Systemic Metabolite Changes in Wild-type C57BL/6 Mice Fed Black Raspberries

Nutrition and Cancer

Volumn 69, Issue 2, 2017, Pages 299-306

  Pan, Pan ^a   Skaer, Chad W ^a   Wang, Hsin Tzu ^a   Kreiser, Michael A ^a   Stirdivant, Steven M ^b   Oshima, Kiyoko ^a   Huang, Yi Wen ^a   Young, Matthew R ^c   Wang, Li Shu ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b METABOLON INC   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYBENZOIC ACID; 3 [3 (SULFOOXY)PHEYL]PROPANOIC ACID; ANTHOCYANIN; APC PROTEIN; ARACHIDONIC ACID; BIOLOGICAL MARKER; CATECHOL; DOCOSAHEXAENOIC ACID; DOCOSAPENTAENOIC ACID; HIPPURIC ACID; ICOSANOID; ICOSAPENTAENOIC ACID; LINOLENIC ACID; LONG CHAIN FATTY ACID; OMEGA 3 FATTY ACID; ORNITHINE; ORNITHINE DECARBOXYLASE; POLYPHENOL; PROPIONIC ACID DERIVATIVE; PROTOCATECHUIC ACID; PUTRESCINE; SPERMIDINE; STEARIDONIC ACID; UNCLASSIFIED DRUG; AMINO ACID; ANTINEOPLASTIC AGENT; BENZOIC ACID DERIVATIVE;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLACK RASPBERRY; C57BL/6N MOUSE; COLON MUCOSA; DIET SUPPLEMENTATION; DIETARY SUPPLEMENT; FATTY ACID SYNTHESIS; FECES CULTURE; LIPID METABOLISM; LIVER; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; METABOLISM; METABOLITE; METABOLOMICS; MOUSE; NONHUMAN; RASPBERRY; SIALYLATION; WILD TYPE MOUSE; ANIMAL; C57BL MOUSE; COLON; FECES; INTESTINE MUCOSA; RUBUS;

AMINO ACIDS; ANIMALS; ANTICARCINOGENIC AGENTS; BENZOATES; COLON; DIETARY SUPPLEMENTS; FATTY ACIDS, OMEGA-3; FECES; INTESTINAL MUCOSA; LIPID METABOLISM; LIVER; MICE, INBRED C57BL; RUBUS;

EID: 85009826802     PISSN: 01635581     EISSN: 15327914     Source Type: Journal    
DOI: 10.1080/01635581.2017.1263748     Document Type: Article

References (37)

