메뉴 건너뛰기




Volumn 16, Issue , 2016, Pages

Lysine-derived alkaloids: Overview and update on biosynthesis and medicinal applications with emphasis on quinolizidine alkaloids

Author keywords

Anabasine; Indolizidine alkaloids; Lycopodium alkaloids; Lysine derived alkaloids; Piperidine alkaloids; Plastidderived alkaloids; Quinolizidine alkaloids

Indexed keywords

ALKALOID DERIVATIVE; INDOLIZIDINE ALKALOID; LYSINE DERIVATIVE; PIPERIDINE DERIVATIVE; QUINOLIZIDINE DERIVATIVE; TRANSCRIPTOME; ALKALOID; INDOLIZIDINE DERIVATIVE; LYSINE; PIPERIDINE;

EID: 85010651877     PISSN: 13895575     EISSN: 18755607     Source Type: Journal    
DOI: 10.2174/1389557516666160506151213     Document Type: Review
Times cited : (27)

References (117)
  • 1
    • 0035780976 scopus 로고    scopus 로고
    • Alkaloid biosynthesis in plants: Biochemistry, cell biology, molecular regulation, and metabolic engineering applications
    • Facchini, P.J. Alkaloid biosynthesis in plants: biochemistry, cell biology, molecular regulation, and metabolic engineering applications. Annu. Rev. Plant Physiol. Plant Mol. Biol., 2001, 52(1), 29-66.
    • (2001) Annu. Rev. Plant Physiol. Plant Mol. Biol. , vol.52 , Issue.1 , pp. 29-66
    • Facchini, P.J.1
  • 2
    • 0035023464 scopus 로고    scopus 로고
    • The expanding universe of alkaloid biosynthesis
    • De Luca, V.; Laflamme, P. The expanding universe of alkaloid biosynthesis. Curr. Opin. Plant Biol., 2001, 4(3), 225-233.
    • (2001) Curr. Opin. Plant Biol. , vol.4 , Issue.3 , pp. 225-233
    • De Luca, V.1    Laflamme, P.2
  • 3
    • 84862983651 scopus 로고    scopus 로고
    • Mining the biodiversity of plants: A revolution in the making
    • De Luca, V.; Salim, V.; Atsumi, S.M.; Yu, F. Mining the biodiversity of plants: a revolution in the making. Science, 2012, 336(6089), 1658-1661.
    • (2012) Science , vol.336 , Issue.6089 , pp. 1658-1661
    • De Luca, V.1    Salim, V.2    Atsumi, S.M.3    Yu, F.4
  • 4
    • 0037004052 scopus 로고    scopus 로고
    • New insights into the regulation and functional significance of lysine metabolism in plants
    • Galili, G. New insights into the regulation and functional significance of lysine metabolism in plants. Annu. Rev. Plant Biol., 2002, 53(1), 27-43.
    • (2002) Annu. Rev. Plant Biol. , vol.53 , Issue.1 , pp. 27-43
    • Galili, G.1
  • 5
    • 84885234353 scopus 로고    scopus 로고
    • Cadaverine: A lysine catabolite involved in plant growth and development
    • Tomar, P.C.; Lakra, N.; Mishra, S.N. Cadaverine: a lysine catabolite involved in plant growth and development. Plant Signal. Behav., 2013, 8(10), e25850.
    • (2013) Plant Signal. Behav. , vol.8 , Issue.10
    • Tomar, P.C.1    Lakra, N.2    Mishra, S.N.3
  • 6
    • 0031260404 scopus 로고    scopus 로고
    • The biosynthesis and metabolism of the aspartate derived amino acids in higher plants
    • Azevedo, R.A.; Arruda, P.; Turner, W.L.; Lea, P.J. The biosynthesis and metabolism of the aspartate derived amino acids in higher plants. Phytochemistry, 1997, 46(3), 395-419.
    • (1997) Phytochemistry , vol.46 , Issue.3 , pp. 395-419
    • Azevedo, R.A.1    Arruda, P.2    Turner, W.L.3    Lea, P.J.4
  • 7
    • 84900843699 scopus 로고    scopus 로고
    • Quinolizidine alkaloid biosynthesis: Recent advances and future prospects
    • Bunsupa, S.; Yamazaki, M.; Saito, K. Quinolizidine alkaloid biosynthesis: recent advances and future prospects. Front. Plant Sci., 2012, 3, 239.
    • (2012) Front. Plant Sci. , vol.3 , pp. 239
    • Bunsupa, S.1    Yamazaki, M.2    Saito, K.3
  • 8
    • 84860188187 scopus 로고    scopus 로고
    • Lysine decarboxylase catalyzes the first step of quinolizidine alkaloid biosynthesis and coevolved with alkaloid production in Leguminosae
    • Bunsupa, S.; Katayama, K.; Ikeura, E.; Oikawa, A.; Toyooka, K.; Saito, K.; Yamazaki, M. Lysine decarboxylase catalyzes the first step of quinolizidine alkaloid biosynthesis and coevolved with alkaloid production in Leguminosae. Plant Cell, 2012, 24(3), 1202-1216.
    • (2012) Plant Cell , vol.24 , Issue.3 , pp. 1202-1216
    • Bunsupa, S.1    Katayama, K.2    Ikeura, E.3    Oikawa, A.4    Toyooka, K.5    Saito, K.6    Yamazaki, M.7
  • 10
    • 0029105875 scopus 로고
    • Patterns of quinolizidine alkaloids in 56 species of the genus Lupinus
    • Wink, M.; Meißner, C.; Witte, L. Patterns of quinolizidine alkaloids in 56 species of the genus Lupinus. Phytochemistry, 1995, 38(1), 139-153.
    • (1995) Phytochemistry , vol.38 , Issue.1 , pp. 139-153
    • Wink, M.1    Meißner, C.2    Witte, L.3
  • 12
    • 85051618269 scopus 로고
    • Bernays E.A., Ed.; CRC Press: Boca Raton
    • Wink, M. In: Insect-Plant Interactions; Bernays E.A., Ed.; CRC Press: Boca Raton, 1992; Vol. 4, pp. 131-166.
    • (1992) Insect-Plant Interactions , vol.4 , pp. 131-166
    • Wink, M.1
  • 13
    • 77957099034 scopus 로고
    • Manske, R.H.F., Ed.; Academic Press: London
    • Wróbel, J.T. In: The Alkaloids: Chemistry and Physiology; Manske, R.H.F., Ed.; Academic Press: London, 1977; Vol. 17, pp. 181-214.
    • (1977) The Alkaloids: Chemistry and Physiology , vol.17 , pp. 181-214
    • Wróbel, J.T.1
  • 14
    • 0343118909 scopus 로고
    • Cell-free synthesis of the alkaloids ammodendrine and smipine
    • Wink, M.; Witte, L. Cell-free synthesis of the alkaloids ammodendrine and smipine. Z. Naturforsch. C, 1987, 42(3), 197-204.
    • (1987) Z. Naturforsch. C , vol.42 , Issue.3 , pp. 197-204
    • Wink, M.1    Witte, L.2
  • 15
    • 82655184882 scopus 로고    scopus 로고
    • Simultaneous determination of two types of active components with different physicochemical properties in Kushen by HPLC-UV
    • Zhang Y.F.; Zhao Q.Q.; Shao Q.; Fan X.H. Simultaneous determination of two types of active components with different physicochemical properties in Kushen by HPLC-UV. Chem. Res. Chin. Univ., 2011, 27(3), 375-379.
