-
1
-
-
79956077563
-
T cell exhaustion
-
PMID:21739672
-
Wherry EJ. T cell exhaustion. Nat Immunol 2011; 12:492-9; PMID:21739672; http://dx.doi.org/10.1038/ni.2035
-
(2011)
Nat Immunol
, vol.12
, pp. 492-499
-
-
Wherry, E.J.1
-
2
-
-
84925545111
-
Clinical blockade of PD1 and LAG3 - potential mechanisms of action
-
PMID:25534622
-
Nguyen LT, Ohashi PS. Clinical blockade of PD1 and LAG3 - potential mechanisms of action. Nat Rev Immunol 2015; 15:45-56; PMID:25534622; http://dx.doi.org/10.1038/nri3790
-
(2015)
Nat Rev Immunol
, vol.15
, pp. 45-56
-
-
Nguyen, L.T.1
Ohashi, P.S.2
-
3
-
-
84928062583
-
Immune checkpoint blockade: A common denominator approach to cancer therapy
-
PMID:25858804
-
Topalian SL, Drake CG, Pardoll DM. Immune checkpoint blockade: a common denominator approach to cancer therapy. Cancer Cell 2015; 27:450-61; PMID:25858804; http://dx.doi.org/10.1016/j.ccell.2015.03.001
-
(2015)
Cancer Cell
, vol.27
, pp. 450-461
-
-
Topalian, S.L.1
Drake, C.G.2
Pardoll, D.M.3
-
4
-
-
42649125225
-
PD1 and its ligands in tolerance and immunity
-
Keir ME, Butte MJ, Freeman GJ, Sharpe AH. PD1 and its ligands in tolerance and immunity. Ann Rev Immunol 2008; 26:677-704; http://dx.doi.org/10.1146/annurev.immunol.26.021607.090331
-
(2008)
Ann Rev Immunol
, vol.26
, pp. 677-704
-
-
Keir, M.E.1
Butte, M.J.2
Freeman, G.J.3
Sharpe, A.H.4
-
5
-
-
5844264920
-
PD-L2 is a second ligand for PD-1 and inhibits T cell activation
-
Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long AJ, Brown JA, Nunes R, et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol 2001 Mar; 2(3):261-8; PMID:11224527; http://dx.doi.org/10.1038/85330
-
(2001)
Nat Immunol
, vol.2
, Issue.3
, pp. 261-268
-
-
Latchman, Y.1
Wood, C.R.2
Chernova, T.3
Chaudhary, D.4
Borde, M.5
Chernova, I.6
Iwai, Y.7
Long, A.J.8
Brown, J.A.9
Nunes, R.10
-
6
-
-
34447646310
-
Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses
-
Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ. Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity 2007 Jul; 27(1):111-22; http://dx.doi.org/10.1016/j.immuni.2007.05.016
-
(2007)
Immunity
, vol.27
, Issue.1
, pp. 111-122
-
-
Butte, M.J.1
Keir, M.E.2
Phamduy, T.B.3
Sharpe, A.H.4
Freeman, G.J.5
-
7
-
-
84899758346
-
RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance
-
Xiao Y, Yu S, Zhu B, Bedoret D, Bu X, Francisco LM, Hua P, Duke-Cohan JS, Umetsu DT, Sharpe AH, et al. RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance. J Exp Med 2014; 211(5):943-59; PMID:24752301; http://dx.doi.org/10.1084/jem.20130790
-
(2014)
J Exp Med
, vol.211
, Issue.5
, pp. 943-959
-
-
Xiao, Y.1
Yu, S.2
Zhu, B.3
Bedoret, D.4
Bu, X.5
Francisco, L.M.6
Hua, P.7
Duke-Cohan, J.S.8
Umetsu, D.T.9
Sharpe, A.H.10
-
8
-
-
21144437398
-
In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses
-
Shin T, Yoshimura K, Shin T, Crafton EB, Tsuchiya H, Housseau F, Koseki H, Schulick RD, Chen L, Pardoll DM. In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses. J Exp Med 2005; 201(10):1531-41; PMID:15897272; http://dx.doi.org/10.1084/jem.20050072
-
(2005)
J Exp Med
, vol.201
, Issue.10
, pp. 1531-1541
-
-
Shin, T.1
Yoshimura, K.2
Shin, T.3
Crafton, E.B.4
Tsuchiya, H.5
Housseau, F.6
Koseki, H.7
Schulick, R.D.8
Chen, L.9
Pardoll, D.M.10
-
9
-
-
33846118474
-
Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma
-
Parsa AT, Waldron JS, Panner A, Crane CA, Parney IF, Barry JJ, Cachola KE, Murray JC, Tihan T, Jensen MC, et al. Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma. Nat Med 2007 13(1):84-8; PMID:17159987; http://dx.doi.org/10.1038/nm1517
-
(2007)
Nat Med
, vol.13
, Issue.1
, pp. 84-88
-
-
Parsa, A.T.1
Waldron, J.S.2
Panner, A.3
Crane, C.A.4
Parney, I.F.5
Barry, J.J.6
Cachola, K.E.7
Murray, J.C.8
Tihan, T.9
Jensen, M.C.10
-
10
-
-
58549102319
-
Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)
-
Marzec M, Zhang Q, Goradia A, Raghunath PN, Liu X, Paessler M, Wang HY, Wysocka M, Cheng M, Ruggeri BA, et al. Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1). Proc Natl Acad Sci U S A 2008; 105(52):20852-7; PMID:19088198; http://dx.doi.org/10.1073/pnas.0810958105
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.52
, pp. 20852-20857
-
-
Marzec, M.1
Zhang, Q.2
Goradia, A.3
Raghunath, P.N.4
Liu, X.5
Paessler, M.6
Wang, H.Y.7
Wysocka, M.8
Cheng, M.9
Ruggeri, B.A.10
-
11
-
-
79952816655
-
MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers
-
Steidl C, Shah SP, Woolcock BW, Rui L, Kawahara M, Farinha P, Johnson NA, Zhao Y, Telenius A, Neriah SB, et al. MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers. Nature 2011; 471(7338):377-81; PMID:21368758; http://dx.doi.org/10.1038/nature09754
-
(2011)
Nature
, vol.471
, Issue.7338
, pp. 377-381
-
-
Steidl, C.1
Shah, S.P.2
Woolcock, B.W.3
Rui, L.4
Kawahara, M.5
Farinha, P.6
Johnson, N.A.7
Zhao, Y.8
Telenius, A.9
Neriah, S.B.10
-
12
-
-
84980590335
-
PD-L1 and PD-L2 genetic alterations define classical hodgkin lymphoma and predict outcome
-
Apr 11
-
Roemer MG, Advani RH, Ligon AH, Natkunam Y, Redd RA, Homer H, Connelly CF, Sun HH, Daadi SE, Freeman GJ, et al. PD-L1 and PD-L2 genetic alterations define classical hodgkin lymphoma and predict outcome. J Clin Oncol 2016 Apr 11
-
(2016)
J Clin Oncol
-
-
Roemer, M.G.1
Advani, R.H.2
Ligon, A.H.3
Natkunam, Y.4
Redd, R.A.5
Homer, H.6
Connelly, C.F.7
Sun, H.H.8
Daadi, S.E.9
Freeman, G.J.10
-
13
-
-
84879866976
-
PD-L1 expression is characteristic of a subset of aggressive B-cell lymphomas and virus-associated malignancies
-
Chen BJ, Chapuy B, Ouyang J, Sun HH, Roemer MG, Xu ML, Yu H, Fletcher CD, Freeman GJ, Shipp MA, et al. PD-L1 expression is characteristic of a subset of aggressive B-cell lymphomas and virus-associated malignancies. Clin Cancer Res 2013; 19(13):3462-73; PMID:23674495; http://dx.doi.org/10.1158/1078-0432.CCR-13-0855
