Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II-induced aortic aneurysm

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 35, Issue 1, 2016, Pages 127-136

  Usui, Fumitake ^a   Shirasuna, Koumei ^a   Kimura, Hiroaki ^a   Tatsumi, Kazuki ^a   Kawashima, Akira ^a   Karasawa, Tadayoshi ^a   Yoshimura, Koichi ^c   Aoki, Hiroki ^d   Tsutsui, Hiroko ^e   Noda, Tetsuo ^f   Sagara, Junji ^b   Taniguchi, Shun'Ichiro ^b   Takahashi, Masafumi ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d KURUME UNIVERSITY   (Japan)

^e HYOGO COLLEGE OF MEDICINE   (Japan)

^f CANCER INSTITUTE   (Japan)

Author keywords

Cytokines; inflammation; macrophages; oxidative stress

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; CRYOPYRIN; CYTOKINE; INFLAMMASOME; INTERLEUKIN 1BETA CONVERTING ENZYME; METALLOPROTEINASE; REACTIVE OXYGEN METABOLITE; APOLIPOPROTEIN E; APOPTOSIS REGULATORY PROTEIN; AUTACOID; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; IL1B PROTEIN, MOUSE; INTERLEUKIN 1BETA; PYCARD PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ANEURYSM; APOPTOSIS; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DEGRADATION KINETICS; FIBROSIS; GENE EXPRESSION; HYPOTHESIS; INFLAMMATION; INFLAMMATORY CELL; MACROPHAGE; MITOCHONDRION; MOUSE; MOUSE MODEL; NONHUMAN; OXIDATIVE STRESS; PROTEIN DOMAIN; ABDOMINAL AORTA; AGED; ANIMAL; AORTIC ANEURYSM, ABDOMINAL; C57BL MOUSE; CELL CULTURE; CHEMICALLY INDUCED; DEFICIENCY; DISEASE MODEL; FEMALE; GENETICS; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; MACROPHAGE ACTIVATION; MALE; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TIME;

AGED; ANGIOTENSIN II; ANIMALS; AORTA, ABDOMINAL; AORTIC ANEURYSM, ABDOMINAL; APOLIPOPROTEINS E; APOPTOSIS REGULATORY PROTEINS; CARRIER PROTEINS; CASPASE 1; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FEMALE; FIBROSIS; HUMANS; INFLAMMASOMES; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; MACROPHAGE ACTIVATION; MACROPHAGES; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84920276169     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.114.303763     Document Type: Article

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