메뉴 건너뛰기




Volumn 2017, Issue , 2017, Pages

Lipids: A Suitable Therapeutic Target in Diabetic Neuropathy?

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; HEMOGLOBIN A1C; HYPOCHOLESTEROLEMIC AGENT; INSULIN; LIPID; OXIDIZED LOW DENSITY LIPOPROTEIN; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; SPHINGOLIPID; THIOCTIC ACID; TRIACYLGLYCEROL; ANTILIPEMIC AGENT;

EID: 85011545687     PISSN: 23146745     EISSN: 23146753     Source Type: Journal    
DOI: 10.1155/2017/6943851     Document Type: Review
Times cited : (39)

References (89)
  • 1
    • 33746441608 scopus 로고    scopus 로고
    • The prevalence, severity, and impact of painful diabetic peripheral neuropathy in type 2 diabetes
    • M. Davies, S. Brophy, R. Williams, and A. Taylor, "The prevalence, severity, and impact of painful diabetic peripheral neuropathy in type 2 diabetes, " Diabetes Care, vol. 29, no. 7, pp. 1518-1522, 2006.
    • (2006) Diabetes Care , vol.29 , Issue.7 , pp. 1518-1522
    • Davies, M.1    Brophy, S.2    Williams, R.3    Taylor, A.4
  • 2
    • 84860818001 scopus 로고    scopus 로고
    • Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the U.K
    • C.A. Abbott, R. A. Malik, E. R. E. Van Ross, J. Kulkarni, and A. J. M. Boulton, "Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the U.K., " Diabetes Care, vol. 34, no. 10, pp. 2220-2224, 2011.
    • (2011) Diabetes Care , vol.34 , Issue.10 , pp. 2220-2224
    • Abbott, C.A.1    Malik, R.A.2    Van Ross, E.R.E.3    Kulkarni, J.4    Boulton, A.J.M.5
  • 3
    • 84891809070 scopus 로고    scopus 로고
    • Mechanisms and management of diabetic painful distal symmetrical polyneuropathy
    • S. Tesfaye, A. J. M. Boulton, and A. H. Dickenson, "Mechanisms and management of diabetic painful distal symmetrical polyneuropathy, " Diabetes Care, vol. 36, no. 9, pp. 2456-2465, 2013.
    • (2013) Diabetes Care , vol.36 , Issue.9 , pp. 2456-2465
    • Tesfaye, S.1    Boulton, A.J.M.2    Dickenson, A.H.3
  • 4
    • 78651101592 scopus 로고    scopus 로고
    • Diabetic neuropathies: Update on definitions, diagnostic criteria, estimation of severity, and treatments
    • S. Tesfaye, A. J. M. Boulton, P. J. Dyck et al., "Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments, " Diabetes Care, vol. 33, no. 10, pp. 2285-2293, 2010.
    • (2010) Diabetes Care , vol.33 , Issue.10 , pp. 2285-2293
    • Tesfaye, S.1    Boulton, A.J.M.2    Dyck, P.J.3
  • 5
    • 84924798837 scopus 로고    scopus 로고
    • The clinical approach to small fiber neuropathy and painful channelopathy
    • A. C. Themistocleous, J. D. Ramirez, J. Serra, and D. L. H. Bennett, "The clinical approach to small fiber neuropathy and painful channelopathy, " Practical Neurology, vol. 14, no. 6, pp. 368-379, 2014.
    • (2014) Practical Neurology , vol.14 , Issue.6 , pp. 368-379
    • Themistocleous, A.C.1    Ramirez, J.D.2    Serra, J.3    Bennett, D.L.H.4
  • 6
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-Term complications in insulindependent diabetesmellitus
    • The Diabetes Control and Complications Trial Research Group
    • The Diabetes Control and Complications Trial Research Group, "The effect of intensive treatment of diabetes on the development and progression of long-Term complications in insulindependent diabetesmellitus, " New England Journal ofMedicine, vol. 329, no. 14, pp. 977-986, 1993.
    • (1993) New England Journal OfMedicine , vol.329 , Issue.14 , pp. 977-986
  • 7
    • 33645700675 scopus 로고    scopus 로고
    • Neuropathy among the diabetes control and complications trial cohort 8 years after trial completion
    • C. L. Martin, J. Albers, W.H. Herman et al., "Neuropathy among the diabetes control and complications trial cohort 8 years after trial completion, " Diabetes Care, vol. 29, no. 2, pp. 340-344, 2006.
    • (2006) Diabetes Care , vol.29 , Issue.2 , pp. 340-344
    • Martin, C.L.1    Albers, J.2    Herman, W.H.3
  • 8
    • 77954966171 scopus 로고    scopus 로고
    • Effect of prior intensive insulin treatment during the diabetes control and complications trial (dcct) on peripheral neuropathy in type 1 diabetes during the epidemiology of diabetes interventions and complications (edic) study
    • J. W. Albers, W.H. Herman, R. Pop-Busui et al., "Effect of prior intensive insulin treatment during the Diabetes Control and Complications Trial (DCCT) on peripheral neuropathy in type 1 diabetes during the Epidemiology of Diabetes Interventions and Complications (EDIC) study, " Diabetes Care, vol. 33, no. 5, pp. 1090-1096, 2010.
    • (2010) Diabetes Care , vol.33 , Issue.5 , pp. 1090-1096
    • Albers, J.W.1    Herman, W.H.2    Pop-Busui, R.3
  • 9
    • 0029147687 scopus 로고
    • Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: A randomized prospective 6-year study
    • Y. Ohkubo, H. Kishikawa, E. Araki et al., "Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: A randomized prospective 6-year study, " Diabetes Research and Clinical Practice, vol. 28, no. 2, pp. 103-117, 1995.
