Decreased bone formative and enhanced resorptive markers in human immunodeficiency virus infection: Indication of normalization of the bone- remodeling process during highly active antiretroviral therapy

Journal of Clinical Endocrinology and Metabolism

Volumn 84, Issue 1, 1999, Pages 145-150

  Aukrust, Pål ^a   Haug, Charlotte J ^c   Ueland, Thor ^a   Lien, Egil ^b   Müller, Fredrik ^a   Espevik, Terje ^b   Bollerslev, Jens ^a   Frøland, Stig S ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CALCITRIOL; DIDANOSINE; INDINAVIR; LAMIVUDINE; OSTEOCALCIN; PARATHYROID HORMONE; PEPTIDE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; ZIDOVUDINE;

ADULT; ARTICLE; BONE METABOLISM; BONE REMODELING; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; OSSIFICATION; OSTEOLYSIS; PRIORITY JOURNAL; VIRUS LOAD; VITAMIN D DEFICIENCY;

ADULT; ANTI-HIV AGENTS; BONE DEVELOPMENT; BONE REMODELING; BONE RESORPTION; CALCITRIOL; COLLAGEN; COLLAGEN TYPE I; CROSS-SECTIONAL STUDIES; FEMALE; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; OSTEOCALCIN; PEPTIDES; RECEPTORS, TUMOR NECROSIS FACTOR;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0032901916     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.84.1.145     Document Type: Article

References (31)

1. 1. Alsina M, Guise TA, Roodman GD. 1996 Cytokine regulation of bone cell differentiation. Vitam Horm. 52:63-98.
2. 2. Manolagas SD. 1995 Role of cytokines in bone resorption. Bone. 17(Suppl):63S-67S.
3. 3. Roodman GD. 1993 Role of cytokines in the regulation of bone resorption. Calcif Tissue Int. 53(Suppl 1):S94-S98.
4. 4. Pacifici R. 1996 Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis. J Bone Miner Res. 11:1043-1051.
5. 5. Poli V, Balenea R, Fattori E, et al. 1994 Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO J. 13:1189-1196.
6. 6. Nguyen L, Dewhirst FE, Hauschka PV, Stashenko P. 1991 Interleukin-1β stimulates bone resorption and inhibits bone formation in vivo. Lymphokine Cytokine Res. 10:15-21.
7. 7. Panagakos FS, Hinojosa LP, Kumar S. 1994 Formation and mineralization of extracellular matrix secreted by an immortal human osteoblastic cell line: modulation by tumor necrosis factor-α. Inflammation. 18:267-284.
8. 8. Dalgleish AG. 1995 The immune response to HIV: potential for immunotherapy? Immunol Today. 16:56-58.
9. 9. Aukrust P, Liabakk N-B, Müller F, Lien E, Espevik T, Froland SS. 1994 Serum levels of tumor necrosis factor (TNF)α and soluble TNF receptors in human immunodeficiency virus type 1 infection-correlations to clinical, immunologic, and virologic parameters. J Infect Dis. 169:420-424.
10. 10. Fauci AS. 1996 Host factors and the pathogenesis of HIV-induced disease. Nature. 384:529-534.
11. 11. Matsuyama T, Kobayashi N, Yamamoto N. 1991 Cytokines and HIV infection: is AIDS a tumor necrosis factor disease? AIDS. 5:1405-1417.
12. 12. Hofbauer LC, Heufelder AE. 1996 Endocrine implications of human immunodeficiency virus infection. Medicine. 75:262-278.
13. 13. Besedovsky HO, del Rey A. 1996 Immune-neuro-endocrine interactions: facts and hypothesis. Endocr Rev. 17:64-102.
14. 3 in HIV infection: correlation with degree of immunodeficiency and survival. J Infect Dis. 169:889-893.
15. 15. Haug CJ, Aukrust P, Lien E, Müller F, Espevik T, Frøland SS. 1996 Disseminated Mycobacterium avium complex infection in AIDS: immunopathogenic significance of an activated tumor necrosis factor system and depressed serum levels of 1,25 dihydroxyvitamin D. J Infect Dis. 173:259-262.
16. 3 in HIV-infection-association with immunological hyperactivity and only minor changes in calcium homeostasis. J Clin Endocrinol Metab. 83:3832-3838.
17. 17. DeLuca HF. 1990 Osteoporosis and the metabolites of vitamin D. Metabolism. 39(Suppl 1):3-9.
18. 3 receptors in osteoblastic ROS 17/2.8 cells. J Bone Miner Res. 8:997-1003.
19. 3 and tumor necrosis factor-α in the rat osteocalcin gene. Endocrinology. 134:1113-1120.
20. 20. Centers for Disease Control and Prevention. 1992 1993 Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. Morbid Mortal Wkly Rep. 41:1-19.
21. 21. Liabakk N-B, Sundan A, Lien E, et al. 1993 The release of p55 receptor from U937 cells studied by a new p55 immunoassay. J Immunol Methods. 163:145-154.
22. 22. Quero JH, Centeno NO, Munoz-Torres M, et al. 1993 Alterations in bone turnover in HIV-positive patients. Infection. 21:220-222.
23. 23. Serrano S, Marinoso ML, Soriano JC, et al. 1995 Bone remodelling in human immunodeficiency virus-1-infected patients. A histomorphometric study. Bone. 16:185-191.
24. 24. Dempster DW, Cosman F, Parisien M, Shen V, Lindsay R. 1993 Anabolic actions of parathyroid hormone on bone. Endocr Rev. 14:690-709.
25. 25. Frost RA, Fuhrer J, Steigbigel R, et al. 1996 Wasting in the acquired immune deficiency syndrome is associated with multiple defects in serum insulin-like growth factor system. Clin Endocrinol (Oxf). 44:501-514.
26. 26. Clerici M, Trabattoni D, Piconi S, et al. 1997 A possible role for the cortisol/ anticortisol imbalance in the progression of human immunodeficiency virus. Psychoneuroendocrinology. 1(Suppl 1 )22:S27-S31.
27. 27. Buck BE, Resnick L, Shah SM, Malinin T. 1990 Human immunodeficiency virus cultured from bone. Implications for transplantation. Clin Orthop. 251:249-253.
28. 28. Mellert W, Kleinschmidt A, Schmidt J, et al. 1990 Infection of human fibroblasts and osteoblast-like cells with HIV-1. AIDS. 4527-534.
29. 29. Levy JA. 1993 Pathogenesis of human immunodeficiency virus infection. Microbiol Rev. 57:163-289.
30. 30. Lacey DL, Timms E, Tan HL, et al. 1998 Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell. 93:165-176.
31. 31. Abu-Amer Y, Tondravi MM. 1997 NF-κB and bone: the breaking point. Nat. Med. 3:189-190.