Autophagy and HIV

Seminars in Cell and Developmental Biology

Volumn 21, Issue 7, 2010, Pages 712-718

  Dinkins, Christina ^a   Arko Mensah, John ^a   Deretic, Vojo ^a  

^a UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

Author keywords

Autophagy; Cvt; Gag; HIV; Nef

Indexed keywords

BECLIN 1; GAG PROTEIN; NEF PROTEIN; PROTEASOME;

AUTOPHAGY; CYTOSOL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION RESISTANCE; MITOCHONDRION; NONHUMAN; PROTEIN DEGRADATION; PROTEIN MOTIF; PROTEIN TRANSPORT; REVIEW; VIROGENESIS; VIRUS RESISTANCE;

EUKARYOTA; HUMAN IMMUNODEFICIENCY VIRUS; PROTOZOA;

EID: 77956179172     PISSN: 10849521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semcdb.2010.04.004     Document Type: Review

References (95)

1. He C., Klionsky D.J. Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 2009.
2. Kroemer G., Levine B. Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol 2008, 9:1004-1010.
3. Deretic V., Levine B. Autophagy, immunity, and microbial adaptations. Cell Host Microbe 2009, 5:527-549.
4. Tatsuta T., Langer T. Quality control of mitochondria: protection against neurodegeneration and ageing. EMBO J 2008, 27:306-314.
5. Mizushima N., Yoshimori T., Levine B. Methods in mammalian autophagy research. Cell 2010, 140:313-326.
6. Mizushima N. The role of the Atg1/ULK1 complex in autophagy regulation. Curr Opin Cell Biol 2010.
7. He C., Levine B. The Beclin 1 interactome. Curr Opin Cell Biol 2010.
8. Hayashi-Nishino M., Fujita N., Noda T., Yamaguchi A., Yoshimori T., Yamamoto A. A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation. Nat Cell Biol 2009.
9. Axe E.L., Walker S.A., Manifava M., Chandra P., Roderick H.L., Habermann A., et al. Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol 2008, 182:685-701.
10. Fujita N., Hayashi-Nishino M., Fukumoto H., Omori H., Yamamoto A., Noda T., et al. An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure. Mol Biol Cell 2008, 19:4651-4659.
11. Zhang J., Ney P.A. Role of BNIP3 and NIX in cell death, autophagy, and mitophagy. Cell Death Differ 2009, 16:939-946.
12. Deretic V. Autophagy in infection. Curr Opin Cell Biol 2010.
13. Yoshikawa Y., Ogawa M., Hain T., Yoshida M., Fukumatsu M., Kim M., et al. Listeria monocytogenes ActA-mediated escape from autophagic recognition. Nat Cell Biol 2009, 11:1233-1240.
14. Zheng Y.T., Shahnazari S., Brech A., Lamark T., Johansen T., Brumell J.H. The adaptor protein p62/SQSTM1 targets invading bacteria to the autophagy pathway. J Immunol 2009, 183:5909-5916.
15. Thurston T.L., Ryzhakov G., Bloor S., von Muhlinen N., Randow F. The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria. Nat Immunol 2009, 10:1215-1221.
16. Orvedahl A., Macpherson S., Sumpter R., Tallóczy Z., Zou Z., Levine B. Autophagy protects against sindbis virus infection of the central nervous system. Cell Host Microbe 2010, 7:115-127.
17. Ponpuak M., Davis A.S., Roberts E.A., Delgado M.A., Dinkins C., Zhao Z., et al. Delivery of cytosolic components by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial properties. Immunity 2010.
18. Delgado M.A., Elmaoued R.A., Davis A.S., Kyei G., Deretic V. Toll-like receptors control autophagy. EMBO J 2008, 27:1110-1121.
19. Yano T., Mita S., Ohmori H., Oshima Y., Fujimoto Y., Ueda R., et al. Autophagic control of listeria through intracellular innate immune recognition in drosophila. Nat Immunol 2008, 9:908-916.
20. Travassos L.H., Carneiro L.A., Ramjeet M., Hussey S., Kim Y.G., Magalhaes J.G., et al. Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol 2009.
21. Tormo D., Checinska A., Alonso-Curbelo D., Perez-Guijarro E., Canon E., Riveiro-Falkenbach E., et al. Targeted activation of innate immunity for therapeutic induction of autophagy and apoptosis in melanoma cells. Cancer Cell 2009, 16:103-114.
22. Biswas D., Qureshi O.S., Lee W.Y., Croudace J.E., Mura M., Lammas D.A. ATP-induced autophagy is associated with rapid killing of intracellular mycobacteria within human monocytes/macrophages. BMC Immunol 2008, 9:35.
23. Chaturvedi A., Dorward D., Pierce S.K. The B cell receptor governs the subcellular location of Toll-like receptor 9 leading to hyperresponses to DNA-containing antigens. Immunity 2008, 28:799-809.