1. World Heath Organization:Cancer [Fact Sheet No. 297]. Available from http://www.who.int/mediacentre/factsheets/fs297/en/
2. Siegel RL, Miller KD, Jemal A, :Cancer statistics, 2016. CA Cancer J Clin 66, 7–30, 2016.
3. Weitz J, Koch M, Debus J, Hohler T, Galle PR, et al.:Colorectal cancer. Lancet 365, 153–165, 2005.
4. Bouvard V, Loomis D, Guyton KZ, Grosse Y, Ghissassi FE, et al.:Carcinogenicity of consumption of red and processed meat. Lancet Oncol 16, 1599–1600, 2015.
5. Aune D, Chan DS, Vieira AR, Navarro Rosenblatt DA, Vieira R, et al.:Red and processed meat intake and risk of colorectal adenomas:a systematic review and meta-analysis of epidemiological studies. Cancer Causes Control 24, 611–627, 2013.
6. Greenwald P, Clifford CK, Milner JA, :Diet and cancer prevention. Eur J Cancer 37, 948–965, 2001.
7. Stoner GD, :Foodstuffs for preventing cancer:the preclinical and clinical development of berries. Cancer Prev Res (Phila) 2, 187–194, 2009.
8. Bobe G, Sansbury LB, Albert PS, Cross AJ, Kahle L, et al.:Dietary flavonoids and colorectal adenoma recurrence in the Polyp Prevention Trial. Cancer Epidemiol Biomarkers Prev 17, 1344–1353, 2008.
9. Tse G, Eslick GD, :Cruciferous vegetables and risk of colorectal neoplasms:a systematic review and meta-analysis. Nutr Cancer 66, 128–139, 2014.
10. Oh S, Gwak J, Park S, Yang CS, :Green tea polyphenol EGCG suppresses Wnt/beta-catenin signaling by promoting GSK-3beta- and PP2A-independent beta-catenin phosphorylation/degradation. BioFactors 40, 586–595, 2014.
11. Wang LS, Arnold M, Huang YW, Sardo C, Seguin C, et al.:Modulation of genetic and epigenetic biomarkers of colorectal cancer in humans by black raspberries:a phase I pilot study. Clin Cancer Res 17, 598–610, 2011.
12. Wang LS, Burke CA, Hasson H, Kuo CT, Molmenti CL, et al.:A phase Ib study of the effects of black raspberries on rectal polyps in patients with familial adenomatous polyposis. Cancer Prev Res (Phila) 7, 666–674, 2014.
13. Bi X, Fang W, Wang LS, Stoner GD, Yang W, :Black raspberries inhibit intestinal tumorigenesis in apc1638+/− and Muc2−/− mouse models of colorectal cancer. Cancer Prev Res (Phila) 3, 1443–1450, 2010.
14. Pan P, Skaer CW, Wang HT, Stirdivant SM, Young MR, et al.:Black raspberries suppress colonic adenoma development in ApcMin/+ mice:relation to metabolite profiles. Carcinogenesis 36, 1245–1253, 2015.
15. Pan P, Skaer CW, Stirdivant SM, Young MR, Stoner GD, et al.:Beneficial regulation of metabolic profiles by black raspberries in human colorectal cancer patients. Cancer Prev Res (Phila) 8, 743–750, 2015.
16. Montrose DC, Horelik NA, Madigan JP, Stoner GD, Wang LS, et al.:Anti-inflammatory effects of freeze-dried black raspberry powder in ulcerative colitis. Carcinogenesis 32, 343–350, 2011.
17. Evans AM, DeHaven CD, Barrett T, Mitchell M, Milgram E, :Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems. Anal Chem 81, 6656–6667, 2009.
18. R Development Core Team:R:A Language and Environment for Statistical Computing. Vienna, Austria:R Foundation for Statistical Computing, 2009.
19. Manna SK, Tanaka N, Krausz KW, Haznadar M, Xue X, et al.:Biomarkers of coordinate metabolic reprogramming in colorectal tumors in mice and humans. Gastroenterology 146, 1313–1324, 2014.
20. Cooke D, Schwarz M, Boocock D, Winterhalter P, Steward WP, et al.:Effect of cyanidin-3-glucoside and an anthocyanin mixture from bilberry on adenoma development in the ApcMin mouse model of intestinal carcinogenesis–relationship with tissue anthocyanin levels. Int J Cancer 119, 2213–2220, 2006.
21. Stoner GD, Wang LS, Casto BC, :Laboratory and clinical studies of cancer chemoprevention by antioxidants in berries. Carcinogenesis 29, 1665–1674, 2008.
22. Talavera S, Felgines C, Texier O, Besson C, Manach C, et al.:Anthocyanins are efficiently absorbed from the small intestine in rats. J Nutr 134, 2275–2279, 2004.
23. Passamonti S, Vrhovsek U, Vanzo A, Mattivi F, :The stomach as a site for anthocyanins absorption from food. FEBS Lett 544, 210–213, 2003.
24. Peiffer DS, Zimmerman NP, Wang LS, Ransom BW, Carmella SG, et al.:Chemoprevention of esophageal cancer with black raspberries, their component anthocyanins, and a major anthocyanin metabolite, protocatechuic acid. Cancer Prev Res (Phila) 7, 574–584, 2014.
25. Wang L-S, Carmella S, Keyes R, Kuo C-T, Huang Y-W, et al.:Anthocyanins and Cancer Prevention. In:Nutraceuticals and Cancer, Sarkar FH (ed.). Detroit:Springer, 2012, pp. 201–230.
26. Roynette CE, Calder PC, Dupertuis YM, Pichard C, :n-3 polyunsaturated fatty acids and colon cancer prevention. Clin Nutr 23, 139–151, 2004.
27. Berquin IM, Edwards IJ, Chen YQ, :Multi-targeted therapy of cancer by omega-3 fatty acids. Cancer Lett 269, 363–377, 2008.
28. Lee HJ, Jung H, Cho H, Lee K, Kwak HK, et al.:Dietary black raspberry seed oil ameliorates inflammatory activities in db/db mice. Lipids 51, 715–727, 2016.
29. de Aguiar Pastore Silva J, Emilia de Souza Fabre M, Waitzberg DL, :Omega-3 supplements for patients in chemotherapy and/or radiotherapy:a systematic review. Clin Nutr 34, 359–366, 2015.
30. van der Meij BS, Langius JA, Smit EF, Spreeuwenberg MD, von Blomberg BM, et al.:Oral nutritional supplements containing (n-3) polyunsaturated fatty acids affect the nutritional status of patients with stage III non-small cell lung cancer during multimodality treatment. J Nutr 140, 1774–1780, 2010.
31. van der Meij BS, Langius JA, Spreeuwenberg MD, Slootmaker SM, Paul MA, et al.:Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment:an RCT. Eur J Clin Nutr 66, 399–404, 2012.
32. Sanchez-Lara K, Turcott JG, Juarez-Hernandez E, Nunez-Valencia C, Villanueva G, et al.:Effects of an oral nutritional supplement containing eicosapentaenoic acid on nutritional and clinical outcomes in patients with advanced non-small cell lung cancer:randomised trial. Clin. Nutr 33, 1017–1023, 2014.
33. Finocchiaro C, Segre O, Fadda M, Monge T, Scigliano M, et al.:Effect of n-3 fatty acids on patients with advanced lung cancer:a double-blind, placebo-controlled study. Br J Nutr 108, 327–333, 2012.
34. Trabal J, Leyes P, Forga M, Maurel J, :Potential usefulness of an EPA-enriched nutritional supplement on chemotherapy tolerability in cancer patients without overt malnutrition. Nutr Hosp 25, 736–740, 2010.
35. Mocellin MC, Pastore e Silva Jde A, Camargo Cde Q, Fabre ME, Gevaerd S, et al.:Fish oil decreases C-reactive protein/albumin ratio improving nutritional prognosis and plasma fatty acid profile in colorectal cancer patients. Lipids 48, 879–888, 2013.
36. Ghoreishi Z, Esfahani A, Djazayeri A, Djalali M, Golestan B, et al.:Omega-3 fatty acids are protective against paclitaxel-induced peripheral neuropathy:a randomized double-blind placebo controlled trial. BMC Cancer 12, 355, 2012.
37. Bonatto SJ, Oliveira HH, Nunes EA, Pequito D, Iagher F, et al.:Fish oil supplementation improves neutrophil function during cancer chemotherapy. Lipids 47, 383–389, 2012.