Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma

Cell Death and Disease

Volumn 4, Issue 1, 2013, Pages

  Syed, N ^a   Langer, J ^a   Janczar, K ^a   Singh, P ^a   Lo Nigro, C ^b   Lattanzio, L ^b   Coley, H M ^c   Hatzimichael, E ^d   Bomalaski, J ^e   Szlosarek, P ^f   Awad, M ^g   O'Neil, K ^g   Roncaroli, F ^a   Crook, T ^h  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b S CROCE E CARLE HOSPITAL   (Italy)

^c UNIVERSITY OF SURREY   (United Kingdom)

^d UNIVERSITY HOSPITAL OF IOANNINA   (Greece)

^e Polaris Pharmaceuticals Inc   (United States)

^f QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^g CHARING CROSS HOSPITAL   (United Kingdom)

^h UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

arginine; argininosuccinate lyase; argininosuccinate synthetase; autophagy; epigenetics; glioblastoma

Indexed keywords

ARGININE; ARGININOSUCCINATE LYASE; ARGININOSUCCINATE SYNTHASE; CD133 ANTIGEN; CHLOROQUINE; 5 AZA 2' DEOXYCYTIDINE; ADI PEG20; AZACITIDINE; BROPARESTROL; DRUG DERIVATIVE; HYDROLASE; MACROGOL DERIVATIVE; SMALL INTERFERING RNA; STILBENE DERIVATIVE;

ARTICLE; AUTOPHAGY; AUXOTROPHY; CANCER STEM CELL; CONTROLLED STUDY; CPG ISLAND; CYTOTOXICITY; EPIGENETICS; EX VIVO STUDY; GLIOBLASTOMA; METHYLATION; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; UPREGULATION; APOPTOSIS; CENTRAL NERVOUS SYSTEM TUMOR; DNA METHYLATION; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; PATHOLOGY; RNA INTERFERENCE; TUMOR CELL CULTURE;

APOPTOSIS; ARGININE; ARGININOSUCCINATE LYASE; ARGININOSUCCINATE SYNTHASE; AUTOPHAGY; AZACITIDINE; CENTRAL NERVOUS SYSTEM NEOPLASMS; CHLOROQUINE; CPG ISLANDS; DNA METHYLATION; EPIGENOMICS; GLIOBLASTOMA; HUMANS; HYDROLASES; POLYETHYLENE GLYCOLS; RNA INTERFERENCE; RNA, SMALL INTERFERING; STILBENES; TUMOR CELLS, CULTURED; UP-REGULATION;

MLCS; MLOWN;

EID: 84872184647     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2012.197     Document Type: Article

References (33)

