메뉴 건너뛰기




Volumn 6, Issue AUG, 2014, Pages

Huperzine A: Is it an effective disease-modifying drug for Alzheimer's disease?

Author keywords

Acetylcho linesterase inhibitor; Alzheimer's disease; Disease modifying agent; Huperzine A; Non cholinergic effects

Indexed keywords

AMYLOID PRECURSOR PROTEIN; HUPERZINE A; IRON; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NERVE GROWTH FACTOR; NUTRACEUTICAL; PROTEIN KINASE C;

EID: 84906276463     PISSN: None     EISSN: 16634365     Source Type: Journal    
DOI: 10.3389/fnagi.2014.00216     Document Type: Review
Times cited : (80)

References (66)
  • 1
    • 25144433893 scopus 로고    scopus 로고
    • Late-phase long-term potentiation: getting to the nucleus
    • doi: 10.1038/nrn1749
    • Adams, J. P., and Dude, S. M. (2005). Late-phase long-term potentiation: getting to the nucleus. Nat. Rev. Neurosci. 6, 737-743. doi: 10.1038/nrn1749
    • (2005) Nat. Rev. Neurosci. , vol.6 , pp. 737-743
    • Adams, J.P.1    Dude, S.M.2
  • 2
    • 84870056899 scopus 로고    scopus 로고
    • Nerve growth factor: from the early discoveries to the potential clinical use
    • doi:10.1186/1479-5876-10-239
    • Aloe, L., Rocco, M. L., Branching, P., and Mani, L. (2012). Nerve growth factor: from the early discoveries to the potential clinical use. J. Transl. Med. 10, 239. doi:10.1186/1479-5876-10-239
    • (2012) J. Transl. Med. , vol.10 , pp. 239
    • Aloe, L.1    Rocco, M.L.2    Branching, P.3    Mani, L.4
  • 3
    • 84884852756 scopus 로고    scopus 로고
    • Homeostasis in Alzheimer's disease
    • doi:10.1016/j.freeradbiomed.2012.10.558
    • Ayton, S., Lei, P., and Bush, A. I. (2012). Homeostasis in Alzheimer's disease. Free Radic. Biol. Med. 62, 76-89. doi:10.1016/j.freeradbiomed.2012.10.558
    • (2012) Free Radic. Biol. Med. , vol.62 , pp. 76-89
    • Ayton, S.1    Lei, P.2    Bush, A.I.3
  • 4
    • 0035378322 scopus 로고    scopus 로고
    • Functional mitochondria are required for amyloid beta-mediated neurotoxicity
    • Cardoso, S. M., Santos, S., Swerdlow, R. H., and Oliveira, C. R. (2001). Functional mitochondria are required for amyloid beta-mediated neurotoxicity. FASEB J. 15, 1439-1441.
    • (2001) FASEB J , vol.15 , pp. 1439-1441
    • Cardoso, S.M.1    Santos, S.2    Swerdlow, R.H.3    Oliveira, C.R.4
  • 5
    • 3042834662 scopus 로고    scopus 로고
    • Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain
    • doi:10.1523/JNEUROSCI.1381-04.2004
    • Caricasole, A., Copani, A., Caraci, F., Aronica, E., Rozemuller, A. J., Caruso, A., et al. (2004). Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain. J. Neurosci. 24, 6021-6027. doi:10.1523/JNEUROSCI.1381-04.2004
    • (2004) J. Neurosci. , vol.24 , pp. 6021-6027
    • Caricasole, A.1    Copani, A.2    Caraci, F.3    Aronica, E.4    Rozemuller, A.J.5    Caruso, A.6
  • 6
    • 84878796119 scopus 로고    scopus 로고
    • Nerve growth factor and Alzheimer's disease: new facts for an old hypothesis
    • doi:10.1007/s12035-012-8310-9
    • Cattaneo, A., and Calissano, P. (2012). Nerve growth factor and Alzheimer's disease: new facts for an old hypothesis. Mol. Neurobiol. 46, 588-604. doi:10.1007/s12035-012-8310-9
    • (2012) Mol. Neurobiol. , vol.46 , pp. 588-604
    • Cattaneo, A.1    Calissano, P.2
  • 7
    • 77951776829 scopus 로고    scopus 로고
    • Alzheimer's disease: strategies for disease modification
    • doi:10.1038/nrd2896
    • Citron, M. (2010). Alzheimer's disease: strategies for disease modification. Nat. Rev. Drug Discov. 9, 387-398. doi:10.1038/nrd2896
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 387-398
    • Citron, M.1
  • 8
    • 0037220599 scopus 로고    scopus 로고
    • Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils
    • doi:10.1038/sj.mp.4001208
    • De Ferrari, G. V., Chacon, M. A., Barria, M. I., Garrido, J. L., Godoy, J. A., Olivares, G., et al. (2003). Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils. Mol. Psychiatry 8, 195-208. doi:10.1038/sj.mp.4001208
    • (2003) Mol. Psychiatry , vol.8 , pp. 195-208
    • De Ferrari, G.V.1    Chacon, M.A.2    Barria, M.I.3    Garrido, J.L.4    Godoy, J.A.5    Olivares, G.6
  • 9
    • 0034076985 scopus 로고    scopus 로고
    • Prospects for pharmacological intervention in Alzheimer disease
    • doi:10.1001/archneur.57.4.454
    • Emilien, G., Beyreuther, K., Masters, C. L., and Maloteaux, J. M. (2000). Prospects for pharmacological intervention in Alzheimer disease. Arch. Neurol. 57, 454-459. doi:10.1001/archneur.57.4.454
    • (2000) Arch. Neurol. , vol.57 , pp. 454-459
