Middle east respiratory syndrome corona virus spike glycoprotein suppresses macrophage responses via DPP4-mediated induction of IRAK-M and PPARγ

Oncotarget

Volumn 8, Issue 6, 2017, Pages 9053-9066

  Al Qahtani, Ahmed A ^a,b   Lyroni, Konstantina ^c   Aznaourova, Marina ^c   Tseliou, Melpomeni ^c   Al Anazi, Mashael R ^a   Al Ahdal, Mohammed N ^a,b   Alkahtani, Saad ^d   Sourvinos, George ^c   Tsatsanis, Christos ^c  

^a KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

^b ALFAISAL UNIVERSITY   (Saudi Arabia)

^c UNIVERSITY OF CRETE   (Greece)

^d KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Cytokines; DPP4; Immune response; Immunity; Immunology and Microbiology Section; IRAK M; Macrophages; MERS CoV

Indexed keywords

CORONAVIRUS SPIKE GLYCOPROTEIN; DIPEPTIDYL PEPTIDASE 4 RECEPTOR; DIPEPTIDYL PEPTIDASE IV; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 3; INTERLEUKIN 10; INTERLEUKIN 6; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VIRUS RECEPTOR; DIPEPTIDYL PEPTIDASE IV INHIBITOR; DPP4 PROTEIN, HUMAN; IL10 PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; IRAK3 PROTEIN, HUMAN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; CORONAVIRIDAE; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; MACROPHAGE; MIDDLE EAST RESPIRATORY SYNDROME CORONA VIRUS; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; VIRUS IDENTIFICATION; VIRUS PARTICLE; VIRUS SPIKE; DRUG EFFECT; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; HOST PATHOGEN INTERACTION; IMMUNOLOGY; MACROPHAGE ACTIVATION; METABOLISM; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; PATHOGENICITY; RNA INTERFERENCE; THP-1 CELL LINE; VIROLOGY;

DIPEPTIDYL PEPTIDASE 4; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; HOST-PATHOGEN INTERACTIONS; HUMANS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; INTERLEUKIN-10; INTERLEUKIN-6; MACROPHAGE ACTIVATION; MACROPHAGES; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; PPAR GAMMA; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SPIKE GLYCOPROTEIN, CORONAVIRUS; THP-1 CELLS; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85011961282     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.14754     Document Type: Article

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