    • (2011) Chem. Res. Chin. Univ. , vol.27 , Issue.3 , pp. 375-379
    • Zhang, Y.F.1    Zhao, Q.Q.2    Shao, Q.3    Fan, X.H.4
  • 16
    • 0037158508 scopus 로고    scopus 로고
    • Analysis of proprietary Chinese medicines for the presence of toxic ingredients by LC/MS/MS
    • Wong, S.K.; Tsui, S.K.; Kwan, S.Y. Analysis of proprietary Chinese medicines for the presence of toxic ingredients by LC/MS/MS. J. Pharm. Biomed. Anal. 2002, 30(1), 161-170.
    • (2002) J. Pharm. Biomed. Anal , vol.30 , Issue.1 , pp. 161-170
    • Wong, S.K.1    Tsui, S.K.2    Kwan, S.Y.3
  • 17
    • 84862119962 scopus 로고    scopus 로고
    • Comparative analysis of quinolizidine alkaloids from different parts of Sophora alopecuroides seeds by UPLC-MS/MS
    • Wang, H.; Guo, S.; Qian, D.; Qian, Y.; Duan, J. Comparative analysis of quinolizidine alkaloids from different parts of Sophora alopecuroides seeds by UPLC-MS/MS. J. Pharm. Biomed. Anal., 2012, 67-68, 16-21.
    • (2012) J. Pharm. Biomed. Anal. , vol.67-68 , pp. 16-21
    • Wang, H.1    Guo, S.2    Qian, D.3    Qian, Y.4    Duan, J.5
  • 18
    • 0023795495 scopus 로고
    • Biosynthesis of the lupine alkaloids. II. Sparteine and lupanine
    • Golebiewski, W.M.; Spenser, I.D. Biosynthesis of the lupine alkaloids. II. Sparteine and lupanine. Can. J. Chem., 1988, 66(7), 1734-1748.
    • (1988) Can. J. Chem. , vol.66 , Issue.7 , pp. 1734-1748
    • Golebiewski, W.M.1    Spenser, I.D.2
  • 19
    • 0342595379 scopus 로고
    • Biosynthesis of the quinolizidine alkaloids. Incorporation of 1-piperideine into matrine
    • Leeper, F.J.; Grue-Sørensen, G.; Spenser, I.D. Biosynthesis of the quinolizidine alkaloids. Incorporation of 1-piperideine into matrine. Can. J. Chem., 1981, 59(1), 106-115.
    • (1981) Can. J. Chem , vol.59 , Issue.1 , pp. 106-115
    • Leeper, F.J.1    Grue-Sørensen, G.2    Spenser, I.D.3
  • 20
    • 0023521171 scopus 로고
    • Quinolizidine alkaloids: Biochemistry, metabolism, and function in plants and cell suspension cultures
    • Wink, M. Quinolizidine alkaloids: biochemistry, metabolism, and function in plants and cell suspension cultures. Planta Med., 1987, 53(6), 509-514.
    • (1987) Planta Med. , vol.53 , Issue.6 , pp. 509-514
    • Wink, M.1
  • 21
    • 0015920792 scopus 로고
    • Biosynthesis of the piperidine nucleus. Incorporation of chirally labeled cadaverine [1-3H]
    • Leistner, E.; Spenser I.D. Biosynthesis of the piperidine nucleus. Incorporation of chirally labeled cadaverine [1-3H]. J. Am. Chem. Soc., 1973, 95(14), 4715-4725.
    • (1973) J. Am. Chem. Soc. , vol.95 , Issue.14 , pp. 4715-4725
    • Leistner, E.1    Spenser, I.D.2
  • 22
    • 77952639671 scopus 로고
    • Stereochemistry of enzymic reactions involved in the formation of tetrahydroanabasine, ammodendrine, smipine and tripiperideine
    • Brown, A.M.; Robins, D.J.; Witte, L.; Wink, M. Stereochemistry of enzymic reactions involved in the formation of tetrahydroanabasine, ammodendrine, smipine and tripiperideine. Plant Physiol. (Life Sci. Adv.), 1992, 10, 179-185.
    • (1992) Plant Physiol. (Life Sci. Adv.) , vol.10 , pp. 179-185
    • Brown, A.M.1    Robins, D.J.2    Witte, L.3    Wink, M.4
  • 23
    • 84944229922 scopus 로고
    • On the role of Δ1-piperideine and tripiperideine in the biosynthesis of quinolizidine alkaloids
    • Perrey, R.; Wink, M. On the role of Δ1-piperideine and tripiperideine in the biosynthesis of quinolizidine alkaloids. Z. Naturforsch. C, 1988, 43(5-6), 363-369.
    • (1988) Z. Naturforsch. C , vol.43 , Issue.5-6 , pp. 363-369
    • Perrey, R.1    Wink, M.2
  • 25
    • 0033783320 scopus 로고    scopus 로고
    • Biochemical and partial molecular characterization of bitter and sweet forms of Lupinus angustifolius, an experimental model for study of molecular regulation of quinolizidine alkaloid biosynthesis
    • Hirai, M.Y.; Suzuki, H.; Yamazaki, M.; Saito, K. Biochemical and partial molecular characterization of bitter and sweet forms of Lupinus angustifolius, an experimental model for study of molecular regulation of quinolizidine alkaloid biosynthesis. Chem. Pharm. Bull. (Tokyo), 2000, 48(10), 1458-1461.
    • (2000) Chem. Pharm. Bull. (Tokyo) , vol.48 , Issue.10 , pp. 1458-1461
    • Hirai, M.Y.1    Suzuki, H.2    Yamazaki, M.3    Saito, K.4
  • 26
    • 79955165270 scopus 로고    scopus 로고
    • An acyltransferase-like gene obtained by differential gene expression profiles of quinolizidine alkaloid-producing and nonproducing cultivars of Lupinus angustifolius
    • Bunsupa, S.; Okada, T.; Saito, K.; Yamazaki, M. An acyltransferase-like gene obtained by differential gene expression profiles of quinolizidine alkaloid-producing and nonproducing cultivars of Lupinus angustifolius. Plant Biotechnol., 2011, 28(1), 89-94.
    • (2011) Plant Biotechnol. , vol.28 , Issue.1 , pp. 89-94
    • Bunsupa, S.1    Okada, T.2    Saito, K.3    Yamazaki, M.4
  • 27
    • 14644391524 scopus 로고    scopus 로고
    • Molecular characterization of a novel quinolizidine alkaloid Otigloyltransferase: CDNA cloning, catalytic activity of recombinant protein and expression analysis in Lupinus plants
    • Okada, T.; Hirai, M.Y.; Suzuki, H.; Yamazaki, M.; Saito, K. Molecular characterization of a novel quinolizidine alkaloid Otigloyltransferase: cDNA cloning, catalytic activity of recombinant protein and expression analysis in Lupinus plants. Plant Cell Physiol., 2005, 46(1), 233-244.
