-
1
-
-
34548186667
-
Cellular senescence: when bad things happen to good cells
-
Campisi J and d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol. 2007; 8:729-740.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 729-740
-
-
Campisi, J.1
d'Adda di Fagagna, F.2
-
2
-
-
84901288438
-
The role of senescent cells in ageing
-
van Deursen JM. The role of senescent cells in ageing. Nature. 2014; 509:439-446.
-
(2014)
Nature
, vol.509
, pp. 439-446
-
-
van Deursen, J.M.1
-
3
-
-
84891713034
-
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
-
Coppe JP, Patil CK, Rodier F, Sun Y, Munoz DP, Goldstein J, Nelson PS, Desprez PY and Campisi J. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS biology. 2008; 6:2853-2868.
-
(2008)
PLoS biology
, vol.6
, pp. 2853-2868
-
-
Coppe, J.P.1
Patil, C.K.2
Rodier, F.3
Sun, Y.4
Munoz, D.P.5
Goldstein, J.6
Nelson, P.S.7
Desprez, P.Y.8
Campisi, J.9
-
4
-
-
0035834121
-
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging
-
Krtolica A, Parrinello S, Lockett S, Desprez PY and Campisi J. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proceedings of the National Academy of Sciences of the United States of America. 2001; 98:12072-12077.
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, pp. 12072-12077
-
-
Krtolica, A.1
Parrinello, S.2
Lockett, S.3
Desprez, P.Y.4
Campisi, J.5
-
5
-
-
34248197982
-
Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion
-
Liu D and Hornsby PJ. Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion. Cancer research. 2007; 67:3117-3126.
-
(2007)
Cancer research
, vol.67
, pp. 3117-3126
-
-
Liu, D.1
Hornsby, P.J.2
-
7
-
-
84950135670
-
Myeloma cells can corrupt senescent mesenchymal stromal cells and impair their anti-tumor activity
-
Ozcan S, Alessio N, Acar MB, Toprak G, Gonen ZB, Peluso G and Galderisi U. Myeloma cells can corrupt senescent mesenchymal stromal cells and impair their anti-tumor activity. Oncotarget. 2015; 6:39482-39492. doi: 10.18632/oncotarget.5430.
-
(2015)
Oncotarget
, vol.6
, pp. 39482-39492
-
-
Ozcan, S.1
Alessio, N.2
Acar, M.B.3
Toprak, G.4
Gonen, Z.B.5
Peluso, G.6
Galderisi, U.7
-
8
-
-
84905453740
-
The gap between the physiological and therapeutic roles of mesenchymal stem cells
-
Galderisi U and Giordano A. The gap between the physiological and therapeutic roles of mesenchymal stem cells. Medicinal research reviews. 2014; 34:1100-1126.
-
(2014)
Medicinal research reviews
, vol.34
, pp. 1100-1126
-
-
Galderisi, U.1
Giordano, A.2
-
10
-
-
84857838864
-
Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease
-
Ranganath SH, Levy O, Inamdar MS and Karp JM. Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease. Cell stem cell. 2012; 10:244-258.
-
(2012)
Cell stem cell
, vol.10
, pp. 244-258
-
-
Ranganath, S.H.1
Levy, O.2
Inamdar, M.S.3
Karp, J.M.4
-
11
-
-
70349423739
-
In vitro senescence of rat mesenchymal stem cells is accompanied by downregulation of stemness-related and DNA damage repair genes
-
Galderisi U, Helmbold H, Squillaro T, Alessio N, Komm N, Khadang B, Cipollaro M, Bohn W and Giordano A. In vitro senescence of rat mesenchymal stem cells is accompanied by downregulation of stemness-related and DNA damage repair genes. Stem Cells Dev. 2009; 18:1033-1042.
-
(2009)
Stem Cells Dev
, vol.18
, pp. 1033-1042
-
-
Galderisi, U.1
Helmbold, H.2
Squillaro, T.3
Alessio, N.4
Komm, N.5
Khadang, B.6
Cipollaro, M.7
Bohn, W.8
Giordano, A.9
-
12
-
-
74949127989
-
Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo
-
Debacq-Chainiaux F, Erusalimsky JD, Campisi J and Toussaint O. Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo. Nature protocols. 2009; 4:1798-1806.
