Salivary IgA as a risk factor for upper respiratory infections in elite professional athletes

Medicine and Science in Sports and Exercise

Volumn 40, Issue 7, 2008, Pages 1228-1236

  Neville, Vernon ^a,b   Gleeson, Michael ^a   Folland, Jonathan P ^a  

^a LOUGHBOROUGH UNIVERSITY   (United Kingdom)

^b NONE   (United Kingdom)

Author keywords

America's Cup; Illness; Immunology; Sailing; Underlying Fatigue

Indexed keywords

IMMUNOGLOBULIN A; SALIVA PROTEIN;

ARTICLE; ATHLETE; EXERCISE; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; PROTEIN SECRETION; RISK FACTOR; TRAINING; UPPER RESPIRATORY TRACT INFECTION;

ACCLIMATIZATION; ADAPTATION, PSYCHOLOGICAL; ADULT; COHORT STUDIES; EXERCISE TOLERANCE; HEALTH STATUS INDICATORS; HUMANS; IMMUNOGLOBULIN A, SECRETORY; INCIDENCE; MALE; MUSCLE FATIGUE; PROSPECTIVE STUDIES; QUESTIONNAIRES; RESPIRATORY TRACT INFECTIONS; RISK FACTORS; SALIVA; SHIPS; SPORTS; STATISTICS AS TOPIC; STRESS, PHYSIOLOGICAL; WORKLOAD;

EID: 61749101507     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0b013e31816be9c3     Document Type: Article

References (42)

