Omega-3 supplements for patients in chemotherapy and/or radiotherapy: A systematic review

Clinical Nutrition

Volumn 34, Issue 3, 2015, Pages 359-366

  de Aguiar Pastore Silva, Juliana ^a   Emilia de Souza Fabre, Maria ^b   Waitzberg, Dan Linetzky ^c  

^a A C CAMARGO CANCER CENTER   (Brazil)

^b Oncologic Research Center   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Chemotherapy; Docosahexaenoic acid; Eicosapentaenoic acid; Omega 3 fatty acids; Oncologic treatment; Radiotherapy

Indexed keywords

CAPECITABINE; CARBOPLATIN; CISPLATIN; DOCOSAHEXAENOIC ACID; FISH OIL; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; ICOSAPENTAENOIC ACID; IRINOTECAN; OLIVE OIL; OMEGA 3 FATTY ACID; OXALIPLATIN; PACLITAXEL; PLACEBO;

ANTINEOPLASTIC ACTIVITY; BODY COMPOSITION; BODY WEIGHT; BODY WEIGHT DISORDER; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER RADIOTHERAPY; CHEMORADIOTHERAPY; COLORECTAL CANCER; DIET SUPPLEMENTATION; HUMAN; IMMUNE STATUS; INFLAMMATORY DISEASE; LUNG CANCER; MALIGNANT NEOPLASTIC DISEASE; OXIDATIVE STRESS; PERIPHERAL NEUROPATHY; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SURVIVAL TIME; SYSTEMATIC REVIEW (TOPIC); TREATMENT OUTCOME; FACTUAL DATABASE; NEOPLASMS;

DATABASES, FACTUAL; DIETARY SUPPLEMENTS; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; HUMANS; NEOPLASMS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME;

EID: 84928170518     PISSN: 02615614     EISSN: 15321983     Source Type: Journal    
DOI: 10.1016/j.clnu.2014.11.005     Document Type: Review

References (37)

