메뉴 건너뛰기




Volumn 16, Issue 1, 2017, Pages

Mesenchymal stem cells: Key players in cancer progression

Author keywords

Cancer progression; Mesenchymal stem cells; Tumour metastasis; Tumour microenvironment; Tumour stroma

Indexed keywords

5' NUCLEOTIDASE; ALPHA SMOOTH MUSCLE ACTIN; BETA1 INTEGRIN; CALVASCULIN; CHEMOKINE RECEPTOR CXCR4; ENDOGLIN; GLUCOSE REGULATED PROTEIN 78; HERMES ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; SMAD PROTEIN; SONIC HEDGEHOG PROTEIN; STEM CELL FACTOR RECEPTOR; STROMAL CELL DERIVED FACTOR 1ALPHA; TENASCIN; THY 1 ANTIGEN; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VIMENTIN;

EID: 85011317431     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/s12943-017-0597-8     Document Type: Review
Times cited : (406)

References (117)
  • 1
    • 77952568396 scopus 로고    scopus 로고
    • Hallmarks of cancer: interactions with the tumor stroma
    • Pietras K, Ostman A. Hallmarks of cancer: interactions with the tumor stroma. Exp Cell Res. 2010;316(8):1324-31.
    • (2010) Exp Cell Res , vol.316 , Issue.8 , pp. 1324-1331
    • Pietras, K.1    Ostman, A.2
  • 2
    • 84962324438 scopus 로고    scopus 로고
    • Tumors: wounds that do not heal-redux
    • Dvorak HF. Tumors: wounds that do not heal-redux. Cancer Immunol Res. 2015;3(1):1-11.
    • (2015) Cancer Immunol Res , vol.3 , Issue.1 , pp. 1-11
    • Dvorak, H.F.1
  • 3
    • 0347123433 scopus 로고    scopus 로고
    • Tumour-educated macrophages promote tumour progression and metastasis
    • Pollard JW. Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer. 2004;4(1):71-8.
    • (2004) Nat Rev Cancer , vol.4 , Issue.1 , pp. 71-78
    • Pollard, J.W.1
  • 4
    • 34547567884 scopus 로고    scopus 로고
    • The participation of mesenchymal stem cells in tumor stroma formation and their application as targeted-gene delivery vehicles
    • Hall B, Andreeff M, Marini F. The participation of mesenchymal stem cells in tumor stroma formation and their application as targeted-gene delivery vehicles. Handb Exp Pharmacol. 2007;180:263-83.
    • (2007) Handb Exp Pharmacol , vol.180 , pp. 263-283
    • Hall, B.1    Andreeff, M.2    Marini, F.3
  • 5
    • 0026471974 scopus 로고
    • Myelopoiesis-associated immune suppressor cells in mice bearing metastatic Lewis lung carcinoma tumors: gamma interferon plus tumor necrosis factor alpha synergistically reduces immune suppressor and tumor growth-promoting activities of bone marrow cells and diminishes tumor recurrence and metastasis
    • Young MR, Wright MA. Myelopoiesis-associated immune suppressor cells in mice bearing metastatic Lewis lung carcinoma tumors: gamma interferon plus tumor necrosis factor alpha synergistically reduces immune suppressor and tumor growth-promoting activities of bone marrow cells and diminishes tumor recurrence and metastasis. Cancer Res. 1992;52(22):6335-40.
    • (1992) Cancer Res , vol.52 , Issue.22 , pp. 6335-6340
    • Young, M.R.1    Wright, M.A.2
  • 6
    • 0742307278 scopus 로고    scopus 로고
    • Tumor-stromal cell contact promotes invasion of human uterine cervical carcinoma cells by augmenting the expression and activation of stromal matrix metalloproteinases
    • Sato T, et al. Tumor-stromal cell contact promotes invasion of human uterine cervical carcinoma cells by augmenting the expression and activation of stromal matrix metalloproteinases. Gynecol Oncol. 2004;92(1):47-56.
    • (2004) Gynecol Oncol , vol.92 , Issue.1 , pp. 47-56
    • Sato, T.1
  • 7
    • 57149112529 scopus 로고    scopus 로고
    • Coevolution of prostate cancer and bone stroma in three-dimensional coculture: implications for cancer growth and metastasis
    • Sung SY, et al. Coevolution of prostate cancer and bone stroma in three-dimensional coculture: implications for cancer growth and metastasis. Cancer Res. 2008;68(23):9996-10003.
    • (2008) Cancer Res , vol.68 , Issue.23 , pp. 9996-10003
    • Sung, S.Y.1
  • 8
    • 0033515827 scopus 로고    scopus 로고
    • Multilineage potential of adult human mesenchymal stem cells
    • Pittenger MF, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284(5411):143-7.
    • (1999) Science , vol.284 , Issue.5411 , pp. 143-147
    • Pittenger, M.F.1
  • 9
    • 33747713246 scopus 로고    scopus 로고
    • Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
    • Dominici M, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006;8(4):315-7.
    • (2006) Cytotherapy , vol.8 , Issue.4 , pp. 315-317
    • Dominici, M.1
  • 10
    • 0028788268 scopus 로고
    • Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine
    • Wakitani S, Saito T, Caplan AI. Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve. 1995;18(12):1417-26.
    • (1995) Muscle Nerve , vol.18 , Issue.12 , pp. 1417-1426
    • Wakitani, S.1    Saito, T.2    Caplan, A.I.3
  • 11
    • 0032874061 scopus 로고    scopus 로고
    • Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains
    • Kopen GC, Prockop DJ, Phinney DG. Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci U S A. 1999;96(19):10711-6.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.19 , pp. 10711-10716
    • Kopen, G.C.1    Prockop, D.J.2    Phinney, D.G.3
  • 12
    • 0034610376 scopus 로고    scopus 로고
    • Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo
    • Gronthos S, et al. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci U S A. 2000;97(25):13625-30.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , Issue.25 , pp. 13625-13630
    • Gronthos, S.1
  • 13
    • 0036192626 scopus 로고    scopus 로고
    • Rat extramedullary adipose tissue as a source of osteochondrogenic progenitor cells
    • Huang JI, et al. Rat extramedullary adipose tissue as a source of osteochondrogenic progenitor cells. Plast Reconstr Surg. 2002;109(3):1033-41. discussion 1042-3.
