Genetic stability of genome-scale deoptimized RNA virus vaccine candidates under selective pressure

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 3, 2017, Pages E386-E395

  Nouën, Cyril Le ^a   McCarty, Thomas ^a   Brown, Michael ^b   Smith, Melissa Laird ^b,e   Lleras, Roberto ^b   Dolan, Michael A ^a   Mehedi, Masfique ^a   Yang, Lijuan ^a   Luongo, Cindy ^a   Liang, Bo ^a   Munir, Shirin ^a   DiNapoli, Joshua M ^a,f   Mueller, Steffen ^c   Wimmer, Eckard ^d   Collins, Peter L ^a   Buchholz, Ursula J ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b PACIFIC BIOSCIENCES   (United States)

^c Codagenix Inc ^*  (United States)

^d STONY BROOK UNIVERSITY   (United States)

^e MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^f Sanofi Pasteur Biologics Co   (United States)

Author keywords

Codon pair deoptimization; Genetic stability; Live attenuated vaccine; Negative strand RNA virus; Respiratory syncytial virus

Indexed keywords

DIHYDROLIPOAMIDE DEHYDROGENASE; GLYCINE DEHYDROGENASE (DECARBOXYLATING); GUANINE NUCLEOTIDE BINDING PROTEIN; M2 1 PROTEIN; RESPIRATORY SYNCYTIAL VIRUS VACCINE; RNA VACCINE; UNCLASSIFIED DRUG; LIVE VACCINE; RECOMBINANT VACCINE; VIRAL PROTEIN; VIRUS VACCINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; GENETIC STABILITY; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PHENOTYPE; PRESSURE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; TEMPERATURE SENSITIVITY; TEMPERATURE STRESS; VIRUS ATTENUATION; VIRUS CULTURE; VIRUS GENOME; VIRUS MUTATION; VIRUS TRANSCRIPTION; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; CHLOROCEBUS AETHIOPS; CODON; GENETICS; HUMAN; HUMAN RESPIRATORY SYNCYTIAL VIRUS; MUTATION; OPEN READING FRAME; RNA VIRUS; VERO CELL LINE; VIRUS REPLICATION;

ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; CODON; GENOME, VIRAL; HUMANS; MICE; MICE, INBRED BALB C; MUTATION; OPEN READING FRAMES; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; RNA VIRUSES; VACCINES, ATTENUATED; VACCINES, SYNTHETIC; VERO CELLS; VIRAL PROTEINS; VIRAL VACCINES; VIRUS REPLICATION;

EID: 85009822167     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1619242114     Document Type: Article

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