    • Emilien, G.1    Beyreuther, K.2    Masters, C.L.3    Maloteaux, J.M.4
  • 10
    • 11844285723 scopus 로고    scopus 로고
    • The anti-inflammatory and cholinesterase inhibitor bifunctional compound IBU-PO protects from beta-amyloid neurotoxicity by acting on Wnt signaling components
    • doi:10.1016/j.nbd.2004.09.012
    • Farias, G. G., Godoy, J. A., Vazquez, M. C., Adani, R., Meshulam, H., Avila, J., et al. (2005). The anti-inflammatory and cholinesterase inhibitor bifunctional compound IBU-PO protects from beta-amyloid neurotoxicity by acting on Wnt signaling components. Neurobiol. Dis. 18, 176-183. doi:10.1016/j.nbd.2004.09.012
    • (2005) Neurobiol. Dis. , vol.18 , pp. 176-183
    • Farias, G.G.1    Godoy, J.A.2    Vazquez, M.C.3    Adani, R.4    Meshulam, H.5    Avila, J.6
  • 11
    • 0023643241 scopus 로고
    • Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor
    • doi:10.1038/329065a0
    • Fischer, W., Wictorin, K., Bjorklund, A., Williams, L. R., Varon, S., and Gage, F. H. (1987). Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor. Nature 329, 65-68. doi:10.1038/329065a0
    • (1987) Nature , vol.329 , pp. 65-68
    • Fischer, W.1    Wictorin, K.2    Bjorklund, A.3    Williams, L.R.4    Varon, S.5    Gage, F.H.6
  • 12
    • 79953275300 scopus 로고    scopus 로고
    • A systematic review of single Chinese herbs for Alzheimer's disease treatment
    • doi:10. 1093/ecam/nep136
    • Fu, L. M., and Li, J. T. (2011). A systematic review of single Chinese herbs for Alzheimer's disease treatment. Evid. Based Complement. Alternat. Med. 2011, 640284. doi:10.1093/ecam/nep136
    • (2011) Evid. Based Complement. Alternat. Med. , vol.2011 , pp. 640284
    • Fu, L.M.1    Li, J.T.2
  • 13
    • 33645855623 scopus 로고    scopus 로고
    • Huperzine A attenuates mitochondrial dysfunction in beta-amyloid-treated PC12 cells by reducing oxygen free radicals accumulation and improving mitochondrial energy metabolism
    • doi:10.1002/jnr.20791
    • Gao, X., and Tang, X. C. (2006). Huperzine A attenuates mitochondrial dysfunction in beta-amyloid-treated PC12 cells by reducing oxygen free radicals accumulation and improving mitochondrial energy metabolism. J. Neurosci. Res. 83, 1048-1057. doi:10.1002/jnr.20791
    • (2006) J. Neurosci. Res. , vol.83 , pp. 1048-1057
    • Gao, X.1    Tang, X.C.2
  • 14
    • 67349281227 scopus 로고    scopus 로고
    • Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptide
    • doi:10.1016/j.freeradbiomed.2009.02.028
    • Gao, X., Zheng, C. Y., Yang, L., Tang, X. C., and Zhang, H. Y. (2009). Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptide. Free Radic. Biol. Med. 46, 1454-1462. doi:10.1016/j.freeradbiomed.2009.02.028
    • (2009) Free Radic. Biol. Med. , vol.46 , pp. 1454-1462
    • Gao, X.1    Zheng, C.Y.2    Yang, L.3    Tang, X.C.4    Zhang, H.Y.5
  • 15
    • 0012809753 scopus 로고    scopus 로고
    • The NMDA receptor ion channel: a site for binding of huperzine A
    • doi:10.1002/jat.805
    • Gordon, R. K., Nigam, S. V., Weitz, J. A., Dave, J. R., Doctor, B. P., and Ved, H. S. (2001). The NMDA receptor ion channel: a site for binding of huperzine A. J. Appl. Toxicol. 21(Suppl. 1), S47-S51. doi:10.1002/jat.805
    • (2001) J. Appl. Toxicol. , vol.21 , Issue.SUPPL. 1
    • Gordon, R.K.1    Nigam, S.V.2    Weitz, J.A.3    Dave, J.R.4    Doctor, B.P.5    Ved, H.S.6
  • 16
    • 79958274796 scopus 로고    scopus 로고
    • The role of phytochemicals in the treatment and prevention of dementia
    • doi:10.2165/11591310-000000000-00000
    • Howes, M. J., and Perry, E. (2011). The role of phytochemicals in the treatment and prevention of dementia. Drugs Aging 28, 439-468. doi:10.2165/11591310-000000000-00000
    • (2011) Drugs Aging , vol.28 , pp. 439-468
    • Howes, M.J.1    Perry, E.2
  • 17
    • 0041488911 scopus 로고    scopus 로고
    • TRK receptors: roles in neuronal signal transduction
    • doi:10.1146/annurev.biochem.72.121801.161629
    • Huang, E. J., and Reichard, L. F. (2003). TRK receptors: roles in neuronal signal transduction. Annu. Rev. Biochem. 72, 609-642. doi:10.1146/annurev.biochem.72.121801.161629
    • (2003) Annu. Rev. Biochem. , vol.72 , pp. 609-642
    • Huang, E.J.1    Reichard, L.F.2
  • 18
    • 84893721804 scopus 로고    scopus 로고
    • Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease
    • doi:10.1016/j.neurobiolaging.2013.11.004
    • Huang, X. T., Qian, Z. M., He, X., Gong, Q., Wu, K. C., Jiang, L. R., et al. (2014). Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease. Neurobiol. Aging 35, 1045-1054. doi:10.1016/j.neurobiolaging.2013.11.004
