMA INTERFERON INDUCIBLE PROTEIN 10; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; PALMITIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P110; PROTEIN P110 DELTA; SECONDARY LYMPHOID TISSUE CHEMOKINE; UNCLASSIFIED DRUG; CXCR3 PROTEIN, HUMAN; FATTY ACID;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DENDRITIC CELL; DIET; DUAL ENERGY X RAY ABSORPTIOMETRY; ENZYME ACTIVATION; FATTY ACID OXIDATION; FEMALE; FLOW CYTOMETRY; HELPER CELL; HOST; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; LYMPHOCYTE COUNT; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE MIGRATION; LYMPHOCYTE SUBPOPULATION; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MALE; MEMORY T LYMPHOCYTE; METABOLIC STRESS; MOUSE; NONHUMAN; OBESITY; OXIDATIVE PHOSPHORYLATION; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPLEEN CELL; T LYMPHOCYTE ACTIVATION; ANIMAL; C57BL MOUSE; CELL DIFFERENTIATION; CELL MOTION; ENZYMOLOGY; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; INFLAMMATION; LIPID DIET; LYMPHOCYTE ACTIVATION; LYMPHOID TISSUE; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY; PHYSIOLOGICAL STRESS;

ADIPOSITY; ANIMALS; ANTIGEN PRESENTATION; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL MOVEMENT; DENDRITIC CELLS; DIET, HIGH-FAT; FATTY ACIDS; FEMALE; HUMANS; IMMUNOLOGIC MEMORY; INFLAMMATION; LYMPHOCYTE ACTIVATION; LYMPHOID TISSUE; MALE; MICE, INBRED C57BL; OBESITY; OXIDATION-REDUCTION; PHENOTYPE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, CXCR3; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL;

EID: 85012916415     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2017.01.008     Document Type: Article

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