HIC1 (hypermethylated in cancer 1) SUMOylation is dispensable for DNA repair but is essential for the apoptotic DNA damage response (DDR) to irreparable DNA double-strand breaks (DSBs)

Oncotarget

Volumn 8, Issue 2, 2017, Pages 2916-2935

  Paget, Sonia ^a   Dubuissez, Marion ^a,c   Dehennaut, Vanessa ^a   Nassour, Joe ^a,d   Harmon, Brennan T ^b   Spruyt, Nathalie ^a   Loison, Ingrid ^a   Abbadie, Corinne ^a   Rood, Brian R ^b   Leprince, Dominique ^a  

^a UNIV LILLE   (France)

^b CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^c UNIVERSITY OF MONTREAL   (Canada)

^d SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

ATM; DNA damage response; HIC1; MTA1, SUMOylation

Indexed keywords

CHECKPOINT KINASE 2; EPHRIN RECEPTOR A4; ETOPOSIDE; MTA1 PROTEIN; MTA3 PROTEIN; ONCOPROTEIN; SIRTUIN 1; STROMAL CELL DERIVED FACTOR 1; TELOMERASE REVERSE TRANSCRIPTASE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 3; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; ATM PROTEIN; HIC1 PROTEIN, HUMAN; HISTONE DEACETYLASE; KRUPPEL LIKE FACTOR; MTA1 PROTEIN, HUMAN; PROTEIN BINDING; PROTEIN P53; REPRESSOR PROTEIN; SIRT1 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ARTICLE; COMET ASSAY; CONTROLLED STUDY; CXCL12 GENE; DNA DAMAGE RESPONSE; DNA REPAIR; DOUBLE STRANDED DNA BREAK; EPHA4 GENE; FIBROBLAST; GENE INTERACTION; GENE REPRESSION; GENE TARGETING; HIC1 GENE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN MOTIF; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUMOYLATION; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 3 GENE; TRIB2 GENE; TUMOR SUPPRESSOR GENE; APOPTOSIS; GENETICS; HUMAN; METABOLISM; MOLECULAR MODEL; NEOPLASM; PROMOTER REGION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; ATAXIA TELANGIECTASIA MUTATED PROTEINS; CELL LINE, TUMOR; CHECKPOINT KINASE 2; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; ETOPOSIDE; HISTONE DEACETYLASES; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MODELS, MOLECULAR; NEOPLASMS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; REPRESSOR PROTEINS; SIRTUIN 1; SUMOYLATION; TRANS-ACTIVATORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 85009727655     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.13807     Document Type: Article

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