메뉴 건너뛰기




Volumn 8, Issue JAN, 2017, Pages

Phosphatase Wip1 in immunity: An overview and update

Author keywords

Immunity; Inflammation; Signaling pathways; Tumorigenesis; Wild type p53 induced phosphatase 1

Indexed keywords

ATM PROTEIN; I KAPPA B; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN P53; PROTEIN PHOSPHATASE 2C; STAT1 PROTEIN; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; WILD TYPE P53 INDUCED PHOSPHATASE 1;

EID: 85012145920     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2017.00008     Document Type: Short Survey
Times cited : (21)

References (39)
  • 1
    • 0030925222 scopus 로고    scopus 로고
    • Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner
    • Fiscella M, Zhang H, Fan S, Sakaguchi K, Shen S, Mercer WE, et al. Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner. Proc Natl Acad Sci U S A (1997) 94(12):6048-53. doi: 10.1073/pnas.94.12.6048
    • (1997) Proc Natl Acad Sci U S A , vol.94 , Issue.12 , pp. 6048-6053
    • Fiscella, M.1    Zhang, H.2    Fan, S.3    Sakaguchi, K.4    Shen, S.5    Mercer, W.E.6
  • 2
    • 84863164879 scopus 로고    scopus 로고
    • Wip1-dependent signaling pathways in health and diseases
    • Zhu YH, Bulavin DV. Wip1-dependent signaling pathways in health and diseases. Prog Mol Biol Transl Sci (2012) 106:307-25. doi:10.1016/B978-0-12-396456-4.00001-8
    • (2012) Prog Mol Biol Transl Sci , vol.106 , pp. 307-325
    • Zhu, Y.H.1    Bulavin, D.V.2
  • 3
    • 34547702285 scopus 로고    scopus 로고
    • Wip1 phosphatase regulates p53-dependent apoptosis of stem cells and tumorigenesis in the mouse intestine
    • Demidov ON, Timofeev O, Lwin HN, Kek C, Appella E, Bulavin DV. Wip1 phosphatase regulates p53-dependent apoptosis of stem cells and tumorigenesis in the mouse intestine. Cell Stem Cell (2007) 1(2):180-90. doi:10.1016/j.stem.2007.05.020
    • (2007) Cell Stem Cell , vol.1 , Issue.2 , pp. 180-190
    • Demidov, O.N.1    Timofeev, O.2    Lwin, H.N.3    Kek, C.4    Appella, E.5    Bulavin, D.V.6
  • 4
    • 84903790666 scopus 로고    scopus 로고
    • Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging
    • Zhu Y, Demidov ON, Goh AM, Virshup DM, Lane DP, Bulavin DV. Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging. J Clin Invest (2014) 124(7):3263-73. doi:10.1172/JCI73015
    • (2014) J Clin Invest , vol.124 , Issue.7 , pp. 3263-3273
    • Zhu, Y.1    Demidov, O.N.2    Goh, A.M.3    Virshup, D.M.4    Lane, D.P.5    Bulavin, D.V.6
  • 5
    • 0036146455 scopus 로고    scopus 로고
    • Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control
    • Choi J, Nannenga B, Demidov ON, Bulavin DV, Cooney A, Brayton C, et al. Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control. Mol Cell Biol (2002) 22(4):1094-105. doi:10.1128/MCB.22.4.1094-1105.2002
    • (2002) Mol Cell Biol , vol.22 , Issue.4 , pp. 1094-1105
    • Choi, J.1    Nannenga, B.2    Demidov, O.N.3    Bulavin, D.V.4    Cooney, A.5    Brayton, C.6
  • 6
    • 3943107573 scopus 로고    scopus 로고
    • Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
    • Sancar A, Lindsey-Boltz LA, Unsal-Kacmaz K, Linn S. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem (2004) 73:39-85. doi:10.1146/annurev.biochem.73.011303.073723
    • (2004) Annu Rev Biochem , vol.73 , pp. 39-85
    • Sancar, A.1    Lindsey-Boltz, L.A.2    Unsal-Kacmaz, K.3    Linn, S.4
  • 7
    • 0034383398 scopus 로고    scopus 로고
    • p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation
    • Takekawa M, Adachi M, Nakahata A, Nakayama I, Itoh F, Tsukuda H, et al. p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation. EMBO J (2000) 19(23):6517-26. doi:10.1093/emboj/19.23.6517