    • (2002) Plast Reconstr Surg , vol.109 , Issue.3 , pp. 1033-1041
    • Huang, J.I.1
  • 14
    • 84989485234 scopus 로고
    • The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells
    • Friedenstein AJ, Chailakhjan RK, Lalykina KS. The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet. 1970;3(4):393-403.
    • (1970) Cell Tissue Kinet , vol.3 , Issue.4 , pp. 393-403
    • Friedenstein, A.J.1    Chailakhjan, R.K.2    Lalykina, K.S.3
  • 15
    • 36248932643 scopus 로고    scopus 로고
    • Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing
    • Chamberlain G, et al. Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells. 2007;25(11):2739-49.
    • (2007) Stem Cells , vol.25 , Issue.11 , pp. 2739-2749
    • Chamberlain, G.1
  • 16
    • 0037478581 scopus 로고    scopus 로고
    • Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects
    • Ortiz LA, et al. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci U S A. 2003;100(14):8407-11.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.14 , pp. 8407-8411
    • Ortiz, L.A.1
  • 17
    • 22144460191 scopus 로고    scopus 로고
    • Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion
    • Sato Y, et al. Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion. Blood. 2005;106(2):756-63.
    • (2005) Blood , vol.106 , Issue.2 , pp. 756-763
    • Sato, Y.1
  • 18
    • 2942555661 scopus 로고    scopus 로고
    • Interactions of chemokines and chemokine receptors mediate the migration of mesenchymal stem cells to the impaired site in the brain after hypoglossal nerve injury
    • Ji JF, et al. Interactions of chemokines and chemokine receptors mediate the migration of mesenchymal stem cells to the impaired site in the brain after hypoglossal nerve injury. Stem Cells. 2004;22(3):415-27.
    • (2004) Stem Cells , vol.22 , Issue.3 , pp. 415-427
    • Ji, J.F.1
  • 19
    • 0037443911 scopus 로고    scopus 로고
    • Migration of mesenchymal stem cells to heart allografts during chronic rejection
    • Wu GD, et al. Migration of mesenchymal stem cells to heart allografts during chronic rejection. Transplantation. 2003;75(5):679-85.
    • (2003) Transplantation , vol.75 , Issue.5 , pp. 679-685
    • Wu, G.D.1
  • 20
    • 33645902493 scopus 로고    scopus 로고
    • Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2
    • Serbina NV, Pamer EG. Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2. Nat Immunol. 2006;7(3):311-7.
    • (2006) Nat Immunol , vol.7 , Issue.3 , pp. 311-317
    • Serbina, N.V.1    Pamer, E.G.2
  • 21
    • 77951455778 scopus 로고    scopus 로고
    • Impact of interactions of cellular components of the bone marrow microenvironment on hematopoietic stem and progenitor cell function
    • Chitteti BR, et al. Impact of interactions of cellular components of the bone marrow microenvironment on hematopoietic stem and progenitor cell function. Blood. 2010;115(16):3239-48.
    • (2010) Blood , vol.115 , Issue.16 , pp. 3239-3248
    • Chitteti, B.R.1
  • 22
    • 0034210222 scopus 로고    scopus 로고
    • Cotransplantation of human stromal cell progenitors into preimmune fetal sheep results in early appearance of human donor cells in circulation and boosts cell levels in bone marrow at later time points after transplantation
    • Almeida-Porada G, et al. Cotransplantation of human stromal cell progenitors into preimmune fetal sheep results in early appearance of human donor cells in circulation and boosts cell levels in bone marrow at later time points after transplantation. Blood. 2000;95(11):3620-7.
    • (2000) Blood , vol.95 , Issue.11 , pp. 3620-3627
    • Almeida-Porada, G.1
  • 23
    • 1842483153 scopus 로고    scopus 로고
    • Human mesenchymal stem cells support unrelated donor hematopoietic stem cells and suppress T-cell activation
    • Maitra B, et al. Human mesenchymal stem cells support unrelated donor hematopoietic stem cells and suppress T-cell activation. Bone Marrow Transplant. 2004;33(6):597-604.
    • (2004) Bone Marrow Transplant , vol.33 , Issue.6 , pp. 597-604
    • Maitra, B.1
  • 24
    • 33846255324 scopus 로고    scopus 로고
    • Human mesenchymal stem cells isolated from bone marrow and lymphoid organs support tumor B-cell growth: role of stromal cells in follicular lymphoma pathogenesis
    • Ame-Thomas P, et al. Human mesenchymal stem cells isolated from bone marrow and lymphoid organs support tumor B-cell growth: role of stromal cells in follicular lymphoma pathogenesis. Blood. 2007;109(2):693-702.
    • (2007) Blood , vol.109 , Issue.2 , pp. 693-702
    • Ame-Thomas, P.1
  • 25
    • 84907080597 scopus 로고    scopus 로고
    • The bidirectional tumor--mesenchymal stromal cell interaction promotes the progression of head and neck cancer
    • Kansy BA, et al. The bidirectional tumor--mesenchymal stromal cell interaction promotes the progression of head and neck cancer. Stem Cell Res Ther. 2014;5(4):95.
    • (2014) Stem Cell Res Ther , vol.5 , Issue.4 , pp. 95
    • Kansy, B.A.1
  • 26
    • 34948896045 scopus 로고    scopus 로고
    • Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
    • Karnoub AE, et al. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature. 2007;449(7162):557-63.
    • (2007) Nature , vol.449 , Issue.7162 , pp. 557-563
    • Karnoub, A.E.1
  • 27
    • 77958470652 scopus 로고    scopus 로고
    • Adipose tissue-derived stem cells promote prostate tumor growth
    • Prantl L, et al. Adipose tissue-derived stem cells promote prostate tumor growth. Prostate. 2010;70(15):1709-15.
    • (2010) Prostate , vol.70 , Issue.15 , pp. 1709-1715
    • Prantl, L.1
  • 28
    • 79960720038 scopus 로고    scopus 로고
    • Mesenchymal stromal cells promote tumor growth through the enhancement of neovascularization
    • Suzuki K, et al. Mesenchymal stromal cells promote tumor growth through the enhancement of neovascularization. Mol Med. 2011;17(7-8):579-87.
    • (2011) Mol Med , vol.17 , Issue.7-8 , pp. 579-587
    • Suzuki, K.1
  • 29
    • 77952720888 scopus 로고    scopus 로고
    • Tumor cell behaviour modulation by mesenchymal stromal cells
    • Kucerova L, et al. Tumor cell behaviour modulation by mesenchymal stromal cells. Mol Cancer. 2010;9:129.
