A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression

Alzheimer's and Dementia

Volumn 13, Issue 6, 2017, Pages 663-673

  Carrasquillo, Minerva M ^a   Allen, Mariet ^a   Burgess, Jeremy D ^a   Wang, Xue ^a   Strickland, Samantha L ^a   Aryal, Shivani ^a   Siuda, Joanna ^a   Kachadoorian, Michaela L ^a   Medway, Christopher ^a,b   Younkin, Curtis S ^a   Nair, Asha ^c   Wang, Chen ^c   Chanana, Pritha ^c   Serie, Daniel ^a   Nguyen, Thuy ^a   Lincoln, Sarah ^a   Malphrus, Kimberly G ^a   Morgan, Kevin ^b   Golde, Todd E ^d   Price, Nathan D ^e   White, Charles C ^f,g,h   De Jager, Philip L ^f,g,h,i   Bennett, David A ^j   Asmann, Yan W ^a   Crook, Julia E ^a   Petersen, Ronald C ^k   Graff Radford, Neill R ^a   Dickson, Dennis W ^a   Younkin, Steven G ^a   Ertekin Taner, Nilüfer ^a   more..

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c MAYO CLINIC ROCHESTER   (United States)

^d UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^e INSTITUTE FOR SYSTEMS BIOLOGY   (United States)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

^g MASSACHUSETTS GENERAL HOSPITAL   (United States)

^h BROAD INSTITUTE OF MIT AND HARVARD   (United States)

ⁱ HARVARD MEDICAL SCHOOL   (United States)

^j RUSH UNIVERSITY MEDICAL CENTER   (United States)

^k MAYO CLINIC   (United States)

more..

Author keywords

Alzheimer's disease; eQTL; Regulatory variant; TREM2; TREML1

Indexed keywords

AGED; ALZHEIMER DISEASE; ARTICLE; CEREBELLUM; ENDOPHENOTYPE; FEMALE; GENE; GENE CLUSTER; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC CODE; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RNA REPLICATION; RNA SEQUENCE; TEMPORAL CORTEX; TREM GENE; TREML1 GENE; TREML2 GENE; GENE LINKAGE DISEQUILIBRIUM; GENETIC PREDISPOSITION; GENETIC VARIATION; GENETICS; META ANALYSIS; METABOLISM; MICROARRAY ANALYSIS; MULTIGENE FAMILY; TEMPORAL LOBE; VERY ELDERLY;

IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; TREM2 PROTEIN, HUMAN; TREML1 PROTEIN, HUMAN;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CEREBELLUM; FEMALE; GENE EXPRESSION; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MEMBRANE GLYCOPROTEINS; MICROARRAY ANALYSIS; MULTIGENE FAMILY; QUANTITATIVE TRAIT LOCI; RECEPTORS, IMMUNOLOGIC; TEMPORAL LOBE;

EID: 85011995307     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2016.10.005     Document Type: Article

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