    • (2005) Plant Cell Physiol. , vol.46 , Issue.1 , pp. 233-244
    • Okada, T.1    Hirai, M.Y.2    Suzuki, H.3    Yamazaki, M.4    Saito, K.5
  • 28
    • 0035089142 scopus 로고    scopus 로고
    • Biosynthesis, oxidation and conjugation of aliphatic polyamines in higher plants
    • Bagni, N.; Tassoni, A. Biosynthesis, oxidation and conjugation of aliphatic polyamines in higher plants. Amino Acids, 2001, 20(3), 301-317.
    • (2001) Amino Acids , vol.20 , Issue.3 , pp. 301-317
    • Bagni, N.1    Tassoni, A.2
  • 29
    • 0001227894 scopus 로고
    • The plant vacuole: A multifunctional compartment
    • Wink, M. The plant vacuole: a multifunctional compartment. J. Exp. Bot., 1993, 44, 231-246.
    • (1993) J. Exp. Bot. , vol.44 , pp. 231-246
    • Wink, M.1
  • 30
    • 0001392658 scopus 로고
    • Uptake of the quinolizidine alkaloid lupanine by protoplasts and isolated vacuoles of suspension-cultured Lupinus polyphyllus cells. Diffusion or carrier-mediated transport
    • Mende, P.; Wink, M. Uptake of the quinolizidine alkaloid lupanine by protoplasts and isolated vacuoles of suspension-cultured Lupinus polyphyllus cells. Diffusion or carrier-mediated transport? J. Plant Physiol., 1987, 129(3), 229-242.
    • (1987) J. Plant Physiol. , vol.129 , Issue.3 , pp. 229-242
    • Mende, P.1    Wink, M.2
  • 31
    • 34247244625 scopus 로고    scopus 로고
    • Synthesis, transport and accumulation of quinolizidine alkaloids in Lupinus albus L. And L. Angustifolius L
    • Lee, M.J.; Pate, J.S.; Harris, D.J.; Atkins, C.A. Synthesis, transport and accumulation of quinolizidine alkaloids in Lupinus albus L. and L. angustifolius L. J. Exp. Bot., 2007, 58(5), 935-946.
    • (2007) J. Exp. Bot. , vol.58 , Issue.5 , pp. 935-946
    • Lee, M.J.1    Pate, J.S.2    Harris, D.J.3    Atkins, C.A.4
  • 32
    • 0030209366 scopus 로고    scopus 로고
    • Subcellular localization of acyltransferases for quinolizidine alkaloid biosynthesis in Lupinus
    • Suzuki, H.; Koike, Y.; Murakoshi, I.; Saito, K. Subcellular localization of acyltransferases for quinolizidine alkaloid biosynthesis in Lupinus. Phytochemistry, 1996, 42(6), 1557-1562.
    • (1996) Phytochemistry , vol.42 , Issue.6 , pp. 1557-1562
    • Suzuki, H.1    Koike, Y.2    Murakoshi, I.3    Saito, K.4
  • 33
    • 0011326481 scopus 로고
    • Non-reversibility of the isoleucineacetate pathway in Datura
    • McGaw, B.A.; Woolley, J.G. Non-reversibility of the isoleucineacetate pathway in Datura. Phytochemistry, 1977, 16(11), 1711-1713.
    • (1977) Phytochemistry , vol.16 , Issue.11 , pp. 1711-1713
    • McGaw, B.A.1    Woolley, J.G.2
  • 34
    • 0011275637 scopus 로고
    • Biosynthetic conversion of α-methylbutyric acid to tiglic acid in Datura meteloides
    • Leete, E. Biosynthetic conversion of α-methylbutyric acid to tiglic acid in Datura meteloides. Phytochemistry, 1973, 12(9), 2203-2205.
    • (1973) Phytochemistry , vol.12 , Issue.9 , pp. 2203-2205
    • Leete, E.1
  • 35
    • 0019230531 scopus 로고
    • The effect of the monocarboxylate translocator inhibitor, α-cyanocinnamate, on the oxidation of branched chain α-keto acids in rat liver
    • Patel, T.B.; Waymack, P.P.; Olson, M.S. The effect of the monocarboxylate translocator inhibitor, α-cyanocinnamate, on the oxidation of branched chain α-keto acids in rat liver. Arch. Biochem. Biophys., 1980, 201(2), 629-635.
    • (1980) Arch. Biochem. Biophys. , vol.201 , Issue.2 , pp. 629-635
    • Patel, T.B.1    Waymack, P.P.2    Olson, M.S.3
  • 36
    • 0019881019 scopus 로고
    • The regulation of branched-chain 2-oxo acid dehydrogenase of liver, kidney and heart by phosphorylation
    • Hughes, W.A.; Halestrap, A.P. The regulation of branched-chain 2-oxo acid dehydrogenase of liver, kidney and heart by phosphorylation. Biochem. J., 1981, 196(2), 459-469.
    • (1981) Biochem. J. , vol.196 , Issue.2 , pp. 459-469
    • Hughes, W.A.1    Halestrap, A.P.2
  • 37
    • 77957084883 scopus 로고
    • Cordell, G.A., Ed.; Academic Press: London
    • Wink, M. In: The Alkaloids: Chemistry and Pharmacology; Cordell, G.A., Ed.; Academic Press: London, 1993; Vol. 43, pp. 1-118.
    • (1993) The Alkaloids: Chemistry and Pharmacology , vol.43 , pp. 1-118
    • Wink, M.1
  • 39
    • 0028089849 scopus 로고
    • Binding of quinolizidine alkaloids to nicotinic and muscarinic acetylcholine receptors
    • Schmeller, T.; Sauerwein, M.; Sporer, F.; Wink, M.; Müller, W.E. Binding of quinolizidine alkaloids to nicotinic and muscarinic acetylcholine receptors. J. Nat. Prod., 1994, 57(9), 1316-1319.
    • (1994) J. Nat. Prod. , vol.57 , Issue.9 , pp. 1316-1319
    • Schmeller, T.1    Sauerwein, M.2    Sporer, F.3    Wink, M.4    Müller, W.E.5
  • 40
    • 77957131858 scopus 로고    scopus 로고
    • Atta-ur-Rahman, Ed.; Elsevier: New York
    • Wink, M. In: Studies in Natural Products Chemistry; Atta-ur-Rahman, Ed.; Elsevier: New York, 2000; Vol. 21, pp. 3-122.
    • (2000) Studies in Natural Products Chemistry , vol.21 , pp. 3-122
    • Wink, M.1
  • 41
    • 0032476049 scopus 로고    scopus 로고
    • Differential effects of alkaloids on sodium currents of isolated single skeletal muscle fibers
    • Körper, S.; Wink, M.; Fink, R.H. Differential effects of alkaloids on sodium currents of isolated single skeletal muscle fibers. FEBS Lett., 1998, 436(2), 251-255.
    • (1998) FEBS Lett. , vol.436 , Issue.2 , pp. 251-255
    • Körper, S.1    Wink, M.2    Fink, R.H.3
  • 43
    • 0022966940 scopus 로고
    • Study of the antipyretic activity of matrine. A lupin alkaloid isolated from Sophora subprostrata
    • Cho, C.; Chuang, C.; Chen, C. Study of the antipyretic activity of matrine. A lupin alkaloid isolated from Sophora subprostrata. Planta Med., 1986, 52(5), 343-345.