1. Calder P.C., Deckelbaum R.J. Omega-3 fatty acids: time to get the messages right!. Curr Opin Clin Nutr Metab Care 2008, 11(2):91-93. 10.1097/MCO.0b013e3282f449f6.
2. Calder P.C. Mechanisms of action of (n-3) fatty acids. JNutr 2012, 142(3):592S-599S. 10.3945/jn.111.155259.
3. Colotta F., Allavena P., Sica A., Garlanda C., Mantovani A. Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 2009, 30(7):1073-1081. 10.1093/carcin/bgp127.
4. Laviano A., Rianda S., Molfino A., Rossi Fanelli F. Omega-3 fatty acids in cancer. Curr Opin Clin Nutr Metab Care 2013, 16(2):156-161. 10.1097/MCO.0b013e32835d2d99.
5. Jing K., Wu T., Lim K. Omega-3 polyunsaturated fatty acids and cancer. Anticancer Agents Med Chem 2013, 13(8):1162-1177. Available at:. http://www.ncbi.nlm.nih.gov/pubmed/25019221.
6. Merendino N., Costantini L., Manzi L., Molinari R., D'Eliseo D., Velotti F. Dietary ω -3 polyunsaturated fatty acid DHA: a potential adjuvant in the treatment of cancer. Biomed Res Int 2013, 2013:310186. 10.1155/2013/310186.
7. Hajjaji N., Bougnoux P. Selective sensitization of tumors to chemotherapy by marine-derived lipids: a review. Cancer Treat Rev 2013, 39(5):473-488. 10.1016/j.ctrv.2012.07.001.
8. Granci V., Cai F., Lecumberri E., Clerc A., Dupertuis Y.M., Pichard C. Colon cancer cell chemosensitisation by fish oil emulsion involves apoptotic mitochondria pathway. Br J Nutr 2013, 109(7):1188-1195. 10.1017/S000711451200308X.
9. Jordan A., Stein J. Effect of an omega-3 fatty acid containing lipid emulsion alone and in combination with 5-fluorouracil (5-FU) on growth of the colon cancer cell line Caco-2. Eur J Nutr 2003, 42(6):324-331. 10.1007/s00394-003-0427-1.
10. Calviello G., Di Nicuolo F., Serini S., Piccioni E., Boninsegna A., Maggiano N., et al. Docosahexaenoic acid enhances the susceptibility of human colorectal cancer cells to 5-fluorouracil. Cancer Chemother Pharmacol 2005, 55(1):12-20. 10.1007/s00280-004-0846-6.
11. Mahéo K., Vibet S., Steghens J.P., Dartigeas C., Lehman M., Bougnoux P., et al. Differential sensitization of cancer cells to doxorubicin by DHA: a role for lipoperoxidation. Free Radic Biol Med 2005, 39(6):742-751. 10.1016/j.freeradbiomed.2005.04.023.
12. Altenburg J.D., Siddiqui Ra Omega-3 polyunsaturated fatty acids down-modulate CXCR4 expression and function in MDA-MB-231 breast cancer cells. Mol Cancer Res 2009, 7(7):1013-1020. 10.1158/1541-7786.MCR-08-0385.
13. Ravacci G.R., Brentani M.M., Tortelli T., Torrinha R.S.M.M., Saldanha T., Torres E.A.F.S., et al. Lipid raft disruption by docosahexaenoic acid induces apoptosis in transformed human mammary luminal epithelial cells harboring HER-2 overexpression. JNutr Biochem 2013, 24(3):505-515. 10.1016/j.jnutbio.2012.02.001.
14. Siddiqui Ra, Harvey Ka, Xu Z., Bammerlin E.M., Walker C., Altenburg J.D. Docosahexaenoic acid: a natural powerful adjuvant that improves efficacy for anticancer treatment with no adverse effects. Biofactors 2011, 37(6):399-412. 10.1002/biof.181.
15. Moher D., Liberati A., Tetzlaff J., Altman D.G. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 2009, 6(7):e1000097. 10.1371/journal.pmed.1000097.
16. Jadad A.R., Moore R.A., Carroll D., Jenkinson C., Reynolds D.J.M., Gavaghan D.J., et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Control Clin Trials 1996, 17(1):1-12. Available at:, Accessed 30.05.14. http://www.ncbi.nlm.nih.gov/pubmed/8721797.
17. Higgins J.P.T., Altman D.G., Gøtzsche P.C., Jüni P., Moher D., Oxman A.D. Research methods & reporting the cochrane collaboration's tool for assessing risk of bias in randomised trials. BMJ 2011, 343:1-9. d5928. 10.1136/bmj.d5928.
18. Van der Meij B.S., Langius J.A.E., Smit E.F., Spreeuwenberg M.D., von Blomberg B.M.E., Heijboer A.C., et al. Oral nutritional supplements containing (n-3) polyunsaturated fatty acids affect the nutritional status of patients with stage III non-small cell lung cancer during multimodality treatment. JNutr 2010, 140(10):1774-1780. 10.3945/jn.110.121202.
19. Van der Meij B.S., Langius JaE, Spreeuwenberg M.D., Slootmaker S.M., Paul M.A., Smit E.F., et al. Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT. Eur J Clin Nutr 2012, 66(3):399-404. 10.1038/ejcn.2011.214.