    • (2000) EMBO J , vol.19 , Issue.23 , pp. 6517-6526
    • Takekawa, M.1    Adachi, M.2    Nakahata, A.3    Nakayama, I.4    Itoh, F.5    Tsukuda, H.6
  • 8
    • 42949171936 scopus 로고    scopus 로고
    • Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage
    • Batchelor E, Mock CS, Bhan I, Loewer A, Lahav G. Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage. Mol Cell (2008) 30(3):277-89. doi:10.1016/j.molcel.2008.03.016
    • (2008) Mol Cell , vol.30 , Issue.3 , pp. 277-289
    • Batchelor, E.1    Mock, C.S.2    Bhan, I.3    Loewer, A.4    Lahav, G.5
  • 9
    • 33748150967 scopus 로고    scopus 로고
    • Wip1 phosphatase modulates ATM-dependent signaling pathways
    • Shreeram S, Demidov ON, Hee WK, Yamaguchi H, Onishi N, Kek C, et al. Wip1 phosphatase modulates ATM-dependent signaling pathways. Mol Cell (2006) 23(5):757-64. doi:10.1016/j.molcel.2006.07.010
    • (2006) Mol Cell , vol.23 , Issue.5 , pp. 757-764
    • Shreeram, S.1    Demidov, O.N.2    Hee, W.K.3    Yamaguchi, H.4    Onishi, N.5    Kek, C.6
  • 10
    • 33745206498 scopus 로고    scopus 로고
    • Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase
    • Fujimoto H, Onishi N, Kato N, Takekawa M, Xu XZ, Kosugi A, et al. Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase. Cell Death Differ (2006) 13(7):1170-80. doi:10.1038/sj.cdd.4401801
    • (2006) Cell Death Differ , vol.13 , Issue.7 , pp. 1170-1180
    • Fujimoto, H.1    Onishi, N.2    Kato, N.3    Takekawa, M.4    Xu, X.Z.5    Kosugi, A.6
  • 11
    • 77952825226 scopus 로고    scopus 로고
    • Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response
    • Cha H, Lowe JM, Li H, Lee JS, Belova GI, Bulavin DV, et al. Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response. Cancer Res (2010) 70(10):4112-22. doi:10.1158/0008-5472.CAN-09-4244
    • (2010) Cancer Res , vol.70 , Issue.10 , pp. 4112-4122
    • Cha, H.1    Lowe, J.M.2    Li, H.3    Lee, J.S.4    Belova, G.I.5    Bulavin, D.V.6
  • 12
    • 77953572222 scopus 로고    scopus 로고
    • Dephosphorylation of gamma-H2AX by WIP1: an important homeostatic regulatory event in DNA repair and cell cycle control
    • Moon SH, Nguyen TA, Darlington Y, Lu X, Donehower LA. Dephosphorylation of gamma-H2AX by WIP1: an important homeostatic regulatory event in DNA repair and cell cycle control. Cell Cycle (2010) 9(11):2092-6. doi:10.4161/cc.9.11.11810
    • (2010) Cell Cycle , vol.9 , Issue.11 , pp. 2092-2096
    • Moon, S.H.1    Nguyen, T.A.2    Darlington, Y.3    Lu, X.4    Donehower, L.A.5
  • 13
    • 77951064789 scopus 로고    scopus 로고
    • Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition
    • Macurek L, Lindqvist A, Voets O, Kool J, Vos HR, Medema RH. Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition. Oncogene (2010) 29(15):2281-91. doi:10.1038/onc.2009.501
    • (2010) Oncogene , vol.29 , Issue.15 , pp. 2281-2291
    • Macurek, L.1    Lindqvist, A.2    Voets, O.3    Kool, J.4    Vos, H.R.5    Medema, R.H.6
  • 14
    • 33845893896 scopus 로고    scopus 로고
    • Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase
    • Shreeram S, Hee WK, Demidov ON, Kek C, Yamaguchi H, Fornace AJ Jr, et al. Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase. J Exp Med (2006) 203(13):2793-9. doi:10.1084/jem.20061563
    • (2006) J Exp Med , vol.203 , Issue.13 , pp. 2793-2799
    • Shreeram, S.1    Hee, W.K.2    Demidov, O.N.3    Kek, C.4    Yamaguchi, H.5    Fornace, A.J.6
  • 15
    • 18844405191 scopus 로고    scopus 로고
    • PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints
    • Lu X, Nannenga B, Donehower LA. PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints. Genes Dev (2005) 19(10):1162-74. doi:10.1101/gad.1291305