-
(2013)
Clin Cancer Res
, vol.19
, Issue.13
, pp. 3462-3473
-
-
Chen, B.J.1
Chapuy, B.2
Ouyang, J.3
Sun, H.H.4
Roemer, M.G.5
Xu, M.L.6
Yu, H.7
Fletcher, C.D.8
Freeman, G.J.9
Shipp, M.A.10
-
14
-
-
0038273853
-
Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity
-
Curiel TJ, Wei S, Dong H, Alvarez X, Cheng P, Mottram P, Krzysiek R, Knutson KL, Daniel B, Zimmermann MC, et al. Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat Med 2003; 9(5):562-7; PMID:12704383; http://dx.doi.org/10.1038/nm863
-
(2003)
Nat Med
, vol.9
, Issue.5
, pp. 562-567
-
-
Curiel, T.J.1
Wei, S.2
Dong, H.3
Alvarez, X.4
Cheng, P.5
Mottram, P.6
Krzysiek, R.7
Knutson, K.L.8
Daniel, B.9
Zimmermann, M.C.10
-
15
-
-
84922369377
-
The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints
-
Llosa NJ, Cruise M, Tam A, Wicks EC, Hechenbleikner EM, Taube JM, Blosser RL, Fan H, Wang H, Luber BS, et al. The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints. Cancer Discov 2015; 5(1):43-51; PMID:25358689; http://dx.doi.org/10.1158/2159-8290.CD-14-0863
-
(2015)
Cancer Discov
, vol.5
, Issue.1
, pp. 43-51
-
-
Llosa, N.J.1
Cruise, M.2
Tam, A.3
Wicks, E.C.4
Hechenbleikner, E.M.5
Taube, J.M.6
Blosser, R.L.7
Fan, H.8
Wang, H.9
Luber, B.S.10
-
16
-
-
73949088551
-
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
-
Francisco LM, Salinas VH, Brown KE, Vanguri VK, Freeman GJ, Kuchroo VK, Sharpe AH. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med 2009; 206(13):3015-29; PMID:20008522; http://dx.doi.org/10.1084/jem.20090847
-
(2009)
J Exp Med
, vol.206
, Issue.13
, pp. 3015-3029
-
-
Francisco, L.M.1
Salinas, V.H.2
Brown, K.E.3
Vanguri, V.K.4
Freeman, G.J.5
Kuchroo, V.K.6
Sharpe, A.H.7
-
17
-
-
13444270323
-
Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity
-
Hirano F, Kaneko K, Tamura H, Dong H, Wang S, Ichikawa M, Rietz C, Flies DB, Lau JS, Zhu G, et al. Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. Cancer Res 2005; 65(3):1089-96; PMID:15705911
-
(2005)
Cancer Res
, vol.65
, Issue.3
, pp. 1089-1096
-
-
Hirano, F.1
Kaneko, K.2
Tamura, H.3
Dong, H.4
Wang, S.5
Ichikawa, M.6
Rietz, C.7
Flies, D.B.8
Lau, J.S.9
Zhu, G.10
-
18
-
-
43549115533
-
B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells
-
Azuma T, Yao S, Zhu G, Flies AS, Flies SJ, Chen L. B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells. Blood 2008; 111(7):3635-43; PMID:18223165; http://dx.doi.org/10.1182/blood-2007-11-123141
-
(2008)
Blood
, vol.111
, Issue.7
, pp. 3635-3643
-
-
Azuma, T.1
Yao, S.2
Zhu, G.3
Flies, A.S.4
Flies, S.J.5
Chen, L.6
-
19
-
-
32544459770
-
Restoring function in exhausted CD8 T cells during chronic viral infection
-
Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, Sharpe AH, Freeman GJ, Ahmed R. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 2006; 439(7077):682-7; PMID:16382236; http://dx.doi.org/10.1038/nature04444
-
(2006)
Nature
, vol.439
, Issue.7077
, pp. 682-687
-
-
Barber, D.L.1
Wherry, E.J.2
Masopust, D.3
Zhu, B.4
Allison, J.P.5
Sharpe, A.H.6
Freeman, G.J.7
Ahmed, R.8
-
20
-
-
33748947326
-
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
-
Day CL, Kaufmann DE, Kiepiela P, Brown JA, Moodley ES, Reddy S, Mackey EW, Miller JD, Leslie AJ, DePierres C, et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 2006; 443(7109):350-4; PMID:16921384; http://dx.doi.org/10.1038/nature05115
-
(2006)
Nature
, vol.443
, Issue.7109
, pp. 350-354
-
-
Day, C.L.1
Kaufmann, D.E.2
Kiepiela, P.3
Brown, J.A.4
Moodley, E.S.5
Reddy, S.6
Mackey, E.W.7
Miller, J.D.8
Leslie, A.J.9
Depierres, C.10
-
21
-
-
84890192860
-
PD-1 dependent exhaustion of CD8+ T cells drives chronic malaria
-
Horne-Debets JM, Faleiro R, Karunarathne DS, Liu XQ, Lineburg KE, Poh CM, Grotenbreg GM, Hill GR, MacDonald KP, Good MF, et al. PD-1 dependent exhaustion of CD8+ T cells drives chronic malaria. Cell Rep 2013; 5(5):1204-13; PMID:24316071; http://dx.doi.org/10.1016/j.celrep.2013.11.002
-
(2013)
Cell Rep
, vol.5
, Issue.5
, pp. 1204-1213
-
-
Horne-Debets, J.M.1
Faleiro, R.2
Karunarathne, D.S.3
Liu, X.Q.4
Lineburg, K.E.5
Poh, C.M.6
Grotenbreg, G.M.7
Hill, G.R.8
Macdonald, K.P.9
Good, M.F.10
-
22
-
-
18544380239
-
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
-
Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, Roche PC, Lu J, Zhu G, Tamada K, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 2002; 8(8):793-800; PMID:12091876
-
(2002)
Nat Med
, vol.8
, Issue.8
, pp. 793-800
-
-
Dong, H.1
Strome, S.E.2
Salomao, D.R.3
Tamura, H.4
Hirano, F.5
Flies, D.B.6
Roche, P.C.7
Lu, J.8
Zhu, G.9
Tamada, K.10
-
23
-
-
77954899030
-
Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
-
Brahmer JR, Drake CG, Wollner I, Powderly JD, Picus J, Sharfman WH, Stankevich E, Pons A, Salay TM, McMiller TL, et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol 2010; 28(19):3167-75; PMID:20516446; http://dx.doi.org/10.1200/JCO.2009.26.7609
-
(2010)
J Clin Oncol
, vol.28
, Issue.19
, pp. 3167-3175
-
-
Brahmer, J.R.1
Drake, C.G.2
Wollner, I.3
Powderly, J.D.4
Picus, J.5
Sharfman, W.H.6
Stankevich, E.7
Pons, A.8
Salay, T.M.9
McMiller, T.L.10
-
24
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, Powderly JD, Carvajal RD, Sosman JA, Atkins MB, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012; 366(26):2443-54; PMID:22658127; http://dx.doi.org/10.1056/NEJMoa1200690
-
(2012)
N Engl J Med
, vol.366
, Issue.26
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
Gettinger, S.N.4
Smith, D.C.5
McDermott, D.F.6
Powderly, J.D.7
Carvajal, R.D.8
Sosman, J.A.9
Atkins, M.B.10
-
25
-
-
84879777241
-
Nivolumab plus ipilimumab in advanced melanoma
