Genetic or pharmaceutical blockade of phosphoinositide 3-kinase p110δ prevents chronic rejection of heart allografts

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Ying, Huijun ^a   Fu, Hongmei ^a   Rose, Marlene L ^b   McCormack, Ann M ^b   Sarathchandra, Padmini ^b   Okkenhaug, Klaus ^c   Marelli Berg, Federica M ^a,d  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b HAREFIELD HOSPITAL   (United Kingdom)

^c BABRAHAM INSTITUTE   (United Kingdom)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 (6 AMINO 9 PURINYLMETHYL) 5 METHYL 3 (2 METHYLPHENYL) 3H QUINAZOLIN 4 ONE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE P100 DELTA; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; ADENINE; DRUG DERIVATIVE; HY ANTIGEN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; QUINAZOLINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; CARDIAC GRAFT REJECTION; CELLULAR DISTRIBUTION; CHRONIC GRAFT REJECTION; CONTROLLED STUDY; DISEASE MODEL; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; FEMALE; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE MIGRATION; LYMPHOCYTIC INFILTRATION; MALE; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; SKIN TRANSPLANTATION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; ALLOTRANSPLANTATION; ANIMAL; C57BL MOUSE; CELL CULTURE; CHRONIC DISEASE; DRUG ANTAGONISM; DRUG EFFECT; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENETICS; GRAFT REJECTION; HUMAN; METABOLISM; METHODOLOGY; MOUSE MUTANT;

MURINAE;

ADENINE; ANIMALS; CELLS, CULTURED; CHRONIC DISEASE; CLASS IA PHOSPHATIDYLINOSITOL 3-KINASE; FEMALE; FLOW CYTOMETRY; GRAFT REJECTION; H-Y ANTIGEN; HEART TRANSPLANTATION; HUMANS; IMMUNE TOLERANCE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, FLUORESCENCE; QUINAZOLINES; SKIN TRANSPLANTATION; T-LYMPHOCYTES; TRANSPLANTATION, HOMOLOGOUS;

EID: 84859122857     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032892     Document Type: Article

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