Beneficial regulation of metabolic profiles by black raspberries in human colorectal cancer patients

Cancer Prevention Research

Volumn 8, Issue 8, 2015, Pages 743-750

  Pan, Pan ^a   Skaer, Chad W ^a   Stirdivant, Steven M ^b   Young, Matthew R ^c   Stoner, Gary D ^a   Lechner, John F ^a   Huang, Yi Wen ^a   Wang, Li Shu ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b METABOLON INC   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 FUROIC ACID; 2 OXINDOLE 3 ACETATE; 3 METHYLHISTIDINE; 4 ACETYLPHENOL SULFATE; 4 METHYLCATECHOL; 5 HYDROXYMETHYL 2 FUROIC ACID; ABSCISATE; ACONITIC ACID; AMINO ACID; ANTHRANILIC ACID; BENZOIC ACID; CATECHOL; CINNAMOYLGLYCINE; DRUG METABOLITE; GENTISIC ACID; GLYCEROPHOSPHATE; HERBACEOUS AGENT; HIPPURIC ACID; HYDROCINNAMIC ACID; HYDROCORTISONE; INOSITOL; METHYL BETA GLUCOPYRANOSIDE; N (2 FUROYL)GLYCINE; POLYPHENOL; SUCCINIMIDE; SULFATE; TRICARBOXYLIC ACID; UNCLASSIFIED DRUG; VANILLIC ACID; XYLITOL; XYLOSE;

AMINO ACID METABOLISM; ARTICLE; BLOOD SAMPLING; CANCER PATIENT; CLINICAL ARTICLE; COLON CANCER; COLORECTAL CANCER; HUMAN; POWDER; PRIORITY JOURNAL; RASPBERRY; TANDEM MASS SPECTROMETRY; TREATMENT DURATION; TUNEL ASSAY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINALYSIS; BLOOD; CHEMISTRY; COLORECTAL TUMOR; DIET THERAPY; DRUG EFFECTS; FRUIT; LIQUID CHROMATOGRAPHY; METABOLOME; ORAL DRUG ADMINISTRATION; RUBUS; URINE;

ADMINISTRATION, ORAL; CHROMATOGRAPHY, LIQUID; COLORECTAL NEOPLASMS; FRUIT; HUMANS; METABOLOME; RUBUS; TANDEM MASS SPECTROMETRY;

EID: 84942033385     PISSN: 19406207     EISSN: 19406215     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-15-0065     Document Type: Article

References (34)