    • (1986) Planta Med. , vol.52 , Issue.5 , pp. 343-345
    • Cho, C.1    Chuang, C.2    Chen, C.3
  • 44
    • 33744899623 scopus 로고    scopus 로고
    • Matrineinduced apoptosis in leukemia U937 cells: Involvement of caspases activation and MAPK-independent pathways
    • Liu, X.S.; Jiang, J.; Jiao, X.Y.; Wu, Y.E.; Lin, J.H. Matrineinduced apoptosis in leukemia U937 cells: involvement of caspases activation and MAPK-independent pathways. Planta Med., 2006, 72(6), 501-506.
    • (2006) Planta Med. , vol.72 , Issue.6 , pp. 501-506
    • Liu, X.S.1    Jiang, J.2    Jiao, X.Y.3    Wu, Y.E.4    Lin, J.H.5
  • 45
    • 1342287277 scopus 로고    scopus 로고
    • Efficacy of intramuscular matrine in the treatment of chronic hepatitis B. Hepatob
    • Long, Y.; Lin, X.T.; Zeng, K.L.; Zhang, L. Efficacy of intramuscular matrine in the treatment of chronic hepatitis B. Hepatob. Pancreat. Dis., 2004, 3(1), 69-72.
    • (2004) Pancreat. Dis , vol.3 , Issue.1 , pp. 69-72
    • Long, Y.1    Lin, X.T.2    Zeng, K.L.3    Zhang, L.4
  • 46
    • 0036435794 scopus 로고    scopus 로고
    • Effects of oxymatrine on the serum levels of T helper cell 1 and 2 cytokines and the expression of the S gene in hepatitis B virus S gene transgenic mice: A study on the anti-hepatitis B virus mechanism of oxymatrine
    • Dong, Y.; Xi, H.; Yu, Y.; Wang, Q.; Jiang, K.; Li, L. Effects of oxymatrine on the serum levels of T helper cell 1 and 2 cytokines and the expression of the S gene in hepatitis B virus S gene transgenic mice: A study on the anti-hepatitis B virus mechanism of oxymatrine. J. Gastroen. Hepatol., 2002, 17(12), 1299-1306.
    • (2002) J. Gastroen. Hepatol. , vol.17 , Issue.12 , pp. 1299-1306
    • Dong, Y.1    Xi, H.2    Yu, Y.3    Wang, Q.4    Jiang, K.5    Li, L.6
  • 47
    • 84920120223 scopus 로고    scopus 로고
    • Antiparasitic effect of matrine and oxymatrine (Quinolizidine alkaloids) on the ciliate Cryptocaryon irritans in the red sea bream Pagrus major
    • Goto, T.; Hirazawa, N.; Takaishi, Y.; Kashiwada, Y. Antiparasitic effect of matrine and oxymatrine (quinolizidine alkaloids) on the ciliate Cryptocaryon irritans in the red sea bream Pagrus major. Aquaculture, 2015, 437, 339-343.
    • (2015) Aquaculture , vol.437 , pp. 339-343
    • Goto, T.1    Hirazawa, N.2    Takaishi, Y.3    Kashiwada, Y.4
  • 48
    • 48749105482 scopus 로고    scopus 로고
    • Cardioprotective effects and underlying mechanisms of oxymatrine against ischemic myocardial injuries of rats
    • Hong-Li, S.; Lei, L.; Lei, S.; Dan, Z.; De-Li, D.; Guo-Len, Q.; Yan, L.; Wen-Feng, C.; Bao-Feng, Y. Cardioprotective effects and underlying mechanisms of oxymatrine against ischemic myocardial injuries of rats. Phytother. Res., 2008, 22(7), 985-989.
    • (2008) Phytother. Res , vol.22 , Issue.7 , pp. 985-989
    • Hong-Li, S.1    Lei, L.2    Lei, S.3    Dan, Z.4    De-Li, D.5    Guo-Len, Q.6    Yan, L.7    Wen-Feng, C.8    Bao-Feng, Y.9
  • 49
    • 41349091860 scopus 로고    scopus 로고
    • Anticancer effects of the Chinese medicine matrine on murine hepatocellular carcinoma cells
    • Ma, L.; Wen, S.; Zhan, Y.; He, Y.; Liu, X.; Jiang, J. Anticancer effects of the Chinese medicine matrine on murine hepatocellular carcinoma cells. Planta Med., 2008, 74(3), 245-251.
    • (2008) Planta Med. , vol.74 , Issue.3 , pp. 245-251
    • Ma, L.1    Wen, S.2    Zhan, Y.3    He, Y.4    Liu, X.5    Jiang, J.6
  • 50
    • 33644634884 scopus 로고    scopus 로고
    • Effects of oxymatrine on proliferation and apoptosis in human hepatoma cells
    • Song, G.; Luo, Q.; Qin, J.; Wang, L.; Shi, Y.; Sun, C. Effects of oxymatrine on proliferation and apoptosis in human hepatoma cells. Colloids Surface B, 2006, 48(1), 1-5.
    • (2006) Colloids Surface B , vol.48 , Issue.1 , pp. 1-5
    • Song, G.1    Luo, Q.2    Qin, J.3    Wang, L.4    Shi, Y.5    Sun, C.6
  • 51
    • 85010677845 scopus 로고    scopus 로고
    • Inhibitory effect of oxymatrine on the proliferation and vascular endothelial growth factor A (VEGF-A) expression in human lung adenocarcinoma (SPC-A-1) cell
    • Liang, R.; Zhang, W.; Jin, S. Inhibitory effect of oxymatrine on the proliferation and vascular endothelial growth factor A (VEGF-A) expression in human lung adenocarcinoma (SPC-A-1) cell. Afr. J. Pharm. Pharmacol., 2012, 6(46), 3195-3200.
    • (2012) Afr. J. Pharm. Pharmacol. , vol.6 , Issue.46 , pp. 3195-3200
    • Liang, R.1    Zhang, W.2    Jin, S.3
  • 53
    • 84863121816 scopus 로고    scopus 로고
    • Impact of the herbal medicine Sophora flavescens on the oral pharmacokinetics of indinavir in rats: The involvement of CYP3A and P-glycoprotein
    • Yang, J.M.; Ip, S.P.; Xian, Y.; Zhao, M.; Lin, Z.X.; Yeung, J.H.K.; Chan, R.C.Y.; Lee, S.S.; Che, C.T. Impact of the herbal medicine Sophora flavescens on the oral pharmacokinetics of indinavir in rats: the involvement of CYP3A and P-glycoprotein. PLoS ONE, 2012, 7(2): e31312.
    • (2012) Plos ONE , vol.7 , Issue.2
    • Yang, J.M.1    Ip, S.P.2    Xian, Y.3    Zhao, M.4    Lin, Z.X.5    Yeung, J.H.K.6    Chan, R.C.Y.7    Lee, S.S.8    Che, C.T.9
  • 54
    • 0031686461 scopus 로고    scopus 로고
    • A comparative study of the effects of sparteine, lupanine and lupin extract on the central nervous system of the mouse
    • Pothier, J.; Cheav, S.L.; Galand, N.; Dormeau, C.; Viel, C. A comparative study of the effects of sparteine, lupanine and lupin extract on the central nervous system of the mouse. J. Pharm. Pharmacol., 1998, 50(8), 949-954.