-
Wolchok JD, Kluger H, Callahan MK, Postow MA, Rizvi NA, Lesokhin AM, Segal NH, Ariyan CE, Gordon RA, Reed K, et al. Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med 2013; 369(2):122-33; PMID:23724867; http://dx.doi.org/10.1056/NEJMoa130236
-
(2013)
N Engl J Med
, vol.369
, Issue.2
, pp. 122-133
-
-
Wolchok, J.D.1
Kluger, H.2
Callahan, M.K.3
Postow, M.A.4
Rizvi, N.A.5
Lesokhin, A.M.6
Segal, N.H.7
Ariyan, C.E.8
Gordon, R.A.9
Reed, K.10
-
26
-
-
84892866206
-
Safety, efficacy, and biomarkers of nivolumab with vaccine in ipilimumab-refractory or -naive melanoma
-
Weber JS, Kudchadkar RR, Yu B, Gallenstein D, Horak CE, Inzunza HD, Zhao X, Martinez AJ, Wang W, Gibney G, et al. Safety, efficacy, and biomarkers of nivolumab with vaccine in ipilimumab-refractory or -naive melanoma. J Clin Oncol 2013; 31(34):4311-8; PMID:24145345; http://dx.doi.org/10.1200/JCO.2013.51.4802
-
(2013)
J Clin Oncol
, vol.31
, Issue.34
, pp. 4311-4318
-
-
Weber, J.S.1
Kudchadkar, R.R.2
Yu, B.3
Gallenstein, D.4
Horak, C.E.5
Inzunza, H.D.6
Zhao, X.7
Martinez, A.J.8
Wang, W.9
Gibney, G.10
-
27
-
-
84883863501
-
Up-regulation of PD-L1, IDO, and T(Regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells
-
Spranger S, Spaapen RM, Zha Y, Williams J, Meng Y, Ha TT, Gajewski TF. Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells. Sci Transl Med 2013; 5(200):200ra116; PMID:23986400; http://dx.doi.org/10.1126/scitranslmed.3006504
-
(2013)
Sci Transl Med
, vol.5
, Issue.200
-
-
Spranger, S.1
Spaapen, R.M.2
Zha, Y.3
Williams, J.4
Meng, Y.5
Ha, T.T.6
Gajewski, T.F.7
-
28
-
-
84862903106
-
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
-
Brahmer JRL, Tykodi SS, Chow LQ, Hwu WJ, Topalian SL, Hwu P, Drake CG, Camacho LH, Kauh J, Odunsi K, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 2012; 366(26):2455-65; PMID:22658128; http://dx.doi.org/10.1056/NEJMoa1200694
-
(2012)
N Engl J Med
, vol.366
, Issue.26
, pp. 2455-2465
-
-
Brahmer, J.1
Tykodi, S.S.2
Chow, L.Q.3
Hwu, W.J.4
Topalian, S.L.5
Hwu, P.6
Drake, C.G.7
Camacho, L.H.8
Kauh, J.9
Odunsi, K.10
-
29
-
-
84923078390
-
MPDL3280A (Anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
-
Powles T, Eder JP, Fine GD, Braiteh FS, Loriot Y, Cruz C, Bellmunt J, Burris HA, Petrylak DP, Teng SL, et al. MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer. Nature 2014; 515(7528):558-62; PMID:25428503; http://dx.doi.org/10.1038/nature13904
-
(2014)
Nature
, vol.515
, Issue.7528
, pp. 558-562
-
-
Powles, T.1
Eder, J.P.2
Fine, G.D.3
Braiteh, F.S.4
Loriot, Y.5
Cruz, C.6
Bellmunt, J.7
Burris, H.A.8
Petrylak, D.P.9
Teng, S.L.10
-
30
-
-
84920956735
-
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
-
Herbst RS, Soria JC, Kowanetz M, Fine GD, Hamid O, Gordon MS, Sosman JA, McDermott DF, Powderly JD, Gettinger SN, et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature 2014; 515(7528):563-7; PMID:25428504; http://dx.doi.org/10.1038/nature14011
-
(2014)
Nature
, vol.515
, Issue.7528
, pp. 563-567
-
-
Herbst, R.S.1
Soria, J.C.2
Kowanetz, M.3
Fine, G.D.4
Hamid, O.5
Gordon, M.S.6
Sosman, J.A.7
McDermott, D.F.8
Powderly, J.D.9
Gettinger, S.N.10
-
31
-
-
84963621254
-
Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy
-
Topalian SL, Taube JM, Anders RA, Pardoll DM. Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy. Nat Rev Cancer 2016; 16(5):275-87; PMID:27079802; http://dx.doi.org/10.1038/nrc.2016.36
-
(2016)
Nat Rev Cancer
, vol.16
, Issue.5
, pp. 275-287
-
-
Topalian, S.L.1
Taube, J.M.2
Ers, R.A.3
Pardoll, D.M.4
-
32
-
-
84879759020
-
Safety and tumor responses with lambrolizumab (Anti-PD-1) in melanoma
-
Hamid O, Robert C, Daud A, Hodi FS, Hwu WJ, Kefford R, Wolchok JD, Hersey P, Joseph RW, Weber JS, et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med 2013; 369(2):134-44; PMID:23724846; http://dx.doi.org/10.1056/NEJMoa1305133
-
(2013)
N Engl J Med
, vol.369
, Issue.2
, pp. 134-144
-
-
Hamid, O.1
Robert, C.2
Daud, A.3
Hodi, F.S.4
Hwu, W.J.5
Kefford, R.6
Wolchok, J.D.7
Hersey, P.8
Joseph, R.W.9
Weber, J.S.10
-
33
-
-
85048097318
-
-
Whitehouse Station, NJ: Merck & Co., Inc, January 10
-
Keytruda [prescribing information]. Whitehouse Station, NJ: Merck & Co., Inc. http://www.merck.com/product/usa/pi_circulars/k/keytruda/keytruda_pi.pdf. Accessed January 10, 2016
-
(2016)
-
-
-
34
-
-
84908354848
-
Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: A randomised dose-comparison cohort of a phase 1 trial
-
Sep 20
-
Robert C, Ribas A, Wolchok JD, Hodi FS, Hamid O, Kefford R, Weber JS, Joshua AM, Hwu WJ, Gangadhar TC, et al. Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial. Lancet 2014 Sep 20; 384(9948):1109-17; http://dx.doi.org/10.1016/S0140-6736(14)60958-2
-
(2014)
Lancet
, vol.384
, Issue.9948
, pp. 1109-1117
-
-
Robert, C.1
Ribas, A.2
Wolchok, J.D.3
Hodi, F.S.4
Hamid, O.5
Kefford, R.6
Weber, J.S.7
Joshua, A.M.8
Hwu, W.J.9
Gangadhar, T.C.10
-
36
-
-
74949143594
-
Final version of 2009 AJCC melanoma staging and classification
-
Balch CM, Gershenwald JE, Soong SJ, Thompson JF, Atkins MB, Byrd DR, Buzaid AC, Cochran AJ, Coit DG, Ding S, et al. Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol 2009 Dec 20; 27(36):6199-206; PMID:19917835; http://dx.doi.org/10.1200/JCO.2009.23.4799
-
(2009)
J Clin Oncol
, vol.27
, Issue.36
, pp. 6199-6206
-
-
Balch, C.M.1
Gershenwald, J.E.2
Soong, S.J.3
Thompson, J.F.4
Atkins, M.B.5
Byrd, D.R.6
Buzaid, A.C.7
Cochran, A.J.8
Coit, D.G.9
Ding, S.10
-
37
-
-
84946887722
-
The genetic evolution of melanoma from precursor lesions
-
Shain AH, Yeh I, Kovalyshyn I, Sriharan A, Talevich E, Gagnon A, Dummer R, North J, Pincus L, Ruben B, et al. The genetic evolution of melanoma from precursor lesions. N Engl J Med 2015; 373(20):1926-36; PMID:26559571; http://dx.doi.org/10.1056/NEJMoa1502583