    • (2005) Genes Dev , vol.19 , Issue.10 , pp. 1162-1174
    • Lu, X.1    Nannenga, B.2    Donehower, L.A.3
  • 16
    • 4043117002 scopus 로고    scopus 로고
    • Wip1-deficient mice are resistant to common cancer genes
    • Harrison M, Li J, Degenhardt Y, Hoey T, Powers S. Wip1-deficient mice are resistant to common cancer genes. Trends Mol Med (2004) 10(8):359-61. doi:10.1016/j.molmed.2004.06.010
    • (2004) Trends Mol Med , vol.10 , Issue.8 , pp. 359-361
    • Harrison, M.1    Li, J.2    Degenhardt, Y.3    Hoey, T.4    Powers, S.5
  • 17
    • 1842483852 scopus 로고    scopus 로고
    • Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway
    • Bulavin DV, Phillips C, Nannenga B, Timofeev O, Donehower LA, Anderson CW, et al. Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway. Nat Genet (2004) 36(4):343-50. doi:10.1038/ng1317
    • (2004) Nat Genet , vol.36 , Issue.4 , pp. 343-350
    • Bulavin, D.V.1    Phillips, C.2    Nannenga, B.3    Timofeev, O.4    Donehower, L.A.5    Anderson, C.W.6
  • 18
    • 84971539859 scopus 로고    scopus 로고
    • Wip1 phosphatase: between p53 and MAPK kinases pathways
    • Goloudina AR, Kochetkova EY, Pospelova TV, Demidov ON. Wip1 phosphatase: between p53 and MAPK kinases pathways. Oncotarget (2016) 7(21):31563-71. doi:10.18632/oncotarget.7325
    • (2016) Oncotarget , vol.7 , Issue.21 , pp. 31563-31571
    • Goloudina, A.R.1    Kochetkova, E.Y.2    Pospelova, T.V.3    Demidov, O.N.4
  • 19
    • 34247099845 scopus 로고    scopus 로고
    • The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis
    • Demidov ON, Kek C, Shreeram S, Timofeev O, Fornace AJ, Appella E, et al. The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis. Oncogene (2007) 26(17):2502-6. doi:10.1038/sj.onc.1210032
    • (2007) Oncogene , vol.26 , Issue.17 , pp. 2502-2506
    • Demidov, O.N.1    Kek, C.2    Shreeram, S.3    Timofeev, O.4    Fornace, A.J.5    Appella, E.6
  • 21
    • 84928038734 scopus 로고    scopus 로고
    • Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways
    • Chen Z, Yi W, Morita Y, Wang H, Cong Y, Liu JP, et al. Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways. Nat Commun (2015) 6:6808. doi:10.1038/ncomms7808
    • (2015) Nat Commun , vol.6 , pp. 6808
    • Chen, Z.1    Yi, W.2    Morita, Y.3    Wang, H.4    Cong, Y.5    Liu, J.P.6
  • 22
    • 84929589913 scopus 로고    scopus 로고
    • Inhibition of wild-type p53-induced phosphatase 1 promotes liver regeneration in mice by direct activation of mammalian target of rapamycin
    • Zhang L, Liu L, He Z, Li G, Liu J, Song Z, et al. Inhibition of wild-type p53-induced phosphatase 1 promotes liver regeneration in mice by direct activation of mammalian target of rapamycin. Hepatology (2015) 61(6):2030-41. doi:10.1002/hep.27755
    • (2015) Hepatology , vol.61 , Issue.6 , pp. 2030-2041
    • Zhang, L.1    Liu, L.2    He, Z.3    Li, G.4    Liu, J.5    Song, Z.6
  • 23
    • 84872593818 scopus 로고    scopus 로고
    • Phosphatase Wip1 negatively regulates neutrophil development through p38 MAPK-STAT1
    • Liu G, Hu X, Sun B, Yang T, Shi J, Zhang L, et al. Phosphatase Wip1 negatively regulates neutrophil development through p38 MAPK-STAT1. Blood (2013) 121(3):519-29. doi:10.1182/blood-2012-05-432674
    • (2013) Blood , vol.121 , Issue.3 , pp. 519-529
    • Liu, G.1    Hu, X.2    Sun, B.3    Yang, T.4    Shi, J.5    Zhang, L.6
  • 24
    • 84893342386 scopus 로고    scopus 로고
    • Phosphatase Wip1 negatively regulates neutrophil migration and inflammation
    • Sun B, Hu X, Liu G, Ma B, Xu Y, Yang T, et al. Phosphatase Wip1 negatively regulates neutrophil migration and inflammation. J Immunol (2014) 192(3):1184-95. doi:10.4049/jimmunol.1300656
