메뉴 건너뛰기




Volumn 113, Issue 4, 2016, Pages 1074-1079

Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier

Author keywords

Blood brain barrier; Clopidogrel; Microglia; Purinergic receptors; Stroke

Indexed keywords

CLOPIDOGREL; PURINERGIC P2Y12 RECEPTOR; ANTITHROMBOCYTIC AGENT; P2RY12 PROTEIN, MOUSE; TICLOPIDINE;

EID: 84955563702     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1520398113     Document Type: Article
Times cited : (232)

References (55)
  • 1
    • 84872168596 scopus 로고    scopus 로고
    • Microglia: Scapegoat, saboteur, or something else?
    • Aguzzi A, Barres BA, Bennett ML (2013) Microglia: Scapegoat, saboteur, or something else? Science 339(6116): 156-161.
    • (2013) Science , vol.339 , Issue.6116 , pp. 156-161
    • Aguzzi, A.1    Barres, B.A.2    Bennett, M.L.3
  • 2
    • 1942447829 scopus 로고    scopus 로고
    • Microglia promote the death of developing Purkinje cells
    • Marín-Teva JL, et al. (2004) Microglia promote the death of developing Purkinje cells. Neuron 41(4): 535-547.
    • (2004) Neuron , vol.41 , Issue.4 , pp. 535-547
    • Marín-Teva, J.L.1
  • 3
    • 80052633284 scopus 로고    scopus 로고
    • Synaptic pruning by microglia is necessary for normal brain development
    • Paolicelli RC, et al. (2011) Synaptic pruning by microglia is necessary for normal brain development. Science 333(6048): 1456-1458.
    • (2011) Science , vol.333 , Issue.6048 , pp. 1456-1458
    • Paolicelli, R.C.1
  • 4
    • 84861427387 scopus 로고    scopus 로고
    • Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner
    • Schafer DP, et al. (2012) Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron 74(4): 691-705.
    • (2012) Neuron , vol.74 , Issue.4 , pp. 691-705
    • Schafer, D.P.1
  • 5
    • 78649976052 scopus 로고    scopus 로고
    • Microglial interactions with synapses are modulated by visual experience
    • Tremblay ME, Lowery RL, Majewska AK (2010) Microglial interactions with synapses are modulated by visual experience. PLoS Biol 8(11): E1000527.
    • (2010) PLoS Biol , vol.8 , Issue.11 , pp. e1000527
    • Tremblay, M.E.1    Lowery, R.L.2    Majewska, A.K.3
  • 6
    • 84876939061 scopus 로고    scopus 로고
    • Layer V cortical neurons require microglial support for survival during postnatal development
    • Ueno M, et al. (2013) Layer V cortical neurons require microglial support for survival during postnatal development. Nat Neurosci 16(5): 543-551.
    • (2013) Nat Neurosci , vol.16 , Issue.5 , pp. 543-551
    • Ueno, M.1
  • 7
    • 84883454794 scopus 로고    scopus 로고
    • M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
    • Miron VE, et al. (2013) M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination. Nat Neurosci 16(9): 1211-1218.
    • (2013) Nat Neurosci , vol.16 , Issue.9 , pp. 1211-1218
    • Miron, V.E.1
  • 8
    • 84866103622 scopus 로고    scopus 로고
    • Neurodegenerative disease: Microglia in early disease stages
    • Kingwell K (2012) Neurodegenerative disease: Microglia in early disease stages. Nat Rev Neurol 8(9): 475.
    • (2012) Nat Rev Neurol , vol.8 , Issue.9 , pp. 475
    • Kingwell, K.1
  • 9
    • 77950858637 scopus 로고    scopus 로고
    • Microglia in neurodegenerative disease
    • Perry VH, Nicoll JA, Holmes C (2010) Microglia in neurodegenerative disease. Nat Rev Neurol 6(4): 193-201.