-
(2015)
N Engl J Med
, vol.373
, Issue.20
, pp. 1926-1936
-
-
Shain, A.H.1
Yeh, I.2
Kovalyshyn, I.3
Sriharan, A.4
Talevich, E.5
Gagnon, A.6
Dummer, R.7
North, J.8
Pincus, L.9
Ruben, B.10
-
38
-
-
84908245075
-
Combined vemurafenib and cobimetinib in BRAF-mutated melanoma
-
Larkin J, Ascierto PA, Dréno B, Atkinson V, Liszkay G, Maio M, Mandalà M, Demidov L, Stroyakovskiy D, Thomas L, et al. Combined vemurafenib and cobimetinib in BRAF-mutated melanoma. N Engl J Med 2014; 371(20):1867-76; PMID:25265494; http://dx.doi.org/10.1056/NEJMoa1408868
-
(2014)
N Engl J Med
, vol.371
, Issue.20
, pp. 1867-1876
-
-
Larkin, J.1
Ascierto, P.A.2
Dréno, B.3
Atkinson, V.4
Liszkay, G.5
Maio, M.6
Mandalà, M.7
Demidov, L.8
Stroyakovskiy, D.9
Thomas, L.10
-
39
-
-
84920394727
-
Improved overall survival in melanoma with combined dabrafenib and trametinib
-
Robert C, Karaszewska B, Schachter J, Rutkowski P, Mackiewicz A, Stroiakovski D, Lichinitser M, Dummer R, Grange F, Mortier L, et al. Improved overall survival in melanoma with combined dabrafenib and trametinib. N Engl J Med 2015; 372(1):30-9; PMID:25399551; http://dx.doi.org/10.1056/NEJMoa1412690
-
(2015)
N Engl J Med
, vol.372
, Issue.1
, pp. 30-39
-
-
Robert, C.1
Karaszewska, B.2
Schachter, J.3
Rutkowski, P.4
Mackiewicz, A.5
Stroiakovski, D.6
Lichinitser, M.7
Dummer, R.8
Grange, F.9
Mortier, L.10
-
40
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi FS, O’Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, Gonzalez R, Robert C, Schadendorf D, Hassel JC, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010; 363(8):711-23; PMID:20525992; http://dx.doi.org/10.1056/NEJMoa1003466
-
(2010)
N Engl J Med
, vol.363
, Issue.8
, pp. 711-723
-
-
Hodi, F.S.1
O’Day, S.J.2
McDermott, D.F.3
Weber, R.W.4
Sosman, J.A.5
Haanen, J.B.6
Gonzalez, R.7
Robert, C.8
Schadendorf, D.9
Hassel, J.C.10
-
41
-
-
84879759020
-
Safety and tumor responses with lambrolizumab (Anti-PD-1) in melanoma
-
Hamid O, Robert C, Daud A, Hodi FS, Hwu WJ, Kefford R, Wolchok JD, Hersey P, Joseph RW, Weber JS, et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med 2013; 369(2):134-44; PMID:23724846; http://dx.doi.org/10.1056/NEJMoa1305133
-
(2013)
N Engl J Med
, vol.369
, Issue.2
, pp. 134-144
-
-
Hamid, O.1
Robert, C.2
Daud, A.3
Hodi, F.S.4
Hwu, W.J.5
Kefford, R.6
Wolchok, J.D.7
Hersey, P.8
Joseph, R.W.9
Weber, J.S.10
-
42
-
-
84908354848
-
Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: A randomised dose-comparison cohort of a phase 1 trial
-
Robert C, Ribas A, Wolchok JD, Hodi FS, Hamid O, Kefford R, Weber JS, Joshua AM, Hwu WJ, Gangadhar TC, et al. Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial. Lancet 2014; 384(9948):1109-17; PMID:25034862; http://dx.doi.org/10.1016/S0140-6736(14)60958-2
-
(2014)
Lancet
, vol.384
, Issue.9948
, pp. 1109-1117
-
-
Robert, C.1
Ribas, A.2
Wolchok, J.D.3
Hodi, F.S.4
Hamid, O.5
Kefford, R.6
Weber, J.S.7
Joshua, A.M.8
Hwu, W.J.9
Gangadhar, T.C.10
-
43
-
-
85048090580
-
Efficacy of pembrolizumab (Pembro; MK-3475) in a pooled analysis of 655 patients (pts) with advanced melanoma (MEL) enrolled in KEYNOTE-001
-
Adil D, Antoni R, Caroline R, Hodi FS, Jedd DW, Anthony MJ, Wen-Jen H, Jeffrey SW, Tara CG, Richard WJ, et al. Efficacy of pembrolizumab (pembro; MK-3475) in a pooled analysis of 655 patients (pts) with advanced melanoma (MEL) enrolled in KEYNOTE-001. J Clin Oncol 2015; 33(suppl 15):9005.
-
(2015)
J Clin Oncol
, vol.33
-
-
Adil, D.1
Antoni, R.2
Caroline, R.3
Hodi, F.S.4
Jedd, D.W.5
Anthony, M.J.6
Wen-Jen, H.7
Jeffrey, S.W.8
Tara, C.G.9
Richard, W.J.10
-
44
-
-
84938205998
-
Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): A randomised, controlled, phase 2 trial
-
Ribas A, Puzanov I, Dummer R, Schadendorf D, Hamid O, Robert C, Hodi FS, Schachter J, Pavlick AC, Lewis KD, et al. Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial. Lancet Oncol 2015; 16(8):908-18; PMID:26115796; http://dx.doi.org/10.1016/S1470-2045(15)00083-2
-
(2015)
Lancet Oncol
, vol.16
, Issue.8
, pp. 908-918
-
-
Ribas, A.1
Puzanov, I.2
Dummer, R.3
Schadendorf, D.4
Hamid, O.5
Robert, C.6
Hodi, F.S.7
Schachter, J.8
Pavlick, A.C.9
Lewis, K.D.10
-
45
-
-
84929481481
-
Pembrolizumab versus ipilimumab in advanced melanoma
-
Robert C, Schachter J, Long GV, Arance A, Grob JJ, Mortier L, Daud A, Carlino MS, McNeil C, Lotem M, et al. Pembrolizumab versus ipilimumab in advanced melanoma. N Engl J Med 2015; 372(26):2521-32; PMID:25891173; http://dx.doi.org/10.1056/NEJMoa1503093
-
(2015)
N Engl J Med
, vol.372
, Issue.26
, pp. 2521-2532
-
-
Robert, C.1
Schachter, J.2
Long, G.V.3
Arance, A.4
Grob, J.J.5
Mortier, L.6
Daud, A.7
Carlino, M.S.8
McNeil, C.9
Lotem, M.10
-
46
-
-
73149092567
-
Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria
-
Wolchok JD, Hoos A, O’Day S, Weber JS, Hamid O, Lebbé C, Maio M, Binder M, Bohnsack O, Nichol G, et al. Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin Cancer Res 2009; 15(23):7412-20; PMID:19934295; http://dx.doi.org/10.1158/1078-0432.CCR-09-1624
-
(2009)
Clin Cancer Res
, vol.15
, Issue.23
, pp. 7412-7420
-
-
Wolchok, J.D.1
Hoos, A.2
O’Day, S.3
Weber, J.S.4
Hamid, O.5
Lebbé, C.6
Maio, M.7
Binder, M.8
Bohnsack, O.9
Nichol, G.10
-
47
-
-
84968779639
-
Evaluation of immune-related response criteria and RECIST v1.1 in patients with advanced melanoma treated with pembrolizumab
-
Hodi FS, Hwu WJ, Kefford R, Weber JS, Daud A, Hamid O, Patnaik A, Ribas A, Robert C, Gangadhar TC, et al. Evaluation of immune-related response criteria and RECIST v1.1 in patients with advanced melanoma treated with pembrolizumab. J Clin Oncol 2016; 34:1510-17.