1. Bishop NC, Walker GJ, Scanlon GA, Richards S, Rogers E. Salivary IgA responses to prolonged intensive exercise following caffeine ingestion. Med Sci Sports Exerc. 2006;38(3):513-9.
2. Bosch JA, Ring C, de Geus EJ, Veerman EC, Amerongen AV. Stress and secretory immunity. Int Rev Neurobiol. 2002;52: 213-53.
3. Brandtzaeg P. Role of secretory antibodies in the defence against infections. Int J Med Microbiol. 2003;293(1):3-15.
4. Calder PC, Jackson AA. Undemutrition, infection and immune function. Nutr Res Rev. 2000;13:3-29.
5. Cohen S, Doyle WJ, Skoner DP. Psychological stress, cytokine production, and severity of upper respiratory illness. Psychosom Med. 1999;61(2):175-80.
6. Dawes C. Circadian rhythms in human salivary flow rate and composition. J Physiol. 1972;220(3):529-45.
7. Department of Health Communicable Disease Control Branch. You've Got What? Prevention and Control of Notifiable and Other Infectious Diseases in Children and Adults. Adelaide (South Australia): Government of Australia; 2005. p. 48-9.
8. Fahlman MM, Engels HJ. Mucosal IgA and URTI in American college football players: a year longitudinal study. Med Sci Sports Exerc. 2005;37(3):374-80.
9. Fahlman MM, Engels HJ, Morgan AL, Kolokouri I. Mucosal IgA response to repeated wingate tests in females. Int J Sports Med. 2001;22(2): 127-31.
10. Francis JL, Gleeson M, Pyne DB, Callister R, Clancy RL. Variation of salivary immunoglobulins in exercising and sedentary populations. Med Sci Sports Exerc. 2005;37(4):571-8.
11. Gleeson M. Immune function in sport and exercise. J Appl Physiol. 2007;103(2):693-9.
12. Gleeson M, Bishop NC. Elite athlete immunology: importance of nutrition. Int J Sports Med. 2000;21(Suppl1):S44-50.
13. Gleeson M, Hall ST, McDonald WA, Flanagan AJ, Clancy RL. Salivary IgA subclasses and infection risk in elite swimmers. Immunol Cell Biol. 1999;77(4):351-5.
14. Gleeson M, McDonald WA, Pyne DB, et al. Salivary IgA levels and infection risk in elite swimmers. Med Sci Sports Exerc. 1999; 31(1):67-73.
15. Gleeson M, McDonald WA, Pyne DB, et al. Immune status and respiratory illness for elite swimmers during a 12-week training cycle. Int J Sports Med. 2000;21(4):302-7.
16. Gleeson M, Pyne DB, Callister R. The missing links in exercise effects on mucosal immunity. Exerc Immunol Rev. 2004;10:107-28.
17. Halson SL, Lancaster GI, Jeukendrup AE, Gleeson M. Immuno-logical responses to overreaching in cyclists. Med Sci Sports Exerc. 2003;35(5):854-61.
18. Hopkins WG. Measures of reliability in sports medicine and science. Sports Med. 2000;30(1):1-15.
19. Klentrou P, Cieslak T, MacNeil M, Vintinner A, Plyley M. Effect of moderate exercise on salivary immunoglobulin A and infection risk in humans. Eur J Appl Physiol. 2002;87(2):153-8.
20. Lamm ME. Interaction of antigens and antibodies at mucosal surfaces. Annu Rev Microbiol. 1997;51:311-40.
21. Libicz S, Mercier B, Bigou N, Le Gallais D, Castex F. Salivary IgA response of triathletes participating in the French Iron Tour. Int J Sports Med. 2006;27(5):389-94.
22. Mackinnon L, Ginn E, Seymour GJ. Temporal relationship between decreased salivary IgA and upper respiratory tract infection in elite athletes. Aus J Sci Med Sport. 1993;25(4):94-9.
23. Mackinnon LT, Ginn E, Seymour GJ. Decreased salivary immunoglobulin A secretion rate after intense interval exercise in elite kayakers. Eur J Appl Physiol Occup Physiol. 1993;67(2): 180-4.
24. Mazanec MB, Nedrud JG, Kaetzel CS, Lamm ME. A three-tiered view of the role of IgA in mucosal defense. Immunol Today. 1993; 14(9):430-5.
25. Nehlsen-Cannarella SL, Nieman DC, Fagoaga OR, et al. Saliva immunoglobulins in elite women rowers. Eur J Appl Physiol. 2000;81(3):222-8.
26. Neville VJ, Molloy J, Brooks JH, Speedy DB, Atkinson G. Epidemiology of injuries and illnesses in America's Cup yacht racing. Br J Sports Med. 2006;40(4):304-11; discussion 311-2.
27. Nieman DC. Is infection risk linked to exercise workload? Med Sci Sports Exerc. 2000;32(7 Suppl):S406-11.
28. Nieman DC, Henson DA, Dumke CL, Lind RH, Shooter LR, Gross SJ. Relationship between salivary IgA secretion and upper respiratory tract infection following a 160-km race. J Sports Med Phys Fitness. 2006;46(1):158-62.
29. Nieman DC, Henson DA, Fagoaga OR, et al. Change in salivary IgA following a competitive marathon race. Int J Sports Med. 2002;23(1):69-75.
30. Novas AM, Rowbottom DG, Jenkins DG. Tennis, incidence of URTI and salivary IgA. Int J Sports Med. 2003;24(3):223-9.
31. Pedersen BK, Kappel M, Klokker M, Nielsen HB, Secher NH. The immune system during exposure to extreme physiologic conditions. Int J Sports Med. 1994;15(Suppl 3):S116-21.
32. Peters EM, Bateman ED. Ultramarathon running and upper respiratory tract infections. An epidemiological survey. S Afr Med J. 1983;64(15):582-4.
33. Pyne DB, Gleeson M. Effects of intensive exercise training on immunity in athletes. Int J Sports Med. 1998;19(Suppl 3):S183-91; discussion S191-4.
34. Pyne DB, Gleeson M, McDonald WA, Clancy RL, Perry C Jr, Fricker PA. Training strategies to maintain immunocompetence in athletes. Int J Sports Med. 2000;21(Suppl 1):S51-60.
35. Robinson D, Milne C. Medicine at the 2000 Sydney Olympic Games: the New Zealand health team. Br J Sports Med. 2002; 36(3):229.
36. Sari-Sarraf V, Reilly T, Doran D, Atkinson G. Effects of repeated bouts of soccer-specific intermittent exercise on salivary IgA. Int J Sports Med. 2008;29:366-71.
37. Sari-Sarraf V, Reilly T, Doran DA. Salivary IgA response to intermittent and continuous exercise. Int J Sports Med. 2006; 27(11):849-55.
38. Shephard RJ. Special feature for the Olympics: effects of exercise on the immune system: overview of the epidemiology of exercise immunology. Immunol Cell Biol. 2000;78(5):485-95.
39. Spence L, Brown WJ, Pyne DB, et al. Incidence, etiology, and symptomatology of upper respiratory illness in elite athletes. Med Sci Sports Exerc. 2007;39(4):577-86.
40. Stone AA, Cox DS, Valdimarsdottir H, Neale JM. Secretory IgA as a measure of immunocompetence. J Human Stress. 1987;13(3): 136-40.
41. Tharp GD. Basketball exercise and secretory immunoglobulin A. Eur J Appl Physiol Occup Physiol. 1991;63(3-4):312-4.
42. Tomasi TB, Trudeau FB, Czerwinski D, Erredge S. Immune parameters in athletes before and after strenuous exercise. J Clin Immunol. 1982;2(3):I73-8.