    • (2014) J Immunol , vol.192 , Issue.3 , pp. 1184-1195
    • Sun, B.1    Hu, X.2    Liu, G.3    Ma, B.4    Xu, Y.5    Yang, T.6
  • 25
    • 84970966357 scopus 로고    scopus 로고
    • Phosphatase Wip1 masters IL-17-producing neutrophil-mediated colitis in mice
    • Hu X, Wang P, Du J, Yang F, Tian Y, Shen X, et al. Phosphatase Wip1 masters IL-17-producing neutrophil-mediated colitis in mice. Inflamm Bowel Dis (2016) 22(6):1316-25. doi:10.1097/MIB.0000000000000751
    • (2016) Inflamm Bowel Dis , vol.22 , Issue.6 , pp. 1316-1325
    • Hu, X.1    Wang, P.2    Du, J.3    Yang, F.4    Tian, Y.5    Shen, X.6
  • 26
    • 84911045925 scopus 로고    scopus 로고
    • Phosphatase Wip1 as a new therapeutic target for intestinal ischemia-reperfusion injury
    • Shen X, Du J, Zhao Y, Guan W. Phosphatase Wip1 as a new therapeutic target for intestinal ischemia-reperfusion injury. Expert Rev Clin Immunol (2014) 10(12):1591-5. doi:10.1586/1744666X.2014.975211
    • (2014) Expert Rev Clin Immunol , vol.10 , Issue.12 , pp. 1591-1595
    • Shen, X.1    Du, J.2    Zhao, Y.3    Guan, W.4
  • 27
    • 33645763906 scopus 로고    scopus 로고
    • Wip1 phosphatase-deficient mice exhibit defective T cell maturation due to sustained p53 activation
    • Schito ML, Demidov ON, Saito S, Ashwell JD, Appella E. Wip1 phosphatase-deficient mice exhibit defective T cell maturation due to sustained p53 activation. J Immunol (2006) 176(8):4818-25. doi:10.4049/jimmunol.176.8.4818
    • (2006) J Immunol , vol.176 , Issue.8 , pp. 4818-4825
    • Schito, M.L.1    Demidov, O.N.2    Saito, S.3    Ashwell, J.D.4    Appella, E.5
  • 28
    • 77958126305 scopus 로고    scopus 로고
    • Transcriptional regulation of thymus organogenesis and thymic epithelial cell differentiation
    • Manley NR, Condie BG. Transcriptional regulation of thymus organogenesis and thymic epithelial cell differentiation. Prog Mol Biol Transl Sci (2010) 92:103-20. doi:10.1016/S1877-1173(10)92005-X
    • (2010) Prog Mol Biol Transl Sci , vol.92 , pp. 103-120
    • Manley, N.R.1    Condie, B.G.2
  • 29
    • 33745532385 scopus 로고    scopus 로고
    • Formation of a functional thymus initiated by a postnatal epithelial progenitor cell
    • Bleul CC, Corbeaux T, Reuter A, Fisch P, Monting JS, Boehm T. Formation of a functional thymus initiated by a postnatal epithelial progenitor cell. Nature (2006) 441(7096):992-6. doi:10.1038/nature04850
    • (2006) Nature , vol.441 , Issue.7096 , pp. 992-996
    • Bleul, C.C.1    Corbeaux, T.2    Reuter, A.3    Fisch, P.4    Monting, J.S.5    Boehm, T.6
  • 30
    • 84884273176 scopus 로고    scopus 로고
    • Phosphatase Wip1 is essential for the maturation and homeostasis of medullary thymic epithelial cells in mice
    • Sun L, Li H, Luo H, Zhang L, Hu X, Yang T, et al. Phosphatase Wip1 is essential for the maturation and homeostasis of medullary thymic epithelial cells in mice. J Immunol (2013) 191(6):3210-20. doi:10.4049/jimmunol.1300363
    • (2013) J Immunol , vol.191 , Issue.6 , pp. 3210-3220
    • Sun, L.1    Li, H.2    Luo, H.3    Zhang, L.4    Hu, X.5    Yang, T.6
  • 31
    • 0035056376 scopus 로고    scopus 로고
    • B cell development pathways
    • Hardy RR, Hayakawa K. B cell development pathways. Annu Rev Immunol (2001) 19:595-621. doi:10.1146/annurev.immunol.19.1.595
    • (2001) Annu Rev Immunol , vol.19 , pp. 595-621
    • Hardy, R.R.1    Hayakawa, K.2
  • 32
    • 84893414788 scopus 로고    scopus 로고
    • Signaling circuits in early B-cell development
    • Reth M, Nielsen P. Signaling circuits in early B-cell development. Adv Immunol (2014) 122:129-75. doi:10.1016/B978-0-12-800267-4.00004-3