-
(2016)
J Clin Oncol
, vol.34
, pp. 1510-1517
-
-
Hodi, F.S.1
Hwu, W.J.2
Kefford, R.3
Weber, J.S.4
Daud, A.5
Hamid, O.6
Patnaik, A.7
Ribas, A.8
Robert, C.9
Gangadhar, T.C.10
-
48
-
-
84954400636
-
Cancer statistics, 2016
-
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin 2016; 66(1):7-30; PMID:26742998; http://dx.doi.org/10.3322/caac.21332
-
(2016)
CA Cancer J Clin
, vol.66
, Issue.1
, pp. 7-30
-
-
Siegel, R.L.1
Miller, K.D.2
Jemal, A.3
-
49
-
-
84941599354
-
Panel Members. 2nd ESMO Consensus Conference in Lung Cancer: Locally advanced stage III non-small-cell lung cancer
-
Eberhardt WE, De Ruysscher D, Weder W, Le Péchoux C, De Leyn P, Hoffmann H, Westeel V, Stahel R, Felip E, Peters S; Panel Members. 2nd ESMO Consensus Conference in Lung Cancer: locally advanced stage III non-small-cell lung cancer. Ann Oncol 2015; 26(8):1573-88; PMID:25897013; http://dx.doi.org/10.1093/annonc/mdv187
-
(2015)
Ann Oncol
, vol.26
, Issue.8
, pp. 1573-1588
-
-
Eberhardt, W.E.1
De Ruysscher, D.2
Weder, W.3
Le Péchoux, C.4
De Leyn, P.5
Hoffmann, H.6
Westeel, V.7
Stahel, R.8
Felip, E.9
Peters, S.10
-
50
-
-
84924901863
-
Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): A phase 2, single-arm trial
-
Rizvi NA, Mazières J, Planchard D, Stinchcombe TE, Dy GK, Antonia SJ, Horn L, Lena H, Minenza E, Mennecier B, et al. Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial. Lancet Oncol 2015; 16(3):257-6547; PMID:25704439; http://dx.doi.org/10.1016/S1470-2045(15)70054-9
-
(2015)
Lancet Oncol
, vol.16
, Issue.3
, pp. 257-6547
-
-
Rizvi, N.A.1
Mazières, J.2
Planchard, D.3
Stinchcombe, T.E.4
Dy, G.K.5
Antonia, S.J.6
Horn, L.7
Lena, H.8
Minenza, E.9
Mennecier, B.10
-
51
-
-
84936791837
-
Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
-
Brahmer J, Reckamp KL, Baas P, Crinl L, Eberhardt WE, Poddubskaya E, Antonia S, Pluzanski A, Vokes EE, Holgado E, et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N Engl J Med 2015; 373(2):123-35; PMID:26028407; http://dx.doi.org/10.1056/NEJMoa1504627
-
(2015)
N Engl J Med
, vol.373
, Issue.2
, pp. 123-135
-
-
Brahmer, J.1
Reckamp, K.L.2
Baas, P.3
Crinl, L.4
Eberhardt, W.E.5
Poddubskaya, E.6
Antonia, S.7
Pluzanski, A.8
Vokes, E.E.9
Holgado, E.10
-
52
-
-
84929481480
-
Pembrolizumab for the treatment of non-small-cell lung cancer
-
Garon EB, Rizvi NA, Hui R, Leighl N, Balmanoukian AS, Eder JP, Patnaik A, Aggarwal C, Gubens M, Horn L, et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med 2015; 372(21):2018-28; PMID:25891174; http://dx.doi.org/10.1056/NEJMoa1501824
-
(2015)
N Engl J Med
, vol.372
, Issue.21
, pp. 2018-2028
-
-
Garon, E.B.1
Rizvi, N.A.2
Hui, R.3
Leighl, N.4
Balmanoukian, A.S.5
Eder, J.P.6
Patnaik, A.7
Aggarwal, C.8
Gubens, M.9
Horn, L.10
-
53
-
-
84950117835
-
Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): A randomised controlled trial
-
Herbst RS, Baas P, Kim DW, Felip E, Pérez-Gracia JL, Han JY, Molina J, Kim JH, Arvis CD, et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet 2016; 387:1540-50.
-
(2016)
Lancet
, vol.387
, pp. 1540-1550
-
-
Herbst, R.S.1
Baas, P.2
Kim, D.W.3
Felip, E.4
Pérez-Gracia, J.L.5
Han, J.Y.6
Molina, J.7
Kim, J.H.8
Arvis, C.D.9
-
54
-
-
84928761118
-
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
-
Rizvi NA, Hellmann MD, Snyder A, Kvistborg P, Makarov V, Havel JJ, Lee W, Yuan J, et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 2015; 348(6230):124-8; PMID:25765070; http://dx.doi.org/10.1126/science.aaa1348
-
(2015)
Science
, vol.348
, Issue.6230
, pp. 124-128
-
-
Rizvi, N.A.1
Hellmann, M.D.2
Snyder, A.3
Kvistborg, P.4
Makarov, V.5
Havel, J.J.6
Lee, W.7
Yuan, J.8
-
55
-
-
84932628341
-
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
-
Le DT, Uram JN, Wang H, Bartlett BR, Kemberling H, Eyring AD, Skora AD, Luber BS, Azad NS, Laheru D, et al. PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. N Engl J Med 2015; 372(26):2509-20; PMID:26028255; http://dx.doi.org/10.1056/NEJMoa1500596
-
(2015)
N Engl J Med
, vol.372
, Issue.26
, pp. 2509-2520
-
-
Le, D.T.1
Uram, J.N.2
Wang, H.3
Bartlett, B.R.4
Kemberling, H.5
Eyring, A.D.6
Skora, A.D.7
Luber, B.S.8
Azad, N.S.9
Laheru, D.10
-
56
-
-
84976511909
-
PD-1 blockade with pembrolizumab in advanced Merkel-Cell carcinoma
-
Nghiem PT, Bhatia S, Lipson EJ, Kudchadkar RR, Miller NJ, Annamalai L, Berry S, Chartash EK, Daud A, Fling SP, et al. PD-1 blockade with pembrolizumab in advanced Merkel-Cell carcinoma. N Engl J Med 2016; 374:2542-52.
