SIL-6R is related to weekly training mileage and psychological well-being in athletes

Medicine and Science in Sports and Exercise

Volumn 49, Issue 6, 2017, Pages 1176-1183

  Cullen, Tom ^a,b   Thomas, Andrew W ^a   Webb, Richard ^a   Phillips, Thom ^c   Hughes, Michael G ^a  

^a CARDIFF METROPOLITAN UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF WORCESTER   (United Kingdom)

^c UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

Author keywords

Athletes; Fatigue; Overreaching; SIL 6R

Indexed keywords

HYDROCORTISONE; INTERLEUKIN 6;

AFFECT; BLOOD; ENDURANCE; EXERCISE; FEMALE; HUMAN; MALE; MENTAL STRESS; PHYSIOLOGY; PROCEDURES; PSYCHOLOGY; QUESTIONNAIRE; RESPIRATORY TRACT INFECTION; RUNNING; SLEEP;

AFFECT; FEMALE; HUMANS; HYDROCORTISONE; INTERLEUKIN-6; MALE; PHYSICAL CONDITIONING, HUMAN; PHYSICAL ENDURANCE; RESPIRATORY TRACT INFECTIONS; RUNNING; SLEEP; STRESS, PSYCHOLOGICAL; SURVEYS AND QUESTIONNAIRES;

EID: 85010868712     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0000000000001210     Document Type: Article

References (44)

