Single-cell profiling of human megakaryocyte-erythroid progenitors identifies distinct megakaryocyte and erythroid differentiation pathways

Genome Biology

Volumn 17, Issue 1, 2016, Pages

  Psaila, Bethan ^a,b,c   Barkas, Nikolaos ^c   Iskander, Deena ^a   Roy, Anindita ^c,d   Anderson, Stacie ^b   Ashley, Neil ^c   Caputo, Valentina S ^a   Lichtenberg, Jens ^b   Loaiza, Sandra ^a   Bodine, David M ^b   Karadimitris, Anastasios ^a   Mead, Adam J ^c   Roberts, Irene ^c,d  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Erythropoiesis; Hematopoiesis; Hematopoietic stem cell; Megakaryopoiesis; Myelopoiesis; Thrombopoiesis

Indexed keywords

BETA3 INTEGRIN; CD123 ANTIGEN; CD135 ANTIGEN; CD34 ANTIGEN; CD38 ANTIGEN; CD45RA ANTIGEN; CD47 ANTIGEN; CD71 ANTIGEN; CD9 ANTIGEN; ENDOGLIN; FIBRINOGEN RECEPTOR; GLYCOPROTEIN IB ALPHA; HERMES ANTIGEN; LYMPHOID ENHANCER FACTOR 1; MYELOPEROXIDASE; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR GATA 2; TRANSFORMING GROWTH FACTOR BETA; VON WILLEBRAND FACTOR;

ANK1 GENE; ARTICLE; CD71 GENE; CELL DIFFERENTIATION; CELL LINEAGE; CONTROLLED STUDY; CSF3R GENE; ERYTHROID CELL; FLI1 GENE; FLT3 GENE; FLUORESCENCE ACTIVATED CELL SORTING; GATA1 GENE; GATA2 GENE; GENE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; KLF1 GENE; LEF1 GENE; LOX GENE; MEGAKARYOCYTE; MEGAKARYOCYTE ERYTHROID PROGENITOR; MEGAKARYOPOIESIS; MPO GENE; NFIB GENE; PROGENY; SINGLE CELL ANALYSIS; SINGLE CELL PROFILING; SOCS3 GENE; TGF BETA GENE; TMOD1 GENE; TRANSCRIPTION REGULATION; VWF GENE; ADULT; AGED; CELL SEPARATION; CLASSIFICATION; CYTOLOGY; FEMALE; HEMATOPOIESIS; MALE; METABOLISM; MIDDLE AGED; PROCEDURES;

ADULT; AGED; CELL LINEAGE; CELL SEPARATION; ERYTHROID CELLS; FEMALE; HEMATOPOIESIS; HUMANS; MALE; MEGAKARYOCYTE-ERYTHROID PROGENITOR CELLS; MEGAKARYOCYTES; MIDDLE AGED; SINGLE-CELL ANALYSIS;

EID: 85008168844     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/s13059-016-0939-7     Document Type: Article

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