Cytokine responses to treadmill running in healthy and illness-prone athletes

Medicine and Science in Sports and Exercise

Volumn 39, Issue 11, 2007, Pages 1918-1926

  Cox, Amanda Julie ^a,b   Pyne, David Bruce ^a,c   Saunders, Philo Urson ^a   Callister, Robin ^b   Gleeson, Maree ^b  

^a AUSTRALIAN INSTITUTE OF SPORT   (Australia)

^b UNIVERSITY OF NEWCASTLE   (Australia)

^c The Australian National University   (Australia)

Author keywords

Cytokines; Exercise; Runners; Upper respiratory illness

Indexed keywords

INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8;

ADULT; ARTICLE; ATHLETE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOKINE RESPONSIVE ELEMENT; DISEASE PREDISPOSITION; EXERCISE INTENSITY; EXERCISE TOLERANCE; HUMAN; IMMUNOMODULATION; MOTOR PERFORMANCE; MUSCLE FUNCTION; NORMAL HUMAN; OXYGEN CONSUMPTION; PHYSICAL CAPACITY; RUNNING; TREADMILL EXERCISE;

ADULT; CASE-CONTROL STUDIES; CYTOKINES; DISEASE SUSCEPTIBILITY; EXERCISE TEST; HUMANS; MALE; RESPIRATORY TRACT INFECTIONS; RUNNING; SPORTS; UNITED STATES;

EID: 35948943095     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/mss.0b013e318149f2aa     Document Type: Article

References (30)