    • (2010) Mol Cancer , vol.9 , pp. 129
    • Kucerova, L.1
  • 30
    • 84875797043 scopus 로고    scopus 로고
    • Quantification of Mesenchymal Stem Cells (MSCs) at sites of human prostate cancer
    • Brennen WN, et al. Quantification of Mesenchymal Stem Cells (MSCs) at sites of human prostate cancer. Oncotarget. 2013;4(1):106-17.
    • (2013) Oncotarget , vol.4 , Issue.1 , pp. 106-117
    • Brennen, W.N.1
  • 31
    • 42549110786 scopus 로고    scopus 로고
    • Bone marrow stromal cells enhance prostate cancer cell invasion through type I collagen in an MMP-12 dependent manner
    • Nabha SM, et al. Bone marrow stromal cells enhance prostate cancer cell invasion through type I collagen in an MMP-12 dependent manner. Int J Cancer. 2008;122(11):2482-90.
    • (2008) Int J Cancer , vol.122 , Issue.11 , pp. 2482-2490
    • Nabha, S.M.1
  • 32
    • 78650739435 scopus 로고    scopus 로고
    • Malignant cells facilitate lung metastasis by bringing their own soil
    • Duda DG, et al. Malignant cells facilitate lung metastasis by bringing their own soil. Proc Natl Acad Sci U S A. 2010;107(50):21677-82.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.50 , pp. 21677-21682
    • Duda, D.G.1
  • 33
    • 49649110387 scopus 로고    scopus 로고
    • Mesenchymal stem cells in early entry of breast cancer into bone marrow
    • Corcoran KE, et al. Mesenchymal stem cells in early entry of breast cancer into bone marrow. PLoS One. 2008;3(6):e2563.
    • (2008) PLoS One , vol.3 , Issue.6
    • Corcoran, K.E.1
  • 34
    • 84937631974 scopus 로고    scopus 로고
    • Mesenchymal stem cells isolated from human gliomas increase proliferation and maintain stemness of glioma stem cells through the IL-6/gp130/STAT3 pathway
    • Hossain A, et al. Mesenchymal stem cells isolated from human gliomas increase proliferation and maintain stemness of glioma stem cells through the IL-6/gp130/STAT3 pathway. Stem Cells. 2015;33(8):2400-15.
    • (2015) Stem Cells , vol.33 , Issue.8 , pp. 2400-2415
    • Hossain, A.1
  • 35
    • 84930202365 scopus 로고    scopus 로고
    • Gastric cancer-derived mesenchymal stem cells prompt gastric cancer progression through secretion of interleukin-8
    • Li W, et al. Gastric cancer-derived mesenchymal stem cells prompt gastric cancer progression through secretion of interleukin-8. J Exp Clin Cancer Res. 2015;34:52.
    • (2015) J Exp Clin Cancer Res , vol.34 , pp. 52
    • Li, W.1
  • 36
    • 33646502840 scopus 로고    scopus 로고
    • Mesenchymal stem cells derived from bone marrow favor tumor cell growth in vivo
    • Zhu W, et al. Mesenchymal stem cells derived from bone marrow favor tumor cell growth in vivo. Exp Mol Pathol. 2006;80(3):267-74.
    • (2006) Exp Mol Pathol , vol.80 , Issue.3 , pp. 267-274
    • Zhu, W.1
  • 37
    • 84926390053 scopus 로고    scopus 로고
    • Mesenchymal stem cells mediate the clinical phenotype of inflammatory breast cancer in a preclinical model
    • Lacerda L, et al. Mesenchymal stem cells mediate the clinical phenotype of inflammatory breast cancer in a preclinical model. Breast Cancer Res. 2015;17:42.
    • (2015) Breast Cancer Res , vol.17 , pp. 42
    • Lacerda, L.1
  • 38
    • 84863958676 scopus 로고    scopus 로고
    • Human bone marrow-derived mesenchymal stem cells produced TGFbeta contributes to progression and metastasis of prostate cancer
    • Ye H, et al. Human bone marrow-derived mesenchymal stem cells produced TGFbeta contributes to progression and metastasis of prostate cancer. Cancer Invest. 2012;30(7):513-8.
    • (2012) Cancer Invest , vol.30 , Issue.7 , pp. 513-518
    • Ye, H.1
  • 39
    • 84879825630 scopus 로고    scopus 로고
    • Oncostatin M promotes mesenchymal stem cell-stimulated tumor growth through a paracrine mechanism involving periostin and TGFBI
    • Lee MJ, et al. Oncostatin M promotes mesenchymal stem cell-stimulated tumor growth through a paracrine mechanism involving periostin and TGFBI. Int J Biochem Cell Biol. 2013;45(8):1869-77.
    • (2013) Int J Biochem Cell Biol , vol.45 , Issue.8 , pp. 1869-1877
    • Lee, M.J.1
  • 40
    • 85067220161 scopus 로고    scopus 로고
    • Stromal Modulators of TGF-beta in Cancer
    • Costanza, B., et al. Stromal Modulators of TGF-beta in Cancer. J Clin Med. 2017. 6(1).
    • (2017) J Clin Med. , vol.6 , Issue.1
    • Costanza, B.1
  • 41
    • 84869021181 scopus 로고    scopus 로고
    • Dependency of colorectal cancer on a TGF-beta-driven program in stromal cells for metastasis initiation
    • Calon A, et al. Dependency of colorectal cancer on a TGF-beta-driven program in stromal cells for metastasis initiation. Cancer Cell. 2012;22(5):571-84.
    • (2012) Cancer Cell , vol.22 , Issue.5 , pp. 571-584
    • Calon, A.1
  • 42
    • 84859191414 scopus 로고    scopus 로고
    • Immunohistochemical expression of epithelial and stromal immunomodulatory signalling molecules is a prognostic indicator in breast cancer
    • Richardsen E, et al. Immunohistochemical expression of epithelial and stromal immunomodulatory signalling molecules is a prognostic indicator in breast cancer. BMC Res Notes. 2012;5:110.