    • (1998) J. Pharm. Pharmacol. , vol.50 , Issue.8 , pp. 949-954
    • Pothier, J.1    Cheav, S.L.2    Galand, N.3    Dormeau, C.4    Viel, C.5
  • 55
    • 80855147676 scopus 로고    scopus 로고
    • How has narrow-leafed lupin changed in its 1st 40 years as an industrial, broad-acre crop? A G x E-based characterization of yield-related traits in Australian cultivars
    • Berger, J.D.; Buirchell, B.; Luckett, D.J.; Palta, J.A.; Ludwig, C.; Liu, D. How has narrow-leafed lupin changed in its 1st 40 years as an industrial, broad-acre crop? A G x E-based characterization of yield-related traits in Australian cultivars. Field Crop Res., 2012, 126, 152-164.
    • (2012) Field Crop Res. , vol.126 , pp. 152-164
    • Berger, J.D.1    Buirchell, B.2    Luckett, D.J.3    Palta, J.A.4    Ludwig, C.5    Liu, D.6
  • 56
    • 0141838724 scopus 로고    scopus 로고
    • Sensory acceptability of white bread with added Australian sweet lupin (Lupinus angustifolius) kernel fibre and its glycaemic and insulinaemic responses when eaten as a breakfast
    • Johnson, S.K.; McQuillan, P.L.; Sin, J.H.; Ball, M.J. Sensory acceptability of white bread with added Australian sweet lupin (Lupinus angustifolius) kernel fibre and its glycaemic and insulinaemic responses when eaten as a breakfast. J. Sci. Food Agric., 2003, 83(13), 1366-1372.
    • (2003) J. Sci. Food Agric. , vol.83 , Issue.13 , pp. 1366-1372
    • Johnson, S.K.1    McQuillan, P.L.2    Sin, J.H.3    Ball, M.J.4
  • 57
    • 84878456619 scopus 로고    scopus 로고
    • Draft genome sequence, and a sequence-defined genetic linkage map of the legume crop species Lupinus angustifolius L
    • Yang, H.; Tao, Y.; Zheng, Z.; Zhang, Q.; Zhou, G.; Sweetingham, M.W.; Howieson, J.G.; Li, C. Draft genome sequence, and a sequence-defined genetic linkage map of the legume crop species Lupinus angustifolius L. PLoS ONE, 2013, 8(5):e64799.
    • (2013) Plos ONE , vol.8 , Issue.5
    • Yang, H.1    Tao, Y.2    Zheng, Z.3    Zhang, Q.4    Zhou, G.5    Sweetingham, M.W.6    Howieson, J.G.7    Li, C.8
  • 60
    • 84919835809 scopus 로고    scopus 로고
    • Transcriptome sequencing of different narrow-leafed lupin tissue types provides a comprehensive uni-gene assembly and extensive gene-based molecular markers
    • Kamphuis, L.G.; Hane, J.K.; Nelson, M.N.; Gao, L.; Atkins, C.A.; Singh, K.B. Transcriptome sequencing of different narrow-leafed lupin tissue types provides a comprehensive uni-gene assembly and extensive gene-based molecular markers. Plant Biotechnol. J., 2015, 13(1), 14-25.
    • (2015) Plant Biotechnol. J. , vol.13 , Issue.1 , pp. 14-25
    • Kamphuis, L.G.1    Hane, J.K.2    Nelson, M.N.3    Gao, L.4    Atkins, C.A.5    Singh, K.B.6
  • 62
    • 11144328091 scopus 로고    scopus 로고
    • The Lycopodium alkaloids
    • Ma, X.; Gang, D.R. The Lycopodium alkaloids. Nat. Prod. Rep., 2004, 21(6), 752-772.
    • (2004) Nat. Prod. Rep , vol.21 , Issue.6 , pp. 752-772
    • Ma, X.1    Gang, D.R.2
  • 63
    • 14644404923 scopus 로고    scopus 로고
    • Is there a better source of huperzine A than Huperzia serrata? Huperzine A content of Huperziaceae species in China
    • Ma, X.; Tan, C.; Zhu, D.; Gang, D.R. Is there a better source of huperzine A than Huperzia serrata? Huperzine A content of Huperziaceae species in China. J. Agric. Food Chem., 2005, 53(5), 1393-1398.
    • (2005) J. Agric. Food Chem. , vol.53 , Issue.5 , pp. 1393-1398
    • Ma, X.1    Tan, C.2    Zhu, D.3    Gang, D.R.4
  • 64
    • 84901373136 scopus 로고    scopus 로고
    • A new Lycopodium alkaloid from Phlegmariurus fargesii
    • Pan, K.; Luo, J.G.; Kong, L.Y. A new Lycopodium alkaloid from Phlegmariurus fargesii. Chin. J. Nat. Med., 2014, 12(5), 373-376.
    • (2014) Chin. J. Nat. Med. , vol.12 , Issue.5 , pp. 373-376
    • Pan, K.1    Luo, J.G.2    Kong, L.Y.3
  • 66
    • 84878953277 scopus 로고    scopus 로고
    • Production of huperzine A and other Lycopodium alkaloids in Huperzia species grown under controlled conditions and in vitro
    • Ishiuchi, K.; Park, J.J.; Long, R.M.; Gang, D.R. Production of huperzine A and other Lycopodium alkaloids in Huperzia species grown under controlled conditions and in vitro. Phytochemistry, 2013, 91, 208-219.
    • (2013) Phytochemistry , vol.91 , pp. 208-219
    • Ishiuchi, K.1    Park, J.J.2    Long, R.M.3    Gang, D.R.4
  • 68
    • 84865489218 scopus 로고    scopus 로고
    • Molecular cloning and characterization of copper amine oxidase from Huperzia serrata
    • Sun, J.; Morita, H.; Chen, G.; Noguchi, H.; Abe, I. Molecular cloning and characterization of copper amine oxidase from Huperzia serrata. Bioorg. Med. Chem. Lett., 2012, 22(18), 5784-5790.
    • (2012) Bioorg. Med. Chem. Lett. , vol.22 , Issue.18 , pp. 5784-5790
    • Sun, J.1    Morita, H.2    Chen, G.3    Noguchi, H.4    Abe, I.5
  • 69
    • 0034098365 scopus 로고    scopus 로고
    • Huperzine A, a potential therapeutic agent for treatment of Alzheimer’s disease
    • Bai, D.L.; Tang, X.C.; He, X.C. Huperzine A, a potential therapeutic agent for treatment of Alzheimer’s disease. Curr. Med. Chem., 2000, 7(3), 355-374.
    • (2000) Curr. Med. Chem. , vol.7 , Issue.3 , pp. 355-374
    • Bai, D.L.1    Tang, X.C.2    He, X.C.3
  • 70
    • 84906276463 scopus 로고    scopus 로고
    • Is it an effective diseasemodifying drug for Alzheimer’s disease? Front
    • Qian, Z.M.; Ke, Y. Huperzine A: Is it an effective diseasemodifying drug for Alzheimer’s disease? Front. Aging Neurosci., 2014, 6, 216.
    • (2014) Aging Neurosci. , vol.6 , pp. 216
    • Qian, Z.M.1    Ke, Y.2    Huperzine, A.3
  • 71
    • 67349262023 scopus 로고    scopus 로고
    • Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer’s disease: An updated meta-analysis
    • Wang, B.; Wang, H.; Wei, Z.; Song, Y.; Zhang, L.; Chen, H. Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer’s disease: an updated meta-analysis. J. Neural Transm., 2009, 116(4), 457-465.
