Improving key enzyme activity in phenylpropanoid pathway with a designed biosensor

Metabolic Engineering

Volumn 40, Issue , 2017, Pages 115-123

  Xiong, Dandan ^a,d   Lu, Shikun ^a,d   Wu, Jieyuan ^a,d   Liang, Chaoning ^a   Wang, Wei ^c   Wang, Wenzhao ^a   Jin, Jian Ming ^b   Tang, Shuang Yan ^a  

^a INSTITUTE OF MICROBIOLOGY   (China)

^b BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY   (China)

^c YUNNAN MINZU UNIVERSITY   (China)

^d UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Biosensor; High throughput screening; p Coumarate:coenzyme A ligase; Phenylpropanoids pathway; Protein engineering; Resveratrol

Indexed keywords

BIOCONVERSION; BIOSENSORS; BIOSYNTHESIS; ENZYMES; ESCHERICHIA COLI; FLAVONOIDS; PROTEINS; RESVERATROL;

BIOSYNTHETIC PATHWAY; COENZYME A; HIGH THROUGHPUT SCREENING; IMPROVED ACTIVITIES; PHENYLPROPANOID PATHWAYS; PHENYLPROPANOIDS; PROTEIN ENGINEERING; VALUE ADDED PRODUCTS;

ENZYME ACTIVITY;

BENZENE DERIVATIVE; NARINGENIN; PROPANE; REGULATOR PROTEIN; RESVERATROL; TTGR PROTEIN; UNCLASSIFIED DRUG; 1-PHENYLPROPANOL; COENZYME A LIGASE; COUMARIC ACID; FLAVANONE DERIVATIVE; PROPANOL; STILBENE DERIVATIVE;

ARTICLE; BACTERIAL STRAIN; BIOSENSOR; BIOSYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ENGINEERING; ESCHERICHIA COLI; KINETICS; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ENGINEERING; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENETIC ENHANCEMENT; GENETIC PROCEDURES; GENETICS; ISOLATION AND PURIFICATION; METABOLIC ENGINEERING; METABOLISM; PHYSIOLOGY; PROCEDURES; UPREGULATION;

BIOSENSING TECHNIQUES; BIOSYNTHETIC PATHWAYS; COENZYME A LIGASES; COUMARIC ACIDS; ENZYME ACTIVATION; ESCHERICHIA COLI; FLAVANONES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENETIC ENHANCEMENT; METABOLIC ENGINEERING; METABOLIC NETWORKS AND PATHWAYS; PROPANOLS; STILBENES; UP-REGULATION;

EID: 85010192491     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2017.01.006     Document Type: Article

References (44)