    • (2012) BMC Res Notes , vol.5 , pp. 110
    • Richardsen, E.1
  • 43
    • 84893423304 scopus 로고    scopus 로고
    • Endogenous gastric-resident mesenchymal stem cells contribute to formation of cancer stroma and progression of gastric cancer
    • Kim EK, et al. Endogenous gastric-resident mesenchymal stem cells contribute to formation of cancer stroma and progression of gastric cancer. Korean J Pathol. 2013;47(6):507-18.
    • (2013) Korean J Pathol , vol.47 , Issue.6 , pp. 507-518
    • Kim, E.K.1
  • 44
    • 68049124516 scopus 로고    scopus 로고
    • Therapeutic potential of mesenchymal stromal cells in a mouse breast cancer metastasis model
    • Sun B, et al. Therapeutic potential of mesenchymal stromal cells in a mouse breast cancer metastasis model. Cytotherapy. 2009;11(3):289-98. 1 p following 298.
    • (2009) Cytotherapy , vol.11 , Issue.3 , pp. 289-298
    • Sun, B.1
  • 45
    • 33646690027 scopus 로고    scopus 로고
    • Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma
    • Khakoo AY, et al. Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma. J Exp Med. 2006;203(5):1235-47.
    • (2006) J Exp Med , vol.203 , Issue.5 , pp. 1235-1247
    • Khakoo, A.Y.1
  • 46
    • 41849115243 scopus 로고    scopus 로고
    • Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model
    • Qiao L, et al. Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model. Cell Res. 2008;18(4):500-7.
    • (2008) Cell Res , vol.18 , Issue.4 , pp. 500-507
    • Qiao, L.1
  • 47
    • 66149135956 scopus 로고    scopus 로고
    • Concentration-dependent inhibition of angiogenesis by mesenchymal stem cells
    • Otsu K, et al. Concentration-dependent inhibition of angiogenesis by mesenchymal stem cells. Blood. 2009;113(18):4197-205.
    • (2009) Blood , vol.113 , Issue.18 , pp. 4197-4205
    • Otsu, K.1
  • 48
    • 4444269045 scopus 로고    scopus 로고
    • Characterization and expression analysis of mesenchymal stem cells from human bone marrow and adipose tissue
    • Lee RH, et al. Characterization and expression analysis of mesenchymal stem cells from human bone marrow and adipose tissue. Cell Physiol Biochem. 2004;14(4-6):311-24.
    • (2004) Cell Physiol Biochem , vol.14 , Issue.4-6 , pp. 311-324
    • Lee, R.H.1
  • 49
    • 27544441193 scopus 로고    scopus 로고
    • Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood
    • Wagner W, et al. Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood. Exp Hematol. 2005;33(11):1402-16.
    • (2005) Exp Hematol , vol.33 , Issue.11 , pp. 1402-1416
    • Wagner, W.1
  • 50
    • 27944435821 scopus 로고    scopus 로고
    • Clarification of the nomenclature for MSC: the international society for cellular therapy position statement
    • Horwitz EM, et al. Clarification of the nomenclature for MSC: the international society for cellular therapy position statement. Cytotherapy. 2005;7(5):393-5.
    • (2005) Cytotherapy , vol.7 , Issue.5 , pp. 393-395
    • Horwitz, E.M.1
  • 51
    • 74649085138 scopus 로고    scopus 로고
    • Embryonic stem cell marker expression pattern in human mesenchymal stem cells derived from bone marrow, adipose tissue, heart and dermis
    • Riekstina U, et al. Embryonic stem cell marker expression pattern in human mesenchymal stem cells derived from bone marrow, adipose tissue, heart and dermis. Stem Cell Rev. 2009;5(4):378-86.
    • (2009) Stem Cell Rev , vol.5 , Issue.4 , pp. 378-386
    • Riekstina, U.1
  • 52
    • 0036839143 scopus 로고    scopus 로고
    • Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    • Mantovani A, et al. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 2002;23(11):549-55.
    • (2002) Trends Immunol , vol.23 , Issue.11 , pp. 549-555
    • Mantovani, A.1
  • 53
    • 0035993208 scopus 로고    scopus 로고
    • Tumor-associated macrophages: a molecular perspective
    • Sica A, Saccani A, Mantovani A. Tumor-associated macrophages: a molecular perspective. Int Immunopharmacol. 2002;2(8):1045-54.
    • (2002) Int Immunopharmacol , vol.2 , Issue.8 , pp. 1045-1054
    • Sica, A.1    Saccani, A.2    Mantovani, A.3
  • 54
    • 41149164902 scopus 로고    scopus 로고
    • The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance
    • Allavena P, et al. The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance. Immunol Rev. 2008;222:155-61.
    • (2008) Immunol Rev , vol.222 , pp. 155-161
    • Allavena, P.1
  • 55
    • 33645991795 scopus 로고    scopus 로고
    • Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy
    • Sica A, et al. Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy. Eur J Cancer. 2006;42(6):717-27.
    • (2006) Eur J Cancer , vol.42 , Issue.6 , pp. 717-727
    • Sica, A.1
  • 56
    • 70350728931 scopus 로고    scopus 로고
    • Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation
    • Solinas G, et al. Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. J Leukoc Biol. 2009;86(5):1065-73.
    • (2009) J Leukoc Biol , vol.86 , Issue.5 , pp. 1065-1073
    • Solinas, G.1
  • 57
    • 38349077498 scopus 로고    scopus 로고
    • Toll-like receptors on human mesenchymal stem cells drive their migration and immunomodulating responses
    • Tomchuck SL, et al. Toll-like receptors on human mesenchymal stem cells drive their migration and immunomodulating responses. Stem Cells. 2008;26(1):99-107.
    • (2008) Stem Cells , vol.26 , Issue.1 , pp. 99-107
    • Tomchuck, S.L.1
  • 58
    • 77956420421 scopus 로고    scopus 로고
    • A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 phenotype
    • Waterman RS, et al. A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 phenotype. PLoS One. 2010;5(4):e10088.
    • (2010) PLoS One , vol.5 , Issue.4
    • Waterman, R.S.1
  • 59
    • 84866689845 scopus 로고    scopus 로고
    • Mesenchymal stem cell 1 (MSC1)-based therapy attenuates tumor growth whereas MSC2-treatment promotes tumor growth and metastasis
    • Waterman RS, Henkle SL, Betancourt AM. Mesenchymal stem cell 1 (MSC1)-based therapy attenuates tumor growth whereas MSC2-treatment promotes tumor growth and metastasis. PLoS One. 2012;7(9):e45590.
