Accurate liability estimation improves power in ascertained case-control studies

Nature Methods

Volumn 12, Issue 4, 2015, Pages 332-334

  Weissbrod, Omer ^a   Lippert, Christoph ^b   Geiger, Dan ^a   Heckerman, David ^b  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b MICROSOFT RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CASE CONTROL STUDY; GENETIC ASSOCIATION; HERITABILITY; HUMAN; LIABILITY ESTIMATOR AS A PHENOTYPE; LINEAR MIXED MODEL; LINEAR REGRESSION ANALYSIS; METHODOLOGY; MODEL; MULTIPLE SCLEROSIS; NORMAL DISTRIBUTION; PHENOTYPE; POPULATION STRUCTURE; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; SIMULATION; UNIVARIATE ANALYSIS; BIOSTATISTICS; GENETICS; PROCEDURES; SAMPLE SIZE; THEORETICAL MODEL;

BIOSTATISTICS; CASE-CONTROL STUDIES; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MODELS, THEORETICAL; MULTIPLE SCLEROSIS; SAMPLE SIZE;

EID: 84926528258     PISSN: 15487091     EISSN: 15487105     Source Type: Journal    
DOI: 10.1038/nmeth.3285     Document Type: Article

References (27)

1. Welter, D. et al. Nucleic Acids Res. 42, D1001-D1006 (2014).
2. Golan, D., Lander, E.S. & Rosset, S. Proc. Natl. Acad. Sci. USA 111, E5272-E5281 (2014).
3. Price, A.L., Zaitlen, N.A., Reich, D. & Patterson, N. Nat. Rev. Genet. 11, 459-463 (2010).
4. Fakiola, M. et al. Nat. Genet. 45, 208-213 (2013).
5. Sawcer, S. et al. Nature 476, 214-219 (2011).
6. Tsoi, L.C. et al. Nat. Genet. 44, 1341-1348 (2012).
7. Yang, J., Zaitlen, N.A., Goddard, M.E., Visscher, P.M. & Price, A.L. Nat. Genet. 46, 100-106 (2014).
8. Dempster, E.R. & Lerner, I.M. Genetics 35, 212-236 (1950).
9. Zaitlen, N. et al. Bioinformatics 28, 1729-1737 (2012).
10. Zaitlen, N. et al. PLoS Genet. 8, e1003032 (2012).
11. Hayeck, T. et al. Preprint at http://biorxiv.org/content/early/2014/09/04/008755 (2014).
12. Price, A.L. et al. Nat. Genet. 38, 904-909 (2006).
13. Wright, S. Ann. Eugen. 15, 323-354 (1949).
14. The Wellcome Trust Case Control Consortium. Nature 447, 661-678 (2007).
15. The UK IBD Genetics Consortium & the Wellcome Trust Case Control Consortium 2. Nat. Genet. 41, 1330-1334 (2009).
16. Yang, J. et al. Eur. J. Hum. Genet. 19, 807-812 (2011).
17. Hindorff, L.A. et al. Proc. Natl. Acad. Sci. USA 106, 9362-9367 (2009).
18. Fusi, N., Lippert, C., Lawrence, N.D. & Stegle, O. Nat. Commun. 5, 4890 (2014).
19. Zhou, X., Carbonetto, P. & Stephens, M. PLoS Genet. 9, e1003264 (2013).
20. Widmer, C. et al. Sci. Rep. 4, 6874 (2014).
21. Yang, J. et al. Nat. Genet. 42, 565-569 (2010).
22. Lee, S.H., Wray, N.R., Goddard, M.E. & Visscher, P.M. Am. J. Hum. Genet. 88, 294-305 (2011).
23. Hastie, T., Tibshirani, R. & Friedman, J. The Elements of Statistical Learning: Data Mining, Inference, and Prediction 2nd edn. (Springer, 2009).
24. Lippert, C. et al. Nat. Methods 8, 833-835 (2011).
25. Listgarten, J. et al. Nat. Methods 9, 525-526 (2012).
26. Patterson, N., Price, A.L. & Reich, D. PLoS Genet. 2, e190 (2006).
27. Balding, D.J. & Nichols, R.A. Genetica 96, 3-12 (1995).