-
(2009)
Nature protocols
, vol.4
, pp. 1798-1806
-
-
Debacq-Chainiaux, F.1
Erusalimsky, J.D.2
Campisi, J.3
Toussaint, O.4
-
13
-
-
34548178909
-
Ingel digestion for mass spectrometric characterization of proteins and proteomes
-
Shevchenko A, Tomas H, Havlis J, Olsen JV and Mann M. Ingel digestion for mass spectrometric characterization of proteins and proteomes. Nature protocols. 2006; 1:2856-2860.
-
(2006)
Nature protocols
, vol.1
, pp. 2856-2860
-
-
Shevchenko, A.1
Tomas, H.2
Havlis, J.3
Olsen, J.V.4
Mann, M.5
-
14
-
-
84866239471
-
Same or not the same?. Comparison of adipose tissue-derived versus bone marrow-derived mesenchymal stem and stromal cells
-
Strioga M, Viswanathan S, Darinskas A, Slaby O and Michalek J. Same or not the same? Comparison of adipose tissue-derived versus bone marrow-derived mesenchymal stem and stromal cells. Stem Cells Dev. 2012; 21:2724-2752.
-
(2012)
Stem Cells Dev
, vol.21
, pp. 2724-2752
-
-
Strioga, M.1
Viswanathan, S.2
Darinskas, A.3
Slaby, O.4
Michalek, J.5
-
15
-
-
84878062174
-
Knowledge-based analysis of proteomics data
-
Bessarabova M, Ishkin A, JeBailey L, Nikolskaya T and Nikolsky Y. Knowledge-based analysis of proteomics data. BMC Bioinformatics. 2012; 16:S13.
-
(2012)
BMC Bioinformatics
, vol.16
, pp. S13
-
-
Bessarabova, M.1
Ishkin, A.2
JeBailey, L.3
Nikolskaya, T.4
Nikolsky, Y.5
-
16
-
-
84873593542
-
STOP using just GO: a multiontology hypothesis generation tool for high throughput experimentation
-
Wittkop T, TerAvest E, Evani US, Fleisch KM, Berman AE, Powell C, Shah NH and Mooney SD. STOP using just GO: a multiontology hypothesis generation tool for high throughput experimentation. BMC Bioinformatics. 2013; 14:53.
-
(2013)
BMC Bioinformatics
, vol.14
, pp. 53
-
-
Wittkop, T.1
TerAvest, E.2
Evani, U.S.3
Fleisch, K.M.4
Berman, A.E.5
Powell, C.6
Shah, N.H.7
Mooney, S.D.8
-
17
-
-
84862891914
-
Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging
-
Blagosklonny MV. Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging. Aging (Albany NY). 2012; 4:159-165. doi: 10.18632/aging.100443
-
(2012)
Aging (Albany NY)
, vol.4
, pp. 159-165
-
-
Blagosklonny, M.V.1
-
18
-
-
84920578477
-
Geroconversion: irreversible step to cellular senescence
-
Blagosklonny MV. Geroconversion: irreversible step to cellular senescence. Cell cycle. 2014; 13:3628-3635.
-
(2014)
Cell cycle
, vol.13
, pp. 3628-3635
-
-
Blagosklonny, M.V.1
-
21
-
-
84950155106
-
Changes in autophagy, proteasome activity and metabolism to determine a specific signature for acute and chronic senescent mesenchymal stromal cells
-
Capasso S, Alessio N, Squillaro T, Di Bernardo G, Melone MA, Cipollaro M, Peluso G and Galderisi U. Changes in autophagy, proteasome activity and metabolism to determine a specific signature for acute and chronic senescent mesenchymal stromal cells. Oncotarget. 2015; 6:39457-39468. doi: 10.18632/oncotarget.6277.
-
(2015)
Oncotarget
, vol.6
, pp. 39457-39468
-
-
Capasso, S.1
Alessio, N.2
Squillaro, T.3
Di Bernardo, G.4
Melone, M.A.5
Cipollaro, M.6
Peluso, G.7
Galderisi, U.8
-
22
-
-
84867705549
-
The history of matrix metalloproteinases: milestones, myths, and misperceptions
-
Iyer RP, Patterson NL, Fields GB and Lindsey ML. The history of matrix metalloproteinases: milestones, myths, and misperceptions. American journal of physiology Heart and circulatory physiology. 2012; 303:H919-930.