    • (1995) Diabetes Research and Clinical Practice , vol.28 , Issue.2 , pp. 103-117
    • Ohkubo, Y.1    Kishikawa, H.2    Araki, E.3
  • 10
    • 77955585592 scopus 로고    scopus 로고
    • Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: An analysis of the ACCORD randomised trial
    • F. Ismail-Beigi, T. Craven, M. A. Banerji et al., "Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: An analysis of the ACCORD randomised trial, " The Lancet, vol. 376, no. 9739, pp. 419-430, 2010.
    • (2010) The Lancet , vol.376 , Issue.9739 , pp. 419-430
    • Ismail-Beigi, F.1    Craven, T.2    Banerji, M.A.3
  • 11
    • 58149389215 scopus 로고    scopus 로고
    • Glucose control and vascular complications in veterans with type 2 diabetes
    • W. Duckworth, C. Abraira, T. Moritz et al., "Glucose control and vascular complications in veterans with type 2 diabetes, " New England Journal of Medicine, vol. 360, no. 2, pp. 129-139, 2009.
    • (2009) New England Journal of Medicine , vol.360 , Issue.2 , pp. 129-139
    • Duckworth, W.1    Abraira, C.2    Moritz, T.3
  • 12
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • R. Turner, "Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33), " The Lancet, vol. 352, no. 9131, pp. 837-853, 1998.
    • (1998) The Lancet , vol.352 , Issue.9131 , pp. 837-853
    • Turner, R.1
  • 13
    • 45149133036 scopus 로고    scopus 로고
    • Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    • ADVANCE Collaborative
    • ADVANCE Collaborative Group, A. Patel, S. MacMahon et al., "Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes, " The New England Journal of Medicine, vol. 358, pp. 2560-2572, 2008.
    • (2008) The New England Journal of Medicine , vol.358 , pp. 2560-2572
    • Patel, A.1    Macmahon, S.2
  • 14
    • 84978839381 scopus 로고    scopus 로고
    • Liraglutide and cardiovascular outcomes in type 2 diabetes
    • S. P. Marso, G. H. Daniels, K. B. Frandsen et al., "Liraglutide and cardiovascular outcomes in type 2 diabetes, " New England Journal of Medicine, vol. 375, no. 4, pp. 311-322, 2016.
    • (2016) New England Journal of Medicine , vol.375 , Issue.4 , pp. 311-322
    • Marso, S.P.1    Daniels, G.H.2    Frandsen, K.B.3
  • 15
    • 84944800184 scopus 로고    scopus 로고
    • Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes
    • B. Zinman, C. Wanner, J. M. Lachin et al., "Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes, " The New England Journal ofMedicine, vol. 373, no. 22, pp. 2117-2128, 2015.
    • (2015) The New England Journal OfMedicine , vol.373 , Issue.22 , pp. 2117-2128
    • Zinman, B.1    Wanner, C.2    Lachin, J.M.3
  • 16
    • 79955482037 scopus 로고    scopus 로고
    • Oxidative stress and Nrf2 in the pathophysiology of diabetic neuropathy: Old perspective with a new angle
    • G. Negi, A. Kumar, R. P. Joshi, and S. S. Sharma, "Oxidative stress and Nrf2 in the pathophysiology of diabetic neuropathy: old perspective with a new angle, " Biochemical and Biophysical Research Communications, vol. 408, no. 1, pp. 1-5, 2011.
    • (2011) Biochemical and Biophysical Research Communications , vol.408 , Issue.1 , pp. 1-5
    • Negi, G.1    Kumar, A.2    Joshi, R.P.3    Sharma, S.S.4
  • 17
    • 84925308650 scopus 로고    scopus 로고
    • Antioxidant strategies in themanagement of diabetic neuropathy
    • Article ID515042
    • A. B. Oyenihi, A. O. Ayeleso, E. Mukwevho, and B. Masola, "Antioxidant strategies in themanagement of diabetic neuropathy, " BioMed Research International, vol. 2015, Article ID515042, 15 pages, 2015.
    • (2015) BioMed Research International , vol.2015 , pp. 15
    • Oyenihi, A.B.1    Ayeleso, A.O.2    Mukwevho, E.3    Masola, B.4
  • 18
    • 84921986543 scopus 로고    scopus 로고
    • Insights into the pathogenesis and treatment of painful diabetic neuropathy
    • M. Greig, S. Tesfaye, D. Selvarajah, and I. D. Wilkinson, "Insights into the pathogenesis and treatment of painful diabetic neuropathy, " Handbook of Clinical Neurology, vol. 126, pp. 559-578, 2014.
    • (2014) Handbook of Clinical Neurology , vol.126 , pp. 559-578
    • Greig, M.1    Tesfaye, S.2    Selvarajah, D.3    Wilkinson, I.D.4
  • 19
    • 34250702110 scopus 로고    scopus 로고
    • The role of protein kinase C activation and the vascular complications of diabetes
    • N. Das Evcimen and G. L. King, "The role of protein kinase C activation and the vascular complications of diabetes, " Pharmacological Research, vol. 55, no. 6, pp. 498-510, 2007.
    • (2007) Pharmacological Research , vol.55 , Issue.6 , pp. 498-510
    • Das Evcimen, N.1    King, G.L.2
  • 20
    • 0034710891 scopus 로고    scopus 로고
    • Hyperglycemiainduced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation
    • X.-L. Du, D. Edelstein, L. Rossetti et al., "Hyperglycemiainduced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation, " Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 22, pp. 12222-12226, 2000.
    • (2000) Proceedings of the National Academy of Sciences of the United States of America , vol.97 , Issue.22 , pp. 12222-12226
    • Du, X.-L.1    Edelstein, D.2    Rossetti, L.3
  • 21
    • 44449172015 scopus 로고    scopus 로고
    • Role of advanced glycation end products in diabetic neuropathy
    • K. Sugimoto, M. Yasujima, and S. Yagihashi, "Role of advanced glycation end products in diabetic neuropathy, " Current Pharmaceutical Design, vol. 14, no. 10, pp. 953-961, 2008.