-
(2016)
N Engl J Med
, vol.374
, pp. 2542-2552
-
-
Nghiem, P.T.1
Bhatia, S.2
Lipson, E.J.3
Kudchadkar, R.R.4
Miller, N.J.5
Annamalai, L.6
Berry, S.7
Chartash, E.K.8
Daud, A.9
Fling, S.P.10
-
57
-
-
84905055451
-
The tumour microenvironment in B cell lymphomas
-
Scott DW, Gascoyne RD. The tumour microenvironment in B cell lymphomas. Nat Rev Cancer 2014; 14(8):517-34; PMID:25008267; http://dx.doi.org/10.1038/nrc3774
-
(2014)
Nat Rev Cancer
, vol.14
, Issue.8
, pp. 517-534
-
-
Scott, D.W.1
Gascoyne, R.D.2
-
58
-
-
84951905956
-
Novel immunotherapies in lymphoid malignancies
-
Batlevi CL, Matsuki E, Brentjens RJ, Younes A. Novel immunotherapies in lymphoid malignancies. Nat Rev Clin Oncol 2016; 13(1):25-40; PMID:26525683; http://dx.doi.org/10.1038/nrclinonc.2015.187
-
(2016)
Nat Rev Clin Oncol
, vol.13
, Issue.1
, pp. 25-40
-
-
Batlevi, C.L.1
Matsuki, E.2
Brentjens, R.J.3
Younes, A.4
-
59
-
-
84925221855
-
PD-1 blockade with nivolumab in relapsed or refractory Hodgkin’s lymphoma
-
Ansell SM, Lesokhin AM, Borrello I, Halwani A, Scott EC, Gutierrez M, Schuster SJ, Millenson MM, Cattry D, Freeman GJ, et al. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin’s lymphoma. N Engl J Med 2015; 372(4):311-9; PMID:25482239; http://dx.doi.org/10.1056/NEJMoa1411087
-
(2015)
N Engl J Med
, vol.372
, Issue.4
, pp. 311-319
-
-
Ansell, S.M.1
Lesokhin, A.M.2
Borrello, I.3
Halwani, A.4
Scott, E.C.5
Gutierrez, M.6
Schuster, S.J.7
Millenson, M.M.8
Cattry, D.9
Freeman, G.J.10
-
60
-
-
84969818538
-
PD-1 blockade with pembrolizumab in patients with classical hodgkin lymphoma after brentuximab vedotin failure: Safety, efficacy, and biomarker assessment
-
abstract 584
-
Armand P, Shipp MA, Ribrag V, Michot JM, Zinzani PL, Gutierrez M, Snyder E, Ricart AD, Balakumaran A, Moskowitz CH. PD-1 blockade with pembrolizumab in patients with classical hodgkin lymphoma after brentuximab vedotin failure: safety, efficacy, and biomarker assessment. Blood 2015; abstract 584.
-
(2015)
Blood
-
-
Armand, P.1
Shipp, M.A.2
Ribrag, V.3
Michot, J.M.4
Zinzani, P.L.5
Gutierrez, M.6
Snyder, E.7
Ricart, A.D.8
Balakumaran, A.9
Moskowitz, C.H.10
-
61
-
-
84964704765
-
Phase 1b study of PD-1 blockade with pembrolizumab in patients with relapsed/refractory primary mediastinal large B-cell lymphoma (PMBCL)
-
Abstract 3968
-
Zinzani PL, Ribrag V, Moskowitz CH, Michot JM, Kuruvilla J, Balakumaran A, Snyder E, Marinello P, Shipp MA, Armand P. Phase 1b study of PD-1 blockade with pembrolizumab in patients with relapsed/refractory primary mediastinal large B-cell lymphoma (PMBCL). Blood 2015; Abstract 3968.
-
(2015)
Blood
-
-
Zinzani, P.L.1
Ribrag, V.2
Moskowitz, C.H.3
Michot, J.M.4
Kuruvilla, J.5
Balakumaran, A.6
Snyder, E.7
Marinello, P.8
Shipp, M.A.9
Armand, P.10
-
62
-
-
84982911383
-
Blockade with pembrolizumab (MK-3475) in relapsed/refractory CLL including richter transformation: An early efficacy report from a phase 2 trial (MC1485)
-
abstract 834
-
Ding W, Dong H, Call TG, Shanafelt TD, Parikh SA, Leis JF, Laplant BR, He R, Witzig TE, Lin Y, et al. Blockade with pembrolizumab (MK-3475) in relapsed/refractory CLL including richter transformation: an early efficacy report from a phase 2 trial (MC1485). Blood 2015; abstract 834.
-
(2015)
Blood
-
-
Ding, W.1
Dong, H.2
Call, T.G.3
Shanafelt, T.D.4
Parikh, S.A.5
Leis, J.F.6
Laplant, B.R.7
He, R.8
Witzig, T.E.9
Lin, Y.10
-
63
-
-
84962897493
-
Targeting the PD-1 pathway in patients with relapsed classic Hodgkin lymphoma following allogeneic stem cell transplant is safe and effective
-
Villasboas JC, Ansell SM, Witzig TE. Targeting the PD-1 pathway in patients with relapsed classic Hodgkin lymphoma following allogeneic stem cell transplant is safe and effective. Oncotarget 2016; 7:13260-264.
-
(2016)
Oncotarget
, vol.7
, pp. 13260-13264
-
-
Villasboas, J.C.1
Ansell, S.M.2
Witzig, T.E.3
-
64
-
-
84982141768
-
Low-dose pembrolizumab induced remission in patients with refractory classical Hodgkin lymphoma
-
Kwong YL, Lopes D, Khong PL. Low-dose pembrolizumab induced remission in patients with refractory classical Hodgkin lymphoma. Br J Haematol 2016 Jan 15
-
(2016)
Br J Haematol
-
-
Kwong, Y.L.1
Lopes, D.2
Khong, P.L.3
-
65
-
-
84961912356
-
Safety of pembrolizumab after allogeneic haematopoietic stem cell transplantation
-
Kwong YL. Safety of pembrolizumab after allogeneic haematopoietic stem cell transplantation. Ann Hematol 2016; 95:1191-92.
-
(2016)
Ann Hematol
, vol.95
, pp. 1191-1192
-
-
Kwong, Y.L.1
-
66
-
-
85084273973
-
14PKEYNOTE-012: A phase Ib study of pembrolizumab (MK-3475) in patients (pts) with metastatic triple-negative breast cancer (mTNBC)
-
Buisseret L, Specht J, Dees EC, Berger R, Gupta S, Geva R, Pusztai L, Gause CK, Karantza V, Nanda R. 14PKEYNOTE-012: a phase Ib study of pembrolizumab (MK-3475) in patients (pts) with metastatic triple-negative breast cancer (mTNBC). Ann Oncol 2015; 26(suppl 3):36-36; http://dx.doi.org/10.1093/annonc/mdv115.02
-
(2015)
Ann Oncol
, vol.26
, pp. 36
-
-
Buisseret, L.1
Specht, J.2
Dees, E.C.3
Berger, R.4
Gupta, S.5
Geva, R.6
Pusztai, L.7
Gause, C.K.8
Karantza, V.9
Nanda, R.10
-
67
-
-
84920993558
-
LBA31A phase IB study of pembrolizumab (Pembro; MK-3475) in patients (PTS) with human papilloma virus (HPV)-positive and negative head and neck cancer (HNC)
-
Chow LQ, Burtness B, Weiss J, Berger R, Eder JP, Gonzalez EJ, Pulini J, Johnson J, Dolled-Filhart M, Emancipator K. LBA31A phase IB study of pembrolizumab (Pembro; MK-3475) in patients (PTS) with human papilloma virus (HPV)-positive and negative head and neck cancer (HNC). Ann Oncol 2014; 25(suppl 4): 432-438.
-
(2014)
Ann Oncol
, vol.25
, pp. 432-438
-
-
Chow, L.Q.1
Burtness, B.2
Weiss, J.3
Berger, R.4
Eder, J.P.5
Gonzalez, E.J.6
Pulini, J.7
Johnson, J.8
Dolled-Filhart, M.9
Emancipator, K.10
-
68
-
-
84940606077
-
Antitumor activity and safety of pembrolizumab in patients (Pts) with advanced squamous cell carcinoma of the head and neck (SCCHN): Preliminary results from KEYNOTE-012 expansion cohort. ASCO Annual Meeting, Abstr LBA6008
-
abstract LBA6008
-
Seiwert TY, Haddad RI, Gupta S, Mehra R, Tahara M, Berger R, Lee SH, Burtness B, Le DT, Heath K, et al. Antitumor activity and safety of pembrolizumab in patients (pts) with advanced squamous cell carcinoma of the head and neck (SCCHN): preliminary results from KEYNOTE-012 expansion cohort. ASCO Annual Meeting, Abstr LBA6008. J Clin Oncol 2015; 33(suppl; abstract LBA6008).
