The HIV proteins tat and nef promote human bone marrow mesenchymal stem cell senescence and alter osteoblastic differentiation

Aging Cell

Volumn 14, Issue 4, 2015, Pages 534-546

  Beaupere, Carine ^a,b,c   Garcia, Marie ^a,b,c   Larghero, Jerome ^d,e,f   Fève, Bruno ^a,b,c,g   Capeau, Jacqueline ^a,b,c,h   Lagathu, Claire ^a,b,c  

^a SORBONNE UNIVERSITÉ   (France)

^b CENTRE DE RECHERCHE SAINT ANTOINE   (France)

^c Institute of Cardiometabolism and Nutrition (ICAN)   (France)

^d INSERM   (France)

^e SAINT LOUIS HOSPITAL   (France)

^f UNIVERSITÉ PARIS DESCARTES   (France)

^g HÔPITAL SAINT ANTOINE   (France)

^h HÔPITAL TENON   (France)

Author keywords

Autophagy; HIV proteins; Inflammation; Osteoblastic differentiation; Oxidative stress; Senescence

Indexed keywords

ACETYLCYSTEINE; CHEMOKINE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; NEF PROTEIN; PARTHENOLIDE; RAPAMYCIN; TRANSACTIVATOR PROTEIN; ANTIOXIDANT; IL6 PROTEIN, HUMAN; OSTEOCALCIN; RECOMBINANT PROTEIN; SESQUITERPENE;

ARTICLE; AUTOPHAGY; BONE DENSITY; BONE MARROW DERIVED MESENCHYMAL STEM CELL; BONE MASS; BONE TURNOVER; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE RELEASE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; IN VITRO STUDY; INFLAMMATION; OSTEOBLAST; OSTEOPENIA; OSTEOPOROSIS; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PREVALENCE; PRIORITY JOURNAL; SENESCENCE; ANTAGONISTS AND INHIBITORS; BONE MARROW CELL; CELL AGING; CELL PROLIFERATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; MESENCHYMAL STROMA CELL; METABOLISM; MITOCHONDRION; PATHOLOGY; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION;

ACETYLCYSTEINE; ANTIOXIDANTS; AUTOPHAGY; BONE MARROW CELLS; CELL AGING; CELL DIFFERENTIATION; CELL PROLIFERATION; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; MESENCHYMAL STROMAL CELLS; MITOCHONDRIA; NEF GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; NF-KAPPA B; OSTEOBLASTS; OSTEOCALCIN; OXIDATIVE STRESS; PRIMARY CELL CULTURE; RECOMBINANT PROTEINS; SESQUITERPENES; SIGNAL TRANSDUCTION; SIROLIMUS; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS;

EID: 85012045987     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12308     Document Type: Article

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