    • (2008) Current Pharmaceutical Design , vol.14 , Issue.10 , pp. 953-961
    • Sugimoto, K.1    Yasujima, M.2    Yagihashi, S.3
  • 23
    • 67650269861 scopus 로고    scopus 로고
    • Elevated triglycerides correlate with progression of diabetic neuropathy
    • T. D. Wiggin, K. A. Sullivan, R. Pop-Busui, A. Amato, A. A. F. Sima, and E. L. Feldman, "Elevated triglycerides correlate with progression of diabetic neuropathy, " Diabetes, vol. 58, no. 7, pp. 1634-1640, 2009.
    • (2009) Diabetes , vol.58 , Issue.7 , pp. 1634-1640
    • Wiggin, T.D.1    Sullivan, K.A.2    Pop-Busui, R.3    Amato, A.4    Sima, A.A.F.5    Feldman, E.L.6
  • 24
    • 84883791552 scopus 로고    scopus 로고
    • Obesity and hyperlipidemia are risk factors for early diabetic neuropathy
    • A. G. Smith and J. R. Singleton, "Obesity and hyperlipidemia are risk factors for early diabetic neuropathy, " Journal of Diabetes and its Complications, vol. 27, no. 5, pp. 436-442, 2013.
    • (2013) Journal of Diabetes and Its Complications , vol.27 , Issue.5 , pp. 436-442
    • Smith, A.G.1    Singleton, J.R.2
  • 25
    • 0034841533 scopus 로고    scopus 로고
    • The metabolic syndrome influences the risk of chronic complications in patients with Type II diabetes
    • B. Isomaa, M. Henricsson, P. Almgren, T. Tuomi, M.-R. Taskinen, and L. Groop, "The metabolic syndrome influences the risk of chronic complications in patients with Type II diabetes, " Diabetologia, vol. 44, no. 9, pp. 1148-1154, 2001.
    • (2001) Diabetologia , vol.44 , Issue.9 , pp. 1148-1154
    • Isomaa, B.1    Henricsson, M.2    Almgren, P.3    Tuomi, T.4    Taskinen, M.-R.5    Groop, L.6
  • 26
    • 85026588059 scopus 로고    scopus 로고
    • P225: Small fiber neuropathy associated with hyperlipidemia: Utility of cutaneous silent periods and autonomic tests
    • A. Leventoglu and G. Morkavuk, "P225: small fiber neuropathy associated with hyperlipidemia: utility of cutaneous silent periods and autonomic tests, " Clinical Neurophysiology, vol. 125, supplement 1, p. S108, 2014.
    • (2014) Clinical Neurophysiology , vol.125 , pp. S108
    • Leventoglu, A.1    Morkavuk, G.2
  • 27
    • 84862777882 scopus 로고    scopus 로고
    • Insulin resistance in the nervous system
    • B. Kim and E. L. Feldman, "Insulin resistance in the nervous system, " Trends in Endocrinology andMetabolism, vol. 23, no. 3, pp. 133-141, 2012.
    • (2012) Trends in Endocrinology AndMetabolism , vol.23 , Issue.3 , pp. 133-141
    • Kim, B.1    Feldman, E.L.2
  • 28
    • 80052711772 scopus 로고    scopus 로고
    • Insulin receptor substrate 2 expression and involvement in neuronal insulin resistance in diabetic neuropathy
    • Article ID 212571
    • C. W. Grote, J. K. Morris, J. M. Ryals, P. C. Geiger, and D. E. Wright, "Insulin receptor substrate 2 expression and involvement in neuronal insulin resistance in diabetic neuropathy, " Experimental Diabetes Research, vol. 2011, Article ID 212571, 12 pages, 2011.
    • (2011) Experimental Diabetes Research , vol.2011 , pp. 12
    • Grote, C.W.1    Morris, J.K.2    Ryals, J.M.3    Geiger, P.C.4    Wright, D.E.5
  • 29
    • 3042785971 scopus 로고    scopus 로고
    • Direct insulin signalling of neurons reverses diabetic neuropathy
    • V. Brussee, F. A. Cunningham, and D. W. Zochodne, "Direct insulin signalling of neurons reverses diabetic neuropathy, " Diabetes, vol. 53, no. 7, pp. 1824-1830, 2004.
    • (2004) Diabetes , vol.53 , Issue.7 , pp. 1824-1830
    • Brussee, V.1    Cunningham, F.A.2    Zochodne, D.W.3
  • 32
    • 80053138275 scopus 로고    scopus 로고
    • Hyperinsulinemia induces insulin resistance in dorsal root ganglion neurons
    • B. Kim, L. L. McLean, S. S. Philip, and E. L. Feldman, "Hyperinsulinemia induces insulin resistance in dorsal root ganglion neurons, " Endocrinology, vol. 152, no. 10, pp. 3638-3647, 2011.
    • (2011) Endocrinology , vol.152 , Issue.10 , pp. 3638-3647
    • Kim, B.1    McLean, L.L.2    Philip, S.S.3    Feldman, E.L.4
  • 33
    • 33749342069 scopus 로고    scopus 로고
    • Molecular mechanisms of insulin resistance: Serine phosphorylation of insulin receptor substrate-1 and increased expression of p85: The two sides of a coin
    • B. Draznin, "Molecular mechanisms of insulin resistance: serine phosphorylation of insulin receptor substrate-1 and increased expression of p85: The two sides of a coin, " Diabetes, vol. 55, no. 8, pp. 2392-2397, 2006.
    • (2006) Diabetes , vol.55 , Issue.8 , pp. 2392-2397
    • Draznin, B.1
  • 34
    • 84942418028 scopus 로고    scopus 로고
    • The role of fatty acids in insulin resistance
    • article 121
    • B. Sears and M. Perry, "The role of fatty acids in insulin resistance, " Lipids in Health and Disease, vol. 14, no. 1, article 121, 2015.