    • (2012) PLoS One , vol.7 , Issue.9
    • Waterman, R.S.1    Henkle, S.L.2    Betancourt, A.M.3
  • 60
    • 78649552269 scopus 로고    scopus 로고
    • Study of TLR3, TLR4 and TLR9 in breast carcinomas and their association with metastasis
    • Gonzalez-Reyes S, et al. Study of TLR3, TLR4 and TLR9 in breast carcinomas and their association with metastasis. BMC Cancer. 2010;10:665.
    • (2010) BMC Cancer , vol.10 , pp. 665
    • Gonzalez-Reyes, S.1
  • 61
    • 64549145804 scopus 로고    scopus 로고
    • Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression
    • Spaeth EL, et al. Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression. PLoS One. 2009;4(4):e4992.
    • (2009) PLoS One , vol.4 , Issue.4
    • Spaeth, E.L.1
  • 62
    • 0037437371 scopus 로고    scopus 로고
    • TGF-beta1-mediated fibroblast-myofibroblast terminal differentiation-the role of Smad proteins
    • Evans RA, et al. TGF-beta1-mediated fibroblast-myofibroblast terminal differentiation-the role of Smad proteins. Exp Cell Res. 2003;282(2):90-100.
    • (2003) Exp Cell Res , vol.282 , Issue.2 , pp. 90-100
    • Evans, R.A.1
  • 63
    • 35948945337 scopus 로고    scopus 로고
    • Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts
    • Zeisberg EM, et al. Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. Cancer Res. 2007;67(21):10123-8.
    • (2007) Cancer Res , vol.67 , Issue.21 , pp. 10123-10128
    • Zeisberg, E.M.1
  • 64
    • 78650563018 scopus 로고    scopus 로고
    • Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
    • Kojima Y, et al. Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts. Proc Natl Acad Sci U S A. 2010;107(46):20009-14.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.46 , pp. 20009-20014
    • Kojima, Y.1
  • 65
    • 84870381911 scopus 로고    scopus 로고
    • Inhibition of TGF-beta/Smad signaling by BAMBI blocks differentiation of human mesenchymal stem cells to carcinoma-associated fibroblasts and abolishes their protumor effects
    • Shangguan L, et al. Inhibition of TGF-beta/Smad signaling by BAMBI blocks differentiation of human mesenchymal stem cells to carcinoma-associated fibroblasts and abolishes their protumor effects. Stem Cells. 2012;30(12):2810-9.
    • (2012) Stem Cells , vol.30 , Issue.12 , pp. 2810-2819
    • Shangguan, L.1
  • 66
    • 84897556892 scopus 로고    scopus 로고
    • TGF-beta in CAF-mediated tumor growth and metastasis
    • Calon A, Tauriello DV, Batlle E. TGF-beta in CAF-mediated tumor growth and metastasis. Semin Cancer Biol. 2014;25:15-22.
    • (2014) Semin Cancer Biol , vol.25 , pp. 15-22
    • Calon, A.1    Tauriello, D.V.2    Batlle, E.3
  • 67
    • 9244236047 scopus 로고    scopus 로고
    • Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts
    • Direkze NC, et al. Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts. Cancer Res. 2004;64(23):8492-5.
    • (2004) Cancer Res , vol.64 , Issue.23 , pp. 8492-8495
    • Direkze, N.C.1
  • 68
    • 0041441245 scopus 로고    scopus 로고
    • Bone-marrow-derived myofibroblasts contribute to the cancer-induced stromal reaction
    • Ishii G, et al. Bone-marrow-derived myofibroblasts contribute to the cancer-induced stromal reaction. Biochem Biophys Res Commun. 2003;309(1):232-40.
    • (2003) Biochem Biophys Res Commun , vol.309 , Issue.1 , pp. 232-240
    • Ishii, G.1
  • 69
    • 32944466121 scopus 로고    scopus 로고
    • Bone marrow-derived stromal cells express lineage-related messenger RNA species
    • Direkze NC, et al. Bone marrow-derived stromal cells express lineage-related messenger RNA species. Cancer Res. 2006;66(3):1265-9.
    • (2006) Cancer Res , vol.66 , Issue.3 , pp. 1265-1269
    • Direkze, N.C.1
  • 70
    • 49249120549 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblast-like differentiation of human mesenchymal stem cells
    • Mishra PJ, et al. Carcinoma-associated fibroblast-like differentiation of human mesenchymal stem cells. Cancer Res. 2008;68(11):4331-9.
    • (2008) Cancer Res , vol.68 , Issue.11 , pp. 4331-4339
    • Mishra, P.J.1
  • 71
    • 84887092894 scopus 로고    scopus 로고
    • GRP78 secreted by tumor cells stimulates differentiation of bone marrow mesenchymal stem cells to cancer-associated fibroblasts
    • Peng Y, Li Z, Li Z. GRP78 secreted by tumor cells stimulates differentiation of bone marrow mesenchymal stem cells to cancer-associated fibroblasts. Biochem Biophys Res Commun. 2013;440(4):558-63.
    • (2013) Biochem Biophys Res Commun , vol.440 , Issue.4 , pp. 558-563
    • Peng, Y.1    Li, Z.2    Li, Z.3
  • 72
    • 79953309908 scopus 로고    scopus 로고
    • Tumour-associated fibroblasts and mesenchymal stem cells: more similarities than differences
    • Paunescu V, et al. Tumour-associated fibroblasts and mesenchymal stem cells: more similarities than differences. J Cell Mol Med. 2011;15(3):635-46.
    • (2011) J Cell Mol Med , vol.15 , Issue.3 , pp. 635-646
    • Paunescu, V.1
  • 73
    • 84984694266 scopus 로고    scopus 로고
    • The biology and function of fibroblasts in cancer
    • Kalluri R. The biology and function of fibroblasts in cancer. Nat Rev Cancer. 2016;16(9):582-98.
    • (2016) Nat Rev Cancer , vol.16 , Issue.9 , pp. 582-598
    • Kalluri, R.1
  • 74
    • 84901020848 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts as another polarized cell type of the tumor microenvironment
    • Augsten M. Cancer-associated fibroblasts as another polarized cell type of the tumor microenvironment. Front Oncol. 2014;4:62.
