Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers

Cell Reports

Volumn 18, Issue 4, 2017, Pages 991-1004

  Kremer, Jeff Charles ^a   Prudner, Bethany Cheree ^a   Lange, Sara Elaine Stubbs ^a   Bean, Gregory Richard ^a   Schultze, Matthew Bailey ^a   Brashears, Caitlyn Brook ^a   Radyk, Megan DeAnna ^a   Redlich, Nathan ^a   Tzeng, Shin Cheng ^a   Kami, Kenjiro ^b   Shelton, Laura ^b   Li, Aixiao ^a   Morgan, Zack ^a   Bomalaski, John Stephen ^c   Tsukamoto, Takashi ^d   McConathy, Jon ^a,e,f   Michel, Loren Scott ^a,e   Held, Jason Matthew ^a,e   Van Tine, Brian Andrew ^a,e  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Keio University and Human Metabolome Technologies Inc   (United States)

^c Polaris Pharmaceuticals   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e USA   (United States)

^f University of Alabama at Birmingham   (United States)

Author keywords

arginine; arginine deprivation; argininosuccinate synthetase 1; cancer metabolism; glutamine; glutamine anaplerosis; sarcoma; serine; serine biosynthesis; Warburg effect

Indexed keywords

ARGININE; ARGININOSUCCINATE SYNTHASE; ARGININOSUCCINATE SYNTHASE 1; GLUTAMINASE; GLUTAMINE; PHOSPHOGLYCERATE DEHYDROGENASE; PYRUVATE KINASE; PYRUVATE KINASE MUSCLE ISOZYME 2; SERINE; UNCLASSIFIED DRUG; CARRIER PROTEIN; GLUCOSE; HYDROLASE; MACROGOL DERIVATIVE; MEMBRANE PROTEIN; PEGARGIMINASE; THYROID HORMONE; THYROID HORMONE-BINDING PROTEINS;

AEROBIC GLYCOLYSIS; AMINO ACID SYNTHESIS; ANAPLEROSIS; ARTICLE; CANCER CELL LINE; CELL STIMULATION; CONTROLLED STUDY; DEPLETION; ENZYME DEFICIENCY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; METABOLIC PARAMETERS; ONCOLOGICAL PARAMETERS; OXIDATIVE PHOSPHORYLATION; PROTEIN EXPRESSION; TUMOR REGRESSION; UPREGULATION; WARBURG EFFECT; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL PROLIFERATION; CHEMISTRY; CITRIC ACID CYCLE; CULTURE MEDIUM; DRUG EFFECTS; GENETICS; GLYCOLYSIS; METABOLISM; METABOLOMICS; MOUSE; PHARMACOLOGY; PHOSPHORYLATION; RNA INTERFERENCE; TUMOR CELL LINE;

ANIMALS; ARGININE; ARGININOSUCCINATE SYNTHASE; CARRIER PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; CITRIC ACID CYCLE; CULTURE MEDIA; GLUCOSE; GLUTAMINASE; GLUTAMINE; GLYCOLYSIS; HUMANS; HYDROLASES; MEMBRANE PROTEINS; METABOLOMICS; MICE; PHOSPHOGLYCERATE DEHYDROGENASE; PHOSPHORYLATION; POLYETHYLENE GLYCOLS; RNA INTERFERENCE; SERINE; THYROID HORMONES; UP-REGULATION;

EID: 85010445349     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.12.077     Document Type: Article

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