    • (2015) Lipids in Health and Disease , vol.14 , Issue.1
    • Sears, B.1    Perry, M.2
  • 35
    • 84928709203 scopus 로고    scopus 로고
    • Peripheral neuropathy is associated with insulin resistance independent of metabolic syndrome
    • article no. 14
    • L. Han, L. Ji, J. Chang et al., "Peripheral neuropathy is associated with insulin resistance independent of metabolic syndrome, " Diabetology and Metabolic Syndrome, vol. 7, no. 1, article no. 14, 2015.
    • (2015) Diabetology and Metabolic Syndrome , vol.7 , Issue.1
    • Han, L.1    Ji, L.2    Chang, J.3
  • 36
    • 4143151941 scopus 로고    scopus 로고
    • Themetabolic syndrome
    • A. J. Garber, "Themetabolic syndrome, " Medical Clinics of North America, vol. 88, no. 4, pp. 837-846, 2004.
    • (2004) Medical Clinics of North America , vol.88 , Issue.4 , pp. 837-846
    • Garber, A.J.1
  • 38
    • 17444415703 scopus 로고    scopus 로고
    • Peripheral diabetic neuropathy and polyunsaturated fatty acid supplementations: Natural sources or biotechnological needs?
    • T. C. Coste, A. Gerbi, P. Vague, J. M. Maixent, G. Pieroni, and D. Raccah, "Peripheral diabetic neuropathy and polyunsaturated fatty acid supplementations: natural sources or biotechnological needs?" Cellular and Molecular Biology, vol. 50, no. 7, pp. 845-853, 2004.
    • (2004) Cellular and Molecular Biology , vol.50 , Issue.7 , pp. 845-853
    • Coste, T.C.1    Gerbi, A.2    Vague, P.3    Maixent, J.M.4    Pieroni, G.5    Raccah, D.6
  • 39
    • 84964226742 scopus 로고    scopus 로고
    • Membrane flexibility, free fatty acids, and the onset of vascular and neurological lesions in type 2 diabetes
    • article 13
    • R. N. M. Weijers, "Membrane flexibility, free fatty acids, and the onset of vascular and neurological lesions in type 2 diabetes, " Journal of Diabetes and Metabolic Disorders, vol. 15, article 13, 2016.
    • Journal of Diabetes and Metabolic Disorders , vol.15 , pp. 2016
    • Weijers, R.N.M.1
  • 40
    • 84874428240 scopus 로고    scopus 로고
    • Adipokine inflammation and insulin resistance: The role of glucose, lipids and endotoxin
    • M. K. Piya, P. G. McTernan, and S. Kumar, "Adipokine inflammation and insulin resistance: The role of glucose, lipids and endotoxin, " Journal of Endocrinology, vol. 216, no. 1, pp. T1-T15, 2013.
    • (2013) Journal of Endocrinology , vol.216 , Issue.1 , pp. T1-T15
    • Piya, M.K.1    McTernan, P.G.2    Kumar, S.3
  • 41
    • 84988972821 scopus 로고    scopus 로고
    • Endothelial dysfunction as a link between cardiovascular risk factors and peripheral neuropathy in diabetes
    • M. Roustit, J. Loader, C. Deusenbery, D. Baltzis, and A. Veves, "Endothelial dysfunction as a link between cardiovascular risk factors and peripheral neuropathy in diabetes, " The Journal of Clinical Endocrinology & Metabolism, vol. 101, no. 9, pp. 3401-3408, 2016.
    • (2016) The Journal of Clinical Endocrinology & Metabolism , vol.101 , Issue.9 , pp. 3401-3408
    • Roustit, M.1    Loader, J.2    Deusenbery, C.3    Baltzis, D.4    Veves, A.5
  • 42
    • 0024100287 scopus 로고
    • Essential fatty acids prevent slowed nerve conduction in streptozotocin diabetic rats
    • P. O. O. Julu, "Essential fatty acids prevent slowed nerve conduction in streptozotocin diabetic rats, " Journal of Diabetic Complications, vol. 2, no. 4, pp. 185-188, 1988.
    • (1988) Journal of Diabetic Complications , vol.2 , Issue.4 , pp. 185-188
    • Julu, P.O.O.1
  • 43
    • 0027492053 scopus 로고
    • Treatment of diabetic neuropathy with-linolenic acid
    • H. Keen, J. Payan, J. Allawi et al., "Treatment of diabetic neuropathy with-linolenic acid, " Diabetes Care, vol. 16, no. 1, pp. 8-15, 1993.
    • (1993) Diabetes Care , vol.16 , Issue.1 , pp. 8-15
    • Keen, H.1    Payan, J.2    Allawi, J.3
  • 44
    • 0034971691 scopus 로고    scopus 로고
    • Role of free fatty acids on cardiac autonomic nervous systemin noninsulindependent diabetic patients: Effects of metabolic control
    • D. Manzella, M. Barbieri, M. R. Rizzo et al., "Role of free fatty acids on cardiac autonomic nervous systemin noninsulindependent diabetic patients: effects of metabolic control, " Journal of Clinical Endocrinology andMetabolism, vol. 86, no. 6, pp. 2769-2774, 2001.
    • (2001) Journal of Clinical Endocrinology AndMetabolism , vol.86 , Issue.6 , pp. 2769-2774
    • Manzella, D.1    Barbieri, M.2    Rizzo, M.R.3
  • 45
    • 77956186984 scopus 로고    scopus 로고
    • Mitochondrial biogenesis and fission in axons in cell culture and animalmodels of diabetic neuropathy
    • A. M. Vincent, J. L. Edwards, L. L. McLean et al., "Mitochondrial biogenesis and fission in axons in cell culture and animalmodels of diabetic neuropathy, " Acta Neuropathologica, vol. 120, no. 4, pp. 477-489, 2010.
    • (2010) Acta Neuropathologica , vol.120 , Issue.4 , pp. 477-489
    • Vincent, A.M.1    Edwards, J.L.2    McLean, L.L.3
  • 46
    • 84876428871 scopus 로고    scopus 로고
    • Aberrant schwann cell lipid metabolism linked to mitochondrial deficits leads to axon degeneration and neuropathy
    • A. Viader, Y. Sasaki, S. Kim et al., "Aberrant schwann cell lipid metabolism linked to mitochondrial deficits leads to axon degeneration and neuropathy, " Neuron, vol. 77, no. 5, pp. 886-898, 2013.