    • (2009) J. Neural Transm. , vol.116 , Issue.4 , pp. 457-465
    • Wang, B.1    Wang, H.2    Wei, Z.3    Song, Y.4    Zhang, L.5    Chen, H.6
  • 72
    • 34447578839 scopus 로고    scopus 로고
    • Huperzine A from Huperzia species -
    • Ma, X.; Tan, C.; Zhu, D.; Gang, D.R.; Xiao, P. Huperzine A from Huperzia species - an ethnopharmacological review. J. Ethnopharmacol., 2007, 113(1), 15-34.
    • (2007) J. Ethnopharmacol. , vol.113 , Issue.1 , pp. 15-34
    • Ma, X.1    Tan, C.2    Zhu, D.3    Gang, D.R.4    Xiao, P.5
  • 73
    • 84881450088 scopus 로고    scopus 로고
    • Phase I study on the pharmacokinetics and tolerance of ZT-1, a prodrug of huperzine A, for the treatment of Alzheimer’s disease
    • Jia, J.; Zhao, Q.; Liu, Y.; Gui, Y.; Liu, G.; Zhu, D.; Yu, C.; Hong, Z. Phase I study on the pharmacokinetics and tolerance of ZT-1, a prodrug of huperzine A, for the treatment of Alzheimer’s disease. Acta Pharmacol. Sin., 2013, 34(7), 976-982.
    • (2013) Acta Pharmacol. Sin , vol.34 , Issue.7 , pp. 976-982
    • Jia, J.1    Zhao, Q.2    Liu, Y.3    Gui, Y.4    Liu, G.5    Zhu, D.6    Yu, C.7    Hong, Z.8
  • 74
    • 0011199378 scopus 로고
    • Biosynthesis of the hemlock and related piperidine alkaloids
    • Leete, E. Biosynthesis of the hemlock and related piperidine alkaloids. Accounts Chem. Res., 1971, 4(3), 100-107.
    • (1971) Accounts Chem. Res. , vol.4 , Issue.3 , pp. 100-107
    • Leete, E.1
  • 75
    • 0035047880 scopus 로고    scopus 로고
    • Constituents of Chinese Piper species and their inhibitory activity on prostaglandin and leukotriene biosynthesis in vitro
    • Stöhr, J.R.; Xiao, P.G.; Bauer, R. Constituents of Chinese Piper species and their inhibitory activity on prostaglandin and leukotriene biosynthesis in vitro. J. Ethnopharmacol., 2001, 75(2-3), 133-139.
    • (2001) J. Ethnopharmacol. , vol.75 , Issue.2-3 , pp. 133-139
    • Stöhr, J.R.1    Xiao, P.G.2    Bauer, R.3
  • 76
    • 44949255367 scopus 로고    scopus 로고
    • A rapid method for isolation of piperine from the fruits of Piper nigrum Linn
    • Kanaki, N.; Dave, M.; Padh, H.; Rajani, M. A rapid method for isolation of piperine from the fruits of Piper nigrum Linn. J. Nat. Med., 2008, 62(3), 281-283.
    • (2008) J. Nat. Med. , vol.62 , Issue.3 , pp. 281-283
    • Kanaki, N.1    Dave, M.2    Padh, H.3    Rajani, M.4
  • 77
    • 4644296823 scopus 로고    scopus 로고
    • History, chemistry and biology of alkaloids from Lobelia inflata
    • Felpin, F.X.; Lebreton, J. History, chemistry and biology of alkaloids from Lobelia inflata. Tetrahedron, 2004, 60(45), 10127-10153.
    • (2004) Tetrahedron , vol.60 , Issue.45 , pp. 10127-10153
    • Felpin, F.X.1    Lebreton, J.2
  • 78
    • 0342265665 scopus 로고
    • The biosynthesis of piperine in Piper nigrum
    • Geisler, J.G.; Gross, G.G. The biosynthesis of piperine in Piper nigrum. Phytochemistry, 1990, 29(2), 489-492.
    • (1990) Phytochemistry , vol.29 , Issue.2 , pp. 489-492
    • Geisler, J.G.1    Gross, G.G.2
  • 80
    • 77955431401 scopus 로고    scopus 로고
    • Genetic diversity analysis in Piper species (Piperaceae) using RAPD markers
    • Sen, S.; Skaria, R.; Muneer, P.M.A. Genetic diversity analysis in Piper species (Piperaceae) using RAPD markers. Mol. Biotechnol., 2010, 46(1), 72-79.
    • (2010) Mol. Biotechnol , vol.46 , Issue.1 , pp. 72-79
    • Sen, S.1    Skaria, R.2    Muneer, P.M.A.3
  • 82
    • 84882851639 scopus 로고    scopus 로고
    • Black pepper and piperine reduce cholesterol uptake and enhance translocation of cholesterol transporter proteins
    • Duangjai, A.; Ingkaninan, K.; Praputbut, S.; Limpeanchob, N. Black pepper and piperine reduce cholesterol uptake and enhance translocation of cholesterol transporter proteins. J. Nat. Med., 2013, 67(2), 303-310.
    • (2013) J. Nat. Med. , vol.67 , Issue.2 , pp. 303-310
    • Duangjai, A.1    Ingkaninan, K.2    Praputbut, S.3    Limpeanchob, N.4
  • 83
    • 84880754269 scopus 로고    scopus 로고
    • Piper nigrum and piperine: An update
    • Meghwal, M.; Goswami, T.K. Piper nigrum and piperine: an update. Phytother. Res., 2013, 27(8), 1121-1130.
    • (2013) Phytother. Res , vol.27 , Issue.8 , pp. 1121-1130
    • Meghwal, M.1    Goswami, T.K.2
  • 84
    • 79959359160 scopus 로고    scopus 로고
    • Pomegranate: Constituents, bioactivities and pharmacokinetics
    • Wang, R.; Ding, Y.; Liu, R; Xiang, L.; Du, L. Pomegranate: constituents, bioactivities and pharmacokinetics. Fruit Veg. Cereal Sci. Biotech., 2010, 4(2), 77-87.
    • (2010) Fruit Veg. Cereal Sci. Biotech , vol.4 , Issue.2 , pp. 77-87
    • Wang, R.1    Ding, Y.2    Liu, R.3    Xiang, L.4    Du, L.5
  • 85
    • 33845602057 scopus 로고    scopus 로고
    • Punica granatum (Pomegranate) and its potential for prevention and treatment of inflammation and cancer
    • Lansky, E.P.; Newman, R.A. Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer. J. Ethnopharmacol., 2007, 109(2), 177-206.
    • (2007) J. Ethnopharmacol. , vol.109 , Issue.2 , pp. 177-206
    • Lansky, E.P.1    Newman, R.A.2
  • 86
    • 47549111139 scopus 로고    scopus 로고
    • Therapeutic applications of pomegranate (Punica granatum L.): A review
    • Jurenka, J.S. Therapeutic applications of pomegranate (Punica granatum L.): a review. Altern. Med. Rev., 2008, 13(2), 128-144.
    • (2008) Altern. Med. Rev , vol.13 , Issue.2 , pp. 128-144
    • Jurenka, J.S.1
  • 87
    • 0020054636 scopus 로고
    • The indolizidine alkaloids
    • Gellert, E. The indolizidine alkaloids. J. Nat. Prod., 1982, 45(1), 50-73.