1. Abu-Amero, K.K., Kondkar, A.A., Chalam, K.V., Resveratrol and ophthalmic diseases. Nutrients, 8, 2016, 200.
2. Alguel, Y., Meng, C.X., Teran, W., Krell, T., Ramos, J.L., Gallegos, M.T., Zhang, X.D., Crystal structures of multidrug binding protein ttgR in complex with antibiotics and plant antimicrobials. J. Mol. Biol. 369 (2007), 829–840.
3. Athar, M., Back, J.H., Tang, X., Kim, K.H., Kopelovich, L., Bickers, D.R., Kim, A.L., Resveratrol: a review of preclinical studies for human cancer prevention. Toxicol. Appl. Pharmacol. 224 (2007), 274–283.
4. Bradford, M.M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976), 248–254.
5. Chen, W., Zhang, S., Jiang, P., Yao, J., He, Y., Chen, L., Gui, X., Dong, Z., Tang, S.Y., Design of an ectoine-responsive AraC mutant and its application in metabolic engineering of ectoine biosynthesis. Metab. Eng. 30 (2015), 149–155.
6. Duan, X., Li, M., Ma, H.J., Xu, X.M., Jin, Z.Y., Liu, X.B., Physicochemical properties and antioxidant potential of phosvitin-resveratrol complexes in emulsion system. Food Chem. 206 (2016), 102–109.
7. Ehlting, J., Buttner, D., Wang, Q., Douglas, C.J., Somssich, I.E., Kombrink, E., Three 4-coumarate: coenzyme A ligases in Arabidopsis thaliana represent two evolutionarily divergent classes in angiosperms. Plant J. 19 (1999), 9–20.
8. Espinosa-Urgel, M., Serrano, L., Ramos, J.L., Fernandez-Escamilla, A.M., Engineering biological approaches for detection of toxic compounds: a new microbial biosensor based on the Pseudomonas putida TtgR repressor. Mol. Biotechnol. 57 (2015), 558–564.
9. Galvao, T.C., de Lorenzo, V., Transcriptional regulators a la carte: engineering new effector specificities in bacterial regulatory proteins. Curr. Opin. Biotechnol. 17 (2006), 34–42.
10. Gibson, D.G., Young, L., Chuang, R.Y., Venter, J.C., Hutchison, C.A., Smith, H.O., Enzymatic assembly of DNA molecules up to several hundred kilobases. Nat. Methods, 6, 2009, 343 (U341).
11. Go, M.K., Wongsantichon, J., Cheung, V.W.N., Chow, J.Y., Robinson, R.C., Yew, W.S., Synthetic polyketide enzymology: platform for biosynthesis of antimicrobial polyketides. ACS Catal. 5 (2015), 4033–4042.
12. Haldimann, A., Wanner, B.L., Conditional-replication, integration, excision, and retrieval plasmid-host systems for gene structure-function studies of bacteria. J. Bacteriol. 183 (2001), 6384–6393.
13. Harikumar, K.B., Kunnumakkara, A.B., Sethi, G., Diagaradjane, P., Anand, P., Pandey, M.K., Gelovani, J., Krishnan, S., Guha, S., Aggarwal, B.B., Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer. Int. J. Cancer 127 (2015), 257–268.
14. Hu, Y., Gai, Y., Yin, L., Wang, X., Feng, C., Feng, L., Li, D., Jiang, X.N., Wang, D.C., Crystal structures of a Populus tomentosa 4-coumarate: CoA ligase shed light on its enzymatic mechanisms. Plant Cell 22 (2010), 3093–3104.
15. Jensen, P.R., Hammer, K., The sequence of spacers between the consensus sequences modulates the strength of prokaryotic promoters. Appl. Environ. Microb. 64 (1998), 82–87.
16. Keasling, J.D., Chou, H., Metabolic engineering delivers next-generation biofuels. Nat. Biotechnol. 26 (2008), 298–299.
17. Kirby, J., Keasling, J.D., Biosynthesis of plant isoprenoids: perspectives for microbial engineering. Annu. Rev. Plant Biol. 60 (2009), 335–355.
18. Knobloch, K.H., Hahlbrock, K., 4-Coumarate:CoA ligase from cell-suspension cultures of Petroselinum hortense Hoffm: partial purification, substrate specificity, and further properties. Arch. Biochem. Biophys. 184 (1977), 237–248.
19. Koopman, F., Beekwilder, J., Crimi, B., van Houwelingen, A., Hall, R.D., Bosch, D., van Maris, A.J.A., Pronk, J.T., Daran, J.-M., De novo production of the flavonoid naringenin in engineered Saccharomyces cerevisiae. Microb. Cell Fact., 11, 2012, 155.
20. Li, M., Kildegaard, K.R., Chen, Y., Rodriguez, A., Borodina, I., Nielsen, J., De novo production of resveratrol from glucose or ethanol by engineered Saccharomyces cerevisiae. Metab. Eng. 32 (2015), 1–11.
21. Li, Z., Nair, S.K., Structural basis for specificity and flexibility in a plant 4-coumarate:CoA ligase. Structure 23 (2015), 2032–2042.
22. Liang, C.N., Xiong, D.D., Zhang, Y., Mu, S.S., Tang, S.Y., Development of a novel uric-acid-responsive regulatory system in Escherichia coli. Appl. Microbiol. Biot. 99 (2015), 2267–2275.
