Overview of the role of vanillin on redox status and cancer development

Oxidative Medicine and Cellular Longevity

Volumn 2016, Issue , 2016, Pages

  Bezerra, Daniel Pereira ^a   Soares, Anne Karine Nascimento ^b   De Sousa, Damião Pergentino ^b  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b FEDERAL UNIVERSITY OF PARAÍBA   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANTS; DISEASES;

ANTI-CANCER AGENTS; ANTICANCER POTENTIALS; ANTIOXIDANT PROPERTIES; CANCER DEVELOPMENT; DRUG DEVELOPMENT; NATURAL PRODUCTS; PHARMACEUTICAL PRODUCTS; PHARMACOLOGICAL ACTIVITY;

DRUG PRODUCTS;

VANILLIN; ANTINEOPLASTIC AGENT; ANTIOXIDANT; BENZALDEHYDE DERIVATIVE; BIOLOGICAL PRODUCT;

ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; BEVERAGE; CARCINOGENESIS; CYTOTOXICITY; DRUG DEVELOPMENT; FOOD; HUMAN; METASTASIS INHIBITION; NONHUMAN; REDOX STRESS; REVIEW; TUMOR INVASION; APOPTOSIS; CHEMISTRY; METABOLISM; NEOPLASMS; OXIDATION REDUCTION REACTION; PATHOLOGY;

CANCERS; PHARMACOLOGY; REDOX POTENTIAL; VANILLIN;

ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; BENZALDEHYDES; BIOLOGICAL PRODUCTS; HUMANS; NEOPLASMS; OXIDATION-REDUCTION;

EID: 85008601997     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2016/9734816     Document Type: Review

References (71)