1. BATTERHAM, A. M., and W. G. HOPKINS. Making meaningful inferences about magnitudes. Int. J. Sports Physiol. Perf. 1:50-57, 2006.
2. BRUUNSGARD, H., H. GALBO, J. HALKJAER- KRISTENSEN, T. L. JOHANSEN, D. A. MACLEAN, and B. K. PEDERSEN. Exercise-induced increase in interleukin-6 is related to muscle damage. J. Physiol. 499:833-841, 1997.
3. COX, A. J., M. GLEESON, D. B. PYNE, P. U. SAUNDERS, R. L. CLANCY, and P. A. FRICKER. Valtrex™ therapy for Epstein-Barr virus reactivation and upper respiratory symptoms in elite runners. Med. Sci. Sports Exerc. 36:1104-1110, 2004.
4. ELENKOV, I. J., and G. P. CHROUSOS. Stress hormones, Th1/Th2 patterns, pro/anti-inflammatory cytokines and susceptibility to disease. Trends Endocrinol. Metab. 10:359-368, 1991.
5. FRICKER, P., and D. PYNE. Why do athletes seem prone to infection? Med. Today 6:66-67, 2005.
6. GASSER, O., and J. A. SCHIFFERLI. Activated polymorphonuclear neutrophils disseminate anti-inflammatory microparticles by ectocytosis. Blood 104:2543-2548, 2004.
7. KASAMA, T., Y. MIWA, T. ISOZAKI, T. ODAI, M. ADACHI, and S. L. KENKEL. Neutrophil-derived cytokine: potential therapeutic targets in inflammation. Curr. Drug Targets Inflamm. Allergy 4:273-279, 2005.
8. LOWRY, S. F. Cytokine mediators of immunity and inflammation. Arch. Surg. 128:1235-1242, 1993.
9. NEMET, D., S. HONG, P. J. MILLS, M. G. ZIEGLER, M. HILL, and D. M. COOPER. Systemic vs local cytokine and leukocyte responses to unilateral wrist flexion exercise. J. Appl. Physiol. 93:546-554, 2002.
10. NEMET, D., C. M. ROSE-GOTTRON, P. J. MILLS, and D. M. COOPER. Effect of water polo practice on cytokines, growth mediators, and leukocytes in girls. Med. Sci. Sports Exerc. 35:356-363, 2003.
11. NIEMAN, D. C., C. I. DUMKE, D. A. HENSON, et al. Immune and oxidative changes during and following the Western States endurance run. Int. J. Sports Med. 24:541-547, 2003.
12. NIEMAN, D. C., C. L. DUMKE, D. A. HENSON, S. R. MCANULTY, S. J. GROSS, and R. H. LIND. Muscle damage is linked to cytokine changes following a 160-km race. Brain Behav. Immun. 19: 398-403, 2005.
13. NIEMAN, D. C., D. A. HENSON, L. L. SMITH, et al. Cytokine changes after a marathon race. J. Appl. Physiol. 91:109-114, 2001.
14. NIESS, A. M., E. FEHRENBACH, R. LEHMANN, et al. Impact of elevated ambient temperatures on acute immune response to intensive endurance exercise. Eur. J. Appl. Physiol. 89:344-351, 2003.
15. OSTROWSKI, K., T. ROHDE, S. ASP, P. SCHJERLING, and B. K. PEDERSEN. Pro-and anti-inflammatory cytokine balance in strenuous exercise in humans. J. Physiol. 515:287-291, 1999.
16. PEAKE, J. M., K. SUZUKI, M. HORDERN, G. WILSON, K. NOSAKA, and J. S. COOMBES. Plasma cytokine changes in relation to exercise intensity and muscle damage. Eur. J. Appl. Physiol. 95:514-521, 2005.
17. PEDERSEN, B. K., A. STEENSBERG, C. FISCHER, C. KELLER, K. OSTROWSKI, and P. SCHJERLING. Exercise and cytokines with particular focus on muscle-derived Il-6. Exerc. Immunol. Rev. 7:18-31, 2001.
18. PEDERSEN, B. K., and H. ULLUM. NK cell response to physical activity: possible mechanisms of action. Med. Sci. Sports Exerc. 26:140-146, 1994.
19. PETERSEN, A. M., and B. K. PEDERSEN. The anti-inflammatory effect of exercise. J. Appl. Physiol. 98:1154-1162, 2005.
20. PETERSEN, E. W., K. OSTROWSKI, T. IBFELT, et al. Effect of vitamin supplementation on cytokine response and on muscle damage after strenuous exercise. Am. J. Physiol. Cell Physiol. 280:C1570-C1575, 2001.
21. SMITH, L. L. Cytokine hypothesis of overtraining: a physiological adaptation to excessive stress. Med. Sci. Sports Exerc. 32:317-331, 2000.
22. SMITH, L. L. Overtraining, excessive exercise, and altered immunity. Sports Med. 33:347-364, 2003.
23. SMITH, L. L., A. ANWAR, M. FRAGEN, C. RANANTO, R. JOHNSON, and D. HOLBERT. Cytokines and cell adhesion molecules associated with high-intensity eccentric exercise. Eur. J. Appl. Physiol. 82:61-67, 2000.
24. STEENSBERG, A., C. P. FISCHER, C. KELLER, K. MOLLER, and B. K. PEDERSEN. Il-6 enhances plasma Il-1ra, Il-10 and cortisol in humans. Am. J. Physiol. Endocrinol. Metab. 285:E422-E437, 2003.
25. STEENSBERG, A., A. D. TOFT, P. SCHJERLING, J. HALKJAER-KRISTENSEN, and B. K. PEDERSEN. Plasma interleukin-6 during strenuous exercise: role of epinephrine. Am. J. Physiol. Cell Physiol. 281:C1001-C1004, 2001.
26. SUZUKI, K., S. NAKAJI, M. YAMADA, et al. Impact of a competitive marathon race on systemic cytokine and neutrophil responses. Med. Sci Sports Exerc. 35:348-355, 2003.
27. SUZUKI, K., S. NAKAJI, M. YAMADA, M. TOTSUKA, K. SATO, and K. SUGAWARA. Systemic inflammatory response to exhaustive exercise. Cytokine kinetics. Exerc. Immunol. Rev. 8:6-48, 2002.
28. SUZUKI, K., M. TOTSUKA, S. NAKAJI, et al. Endurance exercise causes interaction among stress hormones, cytokines, neutrophil dynamics, and muscle damage. J. Appl. Physiol. 87:1360-1367, 1999.
29. SUZUKI, K., M. YAMADA, S. KURAKAKE, et al. Circulating cytokines and hormones with immunosuppressive but neutrophil-priming potentials rise after endurance exercise in humans. Eur. J. Appl. Physiol. 81:281-287, 2000.
30. TOFT, A. D., L. B. JENSEN, H. BRUUNSGAARD, et al. Cytokine response to eccentric exercise in young and elderly humans. Am. J. Physiol. Cell Physiol. 283:C289-C295, 2002.