20. Bonatto S.J.R., Oliveira H.H.P., Nunes E.A., Pequito D., Iagher F., Coelho I., et al. Fish oil supplementation improves neutrophil function during cancer chemotherapy. Lipids 2012, 47(4):383-389. 10.1007/s11745-011-3643-0.
21. Trabal J., Leyes P., Forga M., Maurel J. Potential usefulness of an EPA-enriched nutritional supplement on chemotherapy tolerability in cancer patients without overt malnutrition. Nutr Hosp 2010, 25(5):736-740. 10.3305/nh.2010.25.5.4616.
22. Silva J.D.A.P., Trindade E.B.S.D.M., Fabre M.E.D.S., Menegotto V.M., Gevaerd S., da Z., Buss S., et al. Fish oil supplement alters markers of inflammatory and nutritional status in colorectal cancer patients. Nutr Cancer 2012, 64(2):267-273. 10.1080/01635581.2012.643133.
23. Mocellin M.C., Pastore e Silva J.D.A., Camargo C.D.Q., Gevaerd S., Naliwaiko K., Moreno Y.M.F., et al. Fish oil decreases C-reactive protein/albumin ratio improving nutritional prognosis and plasma fatty acid profile in colorectal cancer patients. Lipids 2013, 48(9):879-888. 10.1007/s11745-013-3816-0.
24. Ghoreishi Z., Esfahani A., Djazayeri A., Golestan B., Ayromlou H., Hashemzade S., et al. Omega-3 fatty acids are protective against paclitaxel-induced peripheral neuropathy: a randomized double-blind placebo controlled trial. BMC Cancer 2012, 12(1):355. 10.1186/1471-2407-12-355.
25. Finocchiaro C., Segre O., Fadda M., Monge T., Scigliano M., Schena M., et al. Effect of n-3 fatty acids on patients with advanced lung cancer: a double-blind, placebo-controlled study. Br J Nutr 2012, 108(2):327-333. 10.1017/S0007114511005551.
26. Sánchez-Lara K., Turcott J.G., Juárez-Hernández E., Nuñez-Valencia C., Villanueva G., Guevara P., et al. Effects of an oral nutritional supplement containing eicosapentaenoic acid on nutritional and clinical outcomes in patients with advanced non-small cell lung cancer: randomised trial. Clin Nutr 2014, 33(6):1017-1023. 10.1016/j.clnu.2014.03.006.
27. Faber J., Berkhout M., Fiedler U., Avlar M., Wittemane B.J., Vos A.P., et al. Rapid EPA and DHA incorporation and reduced PGE2 levels after one week intervention with a medical food in cancer patients receiving radiotherapy, a randomized trial. Clin Nutr 2013, 32(3):338-345. 10.1016/j.clnu.2012.09.009.
28. Guarcello M., Riso S., Buosi R., D'Andrea F. EPA-enriched oral nutritional support in patients with lung cancer: effects on nutritional status and quality of life. Nutr Ther Metab 2007, 25:25-30.
29. Fekete K., Marosvölgyi T. Methods of assessment of n-3 long-chain polyunsaturated fatty acid status in humans: a systematic review. Am J Clin Nutr 2009, 89:2070-2084. 10.3945/ajcn.2009.27230I.1.
30. Gurzell Ea, Wiesinger Ja, Morkam C., Hemmrich S., Harris W.S., Fenton J.I. Is the omega-3 index a valid marker of intestinal membrane phospholipid EPA+DHA content?. Prostagl Leukot Essent Fat Acids 2014, 91(3):87-96. 10.1016/j.plefa.2014.04.001.
31. Awad S., Tan B.H., Cui H., Bhalla A., Fearonb K.C.H., Parsons S.L., et al. Marked changes in body composition following neoadjuvant chemotherapy for oesophagogastric cancer. Clin Nutr 2012, 31(1):74-77. 10.1016/j.clnu.2011.08.008.
32. Murphy Ra, Mourtzakis M., Mazurak V.C. N-3 polyunsaturated fatty acids: the potential role for supplementation in cancer. Curr Opin Clin Nutr Metab Care 2012, 15(3):246-251. 10.1097/MCO.0b013e328351c32f.
33. Murphy Ra, Mourtzakis M., Chu Q.S.C., Baracos V.E., Reiman T., Mazurak V.C. Supplementation with fish oil increases first-line chemotherapy efficacy in patients with advanced nonsmall cell lung cancer. Cancer 2011, 117(16):3774-3780. 10.1002/cncr.25933.
34. Murphy Ra, Mourtzakis M., Chu Q.S.C., Baracos V.E., Reiman T., Mazurak V.C. Nutritional intervention with fish oil provides a benefit over standard of care for weight and skeletal muscle mass in patients with nonsmall cell lung cancer receiving chemotherapy. Cancer 2011, 117(8):1775-1782. 10.1002/cncr.25709.
35. Colomer R., Moreno-Nogueira J.M., García-Luna P.P., et al. N-3 fatty acids, cancer and cachexia: a systematic review of the literature. Br J Nutr 2007, 97(5):823-831. 10.1017/S000711450765795X.
36. Mantovani A., Allavena P., Sica A., Balkwill F. Cancer-related inflammation. Nature 2008, 454(7203):436-444. 10.1038/nature07205.
37. Deng M., Lan Y., Luo S. Quality of life estimate in stomach, colon, and rectal cancer patients in a hospital in China. Tumour Biol 2013, 34(5):2809-2815. 10.1007/s13277-013-0839-3.