-
1
-
-
84926430250
-
UK Biobank: An open access resource for identifying the causes of a wide range of complex diseases of middle and old age
-
Sudlow, C. et al. UK Biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 12, e1001779 (2015).
-
(2015)
PLoS Med.
, vol.12
, pp. e1001779
-
-
Sudlow, C.1
-
2
-
-
77954167176
-
Web-based, participant-driven studies yield novel genetic associations for common traits
-
Eriksson, N. et al. Web-based, participant-driven studies yield novel genetic associations for common traits. PLoS Genet. 6, e1000993 (2010).
-
(2010)
PLoS Genet.
, vol.6
, pp. e1000993
-
-
Eriksson, N.1
-
3
-
-
59349098163
-
Genomic selection in dairy cattle: Progress and challenges
-
Hayes, B.J., Bowman, P.J., Chamberlain, A.J. & Goddard, M.E. Genomic selection in dairy cattle: progress and challenges. J. Dairy Sci. 92, 433-443 (2009).
-
(2009)
J. Dairy Sci.
, vol.92
, pp. 433-443
-
-
Hayes, B.J.1
Bowman, P.J.2
Chamberlain, A.J.3
Goddard, M.E.4
-
4
-
-
77949854404
-
Deregressing estimated breeding values and weighting information for genomic regression analyses
-
Garrick, D.J., Taylor, J.F. & Fernando, R.L. Deregressing estimated breeding values and weighting information for genomic regression analyses. Genet. Sel. Evol. 41, 55 (2009).
-
(2009)
Genet. Sel. Evol.
, vol.41
, pp. 55
-
-
Garrick, D.J.1
Taylor, J.F.2
Fernando, R.L.3
-
5
-
-
67649173408
-
Distribution and location of genetic effects for dairy traits
-
Cole, J.B. et al. Distribution and location of genetic effects for dairy traits. J. Dairy Sci. 92, 2931-2946 (2009).
-
(2009)
J. Dairy Sci.
, vol.92
, pp. 2931-2946
-
-
Cole, J.B.1
-
6
-
-
30344461937
-
The value of relatives with phenotypes but missing genotypes in association studies for quantitative traits
-
Visscher, P.M. & Duffy, D.L. The value of relatives with phenotypes but missing genotypes in association studies for quantitative traits. Genet. Epidemiol. 30, 30-36 (2006).
-
(2006)
Genet. Epidemiol.
, vol.30
, pp. 30-36
-
-
Visscher, P.M.1
Duffy, D.L.2
-
7
-
-
34547628858
-
Family-based association tests for genomewide association scans
-
Chen, W.-M. & Abecasis, G.R. Family-based association tests for genomewide association scans. Am. J. Hum. Genet. 81, 913-926 (2007).
-
(2007)
Am. J. Hum. Genet.
, vol.81
, pp. 913-926
-
-
Chen, W.-M.1
Abecasis, G.R.2
-
8
-
-
0142088521
-
Unique lipoprotein phenotype and genotype associated with exceptional longevity
-
Barzilai, N. et al. Unique lipoprotein phenotype and genotype associated with exceptional longevity. J. Am. Med. Assoc. 290, 2030-2040 (2003).
-
(2003)
J. Am. Med. Assoc.
, vol.290
, pp. 2030-2040
-
-
Barzilai, N.1
-
9
-
-
84962866425
-
Variants near CHRNA3/5 and APOE have age-and sex-related effects on human lifespan
-
Joshi, P.K. et al. Variants near CHRNA3/5 and APOE have age-and sex-related effects on human lifespan. Nat. Commun. 7, 11174 (2016).
-
(2016)
Nat. Commun.
, vol.7
, pp. 11174
-
-
Joshi, P.K.1
-
10
-
-
85016101122
-
Human longevity is influenced by many genetic variants: Evidence from 75,000 UK Biobank participants
-
Pilling, L.C. et al. Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. Aging 8, 547-560 (2016).
-
(2016)
Aging
, vol.8
, pp. 547-560
-
-
Pilling, L.C.1
-
11
-
-
77955554752
-
Power assessment for genetic association study of human longevity using offspring of long-lived subjects
-
Tan, Q., Zhao, J.H., Li, S., Kruse, T.A. & Christensen, K. Power assessment for genetic association study of human longevity using offspring of long-lived subjects. Eur. J. Epidemiol. 25, 501-506 (2010).
-
(2010)
Eur. J. Epidemiol.