    • (1982) J. Nat. Prod. , vol.45 , Issue.1 , pp. 50-73
    • Gellert, E.1
  • 88
    • 0001423353 scopus 로고
    • A spectroscopic investigation of swainsonine: An
    • Colegate, S.M.; Dorling, P.R.; Huxtable, C.R. A spectroscopic investigation of swainsonine: an ‑ mannosidase inhibitor isolated from Swainsona canescens. Aust. J. Chem., 1979, 32(10), 2257-2264.
    • (1979) Aust. J. Chem. , vol.32 , Issue.10 , pp. 2257-2264
    • Colegate, S.M.1    Dorling, P.R.2    Huxtable, C.R.3
  • 90
    • 0034769539 scopus 로고    scopus 로고
    • Analysis of swainsonine: Extraction methods, detection, and measurement in populations of locoweeds (Oxytropis spp.)
    • Gardner, D.R.; Molyneux, R.J.; Ralphs, M.H. Analysis of swainsonine: extraction methods, detection, and measurement in populations of locoweeds (Oxytropis spp.). J. Agric. Food Chem., 2001, 49(10), 4573-4580.
    • (2001) J. Agric. Food Chem. , vol.49 , Issue.10 , pp. 4573-4580
    • Gardner, D.R.1    Molyneux, R.J.2    Ralphs, M.H.3
  • 91
    • 2942700289 scopus 로고    scopus 로고
    • Action of celgosivir (6 O-butanoyl castanospermine) against the pestivirus BVDV: Implications for the treatment of hepatitis C
    • Whitby, K.; Taylor, D.; Patel, D.; Ahmed, P.; Tyms, A.S. Action of celgosivir (6 O-butanoyl castanospermine) against the pestivirus BVDV: implications for the treatment of hepatitis C. Antivir. Chem. Chemother., 2004, 15(3), 141-151.
    • (2004) Antivir. Chem. Chemother. , vol.15 , Issue.3 , pp. 141-151
    • Whitby, K.1    Taylor, D.2    Patel, D.3    Ahmed, P.4    Tyms, A.S.5
  • 92
    • 33747892601 scopus 로고    scopus 로고
    • Antiviral effects of glycosylation and glucose trimming inhibitors on human parainfluenza virus type 3
    • Tanaka, Y.; Kato, J.; Kohara, M.; Galinski, M.S. Antiviral effects of glycosylation and glucose trimming inhibitors on human parainfluenza virus type 3. Antiviral Res., 2006, 72(1), 1-9.
    • (2006) Antiviral Res. , vol.72 , Issue.1 , pp. 1-9
    • Tanaka, Y.1    Kato, J.2    Kohara, M.3    Galinski, M.S.4
  • 93
    • 21644477919 scopus 로고    scopus 로고
    • Castanospermine, a potent inhibitor of dengue virus infection in vitro and in vivo
    • Whitby, K.; Pierson, T.C.; Geiss, B.; Lane, K.; Engle, M.; Zhou, Y.; Doms, R.W.; Diamond, M.S. Castanospermine, a potent inhibitor of dengue virus infection in vitro and in vivo. J. Virol., 2005, 79(14), 8698-8706.
    • (2005) J. Virol. , vol.79 , Issue.14 , pp. 8698-8706
    • Whitby, K.1    Pierson, T.C.2    Geiss, B.3    Lane, K.4    Engle, M.5    Zhou, Y.6    Doms, R.W.7    Diamond, M.S.8
  • 94
    • 84864925701 scopus 로고    scopus 로고
    • Doseand schedule-dependent protective efficacy of celgosivir in a lethal mouse model for dengue virus infection informs dosing regimen for a proof of concept clinical trial
    • Watanabe, S.; Rathore, A.P.S.; Sung, C.; Lu, F.; Khoo, Y.M.; Connolly, J.; Low, J.; Ooi, E.E.; Lee, H.S.; Vasudevan, S.G. Doseand schedule-dependent protective efficacy of celgosivir in a lethal mouse model for dengue virus infection informs dosing regimen for a proof of concept clinical trial. Antiviral Res., 2012, 96(1), 32-35.
    • (2012) Antiviral Res. , vol.96 , Issue.1 , pp. 32-35
    • Watanabe, S.1    Rathore, A.P.S.2    Sung, C.3    Lu, F.4    Khoo, Y.M.5    Connolly, J.6    Low, J.7    Ooi, E.E.8    Lee, H.S.9    Vasudevan, S.G.10
  • 97
    • 84879845708 scopus 로고    scopus 로고
    • New insights into the pharmacological chaperone activity of C2-substituted glucoimidazoles for the treatment of Gaucher disease
    • Li, Z.; Li, T.; Dai, S.; Xie, X.; Ma, X.; Zhao, W.; Zhang, W.; Li, J.; Wang, P.G. New insights into the pharmacological chaperone activity of C2-substituted glucoimidazoles for the treatment of Gaucher disease. Chem. Bio. Chem., 2013, 14(10), 1239-1247.
    • (2013) Chem. Bio. Chem. , vol.14 , Issue.10 , pp. 1239-1247
    • Li, Z.1    Li, T.2    Dai, S.3    Xie, X.4    Ma, X.5    Zhao, W.6    Zhang, W.7    Li, J.8    Wang, P.G.9
  • 99
    • 68649083959 scopus 로고    scopus 로고
    • Celgosivir, an α-glucosidase I inhibitor for the potential treatment of HCV infection
    • Durantel, D. Celgosivir, an α-glucosidase I inhibitor for the potential treatment of HCV infection. Curr. Opin. Investig. Drugs, 2009, 10(8), 860-870.
    • (2009) Curr. Opin. Investig. Drugs , vol.10 , Issue.8 , pp. 860-870
    • Durantel, D.1
  • 101
    • 2942700289 scopus 로고    scopus 로고
    • Action of celgosivir (6 O-butanoyl castanospermine) against the pestivirus BVDV: Implications for the treatment of hepatitis C
    • Whitby, K.; Taylor, D.; Patel, D.; Ahmed, P.; Tyms, A.S. Action of celgosivir (6 O-butanoyl castanospermine) against the pestivirus BVDV: implications for the treatment of hepatitis C. Antivir. Chem. Chemother., 2004, 15(3), 141-151.
    • (2004) Antivir. Chem. Chemother. , vol.15 , Issue.3 , pp. 141-151
    • Whitby, K.1    Taylor, D.2    Patel, D.3    Ahmed, P.4    Tyms, A.S.5
  • 102
    • 0001567368 scopus 로고
    • The alkaloid contents of sixty Nicotiana species
    • Saitoh, F.; Noma, M.; Kawashima, N. The alkaloid contents of sixty Nicotiana species. Phytochemistry, 1985, 24(3), 477-480.
    • (1985) Phytochemistry , vol.24 , Issue.3 , pp. 477-480
    • Saitoh, F.1    Noma, M.2    Kawashima, N.3
  • 103
    • 0037125144 scopus 로고    scopus 로고
    • Accidental fatal poisoning by Nicotiana glauca: Identification of anabasine by high performance liquid chromatography/photodiode array/mass spectrometry
    • Steenkamp, P.A.; van Heerden, F.R.; van Wyk, B.E. Accidental fatal poisoning by Nicotiana glauca: identification of anabasine by high performance liquid chromatography/photodiode array/mass spectrometry. Forensic Sci. Int., 2002, 127(3), 208-217.