23. Lim, C.G., Fowler, Z.L., Hueller, T., Schaffer, S., Koffas, M.A.G., High-yield resveratrol production in engineered Escherichia coli. Appl. Environ. Microb. 77 (2011), 3451–3460.
24. Limem, I., Guedon, E., Hehn, A., Bourgaud, F., Chekir Ghedira, L., Engasser, J.-M., Ghoul, M., Production of phenylpropanoid compounds by recombinant microorganisms expressing plant-specific biosynthesis genes. Process Biochem. 43 (2008), 463–479.
25. Martin, V.J.J., Pitera, D.J., Withers, S.T., Newman, J.D., Keasling, J.D., Engineering a mevalonate pathway in Escherichia coli for production of terpenoids. Nat. Biotechnol. 21 (2003), 796–802.
26. Miyazaki, K., MEGAWHOP cloning: a method of creating random mutagenesis libraries via megaprimer PCR of whole plasmids. Method Enzymol. 498 (2011), 399–406.
27. Raman, S., Rogers, J.K., Taylor, N.D., Church, G.M., Evolution-guided optimization of biosynthetic pathways. Proc. Natl. Acad. Sci. USA 111 (2014), 17803–17808.
28. Rodrigues, J.L., Prather, K.L.J., Kluskens, L.D., Rodrigues, L.R., Heterologous production of curcuminoids. Microbiol. Mol. Biol. Rev. 79 (2015), 39–60.
29. Shetty, R.P., Endy, D., Knight, T.F. Jr., Engineering BioBrick vectors from BioBrick parts. J. Biol. Eng., 2, 2008, 5.
30. Siedler, S., Stahlhut, S.G., Malla, S., Maury, J., Neves, A.R., Novel biosensors based on flavonoid-responsive transcriptional regulators introduced into Escherichia coli. Metab. Eng. 21 (2014), 2–8.
31. Singh, G., Pai, R.S., Recent advances of resveratrol in nanostructured based delivery systems and in the management of HIV/AIDS. J. Control. Release 194 (2014), 178–188.
32. Stockigt, J., Zenk, M.H., Chemical syntheses and properties of hydroxycinnamoyl coenzyme A derivatives. Z. Nat. C. 30 (1975), 352–358.
33. Tang, S.Y., Cirino, P.C., Design and application of a mevalonate-responsive regulatory protein. Angew. Chem. Int. Ed. 50 (2011), 1084–1086.
34. Tang, S.Y., Fazelinia, H., Cirino, P.C., AraC regulatory protein mutants with altered effector specificity. J. Am. Chem. Soc. 130 (2008), 5267–5271.
35. Tang, S.Y., Qian, S., Akinterinwa, O., Frei, C.S., Gredell, J.A., Cirino, P.C., Screening for enhanced triacetic acid lactone production by recombinant Escherichia coli expressing a designed triacetic acid lactone reporter. J. Am. Chem. Soc. 135 (2013), 10099–10103.
36. Taylor, N.D., Garruss, A.S., Moretti, R., Chan, S., Arbing, M.A., Cascio, D., Rogers, J.K., Isaacs, F.J., Kosuri, S., Baker, D., Fields, S., Church, G.M., Raman, S., Engineering an allosteric transcription factor to respond to new ligands. Nat. Methods 13 (2016), 177–183.
37. Teran, W., Felipe, A., Segura, A., Rojas, A., Ramos, J.L., Gallegos, M.T., Antibiotic-dependent induction of Pseudomonas putida DOT-T1E TtgABC efflux pump is mediated by the drug binding repressor TtgR. Antimicrob. Agents Chemother. 47 (2003), 3067–3072.
38. Wang, S.Y., Zhang, S.W., Xiao, A.F., Rasmussen, M., Skidmore, C., Zhan, J.X., Metabolic engineering of Escherichia coli for the biosynthesis of various phenylpropanoid derivatives. Metab. Eng. 29 (2015), 153–159.
39. Wang, Y., Halls, C., Zhang, J., Matsuno, M., Zhang, Y., Yu, O., Stepwise increase of resveratrol biosynthesis in yeast Saccharomyces cerevisiae by metabolic engineering. Metab. Eng. 13 (2011), 455–463.
40. Wang, Y., Yi, H., Wang, M., Yu, O., Jez, J.M., Structural and kinetic analysis of the unnatural fusion protein 4-coumaroyl-CoA ligase::stilbene synthase. J. Am. Chem. Soc. 133 (2011), 20684–20687.
41. Watts, K.T., Lee, P.C., Schmidt-Dannert, C., Biosynthesis of plant-specific stilbene polyketides in metabolically engineered Escherichia coli. BMC Biotechnol., 6, 2006, 12.
42. Wu, G., Yan, Q., Jones, J.A., Tang, Y.J., Fong, S.S., Koffas, M.A., Metabolic burden: cornerstones in synthetic biology and metabolic engineering applications. Trends Biotechnol. 34 (2016), 652–664.
43. Zhao, X., Xu, J., Song, X., Jia, R., Yin, Z., Cheng, A., Jia, R., Zou, Y., Li, L., Yin, L., Yue, G., Lv, C., Jing, B., Antiviral effect of resveratrol in ducklings infected with virulent duck enteritis virus. Antivir. Res. 130 (2016), 93–100.
44. Zhu, Y., Fu, J., Shurlknight, K.L., Soroka, D.N., Hu, Y., Chen, X., Sang, S., Novel resveratrol-based aspirin prodrugs: synthesis, metabolism, and anticancer activity. J. Med. Chem. 58 (2015), 6494–6506.