1. G. Waris and H. Ahsan, "Reactive oxygen species: Role in the development of cancer and various chronic conditions," Journal of Carcinogenesis, vol. 5, article 14, 2006.
2. M. V. Sobral,A. L.Xavier, T. C. Lima, and D. P. De Sousa, "Antitumor activity of monoterpenes found in essential oils," The Scientific World Journal, vol. 2014, Article ID 953451, 35 pages, 2014.
3. A. A. Carvalho, L. N. and rade, E. B. V. de Sousa, and D. P. de Sousa, "Antitumor phenylpropanoids found in essential oils," BioMed Research International, vol. 2015, Article ID 392674, 21 pages, 2015.
4. L. N. and rade, T. C. Lima,R.G.Amaral et al., "Evaluationof the cytotoxicity of structurally correlated p-menthane derivatives," Molecules, vol. 20, no. 7, pp. 13264-13280, 2015.
5. D. P. de Sousa, Bioactive Essential Oils and Cancer, Springer International, New York, NY, USA, 1st edition, 2015.
6. V. Georgiev, A. Ananga, and V. Tsolova, "Recent advances and uses of grape flavonoids as nutraceuticals," Nutrients, vol. 6, no. 1, pp. 391-415, 2014.
7. C. Kandaswami, L. T. Lee, P. P. Lee et al., "The antitumor activities of flavonoids," In Vivo, vol. 19, pp. 895-909, 2005.
8. H. Priefert, J. Rabenhorst, and A. Steinbüchel, "Biotechnological production of vanillin," Applied Microbiology and Biotechnology, vol. 56, no. 3-4, pp. 296-314, 2001.
9. G. S.Clark, "Vanillin: Perfume," Flavour, vol. 15,pp. 45-54, 1990.
10. N. A. Zamzuri and S. Abd-Aziz, "Biovanillin from agro wastes as an alternative food flavour," Journal of the Science of Food and Agriculture, vol. 93, no. 3, pp. 429-438, 2013.
11. L. S. Pedroso, G. M. Fávero, L. E. A.De Camargo, R. M.Mainardes, and N. M. Khalil, "Effect of the o-methyl catechols apocynin, curcumin and vanillin on the cytotoxicity activity of tamoxifen," Journal of Enzyme Inhibition and MedicinalChemistry, vol. 28, no. 4, pp. 734-740, 2013.
12. A. Tai, T. Sawano, F. Yazama, and H. Ito, "Evaluation of antioxidant activity of vanillin by usingmultiple antioxidant assays," Biochimica et Biophysica Acta-General Subjects, vol. 1810,no. 2, pp. 170-177, 2011.
13. T. Sawa,M. Nakao, T. Akaike, K. Ono, and H.Maeda, "Alkylperoxyl radical-scavenging activity of various flavonoids and other phenolic compounds: Implications for the anti-tumorpromoter effect of vegetables," Journal of Agricultural and Food Chemistry, vol. 47, no. 2, pp. 397-402, 1999.
14. B.N. Ames and M. K. Shigenaga, "DNA damage by endogenous oxidants and mitogenesis as causes of aging and cancer," in Molecular Biology of Free Radical Scavengers System, J. G. Scandalios, Ed., pp. 1-22, Cold SpringHarbor Laboratory Press, Plain-View, NY, USA, 1993.
15. B. N. Ames and L. S. Gold, "Chemical carcinogenesis: Too many rodent carcinogens," Proceedings of the National Academy of Sciences of the United States of America, vol. 87, no. 19, pp. 7772-7776, 1990.
16. S. Ahmad, Oxidative Stress and Antioxidant Defenses in Biology, Chapman & Hall, NewYork, NY,USA, 1995.
17. Z. Yan-Chun and Z. Rong-Liang, "Phenolic compounds and an analog as superoxide anion scavengers and anti oxidants," Biochemical Pharmacology, vol. 42, no. 6, pp. 1177-1179, 1991.
18. M. Deters, H. Knochenwefel, D. Lindhorst et al., "Different curcuminoids inhibit T-lymphocyte proliferation independently of their radical scavenging activities," Pharmaceutical Research, vol. 25, no. 8, pp. 1822-1827, 2008.
19. B. N. Shyamala, M. Madhava Naidu, G. Sulochanamma, and P. Srinivas, "Studies on the antioxidant activities of natural vanilla extract and its constituent compounds through in vitromodels," Journal of Agricultural and Food Chemistry, vol. 55, no. 19, pp. 7738-7743, 2007.
20. A. Rosa, M. Deiana, G. Corona et al., "Protective effect of capsinoid on lipid peroxidation in rat tissues induced by Fe- NTA," Free Radical Research, vol. 39, no. 11, pp. 1155-1162, 2005.
21. J. P. Kamat, A. Ghosh, and T. P. A. Devasagayam, "Vanillin as an antioxidant in rat liver mitochondria: Inhibition of protein oxidation and lipid peroxidation induced by photosensitization," Molecular and Cellular Biochemistry, vol. 209, no. 1-2, pp. 47-53, 2000.
