Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution

Genome Biology

Volumn 18, Issue 1, 2017, Pages

  van Iterson, Maarten ^a   van Zwet, Erik W ^a   Heijmans, Bastiaan T ^a   't Hoen, Peter A C ^a   van Meurs, Joyce ^b   Jansen, Rick ^b,c   Franke, Lude ^d   Boomsma, Dorret I ^e   Pool, René ^e   van Dongen, Jenny ^e   Hottenga, Jouke J ^e   van Greevenbroek, Marleen M J ^f   Stehouwer, Coen D A ^f   van der Kallen, Carla J H ^f   Schalkwijk, Casper G ^f   Wijmenga, Cisca ^d   Zhernakova, Sasha ^d   Tigchelaar, Ettje F ^d   Eline Slagboom, P ^a   Beekman, Marian ^a   Deelen, Joris ^a   van Heemst, Diana ^a   Veldink, Jan H ^g   van den Berg, Leonard H ^g   van Duijn, Cornelia M ^b   Hofman, Bert A ^b   Isaacs, Aaron ^b   Uitterlinden, André G ^b   Jhamai, P Mila ^b   Verbiest, Michael ^a   Suchiman, H Eka D ^a   Verkerk, Marijn ^b   van der Breggen, Ruud ^a   van Rooij, Jeroen ^b   Lakenberg, Nico ^a   Mei, Hailiang ^a   van Galen, Michiel ^a   Bot, Jan ^h   Zhernakova, Dasha V ^c,d   van 't Hof, Peter ^a   Deelen, Patrick ^c,d   Nooren, Irene ^h   Moed, Matthijs ^a   Vermaat, Martijn ^a   Luijk, René ^a   Bonder, Marc Jan ^d   van Dijk, Freerk ^d   Arindrarto, Wibowo ^a   Kielbasa, Szymon M ^a   Swertz, Morris A ^d   't Hoen, Peter Bram ^a   more..

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^e VU UNIVERSITY AMSTERDAM   (Netherlands)

^f MAASTRICHT UNIVERSITY   (Netherlands)

^g UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^h SURFSARA   (Netherlands)

Author keywords

Bias; Empirical null distribution; Epigenome and transcriptome wide association studies; Gibbs sampler; Inflation; Meta analysis

Indexed keywords

AGE; ARTICLE; BAYES THEOREM; DNA METHYLATION; EPIGENOME WIDE ASSOCIATION STUDY; GENETIC ASSOCIATION STUDY; GENOME-WIDE ASSOCIATION STUDY; GENOMIC INFLATION FACTOR; LEUKOCYTE COUNT; PREDICTION; RNA SEQUENCE; SIMULATION; SMOKING; STATISTICAL BIAS; STATISTICAL PARAMETERS; TRANSCRIPTOME WIDE ASSOCIATION STUDY; EPIGENETICS; GENETIC EPIGENESIS; HUMAN; META ANALYSIS (TOPIC); PROCEDURES; STANDARDS;

TRANSCRIPTOME;

AGE FACTORS; BAYES THEOREM; BIAS (EPIDEMIOLOGY); EPIGENESIS, GENETIC; EPIGENOMICS; GENOME-WIDE ASSOCIATION STUDY; HUMANS; META-ANALYSIS AS TOPIC; SMOKING; TRANSCRIPTOME;

EID: 85011072560     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/s13059-016-1131-9     Document Type: Article

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