    • (2014) Neurobiol. Aging , vol.35 , pp. 1045-1054
    • Huang, X.T.1    Qian, Z.M.2    He, X.3    Gong, Q.4    Wu, K.C.5    Jiang, L.R.6
  • 19
    • 84856708923 scopus 로고    scopus 로고
    • Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export
    • doi:10.1038/nm.2613
    • Lei, P., Ayton, S., Finkelstein, D. I., Spoerri, L., Ciccotosto, G. D., Wright, D. K., et al. (2012). Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export. Nat. Med. 18, 291-295. doi:10.1038/nm.2613
    • (2012) Nat. Med. , vol.18 , pp. 291-295
    • Lei, P.1    Ayton, S.2    Finkelstein, D.I.3    Spoerri, L.4    Ciccotosto, G.D.5    Wright, D.K.6
  • 20
    • 0029184104 scopus 로고
    • Intelligence promoting Chinese materia medica [Article in Chinese]
    • Liu, M. Y., and Liu, H. C. (1995). Intelligence promoting Chinese materia medica. [Article in Chinese]. Zhongguo Zhong Xi Yi Jie He Za Zhi 15, 59-61.
    • (1995) Zhongguo Zhong Xi Yi Jie He Za Zhi , vol.15 , pp. 59-61
    • Liu, M.Y.1    Liu, H.C.2
  • 21
    • 34447578839 scopus 로고    scopus 로고
    • Huperzine A from Huperzia species - an ethnopharmacolgical review
    • doi:10.1016/j.jep.2007.05.030
    • Ma, X., Tan, C., Zhu, D., Gang, D. R., and Xiao, P. (2007). Huperzine A from Huperzia species - an ethnopharmacolgical review. J. Ethnopharmacol. 113, 15-34. doi:10.1016/j.jep.2007.05.030
    • (2007) J. Ethnopharmacol. , vol.113 , pp. 15-34
    • Ma, X.1    Tan, C.2    Zhu, D.3    Gang, D.R.4    Xiao, P.5
  • 22
    • 79953004994 scopus 로고    scopus 로고
    • In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders
    • doi:10.1523/JNEUROSCI.3076-10.2011
    • Maeda, J., Zhang, M. R., Okauchi, T., Ji, B., Ono, M., Hattori, S., et al. (2011). In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders. J. Neurosci. 31, 4720-4730. doi:10.1523/JNEUROSCI.3076-10.2011
    • (2011) J. Neurosci. , vol.31 , pp. 4720-4730
    • Maeda, J.1    Zhang, M.R.2    Okauchi, T.3    Ji, B.4    Ono, M.5    Hattori, S.6
  • 23
    • 0034042406 scopus 로고    scopus 로고
    • Synaptic plasticity and memory: an evaluation of the hypothesis
    • doi:10.1146/annurev.neuro.23.1.649
    • Martin, S. J., Grimwood, P. D., and Morris, R. G. (2000). Synaptic plasticity and memory: an evaluation of the hypothesis. Annu. Rev. Neurosci. 23, 649-711. doi:10.1146/annurev.neuro.23.1.649
    • (2000) Annu. Rev. Neurosci. , vol.23 , pp. 649-711
    • Martin, S.J.1    Grimwood, P.D.2    Morris, R.G.3
  • 24
    • 0034697903 scopus 로고    scopus 로고
    • Alzheimer's congress
    • doi:10.1126/science.289.5478.375b
    • Marx, J. (2000). Alzheimer's congress. Drug shows promise for advanced disease. Science 289, 375-377. doi:10.1126/science.289.5478.375b
    • (2000) Drug shows promise for advanced disease. Science , vol.289 , pp. 375-377
    • Marx, J.1
  • 25
    • 79960999435 scopus 로고    scopus 로고
    • An overview on natural cholinesterase inhibitors - a multi-targeted drug class - and their mass production
    • doi:10.2174/138955711796575434
    • Orhan, I. E., Orhan, G., and Gurkas, E. (2011). An overview on natural cholinesterase inhibitors - a multi-targeted drug class - and their mass production. Mini Rev. Med. Chem. 11, 836-842. doi:10.2174/138955711796575434
    • (2011) Mini Rev. Med. Chem. , vol.11 , pp. 836-842
    • Orhan, I.E.1    Orhan, G.2    Gurkas, E.3
  • 26
    • 0032850599 scopus 로고    scopus 로고
    • Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes
    • doi:10.1097/00005072-199909000-00011
    • Pei, J. J., Braak, E., Braak, H., Grundke-Iqbal, I., Iqbal, K., Winblad, B., et al. (1999). Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes. J. Neuropathol. Exp. Neurol. 58, 1010-1019. doi:10.1097/00005072-199909000-00011
    • (1999) J. Neuropathol. Exp. Neurol. , vol.58 , pp. 1010-1019
    • Pei, J.J.1    Braak, E.2    Braak, H.3    Grundke-Iqbal, I.4    Iqbal, K.5    Winblad, B.6
  • 27
    • 0035095564 scopus 로고    scopus 로고
    • Brain iron transport and neurodegeneration
    • doi:10.1016/S1471-4914(00)01910-9
    • Qian, Z. M., and Shen, X. (2001). Brain iron transport and neurodegeneration. Trends Mol. Med. 7, 103-110. doi:10.1016/S1471-4914(00)01910-9
    • (2001) Trends Mol. Med. , vol.7 , pp. 103-110
    • Qian, Z.M.1    Shen, X.2
  • 28
    • 0031152017 scopus 로고    scopus 로고
    • Brain iron and neurological disorders
    • Qian, Z. M., Wang, Q., and Pu, Y. (1997). Brain iron and neurological disorders. Chin. Med. J. 110, 455-458.
