Expression site of P2RY12 in residential microglial cells in astrocytomas correlates with M1 and M2 marker expression and tumor grade

Acta Neuropathologica Communications

Volumn 5, Issue 1, 2017, Pages

  Zhu, Changbin ^a   Kros, Johan M ^a   van der Weiden, Marcel ^a   Zheng, Ping Pin ^a   Cheng, Caroline ^a,b   Mustafa, Dana A M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Glioblastoma; Glioma; Immunohistochemical markers; Microglia; TAM

Indexed keywords

CD68 ANTIGEN, HUMAN; DIFFERENTIATION ANTIGEN; LEUKOCYTE ANTIGEN; MESSENGER RNA; TUMOR MARKER;

ADULT; ASTROCYTOMA; BRAIN; BRAIN NEOPLASMS; CANCER GRADING; CELL NUCLEUS; CONFOCAL MICROSCOPY; CYTOPLASM; FACTUAL DATABASE; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; MICROGLIA; MIDDLE AGED; PATHOLOGY; SEQUENCE ANALYSIS; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

ADULT; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; ASTROCYTOMA; BIOMARKERS, TUMOR; BRAIN; BRAIN NEOPLASMS; CELL NUCLEUS; CYTOPLASM; DATABASES, FACTUAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; MICROSCOPY, CONFOCAL; MIDDLE AGED; NEOPLASM GRADING; RNA, MESSENGER; SEQUENCE ANALYSIS, RNA; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 85008613675     PISSN: None     EISSN: 20515960     Source Type: Journal    
DOI: 10.1186/s40478-016-0405-5     Document Type: Article

References (40)