    • (2014) Front Oncol , vol.4 , pp. 62
    • Augsten, M.1
  • 75
    • 79959653793 scopus 로고    scopus 로고
    • Both human and mouse mesenchymal stem cells promote breast cancer metastasis
    • Albarenque SM, Zwacka RM, Mohr A. Both human and mouse mesenchymal stem cells promote breast cancer metastasis. Stem Cell Res. 2011;7(2):163-71.
    • (2011) Stem Cell Res , vol.7 , Issue.2 , pp. 163-171
    • Albarenque, S.M.1    Zwacka, R.M.2    Mohr, A.3
  • 76
    • 78049517433 scopus 로고    scopus 로고
    • Mesenchymal stem cells enhance growth and metastasis of colon cancer
    • Shinagawa K, et al. Mesenchymal stem cells enhance growth and metastasis of colon cancer. Int J Cancer. 2010;127(10):2323-33.
    • (2010) Int J Cancer , vol.127 , Issue.10 , pp. 2323-2333
    • Shinagawa, K.1
  • 77
    • 84873804360 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis
    • Chaturvedi P, et al. Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. J Clin Invest. 2013;123(1):189-205.
    • (2013) J Clin Invest , vol.123 , Issue.1 , pp. 189-205
    • Chaturvedi, P.1
  • 78
    • 71549114206 scopus 로고    scopus 로고
    • Magnetic resonance imaging of mesenchymal stem cells homing to pulmonary metastases using biocompatible magnetic nanoparticles
    • Loebinger MR, et al. Magnetic resonance imaging of mesenchymal stem cells homing to pulmonary metastases using biocompatible magnetic nanoparticles. Cancer Res. 2009;69(23):8862-7.
    • (2009) Cancer Res , vol.69 , Issue.23 , pp. 8862-8867
    • Loebinger, M.R.1
  • 79
    • 28644432204 scopus 로고    scopus 로고
    • VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
    • Kaplan RN, et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature. 2005;438(7069):820-7.
    • (2005) Nature , vol.438 , Issue.7069 , pp. 820-827
    • Kaplan, R.N.1
  • 80
    • 78649320264 scopus 로고    scopus 로고
    • Potential role of mesenchymal stem cells (MSCs) in the breast tumour microenvironment: stimulation of epithelial to mesenchymal transition (EMT)
    • Martin FT, et al. Potential role of mesenchymal stem cells (MSCs) in the breast tumour microenvironment: stimulation of epithelial to mesenchymal transition (EMT). Breast Cancer Res Treat. 2010;124(2):317-26.
    • (2010) Breast Cancer Res Treat , vol.124 , Issue.2 , pp. 317-326
    • Martin, F.T.1
  • 81
    • 84942812101 scopus 로고    scopus 로고
    • Mesenchymal stem cells promote epithelial to mesenchymal transition and metastasis in gastric cancer though paracrine cues and close physical contact
    • Xue Z, et al. Mesenchymal stem cells promote epithelial to mesenchymal transition and metastasis in gastric cancer though paracrine cues and close physical contact. J Cell Biochem. 2015;116(4):618-27.
    • (2015) J Cell Biochem , vol.116 , Issue.4 , pp. 618-627
    • Xue, Z.1
  • 82
    • 84865527612 scopus 로고    scopus 로고
    • Mesenchymal stem cells in inflammation microenvironment accelerates hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition
    • Jing Y, et al. Mesenchymal stem cells in inflammation microenvironment accelerates hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition. PLoS One. 2012;7(8):e43272.
    • (2012) PLoS One , vol.7 , Issue.8
    • Jing, Y.1
  • 83
    • 67349110806 scopus 로고    scopus 로고
    • Human mesenchymal stem cells (hMSCs) target osteosarcoma and promote its growth and pulmonary metastasis
    • Xu WT, et al. Human mesenchymal stem cells (hMSCs) target osteosarcoma and promote its growth and pulmonary metastasis. Cancer Lett. 2009;281(1):32-41.
    • (2009) Cancer Lett , vol.281 , Issue.1 , pp. 32-41
    • Xu, W.T.1
  • 84
    • 79953727008 scopus 로고    scopus 로고
    • Osteopontin promotes CCL5-mesenchymal stromal cell-mediated breast cancer metastasis
    • Mi Z, et al. Osteopontin promotes CCL5-mesenchymal stromal cell-mediated breast cancer metastasis. Carcinogenesis. 2011;32(4):477-87.
    • (2011) Carcinogenesis , vol.32 , Issue.4 , pp. 477-487
    • Mi, Z.1
  • 85
    • 0028853560 scopus 로고
    • A biochemical characterization of the binding of osteopontin to integrins alpha v beta 1 and alpha v beta 5
    • Hu DD, et al. A biochemical characterization of the binding of osteopontin to integrins alpha v beta 1 and alpha v beta 5. J Biol Chem. 1995;270(44):26232-8.
    • (1995) J Biol Chem , vol.270 , Issue.44 , pp. 26232-26238
    • Hu, D.D.1
  • 86
    • 0028855585 scopus 로고
    • The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro
    • Liaw L, et al. The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro. J Clin Invest. 1995;95(2):713-24.
    • (1995) J Clin Invest , vol.95 , Issue.2 , pp. 713-724
    • Liaw, L.1
  • 87
    • 0031813775 scopus 로고    scopus 로고
    • Identification of osteopontin as a novel ligand for the integrin alpha8 beta1 and potential roles for this integrin-ligand interaction in kidney morphogenesis
    • Denda S, Reichardt LF, Muller U. Identification of osteopontin as a novel ligand for the integrin alpha8 beta1 and potential roles for this integrin-ligand interaction in kidney morphogenesis. Mol Biol Cell. 1998;9(6):1425-35.
    • (1998) Mol Biol Cell , vol.9 , Issue.6 , pp. 1425-1435
    • Denda, S.1    Reichardt, L.F.2    Muller, U.3
  • 88
    • 0033579511 scopus 로고    scopus 로고
    • The integrin alpha(9)beta(1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin
    • Yokosaki Y, et al. The integrin alpha(9)beta(1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin. J Biol Chem. 1999;274(51):36328-34.
    • (1999) J Biol Chem , vol.274 , Issue.51 , pp. 36328-36334
    • Yokosaki, Y.1
  • 89
    • 31544469202 scopus 로고    scopus 로고
    • Increased expression of osteopontin contributes to the progression of prostate cancer
    • Khodavirdi AC, et al. Increased expression of osteopontin contributes to the progression of prostate cancer. Cancer Res. 2006;66(2):883-8.