24. Gutierrez M.G., Master S.S., Singh S.B., Taylor G.A., Colombo M.I., Deretic V. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell 2004, 119:753-766.
25. Feng C.G., Weksberg D.C., Taylor G.A., Sher A., Goodell M.A. The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation. Cell Stem Cell 2008, 2:83-89.
26. Zhao Z., Fux B., Goodwin M., Dunay I.R., Strong D., Miller B.C., et al. Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens. Cell Host Microbe 2008, 4:458-469.
27. Singh S.B., Davis A.S., Taylor G.A., Deretic V. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science 2006, 313:1438-1441.
28. Parkes M., Barrett J.C., Prescott N.J., Tremelling M., Anderson C.A., Fisher S.A., et al. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet 2007, 39:830-832.
29. Intemann C.D., Thye T., Niemann S., Browne E.N., Amanua Chinbuah M., Enimil A., et al. Autophagy gene variant IRGM-261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains. PLoS Pathog 2009, 5:e1000577.
30. Harris J., De Haro S.A., Master S.S., Keane J., Roberts E.A., Delgado M., et al. T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis. Immunity 2007, 27:505-517.
31. Paludan C., Schmid D., Landthaler M., Vockerodt M., Kube D., Tuschl T., et al. Endogenous MHC class II processing of a viral nuclear antigen after autophagy. Science 2005, 307:593-596.
32. English L., Chemali M., Duron J., Rondeau C., Laplante A., Gingras D., et al. Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection. Nat Immunol 2009.
33. Nedjic J., Aichinger M., Emmerich J., Mizushima N., Klein L. Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance. Nature 2008, 455:396-400.
34. Jagannath C., Lindsey D.R., Dhandayuthapani S., Xu Y., Hunter R.L., Eissa N.T. Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells. Nat Med 2009, 15:267-276.
35. Brass A.L., Dykxhoorn D.M., Benita Y., Yan N., Engelman A., Xavier R.J., et al. Identification of host proteins required for HIV infection through a functional genomic screen. Science 2008, 319:921-926.
36. Zhou D., Spector S.A. Human immunodeficiency virus type-1 infection inhibits autophagy. AIDS 2008, 22:695-699.
37. Kyei G.B., Dinkins C., Davis A.S., Roberts E., Singh S.B., Dong C., et al. Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages. J Cell Biol 2009, 186:255-268.
38. Espert L., Varbanov M., Robert-Hebmann V., Sagnier S., Robbins I., Sanchez F., et al. Differential role of autophagy in CD4 T cells and macrophages during X4 and R5 HIV-1 infection. PLoS One 2009, 4:e5787.
39. Espert L., Denizot M., Grimaldi M., Robert-Hebmann V., Gay B., Varbanov M., et al. Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4. J Clin Invest 2006, 116:2161-2172.
40. Alirezaei M., Kiosses W.B., Flynn C.T., Brady N.R., Fox H.S. Disruption of neuronal autophagy by infected microglia results in neurodegeneration. PLoS One 2008, 3:e2906.
41. Lai S.K., Hida K., Shukair S., Wang Y.Y., Figueiredo A., Cone R., et al. Human immunodeficiency virus type 1 is trapped by acidic but not by neutralized human cervicovaginal mucus. J Virol 2009, 83:11196-11200.
42. Haase A.T. Targeting early infection to prevent HIV-1 mucosal transmission. Nature 2010, 464:217-223.
43. Wu L., KewalRamani V.N. Dendritic-cell interactions with HIV: infection and viral dissemination. Nat Rev Immunol 2006, 6:859-868.
44. Yu H.J., Reuter M.A., McDonald D. HIV traffics through a specialized, surface-accessible intracellular compartment during trans-infection of T cells by mature dendritic cells. PLoS Pathog 2008, 4:e1000134.
45. Piguet V., Sattentau Q. Dangerous liaisons at the virological synapse. J Clin Invest 2004, 114:605-610.
46. Sherer N.M., Lehmann M.J., Jimenez-Soto L.F., Horensavitz C., Pypaert M., Mothes W. Retroviruses can establish filopodial bridges for efficient cell-to-cell transmission. Nat Cell Biol 2007, 9:310-315.
47. Rudnicka D., Feldmann J., Porrot F., Wietgrefe S., Guadagnini S., Prevost M.C., et al. Simultaneous cell-to-cell transmission of human immunodeficiency virus to multiple targets through polysynapses. J Virol 2009, 83:6234-6246.