    • (2013) Neuron , vol.77 , Issue.5 , pp. 886-898
    • Viader, A.1    Sasaki, Y.2    Kim, S.3
  • 47
    • 84907563036 scopus 로고    scopus 로고
    • Mitochondria-derived reactive oxygen species mediate caspasedependent and-independent neuronal deaths
    • M. J. McManus, M. P. Murphy, and J. L. Franklin, "Mitochondria-derived reactive oxygen species mediate caspasedependent and-independent neuronal deaths, " Molecular and Cellular Neuroscience, vol. 63, pp. 13-23, 2014.
    • (2014) Molecular and Cellular Neuroscience , vol.63 , pp. 13-23
    • McManus, M.J.1    Murphy, M.P.2    Franklin, J.L.3
  • 48
    • 34548848059 scopus 로고    scopus 로고
    • Mitochondrial energetics in the heart in obesity-related diabetes: Direct evidence for increased uncoupled respiration and activation of uncoupling proteins
    • S. Boudina, S. Sena, H. Theobald et al., "Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins, " Diabetes, vol. 56, no. 10, pp. 2457-2466, 2007.
    • (2007) Diabetes , vol.56 , Issue.10 , pp. 2457-2466
    • Boudina, S.1    Sena, S.2    Theobald, H.3
  • 49
    • 0036788293 scopus 로고    scopus 로고
    • Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes
    • D. E. Kelley, J. He, E. V. Menshikova, and V. B. Ritov, "Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes, " Diabetes, vol. 51, no. 10, pp. 2944-2950, 2002.
    • (2002) Diabetes , vol.51 , Issue.10 , pp. 2944-2950
    • Kelley, D.E.1    He, J.2    Menshikova, E.V.3    Ritov, V.B.4
  • 50
    • 0037477855 scopus 로고    scopus 로고
    • Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
    • M. E. Patti, A. J. Butte, S. Crunkhorn et al., "Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1, " Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 14, pp. 8466-8471, 2003.
    • (2003) Proceedings of the National Academy of Sciences of the United States of America , vol.100 , Issue.14 , pp. 8466-8471
    • Patti, M.E.1    Butte, A.J.2    Crunkhorn, S.3
  • 51
    • 78751486039 scopus 로고    scopus 로고
    • Diminished superoxide generation is associated with respiratory chain dysfunction and changes in the mitochondrial proteome of sensory neurons from diabetic rats
    • E. Akude, E. Zherebitskaya, S. K. R. Chowdhury, D. R. Smith, R. T. Dobrowsky, and P. Fernyhough, "Diminished superoxide generation is associated with respiratory chain dysfunction and changes in the mitochondrial proteome of sensory neurons from diabetic rats, " Diabetes, vol. 60, no. 1, pp. 288-297, 2011.
    • (2011) Diabetes , vol.60 , Issue.1 , pp. 288-297
    • Akude, E.1    Zherebitskaya, E.2    Chowdhury, S.K.R.3    Smith, D.R.4    Dobrowsky, R.T.5    Fernyhough, P.6
  • 54
    • 0342614207 scopus 로고    scopus 로고
    • The mechanisms of fatty acid-induced proton permeability of the inner mitochondrial membrane
    • L. Wojtczak and M. R. Wieckowski, "The mechanisms of fatty acid-induced proton permeability of the inner mitochondrial membrane, " Journal of Bioenergetics and Biomembranes, vol. 31, no. 5, pp. 447-455, 1999.
    • (1999) Journal of Bioenergetics and Biomembranes , vol.31 , Issue.5 , pp. 447-455
    • Wojtczak, L.1    Wieckowski, M.R.2
  • 55
    • 84904006203 scopus 로고    scopus 로고
    • Longchain acyl coenzyme a synthetase 1 overexpression in primary cultured schwann cells prevents long chain fatty acid-induced oxidative stress and mitochondrial dysfunction
    • L. M. Hinder, C. Figueroa-Romero, C. Pacut et al., "Longchain acyl coenzyme a synthetase 1 overexpression in primary cultured schwann cells prevents long chain fatty acid-induced oxidative stress and mitochondrial dysfunction, " Antioxidants and Redox Signaling, vol. 21, no. 4, pp. 588-600, 2014.
    • (2014) Antioxidants and Redox Signaling , vol.21 , Issue.4 , pp. 588-600
    • Hinder, L.M.1    Figueroa-Romero, C.2    Pacut, C.3
  • 56
    • 77951168536 scopus 로고    scopus 로고
    • Mitochondrial respiratory chain dysfunction in dorsal root ganglia of streptozotocin-induced diabetic rats and its correction by insulin treatment
    • S. K. Roy Chowdhury, E. Zherebitskaya, D. R. Smith et al., "Mitochondrial respiratory chain dysfunction in dorsal root ganglia of streptozotocin-induced diabetic rats and its correction by insulin treatment, " Diabetes, vol. 59, no. 4, pp. 1082-1091, 2010.
    • (2010) Diabetes , vol.59 , Issue.4 , pp. 1082-1091
    • Roy Chowdhury, S.K.1    Zherebitskaya, E.2    Smith, D.R.3
  • 57
    • 84874405179 scopus 로고    scopus 로고
    • Decreased glycolytic and tricarboxylic acid cycle intermediates coincide with peripheral nervous system oxidative stress in a murine model of type 2 diabetes
    • L. M. Hinder, A. Vivekanandan-Giri, L. L. McLean, S. Pennathur, and E. L. Feldman, "Decreased glycolytic and tricarboxylic acid cycle intermediates coincide with peripheral nervous system oxidative stress in a murine model of type 2 diabetes, " Journal of Endocrinology, vol. 216, no. 1, pp. 1-11, 2013.