    • (2010) Nat Rev Neurol , vol.6 , Issue.4 , pp. 193-201
    • Perry, V.H.1    Nicoll, J.A.2    Holmes, C.3
  • 10
    • 0033199996 scopus 로고    scopus 로고
    • Pathobiology of ischaemic stroke: An integrated view
    • Dirnagl U, Iadecola C, Moskowitz MA (1999) Pathobiology of ischaemic stroke: An integrated view. Trends Neurosci 22(9): 391-397.
    • (1999) Trends Neurosci , vol.22 , Issue.9 , pp. 391-397
    • Dirnagl, U.1    Iadecola, C.2    Moskowitz, M.A.3
  • 11
    • 84984763363 scopus 로고    scopus 로고
    • Mechanisms, challenges and opportunities in stroke
    • Lo EH, Dalkara T, Moskowitz MA (2003) Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci 4(5): 399-415.
    • (2003) Nat Rev Neurosci , vol.4 , Issue.5 , pp. 399-415
    • Lo, E.H.1    Dalkara, T.2    Moskowitz, M.A.3
  • 12
    • 20044369978 scopus 로고    scopus 로고
    • Does drug abuse alter microglial phenotype and cell turnover in the context of advancing HIV infection?
    • Anthony IC, Ramage SN, Carnie FW, Simmonds P, Bell JE (2005) Does drug abuse alter microglial phenotype and cell turnover in the context of advancing HIV infection? Neuropathol Appl Neurobiol 31(3): 325-338.
    • (2005) Neuropathol Appl Neurobiol , vol.31 , Issue.3 , pp. 325-338
    • Anthony, I.C.1    Ramage, S.N.2    Carnie, F.W.3    Simmonds, P.4    Bell, J.E.5
  • 13
    • 84892369064 scopus 로고    scopus 로고
    • Transcranial amelioration of inflammation and cell death after brain injury
    • Roth TL, et al. (2014) Transcranial amelioration of inflammation and cell death after brain injury. Nature 505(7482): 223-228.
    • (2014) Nature , vol.505 , Issue.7482 , pp. 223-228
    • Roth, T.L.1
  • 14
    • 0035843178 scopus 로고    scopus 로고
    • Identification of the platelet ADP receptor targeted by antithrombotic drugs
    • Hollopeter G, et al. (2001) Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature 409(6817): 202-207.
    • (2001) Nature , vol.409 , Issue.6817 , pp. 202-207
    • Hollopeter, G.1
  • 15
    • 0344013132 scopus 로고    scopus 로고
    • Selective expression of Gi/o-coupled ATP receptor P2Y12 in microglia in rat brain
    • Sasaki Y, et al. (2003) Selective expression of Gi/o-coupled ATP receptor P2Y12 in microglia in rat brain. Glia 44(3): 242-250.
    • (2003) Glia , vol.44 , Issue.3 , pp. 242-250
    • Sasaki, Y.1
  • 17
    • 22244464662 scopus 로고    scopus 로고
    • ATP mediates rapid microglial response to local brain injury in vivo
    • Davalos D, et al. (2005) ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci 8(6): 752-758.
    • (2005) Nat Neurosci , vol.8 , Issue.6 , pp. 752-758
    • Davalos, D.1
  • 18
    • 33845259342 scopus 로고    scopus 로고
    • The P2Y12 receptor regulates microglial activation by extracellular nucleotides
    • Haynes SE, et al. (2006) The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nat Neurosci 9(12): 1512-1519.
    • (2006) Nat Neurosci , vol.9 , Issue.12 , pp. 1512-1519
    • Haynes, S.E.1
  • 19
    • 78149435065 scopus 로고    scopus 로고
    • The myeloid cells of the central nervous system parenchyma
    • Ransohoff RM, Cardona AE (2010) The myeloid cells of the central nervous system parenchyma. Nature 468(7321): 253-262.
    • (2010) Nature , vol.468 , Issue.7321 , pp. 253-262
    • Ransohoff, R.M.1    Cardona, A.E.2
  • 20
    • 0034978187 scopus 로고    scopus 로고
    • Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs
    • Foster CJ, et al. (2001) Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs. J Clin Invest 107(12): 1591-1598.