    • (1997) Chin. Med. J. , vol.110 , pp. 455-458
    • Qian, Z.M.1    Wang, Q.2    Pu, Y.3
  • 29
    • 79955444505 scopus 로고    scopus 로고
    • A phase II trial of huperzine A in mild to moderate Alzheimer disease
    • doi:10.1212/WNL.0b013e318216eb7b
    • Rafii, M. S., Walsh, S., Little, J. T., Behan, K., Reynolds, B., Ward, C., et al. (2011). A phase II trial of huperzine A in mild to moderate Alzheimer disease. Neurology 76, 1389-1394. doi:10.1212/WNL.0b013e318216eb7b
    • (2011) Neurology , vol.76 , pp. 1389-1394
    • Rafii, M.S.1    Walsh, S.2    Little, J.T.3    Behan, K.4    Reynolds, B.5    Ward, C.6
  • 30
    • 34249085665 scopus 로고    scopus 로고
    • NMDA and AMPA receptors: old channels, new tricks
    • doi:10.1016/j.tins.2007.03.012
    • Rao, V. R., and Finkbeiner, S. (2007). NMDA and AMPA receptors: old channels, new tricks. Trends Neurosci. 30, 284-291. doi:10.1016/j.tins.2007.03.012
    • (2007) Trends Neurosci , vol.30 , pp. 284-291
    • Rao, V.R.1    Finkbeiner, S.2
  • 31
    • 84873087083 scopus 로고    scopus 로고
    • Huprine X and huperzine A improve cognition and regulate some neurochemical processes related with Alzheimer's disease in triple transgenic mice (3xTg-AD)
    • doi:10.1159/000336427
    • Ratia, M., Giménez-Llort, L., Camps, P., Muñoz-Torrero, D., Pérez, B., Clos, M. V., et al. (2013). Huprine X and huperzine A improve cognition and regulate some neurochemical processes related with Alzheimer's disease in triple transgenic mice (3xTg-AD). Neurodegener. Dis. 11, 129-140. doi:10.1159/000336427
    • (2013) Neurodegener. Dis. , vol.11 , pp. 129-140
    • Ratia, M.1    Giménez-Llort, L.2    Camps, P.3    Muñoz-Torrero, D.4    Pérez, B.5    Clos, M.V.6
  • 32
    • 39149122810 scopus 로고    scopus 로고
    • Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease
    • doi:10.1016/j.molmed.2007.12.002
    • Reddy, P. H., and Beal, M. F. (2008). Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease. Trends Mol. Med. 14, 45-53. doi:10.1016/j.molmed.2007.12.002
    • (2008) Trends Mol. Med. , vol.14 , pp. 45-53
    • Reddy, P.H.1    Beal, M.F.2
  • 33
    • 0001059974 scopus 로고    scopus 로고
    • The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling
    • doi:10.1016/S0301-0082(98)00044-6
    • Rossner, S., Ueberham, U., Schliebs, R., Perez-Polo, J. R., and Bigl, V. (1998). The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling. Prog. Neurobiol. 56, 541-569. doi:10.1016/S0301-0082(98)00044-6
    • (1998) Prog. Neurobiol. , vol.56 , pp. 541-569
    • Rossner, S.1    Ueberham, U.2    Schliebs, R.3    Perez-Polo, J.R.4    Bigl, V.5
  • 34
    • 0033011662 scopus 로고    scopus 로고
    • Transgenic murine cortical neurons expressing human Bcl-2 exhibit increased resistance to amyloid beta-peptide neurotoxicity
    • doi:10.1016/S0306-4522(99)00089-5
    • Saille, C., Marin, P., Martinou, J. C., Nicole, A., London, J., and Ceballos-Picot, I. (1999). Transgenic murine cortical neurons expressing human Bcl-2 exhibit increased resistance to amyloid beta-peptide neurotoxicity. Neuroscience 92, 1455-1463. doi:10.1016/S0306-4522(99)00089-5
    • (1999) Neuroscience , vol.92 , pp. 1455-1463
    • Saille, C.1    Marin, P.2    Martinou, J.C.3    Nicole, A.4    London, J.5    Ceballos-Picot, I.6
  • 35
    • 0029022112 scopus 로고
    • Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis
    • Scott, S. A., Mufson, E. J., Weingartner, J. A., Skau, K. A., and Crutcher, K. A. (1995). Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis. J. Neurosci. 15, 6213-6221.