    • (2013) Journal of Endocrinology , vol.216 , Issue.1 , pp. 1-11
    • Hinder, L.M.1    Vivekanandan-Giri, A.2    McLean, L.L.3    Pennathur, S.4    Feldman, E.L.5
  • 58
    • 84962182345 scopus 로고    scopus 로고
    • Metabolic dysfunction is restricted to the sciatic nerve in experimental diabetic neuropathy
    • O. J. Freeman, R. D. Unwin, A. W. Dowsey et al., "Metabolic dysfunction is restricted to the sciatic nerve in experimental diabetic neuropathy, " Diabetes, vol. 65, no. 1, pp. 228-238, 2016.
    • (2016) Diabetes , vol.65 , Issue.1 , pp. 228-238
    • Freeman, O.J.1    Unwin, R.D.2    Dowsey, A.W.3
  • 59
    • 34249727164 scopus 로고    scopus 로고
    • Transcriptional coregulators in the control of energy homeostasis
    • J. N. Feige and J. Auwerx, "Transcriptional coregulators in the control of energy homeostasis, " Trends in Cell Biology, vol. 17, no. 6, pp. 292-301, 2007.
    • (2007) Trends in Cell Biology , vol.17 , Issue.6 , pp. 292-301
    • Feige, J.N.1    Auwerx, J.2
  • 60
    • 0033538473 scopus 로고    scopus 로고
    • Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
    • Z. Wu, P. Puigserver, U. Andersson et al., "Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1, " Cell, vol. 98, no. 1, pp. 115-124, 1999.
    • (1999) Cell , vol.98 , Issue.1 , pp. 115-124
    • Wu, Z.1    Puigserver, P.2    Andersson, U.3
  • 61
    • 25844432311 scopus 로고    scopus 로고
    • Peroxisome proliferator-Activated receptor-co-Activator 1-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency
    • T. R. Koves, P. Li, J. An et al., "Peroxisome proliferator-Activated receptor-co-Activator 1-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency, " Journal of Biological Chemistry, vol. 280, no. 39, pp. 33588-33598, 2005.
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.39 , pp. 33588-33598
    • Koves, T.R.1    Li, P.2    An, J.3
  • 62
    • 0038054341 scopus 로고    scopus 로고
    • PGC-1-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
    • V. K. Mootha, C. M. Lindgren, K.-F. Eriksson et al., "PGC-1-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes, " Nature Genetics, vol. 34, no. 3, pp. 267-273, 2003.
    • (2003) Nature Genetics , vol.34 , Issue.3 , pp. 267-273
    • Mootha, V.K.1    Lindgren, C.M.2    Eriksson, K.-F.3
  • 63
    • 84861561350 scopus 로고    scopus 로고
    • Impaired adenosine monophosphate-Activated protein kinase signaling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes
    • S. K. Roy Chowdhury, D. R. Smith, A. Saleh et al., "Impaired adenosine monophosphate-Activated protein kinase signaling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes, " Brain, vol. 135, no. 6, pp. 1751-1766, 2012.
    • (2012) Brain , vol.135 , Issue.6 , pp. 1751-1766
    • Roy Chowdhury, S.K.1    Smith, D.R.2    Saleh, A.3
  • 64
    • 0034109448 scopus 로고    scopus 로고
    • Effects of peroxisome proliferator-Activated receptor-And-agonist, JTT-501, on diabetic complications in Zucker diabetic fatty rats
    • T. Shibata, S. Takeuchi, S. Yokota, K. Kakimoto, F. Yonemori, and K. Wakitani, "Effects of peroxisome proliferator-Activated receptor-And- agonist, JTT-501, on diabetic complications in Zucker diabetic fatty rats, " British Journal of Pharmacology, vol. 130, no. 3, pp. 495-504, 2000.
    • (2000) British Journal of Pharmacology , vol.130 , Issue.3 , pp. 495-504
    • Shibata, T.1    Takeuchi, S.2    Yokota, S.3    Kakimoto, K.4    Yonemori, F.5    Wakitani, K.6
  • 65
    • 34547399482 scopus 로고    scopus 로고
    • High-fat diet-induced neuropathy of pre-diabetes and obesity: Effects of "healthy" diet and aldose reductase inhibition
    • I. G. Obrosova, O. Ilnytska, V. V. Lyzogubov et al., "High-fat diet-induced neuropathy of pre-diabetes and obesity: effects of "healthy" diet and aldose reductase inhibition, " Diabetes, vol. 56, no. 10, pp. 2598-2608, 2007.
    • (2007) Diabetes , vol.56 , Issue.10 , pp. 2598-2608
    • Obrosova, I.G.1    Ilnytska, O.2    Lyzogubov, V.V.3
  • 66
    • 73349134989 scopus 로고    scopus 로고
    • Association between oxidized LDL, obesity and type 2 diabetes in a population-based cohort, the health, aging and body composition study
    • O. T. Njajou, A. M. Kanaya, P. Holvoet et al., "Association between oxidized LDL, obesity and type 2 diabetes in a population-based cohort, the health, aging and body composition study, " Diabetes/Metabolism Research and Reviews, vol. 25, no. 8, pp. 733-739, 2009.
    • (2009) Diabetes/Metabolism Research and Reviews , vol.25 , Issue.8 , pp. 733-739
    • Njajou, O.T.1    Kanaya, A.M.2    Holvoet, P.3
  • 68
    • 84940056477 scopus 로고    scopus 로고
    • 1-deoxysphingolipids encountered exogenously and made de novo: Dangerous mysteries inside an enigma
    • J. Duan and A. H. Merrill, "1-deoxysphingolipids encountered exogenously and made de novo: dangerous mysteries inside an enigma, " Journal of Biological Chemistry, vol. 290, no. 25, pp. 15380-15389, 2015.