48. Malim M.H. APOBEC proteins and intrinsic resistance to HIV-1 infection. Philos Trans R Soc Lond B Biol Sci 2009, 364:675-687.
49. Stremlau M., Owens C.M., Perron M.J., Kiessling M., Autissier P., Sodroski J. The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys. Nature 2004, 427:848-853.
50. Johnson W.E., Sawyer S.L. Molecular evolution of the antiretroviral TRIM5 gene. Immunogenetics 2009, 61:163-176.
51. Brenchley J.M., Schacker T.W., Ruff L.E., Price D.A., Taylor J.H., Beilman G.J., et al. CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J Exp Med 2004, 200:749-759.
52. Lackner A.A., Mohan M., Veazey R.S. The gastrointestinal tract and AIDS pathogenesis. Gastroenterology 2009, 136:1965-1978.
53. Gao X., Nelson G.W., Karacki P., Martin M.P., Phair J., Kaslow R., et al. Effect of a single amino acid change in MHC class I molecules on the rate of progression to AIDS. N Engl J Med 2001, 344:1668-1675.
54. Thomas R., Apps R., Qi Y., Gao X., Male V., O'HUigin C., et al. HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C. Nat Genet 2009, 41:1290-1294.
55. Alter G., Altfeld M. NK cells in HIV-1 infection: evidence for their role in the control of HIV-1 infection. J Intern Med 2009, 265:29-42.
56. + T cell response against HIV-1. PLoS Med 2006, 3:e403.
57. Perfettini J.L., Castedo M., Roumier T., Andreau K., Nardacci R., Piacentini M., et al. Mechanisms of apoptosis induction by the HIV-1 envelope. Cell Death Differ 2005, 12(Suppl 1):916-923.
58. Nishimura Y., Brown C.R., Mattapallil J.J., Igarashi T., Buckler-White A., Lafont B.A., et al. Resting naive CD4+ T cells are massively infected and eliminated by X4-tropic simian-human immunodeficiency viruses in macaques. Proc Natl Acad Sci USA 2005, 102:8000-8005.
59. Muthumani K., Choo A.Y., Hwang D.S., Premkumar A., Dayes N.S., Harris C., et al. HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation. Blood 2005, 106:2059-2068.
60. Varbanov M., Espert L., Biard-Piechaczyk M. Mechanisms of CD4 T-cell depletion triggered by HIV-1 viral proteins. AIDS Rev 2006, 8:221-236.
61. Zhou Y., Shen L., Yang H.C., Siliciano R.F. Preferential cytolysis of peripheral memory CD4+ T cells by in vitro X4-tropic human immunodeficiency virus type 1 infection before the completion of reverse transcription. J Virol 2008, 82:9154-9163.
62. Brenchley J.M., Price D.A., Schacker T.W., Asher T.E., Silvestri G., Rao S., et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 2006, 12:1365-1371.
63. Said E.A., Dupuy F.P., Trautmann L., Zhang Y., Shi Y., El-Far M., et al. Programmed death-1-induced interleukin-10 production by monocytes impairs CD4(+) T cell activation during HIV infection. Nat Med 2010.
64. Maldarelli F., Palmer S., King M.S., Wiegand A., Polis M.A., Mican J., et al. ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia. PLoS Pathog 2007, 3:e46.
65. van Lunzen J., Hoffmann C. Virological rebound and its consequences during treatment interruption. Curr Opin HIV AIDS 2007, 2:1-5.
66. Denizot M., Varbanov M., Espert L., Robert-Hebmann V., Sagnier S., Garcia E., et al. HIV-1 gp41 fusogenic function triggers autophagy in uninfected cells. Autophagy 2008, 4:998-1008.
67. Molina L., Grimaldi M., Robert-Hebmann V., Espert L., Varbanov M., Devaux C., et al. Proteomic analysis of the cellular responses induced in uninfected immune cells by cell-expressed X4 HIV-1 envelope. Proteomics 2007, 7:3116-3130.
68. Espert L., Biard-Piechaczyk M. Autophagy in HIV-induced T cell death. Curr Top Microbiol Immunol 2009, 335:307-321.
69. Espert L., Codogno P., Biard-Piechaczyk M. What is the role of autophagy in HIV-1 infection?. Autophagy 2008, 4:273-275.
70. Espert L., Denizot M., Grimaldi M., Robert-Hebmann V., Gay B., Varbanov M., et al. Autophagy and CD4+ T lymphocyte destruction by HIV-1. Autophagy 2007, 3:32-34.
71. Alirezaei M., Kiosses W.B., Fox H.S. Decreased neuronal autophagy in HIV dementia: a mechanism of indirect neurotoxicity. Autophagy 2008, 4:963-966.
72. Gougeon M.L., Piacentini M. New insights on the role of apoptosis and autophagy in HIV pathogenesis. Apoptosis 2009, 14:501-508.