1. Bennett ML, Bennett FC, Liddelow SA, Ajami B, Zamanian JL, Fernhoff NB et al (2016) New tools for studying microglia in the mouse and human CNS. Proc Natl Acad Sci U S A 113(12):E1738-E1746
2. Block ML, Zecca L, Hong JS (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 8(1):57-69
3. Bowman RL, Klemm F, Akkari L, Pyonteck SM, Sevenich L, Quail DF et al (2016) Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies. Cell Rep 17(9):2445-2459
4. Brennan CW, Verhaak RG, McKenna A, Campos B, Noushmehr H, Salama SR et al (2013) The somatic genomic landscape of glioblastoma. Cell 155(2):462-477
5. Butovsky O, Jedrychowski MP, Moore CS, Cialic R, Lanser AJ, Gabriely G et al (2014) Identification of a unique TGF-beta-dependent molecular and functional signature in microglia. Nat Neurosci 17(1):131-143
6. Butowski N, Colman H, De Groot JF, Omuro AM, Nayak L, Wen PY, et al. Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study. Neuro-Oncology. 2015;18:557-64.
7. Cattaneo M (2015) P2Y12 receptors: structure and function. J Thromb Haemost 13(Suppl 1):S10-S16
8. Ciriello G, Cerami E, Sander C, Schultz N (2012) Mutual exclusivity analysis identifies oncogenic network modules. Genome Res 22(2):398-406
9. Gao JJ, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO et al (2013) Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal 6(269):pl1
10. Hambardzumyan D, Gutmann DH, Kettenmann H (2016) The role of microglia and macrophages in glioma maintenance and progression. Nat Neurosci 19(1):20-27
11. Hanisch UK (2002) Microglia as a source and target of cytokines. Glia 40(2):140-155
12. Haynes SE, Hollopeter G, Yang G, Kurpius D, Dailey ME, Gan WB et al (2006) The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nat Neurosci 9(12):1512-1519
13. Jay TR, Miller CM, Cheng PJ, Graham LC, Bemiller S, Broihier ML et al (2015) TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models. J Exp Med 212(3):287-295
14. Kierdorf K, Erny D, Goldmann T, Sander V, Schulz C, Perdiguero EG et al (2013) Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways. Nat Neurosci 16(3):273-280
15. Kierdorf K, Prinz M (2013) Factors regulating microglia activation. Front Cell Neurosci 7:44
16. Koizumi S, Ohsawa K, Inoue K, Kohsaka S (2013) Purinergic receptors in microglia: Functional modal shifts of microglia mediated by P2 and P1 receptors. Glia 61(1):47-54
17. Komohara Y, Ohnishi K, Kuratsu J, Takeya M (2008) Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas. J Pathol 216(1):15-24
18. Lalancette-Hebert M, Gowing G, Simard A, Weng YC, Kriz J (2007) Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain. J Neurosci 27(10):2596-2605
19. Lavin Y, Mortha A, Rahman A, Merad M (2015) Regulation of macrophage development and function in peripheral tissues. Nat Rev Immunol 15(12):731-744
20. Lecchi A, Razzari C, Paoletta S, Dupuis A, Nakamura L, Ohlmann P et al (2015) Identification of a new dysfunctional platelet P2Y12 receptor variant associated with bleeding diathesis. Blood 125(6):1006-1013
21. Lee DK, Lanca AJ, Cheng R, Nguyen T, Ji XD, Gobeil F Jr et al (2004) Agonist-independent nuclear localization of the Apelin, angiotensin AT1, and bradykinin B2 receptors. J Biol Chem 279(9):7901-7908
22. Li W, Graeber MB (2012) The molecular profile of microglia under the influence of glioma. Neuro Oncol 14(8):958-978
23. Lou N, Takano T, Pei Y, Xavier AL, Goldman SA, Nedergaard M (2016) Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier. Proc Natl Acad Sci U S A 113(4):1074-1079
24. Markovic DS, Glass R, Synowitz M, Rooijen N, Kettenmann H (2005) Microglia stimulate the invasiveness of glioma cells by increasing the activity of metalloprotease-2. J Neuropathol Exp Neurol 64(9):754-762
25. Martinez FO, Gordon S (2014) The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000Prime Rep 6:13
26. Nayak D, Roth TL, McGavern DB (2014) Microglia development and function. Annu Rev Immunol 32:367-402
27. Neumann J, Gunzer M, Gutzeit HO, Ullrich O, Reymann KG, Dinkel K (2006) Microglia provide neuroprotection after ischemia. FASEB J 20(6):714-716
28. Noy R, Pollard JW (2014) Tumor-associated macrophages: from mechanisms to therapy. Immunity 41(1):49-61
29. Ohsawa K, Irino Y, Sanagi T, Nakamura Y, Suzuki E, Inoue K et al (2010) P2Y12 receptor-mediated integrin-beta1 activation regulates microglial process extension induced by ATP. Glia 58(7):790-801
30. Orr AG, Orr AL, Li XJ, Gross RE, Traynelis SF (2009) Adenosine A(2A) receptor mediates microglial process retraction. Nat Neurosci 12(7):872-878
31. Ostuni R, Kratochvill F, Murray PJ, Natoli G (2015) Macrophages and cancer: from mechanisms to therapeutic implications. Trends Immunol 36(4):229-239
32. Parkhurst CN, Gan WB (2010) Microglia dynamics and function in the CNS. Curr Opin Neurobiol 20(5):595-600
33. Prosniak M, Harshyne LA, Andrews DW, Kenyon LC, Bedelbaeva K, Apanasovich TV et al (2013) Glioma grade is associated with the accumulation and activity of cells bearing M2 monocyte markers. Clin Cancer Res 19(14):3776-3786
34. Sasaki Y, Hoshi M, Akazawa C, Nakamura Y, Tsuzuki H, Inoue K et al (2003) Selective expression of Gi/o-coupled ATP receptor P2Y12 in microglia in rat brain. Glia 44(3):242-250
35. Sliwa M, Markovic D, Gabrusiewicz K, Synowitz M, Glass R, Zawadzka M et al (2007) The invasion promoting effect of microglia on glioblastoma cells is inhibited by cyclosporin A. Brain 130:476-489
36. Szulzewsky F, Arora S, de Witte L, Ulas T, Markovic D, Schultze JL et al (2016) Human glioblastoma-associated microglia/monocytes express a distinct RNA profile compared to human control and murine samples. Glia 64(8):1416-1436
37. Tremblay ME, Stevens B, Sierra A, Wake H, Bessis A, Nimmerjahn A (2011) The role of microglia in the healthy brain. J Neurosci 31(45):16064-16069
38. Watters JJ, Schartner JM, Badie B (2005) Microglia function in brain tumors. J Neurosci Res 81(3):447-455
39. Zhang M, He Y, Sun X, Li Q, Wang W, Zhao A et al (2014) A high M1/M2 ratio of tumor-associated macrophages is associated with extended survival in ovarian cancer patients. J Ovarian Res 7:19
40. Zheng PP, van der Weiden M, Kros JM (2014) Fast tracking of co-localization of multiple markers by using the nanozoomer slide scanner and NDPViewer. J Cell Physiol 229(8):967-973