    • (2001) J Clin Invest , vol.107 , Issue.12 , pp. 1591-1598
    • Foster, C.J.1
  • 21
    • 57049165937 scopus 로고    scopus 로고
    • Platelet ADP-receptor antagonists for cardiovascular disease: Past, present and future
    • Raju NC, Eikelboom JW, Hirsh J (2008) Platelet ADP-receptor antagonists for cardiovascular disease: Past, present and future. Nat Clin Pract Cardiovasc Med 5(12): 766-780.
    • (2008) Nat Clin Pract Cardiovasc Med , vol.5 , Issue.12 , pp. 766-780
    • Raju, N.C.1    Eikelboom, J.W.2    Hirsh, J.3
  • 22
    • 0034805389 scopus 로고    scopus 로고
    • P2y(12), a new platelet ADP receptor, target of clopidogrel
    • Savi P, et al. (2001) P2y(12), a new platelet ADP receptor, target of clopidogrel. Biochem Biophys Res Commun 283(2): 379-383.
    • (2001) Biochem Biophys Res Commun , vol.283 , Issue.2 , pp. 379-383
    • Savi, P.1
  • 23
    • 51449085994 scopus 로고    scopus 로고
    • Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: A double-blind, active and placebo-controlled study
    • Diener HC, et al.; Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) study group (2008) Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: A double-blind, active and placebo-controlled study. Lancet Neurol 7(10): 875-884.
    • (2008) Lancet Neurol , vol.7 , Issue.10 , pp. 875-884
    • Diener, H.C.1
  • 24
    • 18644372477 scopus 로고    scopus 로고
    • Structure and stereochemistry of the active metabolite of clopidogrel
    • Pereillo JM, et al. (2002) Structure and stereochemistry of the active metabolite of clopidogrel. Drug Metab Dispos 30(11): 1288-1295.
    • (2002) Drug Metab Dispos , vol.30 , Issue.11 , pp. 1288-1295
    • Pereillo, J.M.1
  • 25
    • 0141954237 scopus 로고    scopus 로고
    • Managing PAD with multiple platelet inhibitors: The effect of combination therapy on bleeding time
    • Wilhite DB, et al. (2003) Managing PAD with multiple platelet inhibitors: The effect of combination therapy on bleeding time. J Vasc Surg 38(4): 710-713.
    • (2003) J Vasc Surg , vol.38 , Issue.4 , pp. 710-713
    • Wilhite, D.B.1
  • 26
    • 0030457556 scopus 로고    scopus 로고
    • Platelet anti-aggregating activity and tolerance of clopidogrel in atherosclerotic patients
    • Boneu B, Destelle G (1996) Platelet anti-aggregating activity and tolerance of clopidogrel in atherosclerotic patients. Thromb Haemost 76(6): 939-943.
    • (1996) Thromb Haemost , vol.76 , Issue.6 , pp. 939-943
    • Boneu, B.1    Destelle, G.2
  • 27
    • 85047694005 scopus 로고    scopus 로고
    • P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries
    • Andre P, et al. (2003) P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries. J Clin Invest 112(3): 398-406.
    • (2003) J Clin Invest , vol.112 , Issue.3 , pp. 398-406
    • Andre, P.1
  • 28
    • 85047693299 scopus 로고    scopus 로고
    • Central role of the P2Y12 receptor in platelet activation
    • Dorsam RT, Kunapuli SP (2004) Central role of the P2Y12 receptor in platelet activation. J Clin Invest 113(3): 340-345.
    • (2004) J Clin Invest , vol.113 , Issue.3 , pp. 340-345
    • Dorsam, R.T.1    Kunapuli, S.P.2
  • 29
    • 51649086103 scopus 로고    scopus 로고
    • In vivo manipulation of fluorescently labeled organelles in living cells by multiphoton excitation
    • Watanabe W, Matsunaga S, Higashi T, Fukui K, Itoh K (2008) In vivo manipulation of fluorescently labeled organelles in living cells by multiphoton excitation. J Biomed Opt 13(3): 031213.