1. Gurney JG, Kadan-Lottick N. Brain and other central nervous system tumors: rates, trends, and epidemiology. Curr Opin Oncol 2001; 13: 160-166. (Pubitemid 32433971)
2. Preusser M, de Ribaupierre S, Wǒhrer A, Erridge SC, Hegi M, Weller M et al. Current concepts and management of glioblastoma. Ann Neurol 2011; 70: 9-21.
3. Clarke J, Butowski N, Chang S. Recent advances in therapy for glioblastoma. Arch Neurol 2010; 67: 279-283.
4. Ziegler DS, Kung AL, Kieran MW. Anti-Apoptosis mechanisms in malignant gliomas. J Clin Oncol 2008; 26: 493-500. (Pubitemid 351171704)
5. Ziegler DS, Wright RD, Kesari S, Lemieux ME, Tran MA, Jain M et al. Resistance of human glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis proteins. J Clin Invest 2008; 118: 3109-3122.
6. Liu Q, Nguyen DH, Dong Q, Shitaku P, Chung K, Liu OY et al. Molecular properties of CD133glioblastoma stem cells derived from treatment-refractory recurrent brain tumors. J Neurooncol 2009; 94: 1-19.
7. Kǒ gel D, Fulda S, Mittelbronn M. Therapeutic exploitation of apoptosis and autophagy for glioblastoma. Anticancer Agents Med Chem 2010; 10: 438-449.
8. Lefranc F, Facchini V, Kiss R. Proautophagic drugs: a novel means to combat apoptosisresistant cancers, with a special emphasis on glioblastomas. Oncologist 2007; 12: 1395-1403.
9. Lefranc F, Kiss R. Autophagy, the Trojan horse to combat glioblastomas. Neurosurg Focus 2006; 20: E7.
10. Kanzawa T, Germano IM, Komata T, Ito H, Kondo Y, Kondo S. Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. Cell Death Differ 2004; 11: 448-457. (Pubitemid 38489422)
11. Clarke PG. Developmental cell death: morphological diversity and multiple mechanisms. Anat Embryol (Berl) 1990; 181: 195-213. (Pubitemid 20153523)
12. Yang Z, Klionsky DJ. Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol 2010; 22: 124-131.
13. Haines RJ, Pendleton LC, Eichler DC. Argininosuccinate synthase: at the center of arginine metabolism. Int J Biochem Mol Biol 2011; 2: 8-23.
14. Gong H, Zǒ lzer F, von Recklinghausen G, Havers W, Schweigerer L. Arginine deiminase inhibits proliferation of human leukemia cells more potently than asparaginase by inducing cell cycle arrest and apoptosis. Leukemia 2000; 14: 826-829. (Pubitemid 30235059)
15. Ensor CM, Holtsberg FW, Bomalaski JS, Clark MA. Pegylated arginine deiminase (ADI-SS PEG20,000 mw) inhibits human melanomas and hepatocellular carcinomas in vitro and in vivo. Cancer Res 2002; 62: 5443-5450.
16. Yoon C-Y, Shim Y-J, Kim E-H, Lee JH, Won NH, Kim JH et al. Renal cell carcinoma does not express argininosuccinate synthetase and is highly sensitive to arginine deprivation via arginine deiminase. Int J Cancer 2007; 120: 897-905. (Pubitemid 46175413)
17. Bowles TL, Kim R, Galante J, Parsons CM, Virudachalam S, Kung HJ et al. Pancreatic cancer cell lines deficient in argininosuccinate synthetase are sensitive to arginine deprivation by arginine deiminase. Int J Cancer 2008; 123: 1950-1955.
18. Kim RH, Coates JM, Bowles TL, McNerney GP, Sutcliffe J, Jung JU et al. Arginine deiminase as a novel therapy for prostate cancer induces autophagy and caspaseindependent apoptosis. Cancer Res 2009; 69: 700-708.
19. Delage B, Fennell DA, Nicholson L, McNeish I, Lemoine NR, Crook T et al. Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer. Int J Cancer 2010; 126: 2762-2772.
20. Kelly MP, Jungbluth AA,Wu BW, Bomalaski J, Old LJ, Ritter G. Arginine deiminase PEG20 inhibits growth of small cell lung cancers lacking expression of argininosuccinate synthetase. Br J Cancer 2011; 106: 324-332.
21. Nicholson LJ, Smith PR, Hiller L, Szlosarek PW, Kimberley C, Sehouli J et al. Epigenetic silencing of argininosuccinate synthetase confers resistance to platinum-induced cell death but collateral sensitivity to arginine auxotrophy in ovarian cancer. Int J Cancer 2009; 125: 1454-1463.
22. Savaraj N, You M, Wu C,Wangpaichitr M, Kuo MT, Feun LG. Arginine deprivation, autophagy, apoptosis (AAA) for the treatment of melanoma. Curr Mol Med 2010; 10: 405-412.
23. Wheatley DN. Arginine deprivation and metabolomics: important aspects of intermediary metabolism in relation to the differential sensitivity of normal and tumour cells. Semin Cancer Biol 2005; 15: 247-253. (Pubitemid 41058771)
24. Bizzoco E, Faussone-Pellegrini MS, Vannucchi MG. Activated microglia cells express argininosuccinate synthetase and argininosuccinate lyase in the rat brain after transient ischemia. Exp Neurol 2007; 208: 100-109. (Pubitemid 47600152)
25. Etcheverry A, Aubry M, de Tayrac M, Vauleon E, Boniface R, Guenot F et al. DNA methylation in glioblastoma: impact on gene expression and clinical outcome. BMC Genomics 2010; 11: 701.
26. Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone onsurvival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTCNCIC trial. Lancet Oncol 2009; 10: 459-466.
27. Weller M, Stupp R, Reifenberger G, Brandes AA, van den Bent MJ, Wick W et al. MGMT promoter methylation in malignant gliomas: ready for personalized medicine? Nat Rev Neurol 2010; 6: 39-51.
28. Fafournoux P, Bruhat A, Jousse C. Amino acid regulation of gene expression. Biochem J 2000; 351(Pt 1): 1-12.
29. Chaveroux C, Lambert-Langlais S, Cherasse Y, Averous J, Parry L, Carraro V et al. Molecular mechanisms involved in the adaptation to amino acid limitation in mammals. Biochimie 2010; 92: 736-745.
30. Briceňo E, Reyes S, Sotelo J. Therapy of glioblastoma multiforme improved by the antimutagenic chloroquine. Neurosurg Focus 2003; 14: e3.
31. Briceňo E, Calderon A, Sotelo J. Institutional experience with chloroquine as an adjuvant to the therapy for glioblastoma multiforme. Surg Neurol 2007; 67: 388-391. (Pubitemid 46365851)
32. Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P et al. An integrated genomic analysis of human glioblastoma multiforme. Science 2008; 321: 1807-1812.
33. Geng Y, Kohli L, Klocke BJ, Roth KA. Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent. Neuro Oncol 2010; 12: 473-481.