Plasminogen activator inhibitor 1 - Insulin-like growth factor binding protein 3 cascade regulates stress-induced senescence

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 30, 2012, Pages 12052-12057

  Elzi, David J ^a   Lai, Yanlai ^a   Song, Meihua ^a   Hakala, Kevin ^b   Weintraub, Susan T ^b,c   Shiio, Yuzuru ^a,b,c  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b Mays Cancer Center at UT Health San Antonio   (United States)

^c University of Texas Health Science Center at San Antonio   (United States)

Author keywords

Chemotherapy; Isotope coded affinity tag; Protease; Protease inhibitor; Protein secretion

Indexed keywords

DOXORUBICIN; ETOPOSIDE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN KINASE B; PROTEIN P53; RETINOBLASTOMA PROTEIN; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN 3; TISSUE PLASMINOGEN ACTIVATOR;

ARTICLE; BREAST CANCER; CELL AGING; CELL STRAIN MCF 7; CELLULAR STRESS RESPONSE; DNA DAMAGE; ENZYME INHIBITION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEOMICS; SIGNAL TRANSDUCTION;

ANALYSIS OF VARIANCE; BETA-GALACTOSIDASE; CELL AGING; CELL LINE, TUMOR; CULTURE MEDIA; DNA PRIMERS; DOXORUBICIN; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; NEOPLASMS; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEOLYSIS; PROTEOMICS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; STRESS, PHYSIOLOGICAL; TISSUE PLASMINOGEN ACTIVATOR; TUMOR CELLS, CULTURED;

EID: 84864360549     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1120437109     Document Type: Article

References (29)

1. Hayflick L, Moorhead PS (1961) The serial cultivation of human diploid cell strains. Exp Cell Res 25:585-621.
2. Campisi J, d'Adda di Fagagna F (2007) Cellular senescence: When bad things happen to good cells. Nat Rev Mol Cell Biol 8:729-740.
3. Kuilman T, Michaloglou C, Mooi WJ, Peeper DS (2010) The essence of senescence. Genes Dev 24:2463-2479.
4. Coppé JP, et al. (2008) Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 6:2853-2868.
5. Coppé JP, Desprez PY, Krtolica A, Campisi J (2010) The senescence-associated secretory phenotype: The dark side of tumor suppression. Annu Rev Pathol 5:99-118.
6. Kuilman T, Peeper DS (2009) Senescence-messaging secretome: SMS-ing cellular stress. Nat Rev Cancer 9:81-94.
7. Roninson IB (2003) Tumor cell senescence in cancer treatment. Cancer Res 63:2705-2715.
8. Shay JW, Roninson IB (2004) Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 23:2919-2933. (Pubitemid 38638853)
9. Di X, et al. (2008) A chemotherapy-associated senescence bystander effect in breast cancer cells. Cancer Biol Ther 7:864-872.
10. Gygi SP, et al. (1999) Quantitative analysis of complex protein mixtures using isotope-coded affinity tags. Nat Biotechnol 17:994-999. (Pubitemid 29474856)
11. Shiio Y, Aebersold R (2006) Quantitative proteome analysis using isotope-coded affinity tags and mass spectrometry. Nat Protoc 1:139-145.
12. Jogie-Brahim S, Feldman D, Oh Y (2009) Unraveling insulin-like growth factor binding protein-3 actions in human disease. Endocr Rev 30:417-437.
13. Yamada PM, Lee KW (2009) Perspectives in mammalian IGFBP-3 biology: Local vs. systemic action. Am J Physiol Cell Physiol 296:C954-C976.
14. Murano S, et al. (1991) Diverse gene sequences are overexpressed in Werner syndrome fibroblasts undergoing premature replicative senescence. Mol Cell Biol 11:3905-3914. (Pubitemid 21895779)
15. Goldstein S, Moerman EJ, Jones RA, Baxter RC (1991) Insulin-like growth factor binding protein 3 accumulates to high levels in culture medium of senescent and quiescent human fibroblasts. Proc Natl Acad Sci USA 88:9680-9684. (Pubitemid 21915695)
16. Grimberg A, et al. (2005) p53-Dependent and p53-independent induction of insulin-like growth factor binding protein-3 by deoxyribonucleic acid damage and hypoxia. J Clin Endocrinol Metab 90:3568-3574. (Pubitemid 41014328)
17. Buckbinder L, et al. (1995) Induction of the growth inhibitor IGF-binding protein 3 by p53. Nature 377:646-649.
18. Kim KS, et al. (2007) Regulation of replicative senescence by insulin-like growth factor-binding protein 3 in human umbilical vein endothelial cells. Aging Cell 6:535-545. (Pubitemid 47087058)
19. Bang P, Fielder PJ (1997) Human pregnancy serum contains at least two distinct proteolytic activities with the ability to degrade insulin-like growth factor binding protein-3. Endocrinology 138:3912-3917. (Pubitemid 27351946)
20. Kunz C, Pebler S, Otte J, von der Ahe D (1995) Differential regulation of plasminogen activator and inhibitor gene transcription by the tumor suppressor p53. Nucleic Acids Res 23:3710-3717.
21. Parra M, Jardí M, Koziczak M, Nagamine Y, Muñoz- Cánoves P (2001) p53 Phosphorylation at serine 15 is required for transcriptional induction of the plasminogen activator inhibitor-1 (PAI-1) gene by the alkylating agent N-methyl-N'-nitro-Nnitrosoguanidine. J Biol Chem 276:36303-36310.
22. Kortlever RM, Higgins PJ, Bernards R (2006) Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. Nat Cell Biol 8:877-884.
23. Samson AL, Medcalf RL (2006) Tissue-type plasminogen activator: a multifaceted modulator of neurotransmission and synaptic plasticity. Neuron 50:673-678. (Pubitemid 44218660)
24. Mari D, Coppola R, Provenzano R (2008) Hemostasis factors and aging. Exp Gerontol 43:66-73.
25. Mu XC, Higgins PJ (1995) Differential growth state-dependent regulation of plasminogen activator inhibitor type-1 expression in senescent IMR-90 human diploid fibroblasts. J Cell Physiol 165:647-657.
26. Martens JW, et al. (2003) Aging of stromal-derived human breast fibroblasts might contribute to breast cancer progression. Thromb Haemost 89:393-404. (Pubitemid 36227292)
27. Dimri GP, et al. (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92:9363-9367.
28. Shiio Y, et al. (2002) Quantitative proteomic analysis of Myc oncoprotein function. EMBO J 21:5088-5096.
29. Shiio Y, et al. (2006) Quantitative proteomic analysis of myc-induced apoptosis: A direct role for Myc induction of the mitochondrial chloride ion channel, mtCLIC/CLIC4. J Biol Chem 281:2750-2756. (Pubitemid 43845738)