    • (1995) J. Neurosci. , vol.15 , pp. 6213-6221
    • Scott, S.A.1    Mufson, E.J.2    Weingartner, J.A.3    Skau, K.A.4    Crutcher, K.A.5
  • 36
    • 0032888723 scopus 로고    scopus 로고
    • Improving effects of huperzine A on abnormal lipid peroxidation and superoxide dismutase in aged rats
    • Shang, Y. Z., Ye, J. W., and Tang, X. C. (1999). Improving effects of huperzine A on abnormal lipid peroxidation and superoxide dismutase in aged rats. Zhongguo Yao Li Xue Bao 20, 824-828.
    • (1999) Zhongguo Yao Li Xue Bao , vol.20 , pp. 824-828
    • Shang, Y.Z.1    Ye, J.W.2    Tang, X.C.3
  • 37
    • 84864385007 scopus 로고    scopus 로고
    • Mitochondrial abnormalities in Alzheimer's disease: possible targets for therapeutic intervention
    • doi:10.1016/B978-0-12-394816-8.00003-9
    • Silva, D. F., Selfridge, J. E., Lu, J. H., Lezi, E., Cardoso, S. M., and Swerdlow, R. H. (2012). Mitochondrial abnormalities in Alzheimer's disease: possible targets for therapeutic intervention. Adv. Pharmacol. 64, 83-126. doi:10.1016/B978-0-12-394816-8.00003-9
    • (2012) Adv. Pharmacol. , vol.64 , pp. 83-126
    • Silva, D.F.1    Selfridge, J.E.2    Lu, J.H.3    Lezi, E.4    Cardoso, S.M.5    Swerdlow, R.H.6
  • 38
    • 0031046115 scopus 로고    scopus 로고
    • Old Chinese herbal medicine used for fever yields possible new Alzheimer disease therapy
    • doi:10.1001/jama.1997.03540340010004
    • Skolnick, A. A. (1997). Old Chinese herbal medicine used for fever yields possible new Alzheimer disease therapy. JAMA 277, 776. doi:10.1001/jama.1997.03540340010004
    • (1997) JAMA , vol.277 , pp. 776
    • Skolnick, A.A.1
  • 39
    • 75149152568 scopus 로고    scopus 로고
    • Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment
    • doi:10.3233/JAD-2010-1239
    • Smith, M. A., Zhu, X., Tabaton, M., Liu, G., McKeel, D. W. Jr., Cohen, M. L., et al. (2010). Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment. J. Alzheimers Dis. 19, 363-372. doi:10.3233/JAD-2010-1239
    • (2010) J. Alzheimers Dis. , vol.19 , pp. 363-372
    • Smith, M.A.1    Zhu, X.2    Tabaton, M.3    Liu, G.4    McKeel Jr, D.W.5    Cohen, M.L.6
  • 40
    • 0030273584 scopus 로고    scopus 로고
    • NMDA receptors: from genes to channels
    • doi:10.1016/S0165-6147(96)10046-8
    • Sucher, N. J., Awobuluyi, M., Choi, Y. B., and Lipton, S. A. (1996). NMDA receptors: from genes to channels. Trends Pharmacol. Sci. 17, 348-355. doi:10.1016/S0165-6147(96)10046-8
    • (1996) Trends Pharmacol. Sci. , vol.17 , pp. 348-355
    • Sucher, N.J.1    Awobuluyi, M.2    Choi, Y.B.3    Lipton, S.A.4
  • 41
    • 20444424188 scopus 로고    scopus 로고
    • Effects of huperzine A on secretion of nerve growth factor in cultured rat cortical astrocytes and neurite outgrowth in rat PC12 cells
    • doi:10.1111/j.1745-7254.2005.00130.x
    • Tang, L. L., Wang, R., and Tang, X. C. (2005). Effects of huperzine A on secretion of nerve growth factor in cultured rat cortical astrocytes and neurite outgrowth in rat PC12 cells. Acta Pharmacol. Sin. 26, 673-678. doi:10.1111/j.1745-7254.2005.00130.x
    • (2005) Acta Pharmacol. Sin. , vol.26 , pp. 673-678
    • Tang, L.L.1    Wang, R.2    Tang, X.C.3
  • 42
    • 0026008812 scopus 로고
    • Recombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in the adult primate brain
    • doi:10.1002/ana.410300502
    • Tuszynski, M. H., Sang, H., Yoshida, K., and Gage, F. H. (1991). Recombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in the adult primate brain. Ann. Neurol. 30, 625-636. doi:10.1002/ana.410300502
    • (1991) Ann. Neurol. , vol.30 , pp. 625-636
    • Tuszynski, M.H.1    Sang, H.2    Yoshida, K.3    Gage, F.H.4
  • 43
    • 79952756491 scopus 로고    scopus 로고
    • Huperzine A activates Wnt/ß-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model
    • doi:10.1038/npp.2010.245
    • Wang, C. Y., Zheng, W., Wang, T., Xie, J. W., Wang, S. L., Zhao, B. L., et al. (2011). Huperzine A activates Wnt/ß-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model. Neuropsychopharmacology 36, 1073-1089. doi:10.1038/npp.2010.245
    • (2011) Neuropsychopharmacology , vol.36 , pp. 1073-1089
    • Wang, C.Y.1    Zheng, W.2    Wang, T.3    Xie, J.W.4    Wang, S.L.5    Zhao, B.L.6
