A supramolecular assembly mediates lentiviral DNA integration

Science

Volumn 355, Issue 6320, 2017, Pages 93-95

  Ballandras Colas, Allison ^a   Maskell, Daniel P ^a,g   Serrao, Erik ^b,c   Locke, Julia ^a   Swuec, Paolo ^a   Jónsson, Stefán R ^d   Kotecha, Abhay ^e   Cook, Nicola J ^a   Pye, Valerie E ^a   Taylor, Ian A ^a   Andrésdóttir, Valgerdur ^d   Engelman, Alan N ^b,c   Costa, Alessandro ^a   Cherepanov, Peter ^a,f  

^a THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF ICELAND   (Iceland)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f IMPERIAL COLLEGE LONDON   (United Kingdom)

^g UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; INTASOME; INTEGRASE; LENS EPITHELIUM DERIVED GROWTH FACTOR; LENTIVIRUS VECTOR; NUCLEOPROTEIN; POLYMER; TETRAMER; UNCLASSIFIED DRUG; VIRUS DNA; INTEGRASE INHIBITOR; P31 INTEGRASE PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1;

BIOCHEMISTRY; CATALYSIS; CELLS AND CELL COMPONENTS; DNA; GENETIC ANALYSIS; INHIBITOR; MOLECULAR ANALYSIS; PROTEIN;

ALPHA HELIX; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHROMATIN; CRYOELECTRON MICROSCOPY; DNA INTEGRATION; DNA SEQUENCE; ENZYME ACTIVE SITE; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; SUPRAMOLECULAR CHEMISTRY; SYNAPSE; VISNA VIRUS; CHEMISTRY; DRUG DESIGN; ENZYMOLOGY; HUMAN; MOLECULAR MODEL; PROTEIN DOMAIN; STATIC ELECTRICITY; ULTRASTRUCTURE; VIRUS ASSEMBLY; VIRUS DNA CELL DNA INTERACTION;

HUMAN IMMUNODEFICIENCY VIRUS 1; VISNA/MAEDI VIRUS;

CATALYTIC DOMAIN; CRYOELECTRON MICROSCOPY; DNA, VIRAL; DRUG DESIGN; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; MODELS, MOLECULAR; PROTEIN DOMAINS; STATIC ELECTRICITY; VIRUS ASSEMBLY; VIRUS INTEGRATION;

EID: 85009251300     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aah7002     Document Type: Article

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