Green tea polyphenol EGCG suppresses Wnt/β-catenin signaling by promoting GSK-3β- and PP2A-independent β-catenin phosphorylation/degradation

BioFactors

Volumn 40, Issue 6, 2014, Pages 586-595

  Oh, Sangtaek ^a   Gwak, Jungsug ^a,b   Park, Seoyoung ^a   Yang, Chung S ^c  

^a Kookmin University   (South Korea)

^b Sogang University   (South Korea)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

( ) epigallocatechin 3 gallate; Colon cancer; Phosphorylation; Proteasomal degradation; Wnt catenin signaling

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BETA CATENIN; CYCLIN D1; EPIGALLOCATECHIN GALLATE; GLYCOGEN SYNTHASE KINASE 3BETA; PHOSPHOPROTEIN PHOSPHATASE 2A; WNT3A PROTEIN; ANTINEOPLASTIC AGENT; APC PROTEIN; APC PROTEIN, HUMAN; CATECHIN; CTNNB1 PROTEIN, HUMAN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; PHOSPHOPROTEIN PHOSPHATASE 2; POLYPHENOL; PROTEASOME; PROTEIN KINASE INHIBITOR; TEA; WNT3A PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL PROLIFERATION; COLON CANCER; COLON POLYPOSIS; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; HEK293 CELL LINE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TEA; TUMOR XENOGRAFT; UPREGULATION; WESTERN BLOTTING; WILD TYPE; WNT SIGNALING PATHWAY; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; ANTIBODY SPECIFICITY; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HCT116 CELL LINE; ISOLATION AND PURIFICATION; METABOLISM; MUTATION; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ADENOMATOUS POLYPOSIS COLI PROTEIN; ANTICARCINOGENIC AGENTS; BETA CATENIN; CATECHIN; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOGEN SYNTHASE KINASE 3; HCT116 CELLS; HEK293 CELLS; HUMANS; MUTATION; ORGAN SPECIFICITY; PHOSPHORYLATION; POLYPHENOLS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN KINASE INHIBITORS; PROTEIN PHOSPHATASE 2; PROTEOLYSIS; SIGNAL TRANSDUCTION; TEA; WNT3A PROTEIN;

EID: 84921024176     PISSN: 09516433     EISSN: 18728081     Source Type: Journal    
DOI: 10.1002/biof.1185     Document Type: Article

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