  • 44
    • 0003093544 scopus 로고    scopus 로고
    • Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats
    • doi:10.1016/S0014-2999(00)00291-0
    • Wang, L. M., Han, Y. F., and Tang, X. C. (2000). Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats. Eur. J. Pharmacol. 398, 65-72. doi:10.1016/S0014-2999(00)00291-0
    • (2000) Eur. J. Pharmacol. , vol.398 , pp. 65-72
    • Wang, L.M.1    Han, Y.F.2    Tang, X.C.3
  • 45
    • 0035964415 scopus 로고    scopus 로고
    • Huperzine A attenuates hydrogen peroxide-induced apoptosis by regulating expression of apoptosis-related genes in rat PC12 cells
    • doi:10.1097/00001756-200108280-00009
    • Wang, R., Xiao, X. Q., and Tang, X. C. (2001a). Huperzine A attenuates hydrogen peroxide-induced apoptosis by regulating expression of apoptosis-related genes in rat PC12 cells. Neuroreport 12, 2629-2634. doi:10.1097/00001756-200108280-00009
    • (2001) Neuroreport , vol.12 , pp. 2629-2634
    • Wang, R.1    Xiao, X.Q.2    Tang, X.C.3
  • 46
    • 0035876056 scopus 로고    scopus 로고
    • Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by beta-amyloid protein-(1-40) in rat
    • doi:10.1016/S0014-2999(01)01030-5
    • Wang, R., Zhang, H. Y., and Tang, X. C. (2001b). Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by beta-amyloid protein-(1-40) in rat. Eur. J. Pharmacol. 421, 149-156. doi:10.1016/S0014-2999(01)01030-5
    • (2001) Eur. J. Pharmacol. , vol.421 , pp. 149-156
    • Wang, R.1    Zhang, H.Y.2    Tang, X.C.3
  • 47
    • 0032947742 scopus 로고    scopus 로고
    • Modulation of NMDA receptor by huperzine A in rat cerebral cortex
    • Wang, X. D., Zhang, J. M., Yang, H. H., and Hu, G. Y. (1999). Modulation of NMDA receptor by huperzine A in rat cerebral cortex. Acta Pharmacol. Sin. 20, 31-35.
    • (1999) Acta Pharmacol. Sin. , vol.20 , pp. 31-35
    • Wang, X.D.1    Zhang, J.M.2    Yang, H.H.3    Hu, G.Y.4
  • 48
    • 0022658345 scopus 로고
    • Anti-cholinesterase activity of huperzine A [Article in Chinese]
    • Wang, Y. E., Yue, D. X., and Tang, X. C. (1986). Anti-cholinesterase activity of huperzine A. [Article in Chinese]. Zhongguo Yao Li Xue Bao 7, 110-113.
    • (1986) Zhongguo Yao Li Xue Bao , vol.7 , pp. 110-113
    • Wang, Y.E.1    Yue, D.X.2    Tang, X.C.3
  • 49
    • 33744517635 scopus 로고    scopus 로고
    • Effects of huperzine A on memory deficits and neurotrophic factors production after in mice
    • doi:10.1016/j.pbb.2006.03.027
    • Wang, Z. F., Tang, L. L., Yan, H., Wang, Y. J., and Tang, X. C. (2006). Effects of huperzine A on memory deficits and neurotrophic factors production after in mice. Pharmacol. Biochem. Behav. 83, 603-611. doi:10.1016/j.pbb.2006.03.027
    • (2006) Pharmacol. Biochem. Behav. , vol.83 , pp. 603-611
    • Wang, Z.F.1    Tang, L.L.2    Yan, H.3    Wang, Y.J.4    Tang, X.C.5
  • 50
    • 0034625561 scopus 로고    scopus 로고
    • Protective effects of huperzine A on beta-amyloid(25-35) induced oxidative injury in rat pheochromocytoma cells
    • doi:10.1016/S0304-3940(00)01088-0
    • Xiao, X. Q., Wang, R., Han, Y. F., and Tang, X. C. (2000a). Protective effects of huperzine A on beta-amyloid(25-35) induced oxidative injury in rat pheochromocytoma cells. Neurosci. Lett. 286, 155-158. doi:10.1016/S0304-3940(00)01088-0
    • (2000) Neurosci. Lett. , vol.286 , pp. 155-158
    • Xiao, X.Q.1    Wang, R.2    Han, Y.F.3    Tang, X.C.4
  • 51
    • 0034284410 scopus 로고    scopus 로고
    • Huperzine A and tacrine attenuate beta-amyloid peptide-induced oxidative injury
    • doi:10.1002/1097-4547(20000901)61:5<564::AID-JNR11>3.3.CO;2-O
    • Xiao, X. Q., Wang, R., and Tang, X. C. (2000b). Huperzine A and tacrine attenuate beta-amyloid peptide-induced oxidative injury. J. Neurosci. Res. 61, 564-569. doi:10.1002/1097-4547(20000901)61:5<564::AID-JNR11>3.3.CO;2-O
    • (2000) J. Neurosci. Res. , vol.61 , pp. 564-569
    • Xiao, X.Q.1    Wang, R.2    Tang, X.C.3
  • 52
    • 0036141139 scopus 로고    scopus 로고
    • Huperzine A attenuates amyloid beta-peptide fragment 25-35-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase-3 activation
    • doi:10.1002/jnr.10075