22. R.Harish, S. Divakar, A. Srivastava, and T. Shivanandappa, "Isolation of antioxidant compounds from themethanolic extract of the roots of Decalepis hamiltonii (Wight and Arn.)," Journal of Agricultural and Food Chemistry, vol. 53, no. 20, pp. 7709-7714, 2005.
23. D. K. Maurya, S. Adhikari, C. K. K. Nair, and T. P. A. Devasagayam, "DNA protective properties of vanillin against -radiation under different conditions: Possible mechanisms," Mutation Research, vol. 634, no. 1-2, pp. 69-80, 2007.
24. C. Dhanalakshmi, T.Manivasagam, J. Nataraj, A. J.Thenmozhi, and M. M. Essa, "Neurosupportive role of vanillin, a natural phenolic compound, on rotenone induced neurotoxicity in SHSY5Y neuroblastoma cells," Evidence-Based Complementary and AlternativeMedicine, vol. 2015, Article ID 626028, 11 pages, 2015.
25. M.Makni, Y. Chtourou, H. Fetoui, E. M. Garoui, T. Boudawara, and N. Zeghal, "Evaluation of the antioxidant, anti-inflammatory and hepatoprotective properties of vanillin in carbon tetrachloride- treated rats," European Journal of Pharmacology, vol. 668, no. 1-2, pp. 133-139, 2011.
26. H. Ben Saad,D.Driss, S. Ellouz Chaabouni et al., "Vanillin mitigates potassium bromate-induced molecular, biochemical and histopathological changes in the kidney of adult mice," Chemico- Biological Interactions, vol. 252, pp. 102-113, 2016.
27. L. R. G. Castor, K. A. Locatelli, and V. F. Ximenes, "Pro-oxidant activity of apocynin radical," FreeRadical Biology and Medicine, vol. 48, no. 12, pp. 1636-1643, 2010.
28. K. C.Machado, G. L. S. Oliveira, E. B. V. de Sousa et al., "Spectroscopic studies on the in vitro antioxidant capacity of isopentyl ferulate," Chemico-Biological Interactions, vol. 225, pp. 47-53, 2015.
29. B. Dimitrios, "Sources of natural phenolic antioxidants," Trends in Food Science and Technology, vol. 17, no. 9, pp. 505-512, 2006.
30. R.Harish, S. Divakar, A. Srivastava, and T. Shivanandappa, "Isolation of antioxidant compounds from themethanolic extract of the roots of Decalepis hamiltonii (Wight and Arn.)," Journal of Agricultural and Food Chemistry, vol. 53, no. 20, pp. 7709-7714, 2005.
31. T. Kada and K. Shimoi, "Desmutagens and bio-antimutagens- Their modes of action," BioEssays, vol. 7, no. 3, pp. 113-116, 1987.
32. T. Ohta, M. Watanabe, K.Watanabe, Y. Shirasu, and T. Kada, "Inhibitory effects of flavourings on mutagenesis induced by chemicals in bacteria," Food and Chemical Toxicology, vol. 24, no. 1, pp. 51-54, 1986.
33. T. Ohta, M. Watanabe, Y. Shirasu, and T. Inoue, "Post-replication repair and recombination in uvrAumuC strains of Escherichia coli are enhanced by vanillin, an antimutagenic compound," Mutation Research, vol. 201, no. 1, pp. 107-112, 1988.
34. K. Takahashi, M. Sekiguchi, and Y. Kawazoe, "Effects of vanillin and o-vanillin on induction of DNA-repair networks: Modulation of mutagenesis in Escherichia coli," Mutation Research/ Fundamental and Molecular Mechanisms of Mutagenesis, vol. 230, no. 2, pp. 127-134, 1990.
35. D. T. Shaughnessy, R.W. Setzer, and D. M. DeMarini, "Theantimutagenic effect of vanillin and cinnamaldehyde on spontaneous mutation in Salmonella TA104 is due to a reduction in mutations at GC but not AT sites," Mutation Research/Fundamental and MolecularMechanisms ofMutagenesis, vol. 480-481, pp. 55-69, 2001.
36. S. De Flora, C. Bennicelli, A. Rovida, L. Scatolini, and A. Camoirano, "Inhibition of the 'spontaneous' mutagenicity in Salmonella typhimurium TA102 and TA104,"Mutation Research/ Fundamental and Molecular Mechanisms of Mutagenesis, vol. 307, no. 1, pp. 157-167, 1994.
37. D. T. Shaughnessy, R. M. Schaaper, D. M. Umbach, and D. M. DeMarini, "Inhibition of spontaneous mutagenesis by vanillin and cinnamaldehyde in Escherichia coli: Dependence on recombinational repair," Mutation Research, vol. 602, no. 1-2, pp. 54-64, 2006.