-
(2012)
American journal of physiology Heart and circulatory physiology
, vol.303
, pp. H919-930
-
-
Iyer, R.P.1
Patterson, N.L.2
Fields, G.B.3
Lindsey, M.L.4
-
24
-
-
34547815193
-
Regulation of matrix metalloproteinase-2 (MMP-2) activity by phosphorylation
-
Sariahmetoglu M, Crawford BD, Leon H, Sawicka J, Li L, Ballermann BJ, Holmes C, Berthiaume LG, Holt A, Sawicki G and Schulz R. Regulation of matrix metalloproteinase-2 (MMP-2) activity by phosphorylation. FASEB journal. 2007; 21:2486-2495.
-
(2007)
FASEB journal
, vol.21
, pp. 2486-2495
-
-
Sariahmetoglu, M.1
Crawford, B.D.2
Leon, H.3
Sawicka, J.4
Li, L.5
Ballermann, B.J.6
Holmes, C.7
Berthiaume, L.G.8
Holt, A.9
Sawicki, G.10
Schulz, R.11
-
25
-
-
0032791921
-
Insights into MMP-TIMP interactions
-
Bode W, Fernandez-Catalan C, Grams F, Gomis-Ruth FX, Nagase H, Tschesche H and Maskos K. Insights into MMP-TIMP interactions. Annals of the New York Academy of Sciences. 1999; 878:73-91.
-
(1999)
Annals of the New York Academy of Sciences
, vol.878
, pp. 73-91
-
-
Bode, W.1
Fernandez-Catalan, C.2
Grams, F.3
Gomis-Ruth, F.X.4
Nagase, H.5
Tschesche, H.6
Maskos, K.7
-
26
-
-
0032719798
-
Vascular matrix metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor
-
Fernandez-Patron C, Radomski MW and Davidge ST. Vascular matrix metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor. Circulation research. 1999; 85:906-911.
-
(1999)
Circulation research
, vol.85
, pp. 906-911
-
-
Fernandez-Patron, C.1
Radomski, M.W.2
Davidge, S.T.3
-
27
-
-
0034682885
-
Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3
-
McQuibban GA, Gong JH, Tam EM, McCulloch CA, Clark-Lewis I and Overall CM. Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3. Science. 2000; 289:1202-1206.
-
(2000)
Science
, vol.289
, pp. 1202-1206
-
-
McQuibban, G.A.1
Gong, J.H.2
Tam, E.M.3
McCulloch, C.A.4
Clark-Lewis, I.5
Overall, C.M.6
-
28
-
-
0032194115
-
Generation of biologically active IL-1 beta by matrix metalloproteinases: a novel caspase-1-independent pathway of IL-1 beta processing
-
Schonbeck U, Mach F and Libby P. Generation of biologically active IL-1 beta by matrix metalloproteinases: a novel caspase-1-independent pathway of IL-1 beta processing. Journal of immunology. 1998; 161:3340-3346.
-
(1998)
Journal of immunology
, vol.161
, pp. 3340-3346
-
-
Schonbeck, U.1
Mach, F.2
Libby, P.3
-
29
-
-
84893378509
-
TIMP-2 modulates cancer cell transcriptional profile and enhances E-cadherin/betacatenin complex expression in A549 lung cancer cells
-
Bourboulia D, Han H, Jensen-Taubman S, Gavil N, Isaac B, Wei B, Neckers L and Stetler-Stevenson WG. TIMP-2 modulates cancer cell transcriptional profile and enhances E-cadherin/betacatenin complex expression in A549 lung cancer cells. Oncotarget. 2013; 4:163-173. doi: 10.18632/oncotarget.801.