73. Kirchhoff F., Greenough T.C., Brettler D.B., Sullivan J.L., Desrosiers R.C. Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. N Engl J Med 1995, 332:228-232.
74. Deacon N.J., Tsykin A., Solomon A., Smith K., Ludford-Menting M., Hooker D.J., et al. Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients. Science 1995, 270:988-991.
75. Daniel M.D., Kirchhoff F., Czajak S.C., Sehgal P.K., Desrosiers R.C. Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene. Science 1992, 258:1938-1941.
76. Peterlin B.M. Nef: out and in?. Nat Immunol 2006, 7:229-230.
77. Roeth J.F., Collins K.L. Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathways. Microbiol Mol Biol Rev 2006, 70:548-563.
78. Schindler M., Munch J., Kutsch O., Li H., Santiago M.L., Bibollet-Ruche F., et al. Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1. Cell 2006, 125:1055-1067.
79. Schindler M., Schmokel J., Specht A., Li H., Munch J., Khalid M., et al. Inefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+ T cells in natural SIV infection. PLoS Pathog 2008, 4:e1000107.
80. Stumptner-Cuvelette P., Jouve M., Helft J., Dugast M., Glouzman A.S., Jooss K., et al. Human immunodeficiency virus-1 Nef expression induces intracellular accumulation of multivesicular bodies and major histocompatibility complex class II complexes: potential role of phosphatidylinositol 3-kinase. Mol Biol Cell 2003, 14:4857-4870.
81. Sandrin V., Cosset F.L. Intracellular versus cell surface assembly of retroviral pseudotypes is determined by the cellular localization of the viral glycoprotein, its capacity to interact with Gag, and the expression of the Nef protein. J Biol Chem 2006, 281:528-542.
82. Sanfridson A., Hester S., Doyle C. Nef proteins encoded by human and simian immunodeficiency viruses induce the accumulation of endosomes and lysosomes in human T cells. Proc Natl Acad Sci USA 1997, 94:873-878.
83. Piguet V., Gu F., Foti M., Demaurex N., Gruenberg J., Carpentier J.L., et al. Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes. Cell 1999, 97:63-73.
84. Bentham M., Mazaleyrat S., Harris M. Role of myristoylation and N-terminal basic residues in membrane association of the human immunodeficiency virus type 1 Nef protein. J Gen Virol 2006, 87:563-571.
85. Deretic V. Strange bedfellows expose ancient secrets of autophagy in immunity. Immunity 2009, 30:479-481.
86. Gannage M., Dorman D., Albrecht R., Dengjel J., Torrosi T., Ramer P., et al. Matrix protein 2 of influenza A virus blocks autophagosome fusion with lysosomes. Cell Host and Microbe 2009, 6:367-380.
87. Orvedahl A., Alexander D., Tallóczy Z., Sun Q., Wei Y., Zhang W., et al. HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein. Cell Host Microbe 2007, 1:23-35.
88. Ku B., Woo J.S., Liang C., Lee K.H., Hong H.S., Kim K.S., et al. Structural and biochemical bases for the inhibition of autophagy and apoptosis by viral BCL-2 of murine γ-herpesvirus 68. PLoS Pathog 2008, 4:e25.
89. Sinha S., Colbert C.L., Becker N., Wei Y., Levine B. Molecular basis of the regulation of Beclin 1-dependent autophagy by the γ-herpesvirus 68 Bcl-2 homolog M11. Autophagy 2008, 4:989-997.
90. Xiaofei E., Hwang S., Oh S., Lee J.S., Jeong J.H., Gwack Y., et al. Viral Bcl-2-mediated evasion of autophagy aids chronic infection of γ herpesvirus 68. PLoS Pathog 2009, 5:e1000609.
91. Lee J.S., Li Q., Lee J.Y., Lee S.H., Jeong J.H., Lee H.R., et al. FLIP-mediated autophagy regulation in cell death control. Nat Cell Biol 2009, 11:1355-1362.
92. Deneka M., Pelchen-Matthews A., Byland R., Ruiz-Mateos E., Marsh M. In macrophages, HIV-1 assembles into an intracellular plasma membrane domain containing the tetraspanins CD81, CD9, and CD53. J Cell Biol 2007, 177:329-341.
93. Shintani T., Huang W.-P., Stromhaug P.E., Klionsky D.J. Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway. Dev Cell 2002, 3:825-837.
94. Lynch-Day M.A., Klionsky D.J. The Cvt pathway as a model for selective autophagy. FEBS Lett 2010.
95. Blanchet F., Moris A., Nikolic D., Lehmann M., Cardinaud S., Stadler R., et al. Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses. Immunity 2010, 32:1-16.