    • (2002) Forensic Sci. Int , vol.127 , Issue.3 , pp. 208-217
    • Steenkamp, P.A.1    Van Heerden, F.R.2    Van Wyk, B.E.3
  • 104
    • 0034084910 scopus 로고    scopus 로고
    • Fatal poisoning from Nicotiana glauca leaves: Identification of anabasine by gaschromatography/ mass spectrometry
    • Mizrachi, N.; Levy, S.; Goren, Z.Q. Fatal poisoning from Nicotiana glauca leaves: identification of anabasine by gaschromatography/ mass spectrometry. J. Forensic Sci., 2000, 45(3), 736-741.
    • (2000) J. Forensic Sci. , vol.45 , Issue.3 , pp. 736-741
    • Mizrachi, N.1    Levy, S.2    Goren, Z.Q.3
  • 105
    • 84923423037 scopus 로고    scopus 로고
    • Revisiting anabasine biosynthesis in tobacco hairy roots expressing plant lysine decarboxylase gene by using 15N-labeled lysine
    • Bunsupa, S.; Komatsu, K.; Nakabayashi, R. Revisiting anabasine biosynthesis in tobacco hairy roots expressing plant lysine decarboxylase gene by using 15N-labeled lysine. Plant Biotechnol., 2014, 31, 511-518.
    • (2014) Plant Biotechnol. , vol.31 , pp. 511-518
    • Bunsupa, S.1    Komatsu, K.2    Nakabayashi, R.3
  • 106
    • 49449114320 scopus 로고    scopus 로고
    • Why does anatabine, but not nicotine, accumulate in jasmonate-elicited cultured tobacco BY-2 cells?
    • Shoji, T.; Hashimoto, T. Why does anatabine, but not nicotine, accumulate in jasmonate-elicited cultured tobacco BY-2 cells? Plant Cell Physiol., 2008, 49(8), 1209-1216.
    • (2008) Plant Cell Physiol. , vol.49 , Issue.8 , pp. 1209-1216
    • Shoji, T.1    Hashimoto, T.2
  • 107
    • 2442726418 scopus 로고
    • The biogenesis of nicotine and anabasine
    • Leete, E. The biogenesis of nicotine and anabasine. J. Am. Chem. Soc., 1956, 78(14), 3520-3523.
    • (1956) J. Am. Chem. Soc. , vol.78 , Issue.14 , pp. 3520-3523
    • Leete, E.1
  • 108
    • 1842302744 scopus 로고
    • The biogenesis of nicotine. III. Further observations on the incorporation of ornithine into the pyrrolidine ring
    • Leete, E.; Siegfried, K.J. The biogenesis of nicotine. III. Further observations on the incorporation of ornithine into the pyrrolidine ring. J. Am. Chem. Soc., 1957, 79(16), 4529-4531.
    • (1957) J. Am. Chem. Soc. , vol.79 , Issue.16 , pp. 4529-4531
    • Leete, E.1    Siegfried, K.J.2
  • 109
    • 0015920792 scopus 로고
    • Biosynthesis of the piperidine nucleus. Incorporation of chirally labeled [1-3H] cadaverine
    • Leistner, E.; Spenser, I.D. Biosynthesis of the piperidine nucleus. Incorporation of chirally labeled [1-3H] cadaverine. J. Am. Chem. Soc., 1973, 95(14), 4715-4725.
    • (1973) J. Am. Chem. Soc. , vol.95 , Issue.14 , pp. 4715-4725
    • Leistner, E.1    Spenser, I.D.2
  • 110
    • 0000744728 scopus 로고
    • Perturbation of alkaloid production by cadaverine in hairy root cultures of Nicotiana rustica
    • Walton, N.J.; Robins, R.J.; Rhodes, M.J. Perturbation of alkaloid production by cadaverine in hairy root cultures of Nicotiana rustica. Plant Sci., 1988, 54(2), 125-131.
    • (1988) Plant Sci. , vol.54 , Issue.2 , pp. 125-131
    • Walton, N.J.1    Robins, R.J.2    Rhodes, M.J.3
  • 111
    • 84872031385 scopus 로고    scopus 로고
    • RNAi-mediated down-regulation of ornithine decarboxylase (ODC) impedes wound-stress stimulation of anabasine synthesis in Nicotiana glauca
    • DeBoer, K.D.; Dalton, H.L.; Edward, F.J.; Ryan, S.M.; Hamill, J.D. RNAi-mediated down-regulation of ornithine decarboxylase (ODC) impedes wound-stress stimulation of anabasine synthesis in Nicotiana glauca. Phytochemistry, 2013, 86, 21-28.
    • (2013) Phytochemistry , vol.86 , pp. 21-28
    • Deboer, K.D.1    Dalton, H.L.2    Edward, F.J.3    Ryan, S.M.4    Hamill, J.D.5
  • 112
    • 58549116129 scopus 로고    scopus 로고
    • PIP-family protein is required for biosynthesis of tobacco alkaloids
    • Kajikawa, M.; Hirai, N.; Hashimoto, T. A PIP-family protein is required for biosynthesis of tobacco alkaloids. Plant Mol. Biol., 2009, 69(3), 287-298.
    • (2009) Plant Mol. Biol , vol.69 , Issue.3 , pp. 287-298
    • Kajikawa, M.1    Hirai, N.2    Hashimoto, T.A.3
  • 114
    • 84874951126 scopus 로고    scopus 로고
    • Transcriptome data modeling for targeted plant metabolic engineering
    • Yonekura-Sakakibara, K.; Fukushima, A.; Saito, K. Transcriptome data modeling for targeted plant metabolic engineering. Curr. Opin. Biotech., 2013, 24(2), 285-290.
    • (2013) Curr. Opin. Biotech. , vol.24 , Issue.2 , pp. 285-290
    • Yonekura-Sakakibara, K.1    Fukushima, A.2    Saito, K.3
  • 115
    • 84878982144 scopus 로고    scopus 로고
    • Phytochemical genomics ‑ a new trend
    • Saito, K. Phytochemical genomics ‑ a new trend. Curr. Opin. Plant Biol., 2013, 16(3), 373-380.
    • (2013) Curr. Opin. Plant Biol , vol.16 , Issue.3 , pp. 373-380
    • Saito, K.1
  • 116
    • 84964211599 scopus 로고    scopus 로고
    • Modern plant metabolomics: Advanced natural product gene discoveries, improved technologies, and future prospects
    • Sumner, L.W.; Lei, Z.; Nikolau, B.J.; Saito, K. Modern plant metabolomics: advanced natural product gene discoveries, improved technologies, and future prospects. Nat. Prod. Rep., 2015, 32(2), 212-229.
    • (2015) Nat. Prod. Rep , vol.32 , Issue.2 , pp. 212-229
    • Sumner, L.W.1    Lei, Z.2    Nikolau, B.J.3    Saito, K.4
  • 117
    • 84925134466 scopus 로고    scopus 로고
    • It is easy to get huge candidate gene lists for plant metabolism now, but how to get beyond?
    • Goossens, A. It is easy to get huge candidate gene lists for plant metabolism now, but how to get beyond? Mol. Plant, 2015, 8(1), 2-5.
    • (2015) Mol. Plant , vol.8 , Issue.1 , pp. 2-5
    • Goossens, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.