    • (2008) J Biomed Opt , vol.13 , Issue.3 , pp. 031213
    • Watanabe, W.1    Matsunaga, S.2    Higashi, T.3    Fukui, K.4    Itoh, K.5
  • 30
    • 33646190295 scopus 로고    scopus 로고
    • The role of the AFD neuron in C. elegans thermotaxis analyzed using femtosecond laser ablation
    • Chung SH, Clark DA, Gabel CV, Mazur E, Samuel AD (2006) The role of the AFD neuron in C. elegans thermotaxis analyzed using femtosecond laser ablation. BMC Neurosci 7: 30.
    • (2006) BMC Neurosci , vol.7 , pp. 30
    • Chung, S.H.1    Clark, D.A.2    Gabel, C.V.3    Mazur, E.4    Samuel, A.D.5
  • 31
    • 84896371671 scopus 로고    scopus 로고
    • A cortical circuit for gain control by behavioral state
    • Fu Y, et al. (2014) A cortical circuit for gain control by behavioral state. Cell 156(6): 1139-1152.
    • (2014) Cell , vol.156 , Issue.6 , pp. 1139-1152
    • Fu, Y.1
  • 32
    • 0025726216 scopus 로고
    • A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
    • Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C (1991) A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 139(2): 271-279.
    • (1991) J Immunol Methods , vol.139 , Issue.2 , pp. 271-279
    • Nicoletti, I.1    Migliorati, G.2    Pagliacci, M.C.3    Grignani, F.4    Riccardi, C.5
  • 33
    • 78649487239 scopus 로고    scopus 로고
    • Pericytes are required for bloodbrain barrier integrity during embryogenesis
    • Daneman R, Zhou L, Kebede AA, Barres BA (2010) Pericytes are required for bloodbrain barrier integrity during embryogenesis. Nature 468(7323): 562-566.
    • (2010) Nature , vol.468 , Issue.7323 , pp. 562-566
    • Daneman, R.1    Zhou, L.2    Kebede, A.A.3    Barres, B.A.4
  • 34
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurodegenerative disorders
    • Zlokovic BV (2008) The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 57(2): 178-201.
    • (2008) Neuron , vol.57 , Issue.2 , pp. 178-201
    • Zlokovic, B.V.1
  • 35
    • 0037199938 scopus 로고    scopus 로고
    • Characterization and channel coupling of the P2Y(12) nucleotide receptor of brain capillary endothelial cells
    • Simon J, et al. (2002) Characterization and channel coupling of the P2Y(12) nucleotide receptor of brain capillary endothelial cells. J Biol Chem 277(35): 31390-31400.
    • (2002) J Biol Chem , vol.277 , Issue.35 , pp. 31390-31400
    • Simon, J.1
  • 36
    • 5344257562 scopus 로고    scopus 로고
    • ADP receptor P2Y12 is expressed in vascular smooth muscle cells and stimulates contraction in human blood vessels
    • Wihlborg AK, et al. (2004) ADP receptor P2Y12 is expressed in vascular smooth muscle cells and stimulates contraction in human blood vessels. Arterioscler Thromb Vasc Biol 24(10): 1810-1815.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , Issue.10 , pp. 1810-1815
    • Wihlborg, A.K.1
  • 37
    • 33846807837 scopus 로고    scopus 로고
    • Mitochondrial localization of P2Y1, P2Y2 and P2Y12 receptors in rat astrocytes and glioma C6 cells
    • Krzeminski P, Misiewicz I, Pomorski P, Kasprzycka-Guttman T, Baranska J (2007) Mitochondrial localization of P2Y1, P2Y2 and P2Y12 receptors in rat astrocytes and glioma C6 cells. Brain Res Bull 71(6): 587-592.