    • (2015) Journal of Biological Chemistry , vol.290 , Issue.25 , pp. 15380-15389
    • Duan, J.1    Merrill, A.H.2
  • 70
    • 84949033367 scopus 로고    scopus 로고
    • Neurotoxic 1-deoxysphingolipids and paclitaxel-induced peripheral neuropathy
    • R. Kramer, J. Bielawski, E. Kistner-Griffin et al., "Neurotoxic 1-deoxysphingolipids and paclitaxel-induced peripheral neuropathy, " FASEB Journal, vol. 29, no. 11, pp. 4461-4472, 2015.
    • (2015) FASEB Journal , vol.29 , Issue.11 , pp. 4461-4472
    • Kramer, R.1    Bielawski, J.2    Kistner-Griffin, E.3
  • 71
    • 84976897938 scopus 로고    scopus 로고
    • Altered sphingoid base profiles in type 1 compared to type 2 diabetes
    • article no. 161
    • N. Wei, J. Pan, R. Pop-Busui et al., "Altered sphingoid base profiles in type 1 compared to type 2 diabetes, " Lipids in Health and Disease, vol. 13, no. 1, article no. 161, 2014.
    • (2014) Lipids in Health and Disease , vol.13 , Issue.1
    • Wei, N.1    Pan, J.2    Pop-Busui, R.3
  • 72
    • 77955526888 scopus 로고    scopus 로고
    • Deoxysphingoid bases as plasma markers in diabetes mellitus
    • article no. 84
    • M. Bertea, M. F. Rütti, A. Othman et al., "Deoxysphingoid bases as plasma markers in diabetes mellitus, " Lipids in Health and Disease, vol. 9, article no. 84, 2010.
    • (2010) Lipids in Health and Disease , vol.9
    • Bertea, M.1    Rütti, M.F.2    Othman, A.3
  • 73
    • 84926419123 scopus 로고    scopus 로고
    • Elevation of plasma 1-deoxy-sphingolipids in type 2 diabetes mellitus: A susceptibility to neuropathy?
    • M. F. Dohrn, A. Othman, S. K. Hirshman et al., "Elevation of plasma 1-deoxy-sphingolipids in type 2 diabetes mellitus: A susceptibility to neuropathy?" European Journal of Neurology, vol. 22, no. 5, pp. 806-e55, 2015.
    • (2015) European Journal of Neurology , vol.22 , Issue.5 , pp. e806-e855
    • Dohrn, M.F.1    Othman, A.2    Hirshman, S.K.3
  • 74
    • 85011586708 scopus 로고    scopus 로고
    • Increased plasma levels of select deoxy-ceramide and ceramide species are associated with increased odds of diabetic neuropathy in type 1 diabetes: A pilot study
    • S. M. Hammad, N. L. Baker, J. M. El Abiad et al., "Increased plasma levels of select deoxy-ceramide and ceramide species are associated with increased odds of diabetic neuropathy in type 1 diabetes: A pilot study, " NeuroMolecular Medicine, 2016.
    • NeuroMolecular Medicine , vol.2016
    • Hammad, S.M.1    Baker, N.L.2    El Abiad, J.M.3
  • 75
    • 84928207644 scopus 로고    scopus 로고
    • Lowering plasma 1-deoxysphingolipids improves neuropathy in diabetic rats
    • A. Othman, R. Bianchi, I. Alecu et al., "Lowering plasma 1-deoxysphingolipids improves neuropathy in diabetic rats, " Diabetes, vol. 64, no. 3, pp. 1035-1045, 2015.
    • (2015) Diabetes , vol.64 , Issue.3 , pp. 1035-1045
    • Othman, A.1    Bianchi, R.2    Alecu, I.3
  • 76
    • 84938197335 scopus 로고    scopus 로고
    • Fenofibrate lowers atypical sphingolipids in plasma of dyslipidemic patients: A novel approach for treating diabetic neuropathy?
    • A. Othman, R. Benghozi, I. Alecu et al., "Fenofibrate lowers atypical sphingolipids in plasma of dyslipidemic patients: A novel approach for treating diabetic neuropathy?" Journal of Clinical Lipidology, vol. 9, no. 4, pp. 568-575, 2015.
    • (2015) Journal of Clinical Lipidology , vol.9 , Issue.4 , pp. 568-575
    • Othman, A.1    Benghozi, R.2    Alecu, I.3
  • 77
    • 41149125988 scopus 로고    scopus 로고
    • Lipidlowering therapy and peripheral sensory neuropathy in type 2 diabetes: The fremantle diabetes study
    • T.M. E. Davis, B. B. Yeap, W. A. Davis, andD.G. Bruce, "Lipidlowering therapy and peripheral sensory neuropathy in type 2 diabetes: The Fremantle Diabetes Study, " Diabetologia, vol. 51, no. 4, pp. 562-566, 2008.
    • (2008) Diabetologia , vol.51 , Issue.4 , pp. 562-566
    • Davis, T.M.E.1    Yeap, B.B.2    Davis, W.A.3    Bruce, D.G.4
  • 78
    • 65649142619 scopus 로고    scopus 로고
    • Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): A prespecified analysis of a randomised controlled trial
    • K. Rajamani, P. G. Colman, L. P. Li et al., "Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): A prespecified analysis of a randomised controlled trial, " The Lancet, vol. 373, no. 9677, pp. 1780-1788, 2009.
    • (2009) The Lancet , vol.373 , Issue.9677 , pp. 1780-1788
    • Rajamani, K.1    Colman, P.G.2    Li, L.P.3
  • 79
    • 84894825487 scopus 로고    scopus 로고
    • Therapeutic effects of fenofibrate on diabetic peripheral neuropathy by improving endothelial and neural survival in db/db mice
    • Article ID 0083204
    • Y. R. Cho, J. H. Lim, M. Y. Kim et al., "Therapeutic effects of fenofibrate on diabetic peripheral neuropathy by improving endothelial and neural survival in db/db mice, " PLoS ONE, vol. 9, no. 1, Article ID 0083204, 2014.