38. H. H. R. de and rade, J. H. Santos, M. C. Gimmler-Luz, M. J. F. Correa, M. Lehmann, and M. L. Reguly, "Suppressing effect of vanillin on chromosome aberrations that occur spontaneously or are induced by mitomycin C in the germ cell line of Drosophila melanogaster," Mutation Research, vol. 279, no. 4, pp. 281-287, 1992.
39. J. H. Santos, U. Graf, M. L. Reguly, and H. H. Rodrigues De and rade, "The synergistic effects of vanillin on recombination predominate over its antimutagenic action in relation toMMCinduced lesions in somatic cells of Drosophila melanogaster," Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol. 444, no. 2, pp. 355-365, 1999.
40. M. Sinigaglia, M. L. Reguly, and H. H. Rodrigues De and rade, "Effect of vanillin on toxicant-induced mutation and mitotic recombination in proliferating somatic cells of Drosophila melanogaster," Environmental and Molecular Mutagenesis, vol. 44, no. 5, pp. 394-400, 2004.
41. M. Sinigaglia, M. Lehmann, P. Baumgardt et al., "Vanillin as a modulator agent in SMART test: Inhibition in the steps that precede N-methyl-N-nitrosourea-, N-ethyl-N-nitrosourea-, ethylmethanesulphonate- and bleomycin-genotoxicity," Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol. 607, no. 2, pp. 225-230, 2006.
42. M. P. Furlanetto,M. Sinigaglia, V. S. Do Amaral, R. R. Dihl, and H. H. R. De and rade, "Effect of vanillin on toxicant-induced lethality in the Drosophila melanogaster DNA repair test," Environmental and MolecularMutagenesis, vol. 48, no. 1, pp. 67-70, 2007.
43. Y. F. Sasaki,H. Imanishi, T. Ohta, and Y. Shirasu, "Effects of antimutagenic flavourings on SCEs induced by chemical mutagens in cultured Chinese hamster cells," Mutation Research/Genetic Toxicology, vol. 189, no. 3, pp. 313-318, 1987.
44. Y. Sasaki, H. Imanishi, T. Ohta, and Y. Shirasu, "Effects of vanillin on sister-chromatid exchanges and chromosome aberrations induced by mitomycin C in cultured Chinese hamster ovary cells," Mutation Research Letters, vol. 191, no. 3-4, pp. 193-200, 1987.
45. Y. Sasaki, H. Imanishi, M. Watanabe, T. Ohta, and Y. Shirasu, "Suppressing effect of antimutagenic flavorings on chromosome aberrations induced by UV-light or X-rays in cultured Chinese hamster cells," Mutation Research, vol. 229, no. 1, pp. 1-10, 1990.
46. H. Imanishi, Y. Sasaki, K. Matsumoto et al., "Suppression of 6-TG-resistantmutations in V79 cells and recessive spot formations in mice by vanillin," Mutation Research Letters, vol. 243, no. 2, pp. 151-158, 1990.
47. K. Tamai, H. Tezuka, and Y. Kuroda, "Different modifications by vanillin in cytotoxicity and genetic changes induced by EMS and H2O2 in cultured Chinese hamster cells," Mutation Research, vol. 268, no. 2, pp. 231-237, 1992.
48. C. Keshava, N. Keshava, W. Z. Whong, J. Nath, and T. M. Ong, "Inhibition of methotrexate-induced chromosomal damage by vanillin and chlorophyllin in V79 cells," Teratogenesis, Carcinogenesis and Mutagenesis, vol. 17, pp. 313-326, 1997-1998.
49. C. Keshava, N. Keshava, T.-M. Ong, and J. Nath, "Protective effect of vanillin on radiation-induced micronuclei and chromosomal aberrations in V79 cells," Mutation Research, vol. 397, no. 2, pp. 149-159, 1998.
50. T. Inouye, Y. F. Sasaki,H. Imanishi, M. Watanabe, T.Ohta, and Y. Shirasu, "Suppression of mitomycin C-induced micronuclei in mouse bone marrow cells by post-treatment with vanillin," Mutation Research, vol. 202, no. 1, pp. 93-95, 1988.
51. Y. Sasaki, T. Ohta, H. Imanishi et al., "Suppressing effects of vanillin, cinnamaldehyde, and anisaldehyde on chromosome aberrations induced by X-rays in mice," Mutation Research Letters, vol. 243, no. 4, pp. 299-302, 1990.
52. S. S. Kumar, A. Ghosh, T. P. A.Devasagayam, and P. S. Chauhan, "Effect of vanillin on methylene blue plus light-induced singlestrand breaks in plasmid pBR322DNA," Mutation Research, vol. 469, no. 2, pp. 207-214, 2000.
53. D. L. Gustafson, H. R. Franz, A. M. Ueno, C. J. Smith, D. J. Doolittle, and C. A.Waldren, "Vanillin (3-methoxy-4-hydroxybenzaldehyde) inhibits mutation induced by hydrogen peroxide, N-methyl-N-nitrosoguanidine and mitomycin C but not 137Cs-radiation at the CD59 locus in human-hamster hybrid A cells," Mutagenesis, vol. 15, no. 3, pp. 207-213, 2000.