, vol.25
, pp. 501-506
-
-
Tan, Q.1
Zhao, J.H.2
Li, S.3
Kruse, T.A.4
Christensen, K.5
-
12
-
-
42649118126
-
Many sequence variants affecting diversity of adult human height
-
Gudbjartsson, D.F. et al. Many sequence variants affecting diversity of adult human height. Nat. Genet. 40, 609-615 (2008).
-
(2008)
Nat. Genet.
, vol.40
, pp. 609-615
-
-
Gudbjartsson, D.F.1
-
13
-
-
72449122779
-
Parental origin of sequence variants associated with complex diseases
-
Kong, A. et al. Parental origin of sequence variants associated with complex diseases. Nature 462, 868-874 (2009).
-
(2009)
Nature
, vol.462
, pp. 868-874
-
-
Kong, A.1
-
14
-
-
34547756415
-
Case-control association testing with related individuals: A more powerful quasi-likelihood score test
-
Thornton, T. & McPeek, M.S. Case-control association testing with related individuals: a more powerful quasi-likelihood score test. Am. J. Hum. Genet. 81, 321-337 (2007).
-
(2007)
Am. J. Hum. Genet.
, vol.81
, pp. 321-337
-
-
Thornton, T.1
McPeek, M.S.2
-
15
-
-
0042023711
-
Alzheimer disease in the US population: Prevalence estimates using the 2000 census
-
Hebert, L.E., Scherr, P.A., Bienias, J.L., Bennett, D.A. & Evans, D.A. Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch. Neurol. 60, 1119-1122 (2003).
-
(2003)
Arch. Neurol.
, vol.60
, pp. 1119-1122
-
-
Hebert, L.E.1
Scherr, P.A.2
Bienias, J.L.3
Bennett, D.A.4
Evans, D.A.5
-
16
-
-
33745919520
-
Epidemiology of Parkinson's disease
-
de Lau, L.M. & Breteler, M.M. Epidemiology of Parkinson's disease. Lancet Neurol. 5, 525-535 (2006).
-
(2006)
Lancet Neurol.
, vol.5
, pp. 525-535
-
-
De Lau, L.M.1
Breteler, M.M.2
-
17
-
-
0027194791
-
Gene dose of apolipoprotein e type 4 allele and the risk of Alzheimer's disease in late onset families
-
Corder, E.H. et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261, 921-923 (1993).
-
(1993)
Science
, vol.261
, pp. 921-923
-
-
Corder, E.H.1
-
18
-
-
0034609562
-
Lipoprotein(a) and coronary heart disease. Meta-analysis of prospective studies
-
Danesh, J., Collins, R. & Peto, R. Lipoprotein(a) and coronary heart disease. Meta-analysis of prospective studies. Circulation 102, 1082-1085 (2000).
-
(2000)
Circulation
, vol.102
, pp. 1082-1085
-
-
Danesh, J.1
Collins, R.2
Peto, R.3
-
19
-
-
84969213492
-
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
-
Wellcome Trust Case Control Consortium
-
Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661-678 (2007).
-
(2007)
Nature
, vol.447
, pp. 661-678
-
-
-
20
-
-
80053907554
-
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
-
International Consortium for Blood Pressure Genome-Wide Association Studies
-
International Consortium for Blood Pressure Genome-Wide Association Studies. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 478, 103-109 (2011).
-
(2011)
Nature
, vol.478
, pp. 103-109
-
-
-
21
-
-
34250001297
-
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
-
Hunter, D.J. et al. A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat. Genet. 39, 870-874 (2007).
-
(2007)
Nat. Genet.
, vol.39
, pp. 870-874
-
-
Hunter, D.J.1
-
22
-
-
32544451924
-
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
-
Grant, S.F.A. et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat. Genet. 38, 320-323 (2006).
-
(2006)
Nat. Genet.
, vol.38
, pp. 320-323
-
-
Grant, S.F.A.1
-
23
-
-
41649103682
-
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25
-
Hung, R.J. et al. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature 452, 633-637 (2008).
-
(2008)
Nature
, vol.452
, pp. 633-637
-
-
Hung, R.J.1
-
24
-
-
84939599004
-
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
-
Nalls, M.A. et al. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat. Genet. 46, 989-993 (2014).
-
(2014)
Nat. Genet.
, vol.46
, pp. 989-993
-
-
Nalls, M.A.1
-
25
-
-
0031466983
-
From genotypes to genes: Doubling the sample size
-
Sasieni, P.D. From genotypes to genes: doubling the sample size. Biometrics 53, 1253-1261 (1997).