-
(2015)
J Clin Oncol
, vol.33
-
-
Seiwert, T.Y.1
Haddad, R.I.2
Gupta, S.3
Mehra, R.4
Tahara, M.5
Berger, R.6
Lee, S.H.7
Burtness, B.8
Le, D.T.9
Heath, K.10
-
69
-
-
84931278393
-
Pembrolizumab (Pembro; MK-3475) for advanced urothelial cancer: Results of a phase IB study
-
abstr 296; PMID:25452452
-
Plimack ER, Bellmunt J, Gupta S, Berger R, Montgomery RB, Heath K, Juco J, Emancipator K, Pathiraja K, Lunceford JK, et al. Pembrolizumab (Pembro; MK-3475) for advanced urothelial cancer: results of a phase IB study. J Clin Oncol 2015; 33(suppl 7): abstr 296; PMID:25452452.
-
(2015)
J Clin Oncol
, vol.33
-
-
Plimack, E.R.1
Bellmunt, J.2
Gupta, S.3
Berger, R.4
Montgomery, R.B.5
Heath, K.6
Juco, J.7
Emancipator, K.8
Pathiraja, K.9
Lunceford, J.K.10
-
70
-
-
84937041504
-
Relationship between PD-L1 expression and clinical outcomes in patients with advanced gastric cancer treated with the anti-PD-1 monoclonal antibody pembrolizumab (MK-3475) in KEYNOTE-012
-
abstr 4001; PMID:26282658
-
Bang YJ, Chung HC, Shankaran V, Geva R, Catenacci DVT, Gupta S, Eder JP, Berger R, Ray A, Dolled-Filhart M, et al. Relationship between PD-L1 expression and clinical outcomes in patients with advanced gastric cancer treated with the anti-PD-1 monoclonal antibody pembrolizumab (MK-3475) in KEYNOTE-012. J Clin Oncol 2015; 33(suppl):abstr 4001; PMID:26282658
-
(2015)
J Clin Oncol
, vol.33
-
-
Bang, Y.J.1
Chung, H.C.2
Shankaran, V.3
Geva, R.4
Catenacci, D.5
Gupta, S.6
Eder, J.P.7
Berger, R.8
Ray, A.9
Dolled-Filhart, M.10
-
71
-
-
84965022830
-
Preliminary efficacy and safety of pembrolizumab (MK-3475) in patients with PD-L1–positive, estrogen receptor-positive (ER+)/HER2-negative advanced breast cancer en-rolled in KEYNOTE-028
-
Rugo H, Delord JP, Im SA, Ott P, Piha-Paul S, Bedard P, Sachdev J, Le Tourneau C, Van Brummelen Varga A, Saraf S, et al. Preliminary efficacy and safety of pembrolizumab (MK-3475) in patients with PD-L1–positive, estrogen receptor-positive (ER+)/HER2-negative advanced breast cancer en-rolled in KEYNOTE-028. Cancer Res 2015; 76:S5-07.
-
(2015)
Cancer Res
, vol.76
, pp. S5-S7
-
-
Rugo, H.1
Delord, J.P.2
Im, S.A.3
Ott, P.4
Piha-Paul, S.5
Bedard, P.6
Sachdev, J.7
Le Tourneau, C.8
Van Brummelen Varga, A.9
Saraf, S.10
-
72
-
-
85008476359
-
Pembrolizumab (MK-3475) for patients (pts) with advanced colorectal carcinoma (CRC): Preliminary results from KEYNOTE-028
-
O’Neil BH, BWallmark J, Lorente D, Elez E, Raimbourg J, Gomez-Roca C, Ejadi S, Piha-Paul SA, Moss RA, Siu LL, et al. Pembrolizumab (MK-3475) for patients (pts) with advanced colorectal carcinoma (CRC): preliminary results from KEYNOTE-028. Eur J Cancer 2015; (51):S103; http://dx.doi.org/10.1016/S0959-8049(16)30304-5
-
(2015)
Eur J Cancer
, Issue.51
-
-
O’Neil, B.H.1
Bwallmark, J.2
Lorente, D.3
Elez, E.4
Raimbourg, J.5
Gomez-Roca, C.6
Ejadi, S.7
Piha-Paul, S.A.8
Moss, R.A.9
Siu, L.L.10
-
73
-
-
84998639474
-
Safety and efficacy of pembrolizumab (MK-3475) in patients (pts) with advanced biliary tract cancer: Interim results of KEYNOTE-028
-
Bang YJ, Doi T, De Braud F, Piha-Paul S, Hollebecque A, Razak ARA, Lin CC, Ott PA, He AR, Saraf S, et al. Safety and efficacy of pembrolizumab (MK-3475) in patients (pts) with advanced biliary tract cancer: interim results of KEYNOTE-028. Eur J Cancer 2015; (51):S112; http://dx.doi.org/10.1016/S0959-8049(16)30326-4
-
(2015)
Eur J Cancer
, Issue.51
-
-
Bang, Y.J.1
Doi, T.2
De Braud, F.3
Piha-Paul, S.4
Hollebecque, A.5
Razak, A.6
Lin, C.C.7
Ott, P.A.8
He, A.R.9
Saraf, S.10
-
74
-
-
84937067786
-
Pembrolizumab (MK-3475) for patients (pts) with advanced esophageal carcinoma: Preliminary results from KEYNOTE-028
-
abstr 4010
-
Doi T, Piha-Paul SA, Jalal SI, Mai-Dang H, Yuan S, Koshiji M, Csiki I, Bennouna J. Pembrolizumab (MK-3475) for patients (pts) with advanced esophageal carcinoma: preliminary results from KEYNOTE-028. J Clin Oncol 2015; 33 (suppl):abstr 4010.
-
(2015)
J Clin Oncol
, vol.33
-
-
Doi, T.1
Piha-Paul, S.A.2
Jalal, S.I.3
Mai-Dang, H.4
Yuan, S.5
Koshiji, M.6
Csiki, I.7
Bennouna, J.8
-
75
-
-
84937119283
-
-
ASCO Annual Meeting, Abstract 7502
-
Ott PA, Fernandez MEE, Hiret S, Kim DW, Moss RA, Winser T, Yuan S, Cheng JD, Piperdi B, Mehnert JM. Pembrolizumab (MK-3475) in patients (pts) with extensive-stage small cell lung cancer (SCLC): preliminary safety and efficacy results from KEYNOTE-028. in ASCO Annual Meeting 2015. Abstract 7502.
-
(2015)
Pembrolizumab (MK-3475) in Patients (Pts) with Extensive-Stage Small Cell Lung Cancer (SCLC): Preliminary Safety and Efficacy Results from KEYNOTE-028.