    • Xiao, X. Q., Zhang, H. Y., and Tang, X. C. (2002). Huperzine A attenuates amyloid beta-peptide fragment 25-35-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase-3 activation. J. Neurosci. Res. 67, 30-36. doi:10.1002/jnr.10075
    • (2002) J. Neurosci. Res. , vol.67 , pp. 30-36
    • Xiao, X.Q.1    Zhang, H.Y.2    Tang, X.C.3
  • 53
    • 84896832064 scopus 로고    scopus 로고
    • Huperzine a in the treatment of Alzheimer's disease and vascular dementia: a meta-analysis
    • doi:10.1155/2014/363985
    • Xing, S. H., Zhu, C. X., Zhang, R., and An, L. (2014). Huperzine a in the treatment of Alzheimer's disease and vascular dementia: a meta-analysis. Evid. Based Complement Alternat. Med. 2014, 363985. doi:10.1155/2014/363985
    • (2014) Evid. Based Complement Alternat. Med. , vol.2014 , pp. 363985
    • Xing, S.H.1    Zhu, C.X.2    Zhang, R.3    An, L.4
  • 54
    • 84884528895 scopus 로고    scopus 로고
    • Huperzine a for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials
    • doi:10.1371/journal.pone.0074916
    • Yang, G., Wang, Y., Tian, J., and Liu, J. P. (2014). Huperzine a for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials. PLoS ONE 8:e74916. doi:10.1371/journal.pone.0074916
    • (2014) PLoS ONE , vol.8
    • Yang, G.1    Wang, Y.2    Tian, J.3    Liu, J.P.4
  • 55
    • 84863918272 scopus 로고    scopus 로고
    • Decreased accumulation of subcellular amyloid-beta with improved mitochondrial function mediates the neuroprotective effect of huperzine A
    • doi:10.3233/JAD-2012-120274
    • Yang, L., Ye, C. Y., Huang, X. T., Tang, X. C., and Zhang, H. Y. (2012). Decreased accumulation of subcellular amyloid-beta with improved mitochondrial function mediates the neuroprotective effect of huperzine A. J. Alzheimers Dis. 31, 131-142. doi:10.3233/JAD-2012-120274
    • (2012) J. Alzheimers Dis. , vol.31 , pp. 131-142
    • Yang, L.1    Ye, C.Y.2    Huang, X.T.3    Tang, X.C.4    Zhang, H.Y.5
  • 56
    • 81855164838 scopus 로고    scopus 로고
    • Shift in brain metabolism in late onset Alzheimer's disease: implications for biomarkers and therapeutic interventions
    • doi:10.1016/j.mam.2011.10.005
    • Yao, J., Rettberg, J. R., Klosinski, L. P., Cadenas, E., and Brinton, R. D. (2011). Shift in brain metabolism in late onset Alzheimer's disease: implications for biomarkers and therapeutic interventions. Mol. Aspects Med. 32, 247-257. doi:10.1016/j.mam.2011.10.005
    • (2011) Mol. Aspects Med. , vol.32 , pp. 247-257
    • Yao, J.1    Rettberg, J.R.2    Klosinski, L.P.3    Cadenas, E.4    Brinton, R.D.5
  • 57
    • 0043204247 scopus 로고    scopus 로고
    • The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease
    • doi:10.1016/S0091-3057(03)00111-4
    • Zangara, A. (2003). The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease. Pharmacol. Biochem. Behav. 75, 675-686. doi:10.1016/S0091-3057(03)00111-4
    • (2003) Pharmacol. Biochem. Behav. , vol.75 , pp. 675-686
    • Zangara, A.1
  • 58
    • 0037074075 scopus 로고    scopus 로고
    • Stereoselectivities of enantiomers of huperzine A in protection against amyloid 25-35-induced injury in PC12 and NG108-15 cells and cholinesterase inhibition in mice
    • doi:10.1016/S0304-3940(01)02437-5
    • Zhang, H. Y., Liang, Y. Q., Tang, X. C., He, X. C., and Bai, D. L. (2002a). Stereoselectivities of enantiomers of huperzine A in protection against amyloid 25-35-induced injury in PC12 and NG108-15 cells and cholinesterase inhibition in mice. Neurosci. Lett. 317, 143-146. doi:10.1016/S0304-3940(01)02437-5
    • (2002) Neurosci. Lett. , vol.317 , pp. 143-146
    • Zhang, H.Y.1    Liang, Y.Q.2    Tang, X.C.3    He, X.C.4    Bai, D.L.5
  • 59
    • 0037083260 scopus 로고    scopus 로고
    • Spermidine antagonizes the inhibitory effect of huperzine A on [3H]dizocilpine (MK-801) binding in synaptic membrane of rat cerebral cortex
    • doi:10.1016/S0304-3940(01)02565-4
    • Zhang, Y. H., Zhao, X. Y., Chen, X. Q., Wang, Y., Yang, H. H., and Hu, G. Y. (2002b). Spermidine antagonizes the inhibitory effect of huperzine A on [3H]dizocilpine (MK-801) binding in synaptic membrane of rat cerebral cortex. Neurosci. Lett. 319, 107-110. doi:10.1016/S0304-3940(01)02565-4
    • (2002) Neurosci. Lett. , vol.319 , pp. 107-110
    • Zhang, Y.H.1    Zhao, X.Y.2    Chen, X.Q.3    Wang, Y.4    Yang, H.H.5    Hu, G.Y.6