54. S. Durant and P. Karran, "Vanillins-A novel family of DNA-PK inhibitors," Nucleic Acids Research, vol. 31, no. 19, pp. 5501-5512, 2003.
55. R. Sanyal, F. Darroudi, W. Parzefall, M. Nagao, and S. Knasm üller, "Inhibition of the genotoxic effects of heterocyclic amines in human derived hepatoma cells by dietary bioantimutagens," Mutagenesis, vol. 12, no. 4, pp. 297-303, 1997.
56. A.A.King, D. T. Shaughnessy, K.Mure et al., "Antimutagenicity of cinnamaldehyde and vanillin in human cells: Global gene expression and possible role of DNA damage and repair," Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 616, no. 1-2, pp. 60-69, 2007.
57. J. Lee, J. Y. Cho, S. Y. Lee, K.-W. Lee, J. Lee, and J.-Y. Song, "Vanillin protects human keratinocyte stem cells against Ultraviolet B irradiation," Food and Chemical Toxicology, vol. 63, pp. 30-37, 2014.
58. H. Ben Saad, I. Ben Amara, N. Krayem et al., "Ameliorative effects of vanillin on potassium bromate induces bone and blood disorders in vivo," Cellular and Molecular Biology, vol. 61, pp. 12-22, 2015.
59. H. Ben Saad, D. Driss, I. Ben Amara et al., "Altered hepatic mRNA expression of immune response-associated DNA damage in mice liver induced by potassium bromate: Protective role of vanillin," Environmental Toxicology, vol. 31, no. 12, pp. 1796-1807, 2016.
60. H. Tsuda,N.Uehara, Y. Iwahori et al., "Chemopreventive effects of -carotene, -tocopherol and five naturally occurring antioxidants on initiation of hepatocarcinogenesis by 2-amino-3- methylimidazo[4,5-f ]quinoline in the rat," Japanese Journal of Cancer Research, vol. 85, no. 12, pp. 1214-1219, 1994.
61. K. Akagi, M. Hirose, T. Hoshiya, Y. Mizoguchi, N. Ito, and T. Shirai, "Modulating effects of ellagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model," Cancer Letters, vol. 94, no. 1, pp. 113-121, 1995.
62. K.L.Ho, P. P. Chong, L. S. Yazan, and M. Ismail, "Vanillindifferentially affects azoxymethane-injected rat colon carcinogenesis and gene expression," Journal of Medicinal Food, vol. 15, no. 12, pp. 1096-1102, 2012.
63. S. Kapoor, "Multiorgan anticarcinogenic effects of vanillin," Journal of Medicinal Food, vol. 16, no. 9, pp. 777-777, 2013.
64. K. Lirdprapamongkol, H. Sakurai, N. Kawasaki et al., "Vanillin suppresses in vitro invasion and in vivo metastasis of mouse breast cancer cells," European Journal of Pharmaceutical Sciences, vol. 25, no. 1, pp. 57-65, 2005.
65. J.-A. Liang, S.-L. Wu, H.-Y. Lo, C.-Y. Hsiang, and T.-Y. Ho, "Vanillin inhibits matrix metalloproteinase-9 expression through down-regulation of nuclear factor-B signaling pathway in human hepatocellular carcinoma cells," Molecular Pharmacology, vol. 75, no. 1, pp. 151-157, 2009.
66. K. Lirdprapamongkol, J.-P. Kramb, T. Suthiphongchai et al., "Vanillin suppresses metastatic potential of human cancer cells through PI3K inhibition and decreases angiogenesis in vivo," Journal of Agricultural and Food Chemistry, vol. 57, no. 8, pp. 3055-3063, 2009.
67. H. Babich, E. Borenfreund, and A. Stern, "Comparative cytotoxicities of selected minor dietary non-nutrients with chemopreventive properties," Cancer Letters, vol. 73, no. 2-3, pp. 127-133, 1993.
68. K.Ho, L. S. Yazan,N. Ismail, and M. Ismail, "Apoptosis and cell cycle arrest of human colorectal cancer cell line HT-29 induced by vanillin," Cancer Epidemiology, vol. 33, no. 2, pp. 155-160, 2009.
69. W.-Y. Cheng, C.-Y. Hsiang, D.-T. Bau et al., "Microarray analysis of vanillin-regulated gene expression profile in human hepatocarcinoma cells," Pharmacological Research, vol. 56, no. 6, pp. 474-482, 2007.
70. K. Lirdprapamongkol, H. Sakurai, S. Suzuki et al., "Vanillin enhances TRAIL-induced apoptosis in cancer cells through inhibition of NF-kappaB activation," In Vivo, vol. 24, no. 4, pp. 501-506, 2010.
71. J. Deb, H. Dibra, S. Shan et al., "Activity of aspirin analogues and vanillin in a human colorectal cancer cell line," Oncology Reports, vol. 26, no. 3, pp. 557-565, 2011.