    • (2006) Cancer Res , vol.66 , Issue.2 , pp. 883-888
    • Khodavirdi, A.C.1
  • 90
    • 58149348622 scopus 로고    scopus 로고
    • Activation of the osteopontin/matrix metalloproteinase-9 pathway correlates with prostate cancer progression
    • Castellano G, et al. Activation of the osteopontin/matrix metalloproteinase-9 pathway correlates with prostate cancer progression. Clin Cancer Res. 2008;14(22):7470-80.
    • (2008) Clin Cancer Res , vol.14 , Issue.22 , pp. 7470-7480
    • Castellano, G.1
  • 91
    • 33645664267 scopus 로고    scopus 로고
    • Prognostic significance of osteopontin expression in human prostate cancer
    • Forootan SS, et al. Prognostic significance of osteopontin expression in human prostate cancer. Int J Cancer. 2006;118(9):2255-61.
    • (2006) Int J Cancer , vol.118 , Issue.9 , pp. 2255-2261
    • Forootan, S.S.1
  • 92
    • 33847000174 scopus 로고    scopus 로고
    • Plasma osteopontin in comparison with bone markers as indicator of bone metastasis and survival outcome in patients with prostate cancer
    • Ramankulov A, et al. Plasma osteopontin in comparison with bone markers as indicator of bone metastasis and survival outcome in patients with prostate cancer. Prostate. 2007;67(3):330-40.
    • (2007) Prostate , vol.67 , Issue.3 , pp. 330-340
    • Ramankulov, A.1
  • 93
    • 0035079815 scopus 로고    scopus 로고
    • Osteopontin deficiency reduces experimental tumor cell metastasis to bone and soft tissues
    • Nemoto H, et al. Osteopontin deficiency reduces experimental tumor cell metastasis to bone and soft tissues. J Bone Miner Res. 2001;16(4):652-9.
    • (2001) J Bone Miner Res , vol.16 , Issue.4 , pp. 652-659
    • Nemoto, H.1
  • 94
    • 0035808779 scopus 로고    scopus 로고
    • Enhancement of osteoclastic bone resorption and suppression of osteoblastic bone formation in response to reduced mechanical stress do not occur in the absence of osteopontin
    • Ishijima M, et al. Enhancement of osteoclastic bone resorption and suppression of osteoblastic bone formation in response to reduced mechanical stress do not occur in the absence of osteopontin. J Exp Med. 2001;193(3):399-404.
    • (2001) J Exp Med , vol.193 , Issue.3 , pp. 399-404
    • Ishijima, M.1
  • 95
    • 12244312775 scopus 로고    scopus 로고
    • Osteopontin deficiency produces osteoclast dysfunction due to reduced CD44 surface expression
    • Chellaiah MA, et al. Osteopontin deficiency produces osteoclast dysfunction due to reduced CD44 surface expression. Mol Biol Cell. 2003;14(1):173-89.
    • (2003) Mol Biol Cell , vol.14 , Issue.1 , pp. 173-189
    • Chellaiah, M.A.1
  • 96
    • 0025371582 scopus 로고
    • Osteopontin--a possible anchor of osteoclasts to bone
    • Reinholt FP, et al. Osteopontin--a possible anchor of osteoclasts to bone. Proc Natl Acad Sci U S A. 1990;87(12):4473-5.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , Issue.12 , pp. 4473-4475
    • Reinholt, F.P.1
  • 97
    • 0027158885 scopus 로고
    • Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorption
    • Ross FP, et al. Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorption. J Biol Chem. 1993;268(13):9901-7.
    • (1993) J Biol Chem , vol.268 , Issue.13 , pp. 9901-9907
    • Ross, F.P.1
  • 98
    • 0030924823 scopus 로고    scopus 로고
    • Osteopontin expression by osteoclast and osteoblast progenitors in the murine bone marrow: demonstration of its requirement for osteoclastogenesis and its increase after ovariectomy
    • Yamate T, et al. Osteopontin expression by osteoclast and osteoblast progenitors in the murine bone marrow: demonstration of its requirement for osteoclastogenesis and its increase after ovariectomy. Endocrinology. 1997;138(7):3047-55.
    • (1997) Endocrinology , vol.138 , Issue.7 , pp. 3047-3055
    • Yamate, T.1
  • 99
    • 0035058961 scopus 로고    scopus 로고
    • Expression of bone sialoprotein and osteopontin in breast cancer bone metastases
    • Ibrahim T, et al. Expression of bone sialoprotein and osteopontin in breast cancer bone metastases. Clin Exp Metastasis. 2000;18(3):253-60.
    • (2000) Clin Exp Metastasis , vol.18 , Issue.3 , pp. 253-260
    • Ibrahim, T.1
  • 100
    • 0942279599 scopus 로고    scopus 로고
    • Downregulation of osteopontin and bone sialoprotein II is related to reduced colony formation and metastasis formation of MDA-MB-231 human breast cancer cells
    • Adwan H, Bauerle TJ, Berger MR. Downregulation of osteopontin and bone sialoprotein II is related to reduced colony formation and metastasis formation of MDA-MB-231 human breast cancer cells. Cancer Gene Ther. 2004;11(2):109-20.
    • (2004) Cancer Gene Ther , vol.11 , Issue.2 , pp. 109-120
    • Adwan, H.1    Bauerle, T.J.2    Berger, M.R.3
  • 101
    • 0030749321 scopus 로고    scopus 로고
    • Skeletal complications of malignancy
    • Coleman RE. Skeletal complications of malignancy. Cancer. 1997;80(8 Suppl):1588-94.
    • (1997) Cancer , vol.80 , Issue.8 , pp. 1588-1594
    • Coleman, R.E.1
  • 102
    • 0037304044 scopus 로고    scopus 로고
    • Stromal factors involved in prostate carcinoma metastasis to bone
    • Cooper CR, et al. Stromal factors involved in prostate carcinoma metastasis to bone. Cancer. 2003;97(3 Suppl):739-47.
    • (2003) Cancer , vol.97 , Issue.3 , pp. 739-747
    • Cooper, C.R.1
  • 103
    • 84883377982 scopus 로고    scopus 로고
    • Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma
    • Zhang XH, et al. Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma. Cell. 2013;154(5):1060-73.
