Random Codon Re-encoding Induces Stable Reduction of Replicative Fitness of Chikungunya Virus in Primate and Mosquito Cells

PLoS Pathogens

Volumn 9, Issue 2, 2013, Pages

  Nougairede, Antoine ^a   de Fabritus, Lauriane ^a   Aubry, Fabien ^a   Gould, Ernest A ^a   Holmes, Edward C ^b,c   de Lamballerie, Xavier ^a  

^a Aix Marseille University IRD 190 Inserm 1207   (France)

^b UNIVERSITY OF SYDNEY   (Australia)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMAGGLUTININ; LIVE VACCINE; NONSTRUCTURAL PROTEIN 1; NONSTRUCTURAL PROTEIN 4; STRUCTURAL PROTEIN; VIRUS PROTEIN; VIRUS RNA;

ANIMAL CELL; ARTICLE; CHIKUNGUNYA ALPHAVIRUS; CODON; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; EVOLUTION; HEMAGGLUTINATION; HUMAN; HUMAN CELL; MOSQUITO; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIMATE; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; VIRUS REPLICATION;

AEDES; ALPHAVIRUS INFECTIONS; AMINO ACID SUBSTITUTION; ANIMALS; BASE SEQUENCE; CELL LINE; CERCOPITHECUS AETHIOPS; CHIKUNGUNYA VIRUS; CODON; CONSENSUS SEQUENCE; EVOLUTION, MOLECULAR; GENETIC FITNESS; GENETIC VARIATION; GENOME, VIRAL; HUMANS; MUTATION; PRIMATES; RNA, VIRAL; SEQUENCE ANALYSIS, DNA; SERIAL PASSAGE; VERO CELLS; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 84874788781     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003172     Document Type: Article

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