-
-
Ott, P.A.1
Fernandez, M.2
Hiret, S.3
Kim, D.W.4
Moss, R.A.5
Winser, T.6
Yuan, S.7
Cheng, J.D.8
Piperdi, B.9
Mehnert, J.M.10
-
76
-
-
84975179144
-
Clinical safety and efficacy of pembrolizumab (MK-3475) in patients with malignant pleural mesothelioma: Preliminary results from KEYNOTE-028
-
AACR Annual Meeting. 2015
-
Alley EW, Molife R, Santoro A, Becey K, Yuan S, Cheng J, Piperdi B, Schellens JHM. Clinical safety and efficacy of pembrolizumab (MK-3475) in patients with malignant pleural mesothelioma: preliminary results from KEYNOTE-028. in AACR Annual Meeting. 2015. Cancer Res 2015; 75:CT103; http://dx.doi.org/10.1158/1538-7445.AM2015-CT103
-
(2015)
Cancer Res
, vol.75
-
-
Alley, E.W.1
Molife, R.2
Santoro, A.3
Becey, K.4
Yuan, S.5
Cheng, J.6
Piperdi, B.7
Schellens, J.H.M.8
-
77
-
-
85010686163
-
Pembrolizumab (MK-3475) for PD-L1-positive squamous cell carci-noma (SCC) of the anal canal: Preliminary safety and efficacy results from KEYNOTE-028
-
Ott PA, Piha-Paul SA, Munster P, Pishvaian MJ, Van Brummelen E, Cohen R, Gomez-Roca C, Ejadi S, et al. Pembrolizumab (MK-3475) for PD-L1-positive squamous cell carci-noma (SCC) of the anal canal: preliminary safety and efficacy results from KEYNOTE-028. Eur J Cancer 2015(51):S102; http://dx.doi.org/10.1016/S0959-8049(15)30008-3
-
(2015)
Eur J Cancer
, Issue.51
-
-
Ott, P.A.1
Piha-Paul, S.A.2
Munster, P.3
Pishvaian, M.J.4
Van Brummelen, E.5
Cohen, R.6
Gomez-Roca, C.7
Ejadi, S.8
-
78
-
-
84997695570
-
Antitumor activity and safety of pembrolizumab in patients with PD-L1-positive nasopharyngeal carcinoma: Interim results from a phase 1b study
-
Hsu C, Lee SH, Ejadi S, Even C, Cohen R, Le Tourneau C, Mehnert J, Algazi A, Van Brummelen E, Saraf S, et al. Antitumor activity and safety of pembrolizumab in patients with PD-L1-positive nasopharyngeal carcinoma: interim results from a phase 1b study. Eur J of Cancer 2015; (51):S558; http://dx.doi.org/10.1016/S0959-8049(16)31545-3
-
(2015)
Eur J of Cancer
, Issue.51
-
-
Hsu, C.1
Lee, S.H.2
Ejadi, S.3
Even, C.4
Cohen, R.5
Le Tourneau, C.6
Mehnert, J.7
Algazi, A.8
Van Brummelen, E.9
Saraf, S.10
-
79
-
-
84937721776
-
Antitumor activity and safety of pembrolizumab in patients (Pts) with PD-L1 positive advanced ovarian cancer: Interim results from a phase Ib study
-
abstr 5510
-
Varga A, Piha-Paul SA, Ott PA, Mehnert JM, Berton-Rigaud D, Johnson EA, Cheng JD, Yuan S, Rubin EH, Puhlmann M, et al. Antitumor activity and safety of pembrolizumab in patients (pts) with PD-L1 positive advanced ovarian cancer: interim results from a phase Ib study. J Clin Oncol 2015; 33(suppl; abstr 5510).
-
(2015)
J Clin Oncol
, vol.33
-
-
Varga, A.1
Piha-Paul, S.A.2
Ott, P.A.3
Mehnert, J.M.4
Berton-Rigaud, D.5
Johnson, E.A.6
Cheng, J.D.7
Yuan, S.8
Rubin, E.H.9
Puhlmann, M.10
-
80
-
-
84946226475
-
Acute skin reaction suggestive of pembrolizumab-induced radiosensitization
-
Sibaud V, David I, Lamant L, Resseguier S, Radut R, Attal J, Meyer N, Delord JP. Acute skin reaction suggestive of pembrolizumab-induced radiosensitization. Melanoma Res 2015; 25(6):555-8; PMID:26312439; http://dx.doi.org/10.1097/CMR.0000000000000191
-
(2015)
Melanoma Res
, vol.25
, Issue.6
, pp. 555-558
-
-
Sibaud, V.1
David, I.2
Lamant, L.3
Resseguier, S.4
Radut, R.5
Attal, J.6
Meyer, N.7
Delord, J.P.8
-
81
-
-
84962385750
-
Anti-PD1 pembrolizumab can induce exceptional fulminant Type 1 diabetes
-
Gaudy C, Clévy C, Monestier S, Dubois N, Préau Y, Mallet S, Richard MA, Grob JJ, Valéro R, Béliard S. Anti-PD1 pembrolizumab can induce exceptional fulminant Type 1 diabetes. Diabetes Care 2015; 38(11):e182-3; PMID:26310693; http://dx.doi.org/10.2337/dc15-1331
-
(2015)
Diabetes Care
, vol.38
, Issue.11
, pp. e182-e183
-
-
Gaudy, C.1
Clévy, C.2
Monestier, S.3
Dubois, N.4
Préau, Y.5
Mallet, S.6
Richard, M.A.7
Grob, J.J.8
Valéro, R.9
Béliard, S.10
-
82
-
-
84964573640
-
Management of immune checkpoint blockade dysimmune toxicities: A collaborative position paper
-
Champiat S, Lambotte O, Barreau E, Belkhir R, Berdelou A, Carbonnel F, Cauquil C, Chanson P, Collins M, Durrbach A, et al. Management of immune checkpoint blockade dysimmune toxicities: a collaborative position paper. Ann Oncol 2016; 27(4):559-74; PMID:26715621; http://dx.doi.org/10.1093/annonc/mdv623
-
(2016)
Ann Oncol
, vol.27
, Issue.4
, pp. 559-574
-
-
Champiat, S.1
Lambotte, O.2
Barreau, E.3
Belkhir, R.4
Berdelou, A.5
Carbonnel, F.6
Cauquil, C.7
Chanson, P.8
Collins, M.9
Durrbach, A.10
-
83
-
-
84964389238
-
Neurological, respiratory, musculoskeletal, cardiac and ocular side-effects of anti-PD-1 therapy
-
Zimmer L, Goldinger SM, Hofmann L, Loquai C, Ugurel S, Thomas I, Schmidgen MI, Gutzmer R, Utikal JS, Göppner D, et al. Neurological, respiratory, musculoskeletal, cardiac and ocular side-effects of anti-PD-1 therapy. Eur J Cancer 2016; 60:210-15.
-
(2016)
Eur J Cancer
, vol.60
, pp. 210-215
-
-
Zimmer, L.1
Goldinger, S.M.2
Hofmann, L.3
Loquai, C.4
Ugurel, S.5
Thomas, I.6
Schmidgen, M.I.7
Gutzmer, R.8
Utikal, J.S.9
Göppner, D.10
-
84
-
-
84964345287
-
Cutaneous, gastrointestinal, hepatic, endocrine, and renal side-effects of anti-PD-1 therapy
-
Hofmann L, Forschner A, Loquai C, Goldinger SM, Zimmer L, Ugurel S, Schmidgen MI, Gutzmer R, Utikal JS, Göppner D, et al. Cutaneous, gastrointestinal, hepatic, endocrine, and renal side-effects of anti-PD-1 therapy. Eur J Cancer 2016; 60:190-209.
-
(2016)
Eur J Cancer
, vol.60
, pp. 190-209
-
-
Hofmann, L.1
Forschner, A.2
Loquai, C.3
Goldinger, S.M.4
Zimmer, L.5
Ugurel, S.6
Schmidgen, M.I.7
Gutzmer, R.8
Utikal, J.S.9
Göppner, D.10
|