    • (2007) Brain Res Bull , vol.71 , Issue.6 , pp. 587-592
    • Krzeminski, P.1    Misiewicz, I.2    Pomorski, P.3    Kasprzycka-Guttman, T.4    Baranska, J.5
  • 38
    • 84906901689 scopus 로고    scopus 로고
    • An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex
    • Zhang Y, et al. (2014) An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J Neurosci 34(36): 11929-11947.
    • (2014) J Neurosci , vol.34 , Issue.36 , pp. 11929-11947
    • Zhang, Y.1
  • 39
    • 0037899612 scopus 로고    scopus 로고
    • Pharmacological characterization of the human P2Y13 receptor
    • Marteau F, et al. (2003) Pharmacological characterization of the human P2Y13 receptor. Mol Pharmacol 64(1): 104-112.
    • (2003) Mol Pharmacol , vol.64 , Issue.1 , pp. 104-112
    • Marteau, F.1
  • 40
    • 33746659807 scopus 로고    scopus 로고
    • The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts
    • Savi P, et al. (2006) The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts. Proc Natl Acad Sci USA 103(29): 11069-11074.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.29 , pp. 11069-11074
    • Savi, P.1
  • 41
    • 0035899289 scopus 로고    scopus 로고
    • Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation
    • Yusuf S, et al.; Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators (2001) Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 345(7): 494-502.
    • (2001) N Engl J Med , vol.345 , Issue.7 , pp. 494-502
    • Yusuf, S.1
  • 42
    • 0037145863 scopus 로고    scopus 로고
    • Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: A randomized controlled trial
    • Steinhubl SR, et al.; CREDO Investigators. Clopidogrel for the Reduction of Events During Observation (2002) Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: A randomized controlled trial. JAMA 288(19): 2411-2420.
    • (2002) JAMA , vol.288 , Issue.19 , pp. 2411-2420
    • Steinhubl, S.R.1
  • 43
    • 65649145705 scopus 로고    scopus 로고
    • Effect of clopidogrel added to aspirin in patients with atrial fibrillation
    • Connolly SJ, et al.; ACTIVE Investigators (2009) Effect of clopidogrel added to aspirin in patients with atrial fibrillation. N Engl J Med 360(20): 2066-2078.
    • (2009) N Engl J Med , vol.360 , Issue.20 , pp. 2066-2078
    • Connolly, S.J.1
  • 44
    • 77955173801 scopus 로고    scopus 로고
    • Effect of clopidogrel on the rate and functional severity of stroke among high vascular risk patients: A prespecified substudy of the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA) trial
    • Hankey GJ, et al.; CHARISMA Trial Investigators (2010) Effect of clopidogrel on the rate and functional severity of stroke among high vascular risk patients: A prespecified substudy of the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA) trial. Stroke 41(8): 1679-1683.
    • (2010) Stroke , vol.41 , Issue.8 , pp. 1679-1683
    • Hankey, G.J.1
  • 45
    • 33645861080 scopus 로고    scopus 로고
    • Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events
    • Bhatt DL, et al.; CHARISMA Investigators (2006) Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med 354(16): 1706-1717.
    • (2006) N Engl J Med , vol.354 , Issue.16 , pp. 1706-1717
    • Bhatt, D.L.1
  • 46
    • 34247869852 scopus 로고    scopus 로고
    • Patients with prior myocardial infarction, stroke, or symptomatic peripheral arterial disease in the CHARISMA trial
    • Bhatt DL, et al.; CHARISMA Investigators (2007) Patients with prior myocardial infarction, stroke, or symptomatic peripheral arterial disease in the CHARISMA trial. J Am Coll Cardiol 49(19): 1982-1988.
    • (2007) J Am Coll Cardiol , vol.49 , Issue.19 , pp. 1982-1988
    • Bhatt, D.L.1
  • 47
    • 33846591479 scopus 로고    scopus 로고
    • Microglial activation and matrix protease generation during focal cerebral ischemia
    • del Zoppo GJ, et al. (2007) Microglial activation and matrix protease generation during focal cerebral ischemia. Stroke 38(2, Suppl): 646-651.