1. Adamopoulos S, Parissis J, Karatzas D, et al. Physical training modulates proinflammatory cytokines and the soluble Fas/soluble Fas ligand system in patients with chronic heart failure. J Am Coll Cardiol. 2002;39(4):653-63.
2. Cox AJ, Gleeson M, Pyne DB, Callister R, Hopkins WG, Fricker PA. Clinical and laboratory evaluation of upper respiratory symptoms in elite athletes. Clin J Sport Med. 2008;18(5):438-45.
3. Cox AJ, Pyne DB, Saunders PU, Callister R, Gleeson M. Cytokine responses to treadmill running in healthy and illness-prone athletes. Med Sci Sports Exerc. 2007;39(11):1918-26.
4. Cullen T, Thomas AW, Webb R, Hughes MG. The relationship between interleukin-6 in saliva, venous and capillary plasma, at rest and in response to exercise. Cytokine. 2015;71(2):397-400.
5. Cunniffe B, Griffiths H, Proctor W, Davies B, Baker JS, Jones KP. Mucosal immunity and illness incidence in elite rugby union players across a season. Med Sci Sports Exerc. 2011;43(3):388-97.
6. De Vries J, Michielsen HJ, Van Heck GL. Assessment of fatigue among working people: a comparison of six questionnaires. Occup Environ Med. 2003;60(1 Suppl):i10-5.
7. Dimitrov S, Lange T, Benedict C, et al. Sleep enhances IL-6 transsignaling in humans. FASEB J. 2006;20(12):2174-6.
8. Dowlati Y, Herrmann N, Swardfager W, et al. A meta-analysis of cytokines in major depression. Biol Psychiatry. 2010;67(5):446-57.
9. Fahlman MM, Engels HJ. Mucosal IgA and URTI in American college football players: a year longitudinal study. Med Sci Sports Exerc. 2005;37(3):374-80.
10. Gleeson M. Immune function in sport and exercise. J Appl Physiol (1985). 2007;103(2):693-9.
11. Gleeson M, Bishop NC, Stensel DJ, Lindley MR, Mastana SS, Nimmo MA. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol. 2011;11(9):607-15.
12. Gleeson M, McDonald WA, Pyne DB, et al. Salivary IgA levels and infection risk in elite swimmers. Med Sci Sports Exerc. 1999;31(1):67-73.
13. Gray SR, Ratkevicius A, Wackerhage H, Coats P, Nimmo MA. The effect of interleukin-6 and the interleukin-6 receptor on glucose transport in mouse skeletal muscle. Exp Physiol. 2009;94(8): 899-905.
14. Gray SR, Robinson M, Nimmo MA. Response of plasma IL-6 and its soluble receptors during submaximal exercise to fatigue in sedentary middle-aged men. Cell Stress Chaperones. 2008;13(2):247-51.
15. Halson SL, Jeukendrup AE. Does overtraining exist? An analysis of overreaching and overtraining research. Sports Med. 2004; 34(14):967-81.
16. Halson SL, Lancaster GI, Jeukendrup AE, Gleeson M. Immunological responses to overreaching in cyclists. Med Sci Sports Exerc. 2003;35(5):854-61.
17. Jones SA, Horiuchi S, Topley N, Yamamoto N, Fuller GM. The soluble interleukin 6 receptor: mechanisms of production and implications in disease. FASEB J. 2001;15(1):43-58.
18. Kallen KJ. The role of transsignalling via the agonistic soluble IL-6 receptor in human diseases. Biochim Biophys Acta. 2002;1592(3): 323-43.
19. Keller C, Steensberg A, Hansen AK, Fischer CP, Plomgaard P, Pedersen BK. Effect of exercise, training, and glycogen availability on IL-6 receptor expression in human skeletal muscle. J Appl Physiol (1985). 2005;99(6):2075-9.
20. Leggate M, Carter WG, Evans MJ, Vennard RA, Sribala-Sundaram S, Nimmo MA. Determination of inflammatory and prominent proteomic changes in plasma and adipose tissue after high-intensity intermittent training in overweight and obese males. J Appl Physiol (1985). 2012;112(8):1353-60.
21. Leggate M, Nowell MA, Jones SA, Nimmo MA. The response of interleukin-6 and soluble interleukin-6 receptor isoforms following intermittent high intensity and continuous moderate intensity cycling. Cell Stress Chaperones. 2010;15(6):827-33.
22. Main LC, Dawson B, Grove JR, Landers GJ, Goodman C. Impact of training on changes in perceived stress and cytokine production. Res Sports Med. 2009;17(2):121-32.
23. Main LC, Dawson B, Heel K, Grove JR, Landers GJ, Goodman C. Relationship between inflammatory cytokines and self-report measures of training overload. Res Sports Med. 2010;18(2):127-39.
24. McLean BD, Coutts AJ, Kelly V, McGuigan MR, Cormack SJ. Neuromuscular, endocrine, and perceptual fatigue responses during different length between-match microcycles in professional rugby league players. Int J Sports Physiol Perform. 2010;5(3):367-83.
25. Morgan WP, Brown DR, Raglin JS, O'Connor PJ, Ellickson KA. Psychological monitoring of overtraining and staleness. Br J Sports Med. 1987;21(3):107-14.
26. Neville V, Gleeson M, Folland JP. Salivary IgA as a risk factor for upper respiratory infections in elite professional athletes. Med Sci Sports Exerc. 2008;40(7):1228-36.
27. Nishimoto N, Sasai M, Shima Y, et al. Improvement in Castleman's disease by humanized anti-interleukin-6 receptor antibody therapy. Blood. 2000;95(1):56-61.
28. Patterson S, Reid S, Gray S, Nimmo M. The response of plasma interleukin-6 and its soluble receptors to exercise in the cold in humans. J Sports Sci. 2008;26(9):927-33.
29. Petersen AM, Pedersen BK. The anti-inflammatory effect of exercise. J Appl Physiol (1985). 2005;98(4):1154-62.
30. Purge P, Jürimäe J, Jürimäe T. Hormonal and psychological adaptation in elite male rowers during prolonged training. J Sports Sci. 2006;24(10):1075-82.
31. Robson-Ansley P, Barwood M, Canavan J, et al. The effect of repeated endurance exercise on IL-6 and sIL-6R and their relationship with sensations of fatigue at rest [Internet]. Cytokine. 2009;45(2):111-6.
32. Robson-Ansley P, Cockburn E, Walshe I, Stevenson E, Nimmo M. The effect of exercise on plasma soluble IL-6 receptor concentration: a dichotomous response. Exerc Immunol Rev. 2010;16:56-76.
33. Robson-Ansley PJ, Blannin A, Gleeson M. Elevated plasma interleukin-6 levels in trained male triathletes following an acute period of intense interval training. Eur J Appl Physiol. 2007; 99(4):353-60.
34. Robson-Ansley PJ, de Milander L, Collins M, Noakes TD. Acute interleukin-6 administration impairs athletic performance in healthy, trained male runners. Can J Appl Physiol. 2004;29(4):411-8.
35. Robson PJ. Elucidating the unexplained underperformance syndrome in endurance athletes: the interleukin-6 hypothesis. Sports Med. 2003;33(10):771-81.
36. Rose-John S. Il-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6. Int J Biol Sci. 2012;8(9):1237-47.
37. Schöbitz B, Pezeshki G, Pohl T, et al. Soluble interleukin-6 (IL-6) receptor augments central effects of IL-6 in vivo. FASEB J. 1995; 9(8):659-64.
38. Schuett H, Oestreich R, Waetzig GH, et al. Transsignaling of interleukin-6 crucially contributes to atherosclerosis in mice. Arterioscler Thromb Vasc Biol. 2012;32(2):281-90.
39. Steensberg A, Fischer CP, Keller C, MLller K, Pedersen BK. IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans. Am J Physiol Endocrinol Metab. 2003;285(2):E433-7.
40. Tanaka T, NarazakiM, Kishimoto T. IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol. 2014;6(10):a016295.
41. Walsh NP, Gleeson M, Shephard RJ, et al. Position statement. Part one: immune function and exercise. Exerc Immunol Rev. 2011;17:6-63.
42. Walshe I, Robson-Ansley P, St Clair Gibson A, Lawrence C, Thompson KG, Ansley L. The reliability of the IL-6, sIL-6R and sgp130 response to a preloaded time trial. Eur J Appl Physiol. 2010;110(3):619-25.
43. Wittert GA, Livesey JH, Espiner EA, Donald RA. Adaptation of the hypothalamopituitary adrenal axis to chronic exercise stress in humans. Med Sci Sports Exerc. 1996;28(8):1015-9.
44. You T, Berman DM, Ryan AS, Nicklas BJ. Effects of hypocaloric diet and exercise training on inflammation and adipocyte lipolysis in obese postmenopausal women. J Clin Endocrinol Metab. 2004; 89(4):1739-46.