  • 60
    • 1842713364 scopus 로고    scopus 로고
    • Huperzine A enhances the level of secretory amyloid precursor protein and protein kinase C-alpha in intracerebroventricular beta-amyloid-(1-40) infused rats and human embryonic kidney 293 Swedish mutant cells
    • doi:10.1016/j.neulet.2004.01.055
    • Zhang, H. Y., Yan, H., and Tang, X. C. (2004). Huperzine A enhances the level of secretory amyloid precursor protein and protein kinase C-alpha in intracerebroventricular beta-amyloid-(1-40) infused rats and human embryonic kidney 293 Swedish mutant cells. Neurosci. Lett. 360, 21-24. doi:10.1016/j.neulet.2004.01.055
    • (2004) Neurosci. Lett. , vol.360 , pp. 21-24
    • Zhang, H.Y.1    Yan, H.2    Tang, X.C.3
  • 61
    • 0035882125 scopus 로고    scopus 로고
    • Huperzine A, a nootropic alkaloid, inhibits N-methyl-d-aspartate-induced current in rat dissociated hippocampal neurons
    • doi:10.1016/S0306-4522(01)00206-8
    • Zhang, J. M., and Hu, G. Y. (2001). Huperzine A, a nootropic alkaloid, inhibits N-methyl-d-aspartate-induced current in rat dissociated hippocampal neurons. Neuroscience 105, 663-669. doi:10.1016/S0306-4522(01)00206-8
    • (2001) Neuroscience , vol.105 , pp. 663-669
    • Zhang, J.M.1    Hu, G.Y.2
  • 62
    • 75549091622 scopus 로고    scopus 로고
    • Cyclic-AMP response element binding protein and tau are involved in the neuroprotective mechanisms of nerve growth factor during focal cerebral ischemia/reperfusion in rats
    • doi:10.1016/j.jocn.2009.07.086
    • Zhang, Z. H., Xi, G. M., Li, W. C., Ling, H. Y., Qu, P., and Fang, X. B. (2010). Cyclic-AMP response element binding protein and tau are involved in the neuroprotective mechanisms of nerve growth factor during focal cerebral ischemia/reperfusion in rats. J. Clin. Neurosci. 17, 353-356. doi:10.1016/j.jocn.2009.07.086
    • (2010) J. Clin. Neurosci. , vol.17 , pp. 353-356
    • Zhang, Z.H.1    Xi, G.M.2    Li, W.C.3    Ling, H.Y.4    Qu, P.5    Fang, X.B.6
  • 63
    • 38349179703 scopus 로고    scopus 로고
    • Amyloid beta-peptide 31-35-induced neuronal apoptosis is mediated by caspase-dependent pathways via cAMP-dependent protein kinase A activation
    • doi:10.1111/j.1474-9726.2007.00352.x
    • Zhao, L., Qian, Z. M., Zhang, C., Wing, H. Y., Du, F., and Ya, K. (2008). Amyloid beta-peptide 31-35-induced neuronal apoptosis is mediated by caspase-dependent pathways via cAMP-dependent protein kinase A activation. Aging Cell 7, 47-57. doi:10.1111/j.1474-9726.2007.00352.x
    • (2008) Aging Cell , vol.7 , pp. 47-57
    • Zhao, L.1    Qian, Z.M.2    Zhang, C.3    Wing, H.Y.4    Du, F.5    Ya, K.6
  • 64
    • 70449526436 scopus 로고    scopus 로고
    • Activation of group III metabotropic glutamate receptor reduces intracellular calcium in beta-amyloid peptide [31-35]-treated cortical neurons
    • doi:10.1007/s12640-009-9068-3
    • Zhao, L., Zhao, S. T., Qian, Z. M., Zhang, C., Wu, X. M., Du, F., et al. (2009). Activation of group III metabotropic glutamate receptor reduces intracellular calcium in beta-amyloid peptide [31-35]-treated cortical neurons. Neurotox. Res. 16, 174-183. doi:10.1007/s12640-009-9068-3
    • (2009) Neurotox. Res. , vol.16 , pp. 174-183
    • Zhao, L.1    Zhao, S.T.2    Qian, Z.M.3    Zhang, C.4    Wu, X.M.5    Du, F.6
  • 65
    • 1642358352 scopus 로고    scopus 로고
    • Alzheimer's disease: the two-hit hypothesis
    • doi:10.1016/S1474-4422(04)00707-0
    • Zhu, X., Raina, A. K., Perry, G., and Smith, M. A. (2004). Alzheimer's disease: the two-hit hypothesis. Lancet Neurol. 3, 219-226. doi:10.1016/S1474-4422(04)00707-0
    • (2004) Lancet Neurol , vol.3 , pp. 219-226
    • Zhu, X.1    Raina, A.K.2    Perry, G.3    Smith, M.A.4
  • 66
    • 0029081083 scopus 로고
    • Second generation cholinesterase inhibitors: effect of (L)-huperzine-A on cortical biogenic amines
    • doi:10.1002/jnr.490410613
    • Zhu, X. D., and Giacobini, E. (1995). Second generation cholinesterase inhibitors: effect of (L)-huperzine-A on cortical biogenic amines. J. Neurosci. Res. 41, 828-835. doi:10.1002/jnr.490410613
    • (1995) J. Neurosci. Res. , vol.41 , pp. 828-835
    • Zhu, X.D.1    Giacobini, E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.