    • (2007) Stroke , vol.38 , Issue.2 , pp. 646-651
    • Del Zoppo, G.J.1
  • 48
    • 0028269001 scopus 로고
    • Blood-brain barrier disruption in experimental focal ischemia: Comparison between in vivo MRI and immunocytochemistry
    • Lo EH, Pan Y, Matsumoto K, Kowall NW (1994) Blood-brain barrier disruption in experimental focal ischemia: Comparison between in vivo MRI and immunocytochemistry. Magn Reson Imaging 12(3): 403-411.
    • (1994) Magn Reson Imaging , vol.12 , Issue.3 , pp. 403-411
    • Lo, E.H.1    Pan, Y.2    Matsumoto, K.3    Kowall, N.W.4
  • 49
    • 84881116173 scopus 로고    scopus 로고
    • Microglial P2Y12 deficiency/inhibition protects against brain ischemia
    • Webster CM, et al. (2013) Microglial P2Y12 deficiency/inhibition protects against brain ischemia. PLoS One 8(8): E70927.
    • (2013) PLoS One , vol.8 , Issue.8 , pp. e70927
    • Webster, C.M.1
  • 50
    • 84901829182 scopus 로고    scopus 로고
    • Microglia is a key player in the reduction of stroke damage promoted by the new antithrombotic agent ticagrelor
    • Gelosa P, et al. (2014) Microglia is a key player in the reduction of stroke damage promoted by the new antithrombotic agent ticagrelor. J Cereb Blood Flow Metab 34(6): 979-988.
    • (2014) J Cereb Blood Flow Metab , vol.34 , Issue.6 , pp. 979-988
    • Gelosa, P.1
  • 51
    • 4444353174 scopus 로고    scopus 로고
    • Pharmacokinetics of clopidogrel after administration of a high loading dose
    • Taubert D, et al. (2004) Pharmacokinetics of clopidogrel after administration of a high loading dose. Thromb Haemost 92(2): 311-316.
    • (2004) Thromb Haemost , vol.92 , Issue.2 , pp. 311-316
    • Taubert, D.1
  • 52
    • 31544456102 scopus 로고    scopus 로고
    • Astrocyte-mediated control of cerebral blood flow
    • Takano T, et al. (2006) Astrocyte-mediated control of cerebral blood flow. Nat Neurosci 9(2): 260-267.
    • (2006) Nat Neurosci , vol.9 , Issue.2 , pp. 260-267
    • Takano, T.1
  • 53
    • 31744448499 scopus 로고    scopus 로고
    • Targeted insult to subsurface cortical blood vessels using ultrashort laser pulses: Three models of stroke
    • Nishimura N, et al. (2006) Targeted insult to subsurface cortical blood vessels using ultrashort laser pulses: Three models of stroke. Nat Methods 3(2): 99-108.
    • (2006) Nat Methods , vol.3 , Issue.2 , pp. 99-108
    • Nishimura, N.1
  • 54
    • 31544475409 scopus 로고    scopus 로고
    • Thrombospondin-1 controls vascular platelet recruitment and thrombus adherence in mice by protecting (sub)endothelial VWF from cleavage by ADAMTS13
    • Bonnefoy A, et al. (2006) Thrombospondin-1 controls vascular platelet recruitment and thrombus adherence in mice by protecting (sub)endothelial VWF from cleavage by ADAMTS13. Blood 107(3): 955-964.
    • (2006) Blood , vol.107 , Issue.3 , pp. 955-964
    • Bonnefoy, A.1
  • 55
    • 84901318849 scopus 로고    scopus 로고
    • Thrombus formation induced by laser in a mouse model
    • Pérez P, Alarcón M, Fuentes E, Palomo I (2014) Thrombus formation induced by laser in a mouse model. Exp Ther Med 8(1): 64-68.
    • (2014) Exp Ther Med , vol.8 , Issue.1 , pp. 64-68
    • Pérez, P.1    Alarcón, M.2    Fuentes, E.3    Palomo, I.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.