-
(2013)
Oncotarget
, vol.4
, pp. 163-173
-
-
Bourboulia, D.1
Han, H.2
Jensen-Taubman, S.3
Gavil, N.4
Isaac, B.5
Wei, B.6
Neckers, L.7
Stetler-Stevenson, W.G.8
-
30
-
-
77649143135
-
TIMP-2 modulates VEGFR-2 phosphorylation and enhances phosphodiesterase activity in endothelial cells
-
Lee SJ, Tsang PS, Diaz TM, Wei BY and Stetler-Stevenson WG. TIMP-2 modulates VEGFR-2 phosphorylation and enhances phosphodiesterase activity in endothelial cells. Laboratory investigation. 2010; 90:374-382.
-
(2010)
Laboratory investigation
, vol.90
, pp. 374-382
-
-
Lee, S.J.1
Tsang, P.S.2
Diaz, T.M.3
Wei, B.Y.4
Stetler-Stevenson, W.G.5
-
31
-
-
53849109150
-
TIMP-2 disrupts FGF-2-induced downstream signaling pathways
-
Seo DW, Kim SH, Eom SH, Yoon HJ, Cho YR, Kim PH, Kim YK, Han JW, Diaz T, Wei BY and Stetler-Stevenson WG. TIMP-2 disrupts FGF-2-induced downstream signaling pathways. Microvascular research. 2008; 76:145-151.
-
(2008)
Microvascular research
, vol.76
, pp. 145-151
-
-
Seo, D.W.1
Kim, S.H.2
Eom, S.H.3
Yoon, H.J.4
Cho, Y.R.5
Kim, P.H.6
Kim, Y.K.7
Han, J.W.8
Diaz, T.9
Wei, B.Y.10
Stetler-Stevenson, W.G.11
-
33
-
-
84889571932
-
Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells
-
Severino V, Alessio N, Farina A, Sandomenico A, Cipollaro M, Peluso G, Galderisi U and Chambery A. Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells. Cell death & disease. 2013; 4:e911.
-
(2013)
Cell death & disease
, vol.4
, pp. e911
-
-
Severino, V.1
Alessio, N.2
Farina, A.3
Sandomenico, A.4
Cipollaro, M.5
Peluso, G.6
Galderisi, U.7
Chambery, A.8
-
34
-
-
84864360549
-
Plasminogen activator inhibitor 1-insulin-like growth factor binding protein 3 cascade regulates stress-induced senescence
-
Elzi DJ, Lai Y, Song M, Hakala K, Weintraub ST and Shiio Y. Plasminogen activator inhibitor 1-insulin-like growth factor binding protein 3 cascade regulates stress-induced senescence. Proceedings of the National Academy of Sciences of the United States of America. 2012; 109:12052-12057.
-
(2012)
Proceedings of the National Academy of Sciences of the United States of America
, vol.109
, pp. 12052-12057
-
-
Elzi, D.J.1
Lai, Y.2
Song, M.3
Hakala, K.4
Weintraub, S.T.5
Shiio, Y.6
-
35
-
-
34447645303
-
Regulation of replicative senescence by insulin-like growth factor-binding protein 3 in human umbilical vein endothelial cells
-
Kim KS, Kim MS, Seu YB, Chung HY, Kim JH and Kim JR. Regulation of replicative senescence by insulin-like growth factor-binding protein 3 in human umbilical vein endothelial cells. Aging cell. 2007; 6:535-545.
-
(2007)
Aging cell
, vol.6
, pp. 535-545
-
-
Kim, K.S.1
Kim, M.S.2
Seu, Y.B.3
Chung, H.Y.4
Kim, J.H.5
Kim, J.R.6
-
36
-
-
84900505659
-
PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice
-
Eren M, Boe AE, Murphy SB, Place AT, Nagpal V, Morales-Nebreda L, Urich D, Quaggin SE, Budinger GR, Mutlu GM, Miyata T and Vaughan DE. PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice. Proceedings of the National Academy of Sciences of the United States of America. 2014; 111:7090-7095.