    • (2014) Adv Immunol , vol.122 , pp. 129-175
    • Reth, M.1    Nielsen, P.2
  • 33
    • 84940099839 scopus 로고    scopus 로고
    • Phosphatase Wip1 controls antigen-independent B-cell development in a p53-dependent manner
    • Yi W, Hu X, Chen Z, Liu L, Tian Y, Chen H, et al. Phosphatase Wip1 controls antigen-independent B-cell development in a p53-dependent manner. Blood (2015) 126(5):620-8. doi:10.1182/blood-2015-02-624114
    • (2015) Blood , vol.126 , Issue.5 , pp. 620-628
    • Yi, W.1    Hu, X.2    Chen, Z.3    Liu, L.4    Tian, Y.5    Chen, H.6
  • 34
    • 0032773042 scopus 로고    scopus 로고
    • Regulation of cell survival during B lymphopoiesis: suppressed apoptosis of pro-B cells in P53-deficient mouse bone marrow
    • Lu L, Lejtenyi D, Osmond DG. Regulation of cell survival during B lymphopoiesis: suppressed apoptosis of pro-B cells in P53-deficient mouse bone marrow. Eur J Immunol (1999) 29(8):2484-90. doi:10.1002/(SICI)1521-4141(199908)29:08<2484::AID-IMMU2484>3.0.CO;2-B
    • (1999) Eur J Immunol , vol.29 , Issue.8 , pp. 2484-2490
    • Lu, L.1    Lejtenyi, D.2    Osmond, D.G.3
  • 35
    • 0033557693 scopus 로고    scopus 로고
    • Regulation of cell survival during B lymphopoiesis: apoptosis and Bcl-2/Bax content of precursor B cells in bone marrow of mice with altered expression of IL-7 and recombinase-activating gene-2
    • Lu L, Chaudhury P, Osmond DG. Regulation of cell survival during B lymphopoiesis: apoptosis and Bcl-2/Bax content of precursor B cells in bone marrow of mice with altered expression of IL-7 and recombinase-activating gene-2. J Immunol (1999) 162(4):1931-40.
    • (1999) J Immunol , vol.162 , Issue.4 , pp. 1931-1940
    • Lu, L.1    Chaudhury, P.2    Osmond, D.G.3
  • 36
    • 0035936802 scopus 로고    scopus 로고
    • Atherosclerosis: the road ahead
    • Glass CK, Witztum JL. Atherosclerosis: the road ahead. Cell (2001) 104(4):503-16. doi:10.1016/S0092-8674(01)00238-0
    • (2001) Cell , vol.104 , Issue.4 , pp. 503-516
    • Glass, C.K.1    Witztum, J.L.2
  • 37
    • 84922320237 scopus 로고    scopus 로고
    • Wip1-deficient neutrophils significantly promote intestinal ischemia/reperfusion injury in mice
    • Du J, Shen X, Zhao Y, Hu X, Sun B, Guan W, et al. Wip1-deficient neutrophils significantly promote intestinal ischemia/reperfusion injury in mice. Curr Mol Med (2015) 15(1):100-8. doi:10.2174/1566524015666150114122929
    • (2015) Curr Mol Med , vol.15 , Issue.1 , pp. 100-108
    • Du, J.1    Shen, X.2    Zhao, Y.3    Hu, X.4    Sun, B.5    Guan, W.6
  • 38
    • 84885954924 scopus 로고    scopus 로고
    • Wip1 phosphatase involved in lipopolysaccharide-induced neuroinflammation
    • Tan X, Zhang J, Jin W, Li L, Xu W, Zheng H, et al. Wip1 phosphatase involved in lipopolysaccharide-induced neuroinflammation. J Mol Neurosci (2013) 51(3):959-66. doi:10.1007/s12031-013-0080-y
    • (2013) J Mol Neurosci , vol.51 , Issue.3 , pp. 959-966
    • Tan, X.1    Zhang, J.2    Jin, W.3    Li, L.4    Xu, W.5    Zheng, H.6
  • 39
    • 84969793383 scopus 로고    scopus 로고
    • Up-regulation of Wip1 involves in neuroinflammation of retinal astrocytes after optic nerve crush via NF-kappaB signaling pathway
    • Zhong H, Cui L, Xu F, Chen L, Jiang L, Huang H, et al. Up-regulation of Wip1 involves in neuroinflammation of retinal astrocytes after optic nerve crush via NF-kappaB signaling pathway. Inflamm Res (2016) 65(9):709-15. doi:10.1007/s00011-016-0952-z
    • (2016) Inflamm Res , vol.65 , Issue.9 , pp. 709-715
    • Zhong, H.1    Cui, L.2    Xu, F.3    Chen, L.4    Jiang, L.5    Huang, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.