Hydroxytyrosol modulates the levels of microRNA-9 and its target sirtuin-1 thereby counteracting oxidative stress-induced chondrocyte death

Osteoarthritis and Cartilage

Volumn 25, Issue 4, 2017, Pages 600-610

  D'Adamo, S ^a   Cetrullo, S ^a   Guidotti, S ^a,b   Borzi R M ^b   Flamigni, F ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

Author keywords

Cartilage; Chondrocyte; Hydroxytyrosol; microRNA; Oxidative stress

Indexed keywords

CASPASE; COLLAGENASE 3; HYDROXYTYROSOL; MESSENGER RNA; MICRORNA 9; SIRTUIN 1; TRANSCRIPTION FACTOR RUNX2; VASCULOTROPIN; 3,4-DIHYDROXYPHENYLETHANOL; HYDROGEN PEROXIDE; MICRORNA; MIRN92 MICRORNA, HUMAN; MMP13 PROTEIN, HUMAN; OXIDIZING AGENT; PHENETHYL ALCOHOL; RUNX2 PROTEIN, HUMAN; SIRT1 PROTEIN, HUMAN; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ARTICLE; CELL DEATH; CELL VIABILITY; CHONDROCYTE; CHONDROPROTECTION; CONTROLLED STUDY; DOWN REGULATION; DRUG DETERMINATION; DRUG EFFECT; ENZYME ACTIVITY; GENE; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIMARY CELL CULTURE; SIRT 1 GENE; UPREGULATION; ANALOGS AND DERIVATIVES; DRUG EFFECTS; GENETICS; METABOLISM;

CELL DEATH; CHONDROCYTES; CORE BINDING FACTOR ALPHA 1 SUBUNIT; GENE EXPRESSION; HUMANS; HYDROGEN PEROXIDE; MATRIX METALLOPROTEINASE 13; MICRORNAS; OXIDANTS; OXIDATIVE STRESS; PHENYLETHYL ALCOHOL; RNA, MESSENGER; SIRTUIN 1; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 85008506362     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2016.11.014     Document Type: Article

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