Porcine reproductive and respiratory syndrome virus antagonizes JAK/STAT3 signaling via nsp5, which induces STAT3 degradation

Journal of Virology

Volumn 91, Issue 3, 2017, Pages

  Yang, Liping ^a   Wang, Rong ^a,b   Ma, Zexu ^a   Xiao, Yueqiang ^a,c   Nan, Yuchen ^a,d   Wang, Yu ^a,e   Lin, Shaoli ^a   Zhang, Yan Jin ^a  

^a UNIVERSITY OF MARYLAND   (United States)

^b XI'AN JIAOTONG UNIVERSITY   (China)

^c SHANDONG PEANUT RESEARCH INSTITUTE   (China)

^d NORTHWEST A F UNIVERSITY   (China)

^e TAISHAN MEDICAL UNIVERSITY   (China)

Author keywords

Innate immunity; JAK STAT signaling; Porcine reproductive and respiratory syndrome virus (PRRSV); PRRSV nsp5; Signal transducer and activator of transcription 3; STAT3

Indexed keywords

GREEN FLUORESCENT PROTEIN; JANUS KINASE; NONSTRUCTURAL PROTEIN 5; PROTEASOME; STAT3 PROTEIN; UBIQUITIN; ONCOSTATIN M; PROTEIN BINDING; VIRAL PROTEIN;

ADAPTIVE IMMUNITY; ARTICLE; AUTOPHAGY; CELL DIFFERENTIATION; CELL MATURATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DENSITOMETRY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOPRECIPITATION; INNATE IMMUNITY; NONHUMAN; PLASMID; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS; PROTEIN DEGRADATION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; VIRUS NEUTRALIZATION; ANIMAL; CELL LINE; CHEMISTRY; DRUG EFFECTS; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; PIG; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PROTEIN DOMAIN; UBIQUITINATION; VIROLOGY; VIRUS REPLICATION;

ANIMALS; CELL LINE; HUMANS; IMMUNITY, INNATE; JANUS KINASES; ONCOSTATIN M; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEOLYSIS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; SWINE; TRANSCRIPTION, GENETIC; UBIQUITIN; UBIQUITINATION; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 85010900090     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02087-16     Document Type: Article

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