1. Available from: http://www.cancer.org/cancer/colonandrectumcancer/detailedguide/colorectal-cancer-treating-by-stage-colon.
2. Available from: http://publications.cancerresearchuk.org/downloads/product/CS_REPORT_WORLD.pdf.
3. Available from: http://www.cancer.org/acs/groups/content/editorial/documents/document/acspc-044552.pdf.
4. Available from: http://www.cancer.org/cancer/colonandrectumcancer/detailedguide/colorectal-cancer-risk-factors.
5. Miller AB, Linseisen J. Achievements and future of nutritional cancer epidemiology. Int J Cancer 2010;126:1531-7.
6. van Duijnhoven FJ, Bueno-De-Mesquita HB, Ferrari P, Jenab M, Boshuizen HC, Ros MM, et al. Fruit, vegetables, and colorectal cancer risk: the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr 2009;89:1441-52.
7. Bobe G, Sansbury LB, Albert PS, Cross AJ, Kahle L, Ashby J, et al. Dietary flavonoids and colorectal adenoma recurrence in the Polyp Prevention Trial. Cancer Epidemiol Biomarkers Prev 2008;17:1344-53.
8. Wang H, Tso VK, Slupsky CM, Fedorak RN. Metabolomics and detection of colorectal cancer in humans: a systematic review. Future Oncol 2010;6: 1395-406.
9. Mamas M, Dunn WB, Neyses L, Goodacre R. The role of metabolites and metabolomics in clinically applicable biomarkers of disease. Arch Toxicol 2011;85:5-17.
10. Nicholson JK, Lindon JC, Holmes E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 1999;29:1181-9.
11. Tan B, Qiu Y, Zou X, Chen T, Xie G, Cheng Y, et al. Metabonomics identifies serum metabolite markers of colorectal cancer. J Proteome Res 2013;12: 3000-9.
12. Manna SK, Tanaka N, Krausz KW, Haznadar M, Xue X, Matsubara T, et al. Biomarkers of coordinate metabolic reprogramming in colorectal tumors in mice and humans. Gastroenterology 2014;146: 1313-24.
13. Qiu Y, Cai G, Su M, Chen T, Liu Y, Xu Y, et al. Urinary metabonomic study on colorectal cancer. J Proteome Res 2010;9:1627-34.
14. Cheng Y, Xie G, Chen T, Qiu Y, Zou X, Zheng M, et al. Distinct urinary metabolic profile of human colorectal cancer. J Proteome Res 2012;11: 1354-63.
15. Zhu J, Djukovic D, Deng L, Gu H, Himmati F, Chiorean EG, et al. Colorectal cancer detection using targeted serum metabolic profiling. J Proteome Res 2014;13:4120-30.
16. Kim YS, Milner JA. Bioactive food components and cancerspecific metabonomic profiles. J Biomed Biotechnol 2011;2011:721213.
17. Paudel L, Wyzgoski FJ, Giusti MM, Johnson JL, Rinaldi PL, Scheerens JC, et al. NMR-based metabolomic investigation of bioactivity of chemical constituents in black raspberry (Rubus occidentalis L.) fruit extracts. J Agric Food Chem 2014;62:1989-98.
18. McNiven EM, German JB, Slupsky CM. Analytical metabolomics: nutritional opportunities for personalized health. J Nutr Biochem 2011;22: 995-1002.
19. Wang LS, Arnold M, Huang YW, Sardo C, Seguin C, Martin E, et al. Modulation of genetic and epigenetic biomarkers of colorectal cancer in humans by black raspberries: a phase I pilot study. Clin Cancer Res 2011;17:598-610.
20. Evans AM, DeHaven CD, Barrett T, Mitchell M, Milgram E. Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems. Anal Chem 2009;81:6656-67.
21. Team RC.R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing; 2013.
22. Qiu Y, Cai G, Su M, Chen T, Zheng X, Xu Y, et al. Serum metabolite profiling of human colorectal cancer using GC-TOFMS and UPLC-QTOFMS. J Proteome Res 2009;8:4844-50.
23. Chan EC, Koh PK, Mal M, Cheah PY, Eu KW, Backshall A, et al. Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS). J Proteome Res 2009; 8:352-61.
24. Denkert C, Budczies J, Weichert W, Wohlgemuth G, Scholz M, Kind T, et al. Metabolite profiling of human colon carcinoma-deregulation of TCA cycle and amino acid turnover. Mol Cancer 2008;7:72.
25. Scott KP, Gratz SW, Sheridan PO, Flint HJ, Duncan SH. The influence of diet on the gut microbiota. Pharmacol Res 2013;69:52-60.
26. Leichtle AB, Nuoffer JM, Ceglarek U, Kase J, Conrad T, Witzigmann H, et al. Serum amino acid profiles and their alterations in colorectal cancer. Metabolomics 2012;8:643-53.
27. Nishiumi S, Kobayashi T, Ikeda A, Yoshie T, Kibi M, Izumi Y, et al. A novel serum metabolomics-based diagnostic approach for colorectal cancer. PLoS ONE 2012;7:e40459.
28. Ma YL, Qin HL, Liu WJ, Peng JY, Huang L, Zhao XP, et al. Ultra-high performance liquid chromatography-mass spectrometry for the metabolomic analysis of urine in colorectal cancer. Dig Dis Sci 2009;54:2655-62.
29. Ong ES, Zou L, Li S, Cheah PY, Eu KW, Ong CN. Metabolic profiling in colorectal cancer reveals signature metabolic shifts during tumorigenesis. Mol Cell Proteomics: MCP, 2010.
30. Ni Y, Xie G, Jia W. Metabonomics of human colorectal cancer: new approaches for early diagnosis and biomarker discovery. J Proteome Res 2014;13:3857-70.
31. Qiu Y, Cai G, Zhou B, Li D, Zhao A, Xie G, et al. A distinct metabolic signature of human colorectal cancer with prognostic potential. Clin Cancer Res 2014;20:2136-46.
32. Warburg O, Wind F, Negelein E. The metabolism of tumors in the body. J Gen Physiol 1927;8:519-30.
33. Aura AM, O'Leary KA, Williamson G, Ojala M, Bailey M, Puupponen-Pimia R, et al. Quercetin derivatives are deconjugated and converted to hydroxyphenylacetic acids but not methylated by human fecal flora in vitro. J Agric Food Chem 2002;50:1725-30.
34. Prior RL, Wu X, Gu L. Identification and urinary excretion of metabolites of 5-(hydroxymethyl)-2-furfural in human subjects following consumption of dried plums or dried plum juice. J Agric Food Chem 2006;54:3744-9.