-
(2014)
Proceedings of the National Academy of Sciences of the United States of America
, vol.111
, pp. 7090-7095
-
-
Eren, M.1
Boe, A.E.2
Murphy, S.B.3
Place, A.T.4
Nagpal, V.5
Morales-Nebreda, L.6
Urich, D.7
Quaggin, S.E.8
Budinger, G.R.9
Mutlu, G.M.10
Miyata, T.11
Vaughan, D.E.12
-
37
-
-
79953249112
-
Peroxiredoxin 6: a bifunctional enzyme with glutathione peroxidase and phospholipase A(2) activities
-
Fisher AB. Peroxiredoxin 6: a bifunctional enzyme with glutathione peroxidase and phospholipase A(2) activities. Antioxidants & redox signaling. 2011; 15:831-844.
-
(2011)
Antioxidants & redox signaling
, vol.15
, pp. 831-844
-
-
Fisher, A.B.1
-
38
-
-
84919360593
-
TXNDC5, a newly discovered disulfide isomerase with a key role in cell physiology and pathology
-
Horna-Terron E, Pradilla-Dieste A, Sanchez-de-Diego C and Osada J. TXNDC5, a newly discovered disulfide isomerase with a key role in cell physiology and pathology. International journal of molecular sciences. 2014; 15:23501-23518.
-
(2014)
International journal of molecular sciences
, vol.15
, pp. 23501-23518
-
-
Horna-Terron, E.1
Pradilla-Dieste, A.2
Sanchez-de-Diego, C.3
Osada, J.4
-
39
-
-
59049105937
-
DJ-1/PARK7 is an important mediator of hypoxiainduced cellular responses
-
Vasseur S, Afzal S, Tardivel-Lacombe J, Park DS, Iovanna JL and Mak TW. DJ-1/PARK7 is an important mediator of hypoxiainduced cellular responses. Proceedings of the National Academy of Sciences of the United States of America. 2009; 106:1111-1116.
-
(2009)
Proceedings of the National Academy of Sciences of the United States of America
, vol.106
, pp. 1111-1116
-
-
Vasseur, S.1
Afzal, S.2
Tardivel-Lacombe, J.3
Park, D.S.4
Iovanna, J.L.5
Mak, T.W.6
-
40
-
-
66349101884
-
Cathepsin D and eukaryotic translation elongation factor 1 as promising markers of cellular senescence
-
Byun HO, Han NK, Lee HJ, Kim KB, Ko YG, Yoon G, Lee YS, Hong SI and Lee JS. Cathepsin D and eukaryotic translation elongation factor 1 as promising markers of cellular senescence. Cancer research. 2009; 69:4638-4647.
-
(2009)
Cancer research
, vol.69
, pp. 4638-4647
-
-
Byun, H.O.1
Han, N.K.2
Lee, H.J.3
Kim, K.B.4
Ko, Y.G.5
Yoon, G.6
Lee, Y.S.7
Hong, S.I.8
Lee, J.S.9
-
41
-
-
58149502680
-
Vaults and the major vault protein: novel roles in signal pathway regulation and immunity
-
Berger W, Steiner E, Grusch M, Elbling L and Micksche M. Vaults and the major vault protein: novel roles in signal pathway regulation and immunity. Cellular and molecular life sciences. 2009; 66:43-61.
-
(2009)
Cellular and molecular life sciences
, vol.66
, pp. 43-61
-
-
Berger, W.1
Steiner, E.2
Grusch, M.3
Elbling, L.4
Micksche, M.5
-
42
-
-
84920393148
-
Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation
-
Pasillas MP, Shields S, Reilly R, Strnadel J, Behl C, Park R, Yates JR, 3rd, Klemke R, Gonias SL and Coppinger JA. Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation. Molecular & cellular proteomics. 2015; 14:1-14.
-
(2015)
Molecular & cellular proteomics
, vol.14
, pp. 1-14
-
-
Pasillas, M.P.1
Shields, S.2
Reilly, R.3
Strnadel, J.4
Behl, C.5
Park, R.6
Yates, J.R.7
Klemke, R.8
Gonias, S.L.9
Coppinger, J.A.10
-
43
-
-
67649215113
-
Targeting major vault protein in senescence-associated apoptosis resistance
-
Ryu SJ and Park SC. Targeting major vault protein in senescence-associated apoptosis resistance. Expert opinion on therapeutic targets. 2009; 13:479-484.
-
(2009)
Expert opinion on therapeutic targets
, vol.13
, pp. 479-484
-
-
Ryu, S.J.1
Park, S.C.2
|