    • (2013) Cell , vol.154 , Issue.5 , pp. 1060-1073
    • Zhang, X.H.1
  • 104
    • 0037085938 scopus 로고    scopus 로고
    • Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone
    • Taichman RS, et al. Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. Cancer Res. 2002;62(6):1832-7.
    • (2002) Cancer Res , vol.62 , Issue.6 , pp. 1832-1837
    • Taichman, R.S.1
  • 105
    • 10044284415 scopus 로고    scopus 로고
    • CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion
    • Singh S, et al. CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion. Lab Invest. 2004;84(12):1666-76.
    • (2004) Lab Invest , vol.84 , Issue.12 , pp. 1666-1676
    • Singh, S.1
  • 106
    • 84856426449 scopus 로고    scopus 로고
    • Roles of bone marrow cells in skeletal metastases: no longer bystanders
    • Park SI, Soki FN, McCauley LK. Roles of bone marrow cells in skeletal metastases: no longer bystanders. Cancer Microenviron. 2011;4(3):237-46.
    • (2011) Cancer Microenviron , vol.4 , Issue.3 , pp. 237-246
    • Park, S.I.1    Soki, F.N.2    McCauley, L.K.3
  • 107
    • 84862012341 scopus 로고    scopus 로고
    • Prostate cancer cells and bone stromal cells mutually interact with each other through bone morphogenetic protein-mediated signals
    • Nishimori, H., et al. Prostate cancer cells and bone stromal cells mutually interact with each other through bone morphogenetic protein-mediated signals. J Biol Chem. 2012;287(24):20037-46.
    • (2012) J Biol Chem. , vol.287 , Issue.24 , pp. 20037-20046
    • Nishimori, H.1
  • 108
    • 84863338444 scopus 로고    scopus 로고
    • Disseminated prostate cancer cells can instruct hematopoietic stem and progenitor cells to regulate bone phenotype
    • Joseph J, et al. Disseminated prostate cancer cells can instruct hematopoietic stem and progenitor cells to regulate bone phenotype. Mol Cancer Res. 2012;10(3):282-92.
    • (2012) Mol Cancer Res , vol.10 , Issue.3 , pp. 282-292
    • Joseph, J.1
  • 109
    • 27544476971 scopus 로고    scopus 로고
    • The role of IL-6 and STAT3 in inflammation and cancer
    • Hodge DR, Hurt EM, Farrar WL. The role of IL-6 and STAT3 in inflammation and cancer. Eur J Cancer. 2005;41(16):2502-12.
    • (2005) Eur J Cancer , vol.41 , Issue.16 , pp. 2502-2512
    • Hodge, D.R.1    Hurt, E.M.2    Farrar, W.L.3
  • 110
    • 0032450975 scopus 로고    scopus 로고
    • Interdependence between cytokines and cell adhesion molecules to induce interleukin-6 production by stromal cells in myeloma
    • Thomas X, et al. Interdependence between cytokines and cell adhesion molecules to induce interleukin-6 production by stromal cells in myeloma. Leuk Lymphoma. 1998;32(1-2):107-19.
    • (1998) Leuk Lymphoma , vol.32 , Issue.1-2 , pp. 107-119
    • Thomas, X.1
  • 111
    • 0034284054 scopus 로고    scopus 로고
    • Cell-cell contact between marrow stromal cells and myeloma cells via VCAM-1 and alpha(4)beta(1)-integrin enhances production of osteoclast-stimulating activity
    • Michigami T, et al. Cell-cell contact between marrow stromal cells and myeloma cells via VCAM-1 and alpha(4)beta(1)-integrin enhances production of osteoclast-stimulating activity. Blood. 2000;96(5):1953-60.
    • (2000) Blood , vol.96 , Issue.5 , pp. 1953-1960
    • Michigami, T.1
  • 112
    • 58249095935 scopus 로고    scopus 로고
    • Interleukin-6 in the bone marrow microenvironment promotes the growth and survival of neuroblastoma cells
    • Ara T, et al. Interleukin-6 in the bone marrow microenvironment promotes the growth and survival of neuroblastoma cells. Cancer Res. 2009;69(1):329-37.
    • (2009) Cancer Res , vol.69 , Issue.1 , pp. 329-337
    • Ara, T.1
  • 113
    • 9144231336 scopus 로고    scopus 로고
    • Interleukin-6-dependent gene expression profiles in multiple myeloma INA-6 cells reveal a Bcl-2 family-independent survival pathway closely associated with Stat3 activation
    • Brocke-Heidrich K, et al. Interleukin-6-dependent gene expression profiles in multiple myeloma INA-6 cells reveal a Bcl-2 family-independent survival pathway closely associated with Stat3 activation. Blood. 2004;103(1):242-51.
    • (2004) Blood , vol.103 , Issue.1 , pp. 242-251
    • Brocke-Heidrich, K.1
  • 114
    • 79951841819 scopus 로고    scopus 로고
    • Concise review: dissecting a discrepancy in the literature: do mesenchymal stem cells support or suppress tumor growth?
    • Klopp AH, et al. Concise review: dissecting a discrepancy in the literature: do mesenchymal stem cells support or suppress tumor growth? Stem Cells. 2011;29(1):11-9.
    • (2011) Stem Cells , vol.29 , Issue.1 , pp. 11-19
    • Klopp, A.H.1
  • 115
    • 58149334773 scopus 로고    scopus 로고
    • A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer
    • Farmer P, et al. A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer. Nat Med. 2009;15(1):68-74.
    • (2009) Nat Med , vol.15 , Issue.1 , pp. 68-74
    • Farmer, P.1
  • 116
    • 43249121177 scopus 로고    scopus 로고
    • Stromal gene expression predicts clinical outcome in breast cancer
    • Finak G, et al. Stromal gene expression predicts clinical outcome in breast cancer. Nat Med. 2008;14(5):518-27.
    • (2008) Nat Med , vol.14 , Issue.5 , pp. 518-527
    • Finak, G.1
  • 117
    • 84954154754 scopus 로고    scopus 로고
    • Cisplatin-induced mesenchymal stromal cells-mediated mechanism contributing to decreased antitumor effect in breast cancer cells
    • Skolekova S, et al. Cisplatin-induced mesenchymal stromal cells-mediated mechanism contributing to decreased antitumor effect in breast cancer cells. Cell Commun Signal. 2016;14(1):4.
    • (2016) Cell Commun Signal , vol.14 , Issue.1 , pp. 4
    • Skolekova, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.