-
(1997)
Biometrics
, vol.53
, pp. 1253-1261
-
-
Sasieni, P.D.1
-
26
-
-
68449086236
-
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
-
International Schizophrenia Consortium
-
International Schizophrenia Consortium. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460, 748-752 (2009).
-
(2009)
Nature
, vol.460
, pp. 748-752
-
-
-
27
-
-
84888317489
-
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
-
Lambert, J.-C. et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat. Genet. 45, 1452-1458 (2013).
-
(2013)
Nat. Genet.
, vol.45
, pp. 1452-1458
-
-
Lambert, J.-C.1
-
28
-
-
84942987885
-
A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease
-
CARDIoGRAMplusC4D Consortium
-
CARDIoGRAMplusC4D Consortium. A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat. Genet. 47, 1121-1130 (2015).
-
(2015)
Nat. Genet.
, vol.47
, pp. 1121-1130
-
-
-
29
-
-
84895868553
-
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
-
DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium
-
DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium. et al. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat. Genet. 46, 234-244 (2014).
-
(2014)
Nat. Genet.
, vol.46
, pp. 234-244
-
-
-
30
-
-
84879892380
-
A mega-analysis of genome-wide association studies for major depressive disorder
-
Ripke, S. et al. A mega-analysis of genome-wide association studies for major depressive disorder. Mol. Psychiatry 18, 497-511 (2013).
-
(2013)
Mol. Psychiatry
, vol.18
, pp. 497-511
-
-
Ripke, S.1
-
31
-
-
10944270703
-
Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins
-
Friedmann, E. et al. Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins. J. Biol. Chem. 279, 50790-50798 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 50790-50798
-
-
Friedmann, E.1
-
32
-
-
84945443544
-
CD33 modulates TREM2: Convergence of Alzheimer loci
-
Chan, G. et al. CD33 modulates TREM2: convergence of Alzheimer loci. Nat. Neurosci. 18, 1556-1558 (2015).
-
(2015)
Nat. Neurosci.
, vol.18
, pp. 1556-1558
-
-
Chan, G.1
-
33
-
-
84923377359
-
Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease
-
Gjoneska, E. et al. Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease. Nature 518, 365-369 (2015).
-
(2015)
Nature
, vol.518
, pp. 365-369
-
-
Gjoneska, E.1
-
34
-
-
84858699678
-
FGD5 mediates proangiogenic action of vascular endothelial growth factor in human vascular endothelial cells
-
Kurogane, Y. et al. FGD5 mediates proangiogenic action of vascular endothelial growth factor in human vascular endothelial cells. Arterioscler. Thromb. Vasc. Biol. 32, 988-996 (2012).
-
(2012)
Arterioscler. Thromb. Vasc. Biol.
, vol.32
, pp. 988-996
-
-
Kurogane, Y.1
-
35
-
-
84883144097
-
Vascular endothelial growth factor in heart failure
-
Taimeh, Z., Loughran, J., Birks, E.J. & Bolli, R. Vascular endothelial growth factor in heart failure. Nat. Rev. Cardiol. 10, 519-530 (2013).
-
(2013)
Nat. Rev. Cardiol.
, vol.10
, pp. 519-530
-
-
Taimeh, Z.1
Loughran, J.2
Birks, E.J.3
Bolli, R.4
-
36
-
-
84866427376
-
Phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) binds and transfers phosphatidic acid
-
Garner, K. et al. Phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) binds and transfers phosphatidic acid. J. Biol. Chem. 287, 32263-32276 (2012).
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 32263-32276
-
-
Garner, K.1
-
37
-
-
77956449477
-
Personalized investigation
-
Dolgin, E. Personalized investigation. Nat. Med. 16, 953-955 (2010).
-
(2010)
Nat. Med.
, vol.16
, pp. 953-955
-
-
Dolgin, E.1
-
38
-
-
84942936407
-
Genome hacker uncovers largest-ever family tree
-
Ledford. H. Genome hacker uncovers largest-ever family tree. Nature http://dx.doi.org/10.1038/nature.2013.14037 (2013).
-
(2013)
Nature
-
-
Ledford, H.1
-
39
-
-
76649113727
-
Software for generating liability distributions for pedigrees conditional on their observed disease states and covariates
-
Campbell, D.D., Sham, P.C., Knight, J., Wickham, H. & Landau, S. Software for generating liability distributions for pedigrees conditional on their observed disease states and covariates. Genet. Epidemiol. 34, 159-170 (2010).
-
(2010)
Genet. Epidemiol.
