NLRP3 (Nucleotide oligomerization domain-like receptor family, pyrin domain containing 3)-caspase-1 inflammasome degrades contractile proteins implications for aortic biomechanical dysfunction and aneurysm and dissection formation

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 37, Issue 4, 2017, Pages 694-706

  Wu, Darrell ^a,b   Ren, Pingping ^a,b   Zheng, Yanqiu ^a   Zhang, Lin ^a,b   Xu, Gaiping ^a,b   Xie, Wanmu ^a,b   Lloyd, Eric E ^a   Zhang, Sui ^c   Zhang, Qianzi ^a   Curci, John A ^d   Coselli, Joseph S ^a,b   Milewicz, Dianna M ^e   Shen, Ying H ^a,b   LeMaire, Scott A ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b TEXAS HEART INSTITUTE   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Baylor UT Houston Center for AIDS Research   (United States)

Author keywords

Aortic aneurysm; Caspase 1; Contractile proteins; Glyburide; Inflammasomes; Proteolysis

Indexed keywords

ANGIOTENSIN II; CONTRACTILE PROTEIN; CRYOPYRIN; GLIBENCLAMIDE; INFLAMMASOME; INTERLEUKIN 1BETA CONVERTING ENZYME; MUSCLE PROTEIN; NLRP3 PROTEIN, MOUSE;

ABDOMINAL AORTA; ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA DISSECTING ANEURYSM; ARTICLE; BIOMECHANICS; CONTROLLED STUDY; DRUG EFFECT; DRUG TARGETING; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN TISSUE; INFLAMMATION; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SMOOTH MUSCLE CELL; THORACIC AORTA; 129 MOUSE; ANEURYSM, DISSECTING; ANIMAL; ANTAGONISTS AND INHIBITORS; AORTIC ANEURYSM, ABDOMINAL; AORTIC ANEURYSM, THORACIC; C57BL MOUSE; CELL CULTURE; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; GENETIC PREDISPOSITION; GENETICS; KNOCKOUT MOUSE; METABOLISM; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION;

AGED; ANEURYSM, DISSECTING; ANGIOTENSIN II; ANIMALS; AORTA, ABDOMINAL; AORTA, THORACIC; AORTIC ANEURYSM, ABDOMINAL; AORTIC ANEURYSM, THORACIC; BIOMECHANICAL PHENOMENA; CASPASE 1; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GLYBURIDE; HUMANS; INFLAMMASOMES; MALE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; MIDDLE AGED; MUSCLE PROTEINS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PHENOTYPE; PROTEOLYSIS; VASOCONSTRICTION;

EID: 85011691088     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.116.307648     Document Type: Article

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