    • (2014) PLoS ONE , vol.9 , Issue.1
    • Cho, Y.R.1    Lim, J.H.2    Kim, M.Y.3
  • 80
    • 84906933522 scopus 로고    scopus 로고
    • Serum phospholipid omega-3 polyunsaturated fatty acids and insulin resistance in type 2 diabetes mellitus and non-Alcoholic fatty liver disease
    • D.-J. Lou, Q.-Q. Zhu, X.-W. Si et al., "Serum phospholipid omega-3 polyunsaturated fatty acids and insulin resistance in type 2 diabetes mellitus and non-Alcoholic fatty liver disease, " Journal of Diabetes and Its Complications, vol. 28, no. 5, pp. 711-714, 2014.
    • (2014) Journal of Diabetes and Its Complications , vol.28 , Issue.5 , pp. 711-714
    • Lou, D.-J.1    Zhu, Q.-Q.2    Si, X.-W.3
  • 81
    • 84905241884 scopus 로고    scopus 로고
    • Endogenous-3 polyunsaturated fatty acid production confers resistance to obesity, dyslipidemia, and diabetes in mice
    • J. Li, F. R. Li, D. Wei et al., "Endogenous-3 polyunsaturated fatty acid production confers resistance to obesity, dyslipidemia, and diabetes in mice, " Molecular Endocrinology, vol. 28, no. 8, pp. 1316-1328, 2014.
    • (2014) Molecular Endocrinology , vol.28 , Issue.8 , pp. 1316-1328
    • Li, J.1    Li, F.R.2    Wei, D.3
  • 82
    • 0141755315 scopus 로고    scopus 로고
    • Neuroprotective effect of docosahexaenoic acid-enriched phospholipids in experimental diabetic neuropathy
    • T. C. Coste, A. Gerbi, P. Vague, G. Pieroni, and D. Raccah, "Neuroprotective effect of docosahexaenoic acid-enriched phospholipids in experimental diabetic neuropathy, " Diabetes, vol. 52, no. 10, pp. 2578-2585, 2003.
    • (2003) Diabetes , vol.52 , Issue.10 , pp. 2578-2585
    • Coste, T.C.1    Gerbi, A.2    Vague, P.3    Pieroni, G.4    Raccah, D.5
  • 83
    • 0032924798 scopus 로고    scopus 로고
    • Fish oil supplementation prevents diabetes-induced nerve conduction velocity and neuroanatomical changes in rats
    • A. Gerbi, J.-M. Maixent, J.-L. Ansaldi et al., "Fish oil supplementation prevents diabetes-induced nerve conduction velocity and neuroanatomical changes in rats, " Journal of Nutrition, vol. 129, no. 1, pp. 207-213, 1999.
    • (1999) Journal of Nutrition , vol.129 , Issue.1 , pp. 207-213
    • Gerbi, A.1    Maixent, J.-M.2    Ansaldi, J.-L.3
  • 85
    • 0042669971 scopus 로고    scopus 로고
    • Looking to the future: Diabetic neuropathy and effects of rosuvastatin on neurovascular function in diabetes models
    • N. Cameron, M. Cotter, M. Inkster, and M. Nangle, "Looking to the future: diabetic neuropathy and effects of rosuvastatin on neurovascular function in diabetes models, " Diabetes Research and Clinical Practice, vol. 61, supplement 1, pp. S35-S39, 2003.
    • (2003) Diabetes Research and Clinical Practice , vol.61 , pp. S35-S39
    • Cameron, N.1    Cotter, M.2    Inkster, M.3    Nangle, M.4
  • 86
    • 84939171665 scopus 로고    scopus 로고
    • Effects of ezetimibe/simvastatin and rosuvastatin on oxidative stress in diabetic neuropathy: A randomized, doubleblind, placebo-controlled clinical trial
    • ticle ID 756294
    • G. Villegas-Rivera, L. M. Roḿan-Pintos, E. G. Cardona-Muñoz et al., "Effects of ezetimibe/simvastatin and rosuvastatin on oxidative stress in diabetic neuropathy: A randomized, doubleblind, placebo-controlled clinical trial, " OxidativeMedicine and Cellular Longevity, vol. 2015, Article ID 756294, 10 pages, 2015.
    • (2015) OxidativeMedicine and Cellular Longevity , vol.2015 , pp. 10
    • Villegas-Rivera, G.1    Roḿan-Pintos, L.M.2    Cardona-Muñoz, E.G.3
  • 87
    • 0034773628 scopus 로고    scopus 로고
    • Molecular aspects of lipoic acid in the prevention of diabetes complications
    • L. Packer, K. Kraemer, and G. Rimbach, "Molecular aspects of lipoic acid in the prevention of diabetes complications, " Nutrition, vol. 17, no. 10, pp. 888-895, 2001.
    • (2001) Nutrition , vol.17 , Issue.10 , pp. 888-895
    • Packer, L.1    Kraemer, K.2    Rimbach, G.3
  • 88
    • 84866703792 scopus 로고    scopus 로고
    • A systematic review andmetaanalysis of-lipoic acid in the treatment of diabetic peripheral neuropathy
    • T. Han, J. Bai, W. Liu, and Y. Hu, "A systematic review andmetaanalysis of-lipoic acid in the treatment of diabetic peripheral neuropathy, " European Journal of Endocrinology, vol. 167, no. 4, pp. 465-471, 2012.
    • (2012) European Journal of Endocrinology , vol.167 , Issue.4 , pp. 465-471
    • Han, T.1    Bai, J.2    Liu, W.3    Hu, Y.4
  • 89
    • 79955917862 scopus 로고    scopus 로고
    • Diagnosis and treatment of pain in small-fiber neuropathy
    • A. Hovaguimian and C. H. Gibbons, "Diagnosis and treatment of pain in small-fiber neuropathy, " Current Pain and Headache Reports, vol. 15, no. 3, pp. 193-200, 2011.
    • (2011) Current Pain and Headache Reports , vol.15 , Issue.3 , pp. 193-200
    • Hovaguimian, A.1    Gibbons, C.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.