, vol.34
, pp. 159-170
-
-
Campbell, D.D.1
Sham, P.C.2
Knight, J.3
Wickham, H.4
Landau, S.5
-
40
-
-
84929274500
-
Mixed model with correction for case-control ascertainment increases association power
-
Hayeck, T.J. et al. Mixed model with correction for case-control ascertainment increases association power. Am. J. Hum. Genet. 96, 720-730 (2015).
-
(2015)
Am. J. Hum. Genet.
, vol.96
, pp. 720-730
-
-
Hayeck, T.J.1
-
41
-
-
84926528258
-
Accurate liability estimation improves power in ascertained case-control studies
-
Weissbrod, O., Lippert, C., Geiger, D. & Heckerman, D. Accurate liability estimation improves power in ascertained case-control studies. Nat. Methods 12, 332-334 (2015).
-
(2015)
Nat. Methods
, vol.12
, pp. 332-334
-
-
Weissbrod, O.1
Lippert, C.2
Geiger, D.3
Heckerman, D.4
-
42
-
-
84902504030
-
Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel
-
1000 Genomes Project Consortium
-
Delaneau, O., Marchini, J. & 1000 Genomes Project Consortium. Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel. Nat. Commun. 5, 3934 (2014).
-
(2014)
Nat. Commun.
, vol.5
, pp. 3934
-
-
Delaneau, O.1
Marchini, J.2
-
43
-
-
67651222400
-
A flexible and accurate genotype imputation method for the next generation of genome-wide association studies
-
Howie, B.N., Donnelly, P. & Marchini, J. A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet. 5, e1000529 (2009).
-
(2009)
PLoS Genet.
, vol.5
, pp. e1000529
-
-
Howie, B.N.1
Donnelly, P.2
Marchini, J.3
-
44
-
-
84943182742
-
The UK10K project identifies rare variants in health and disease
-
UK10K Consortium
-
UK10K Consortium. The UK10K project identifies rare variants in health and disease. Nature 526, 82-90 (2015).
-
(2015)
Nature
, vol.526
, pp. 82-90
-
-
-
45
-
-
84943171338
-
A global reference for human genetic variation
-
1000 Genomes Project Consortium.
-
1000 Genomes Project Consortium. A global reference for human genetic variation. Nature 526, 68-74 (2015).
-
(2015)
Nature
, vol.526
, pp. 68-74
-
-
-
46
-
-
80054973810
-
Mutations in BRIP1 confer high risk of ovarian cancer
-
Rafnar, T. et al. Mutations in BRIP1 confer high risk of ovarian cancer. Nat. Genet. 43, 1104-1107 (2011).
-
(2011)
Nat. Genet.
, vol.43
, pp. 1104-1107
-
-
Rafnar, T.1
-
47
-
-
33748317890
-
In silico method for inferring genotypes in pedigrees
-
Burdick, J.T., Chen, W.-M., Abecasis, G.R. & Cheung, V.G. In silico method for inferring genotypes in pedigrees. Nat. Genet. 38, 1002-1004 (2006).
-
(2006)
Nat. Genet.
, vol.38
, pp. 1002-1004
-
-
Burdick, J.T.1
Chen, W.-M.2
Abecasis, G.R.3
Cheung, V.G.4
-
48
-
-
84930213392
-
Second-generation PLINK: Rising to the challenge of larger and richer datasets
-
Chang, C.C. et al. Second-generation PLINK: rising to the challenge of larger and richer datasets. Gigascience 4, 7 (2015).
-
(2015)
Gigascience
, vol.4
, pp. 7
-
-
Chang, C.C.1
-
49
-
-
85000692305
-
An atlas of genetic correlations across human diseases and traits
-
Bulik-Sullivan, B. et al. An atlas of genetic correlations across human diseases and traits. Nat. Genet. 47, 1236-1241 (2015).
-
(2015)
Nat. Genet.
, vol.47
, pp. 1236-1241
-
-
Bulik-Sullivan, B.1
-
50
-
-
84924060689
-
Efficient Bayesian mixed-model analysis increases association power in large cohorts
-
Loh, P.-R. et al. Efficient Bayesian mixed-model analysis increases association power in large cohorts. Nat. Genet. 47, 284-290 (2015).
-
(2015)
Nat. Genet.
, vol.47
, pp. 284-290
-
-
Loh, P.-R.1
-
51
-
-
84862832570
-
Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits
-
S1-S3
-
Yang, J. et al. Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat. Genet. 44, 369-375, S1-S3 (2012).
-
(2012)
Nat. Genet.
, vol.44
, pp. 369-375
-
-
Yang, J.1
|