Unipotent megakaryopoietic pathway bridging hematopoietic stem cells and mature megakaryocytes

Stem Cells

Volumn 33, Issue 7, 2015, Pages 2196-2207

  Nishikii, Hidekazu ^a,b,c   Kanazawa, Yosuke ^b   Umemoto, Terumasa ^c   Goltsev, Yury ^b   Matsuzaki, Yu ^c   Matsushita, Kenji ^b   Yamato, Masayuki ^c   Nolan, Garry P ^b   Negrin, Robert ^d   Chiba, Shigeru ^a,b  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Adult hematopoietic stem cells; Hematopoietic progenitors; Megakaryocyte; Thrombopoiesis; Thrombopoietin

Indexed keywords

CD135 ANTIGEN; FIBRINOGEN RECEPTOR; FLUOROURACIL; GLYCOPROTEIN IB ALPHA; MESSENGER RNA; THROMBOPOIETIN;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL CULTURE; CELL DIFFERENTIATION; CELL LINEAGE; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IN VITRO STUDY; IN VIVO STUDY; LYMPHOID CELL; MEGAKARYOCYTE; MEGAKARYOCYTE ERYTHROID PROGENITOR; MEGAKARYOPOIESIS; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PROGENY; PROTEIN PHOSPHORYLATION; THROMBOCYTE; THROMBOCYTOPOIESIS; UNIPOTENT MEGAKARYOPOIETIC PATHWAY; ANIMAL; C57BL MOUSE; CYTOLOGY; GENE EXPRESSION; METABOLISM; TRANSGENIC MOUSE;

ANIMALS; CELL DIFFERENTIATION; GENE EXPRESSION; HEMATOPOIETIC STEM CELLS; MEGAKARYOCYTES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC;

EID: 84931561404     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1985     Document Type: Article

References (31)

1. Akashi K, Traver D, Miyamoto T, et al., A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 2000; 404: 193-197.
2. Pronk CJ, Rossi DJ, Mansson R, et al., Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy. Cell Stem Cell 2007; 1: 428-442.
3. Cornejo MG, Mabialah V, Sykes SM, et al., Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification. Blood 2012; 118: 1264-1273.
4. Mercher T, Cornejo MG, Sears C, et al., Notch signaling specifies megakaryocyte development from hematopoietic stem cells. Cell Stem Cell 2008; 3: 314-326.
5. Sanchez M, Weissman IL, Pallavicini M, et al., Differential amplification of murine bipotent megakaryocytic/erythroid progenitor and precursor cells during recovery from acute and chronic erythroid stress. Stem Cells 2006; 24: 337-348.
6. Klimchenko O, Mori M, Distefano A, et al., A common bipotent progenitor generates the erythroid and megakaryocyte lineages in embryonic stem cell-derived primitive hematopoiesis. Blood 2009; 114: 1506-1517.
7. Sanjuan-Pla A, Macaulay IC, Jensen CT, et al., Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy. Nature 2013; 502: 232-236.
8. Yamamoto R, Morita Y, Ooehara J, et al., Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells. Cell 2013; 154: 1112-1126.
9. Nakorn TN, Miyamoto T, Weissman IL,. Characterization of mouse clonogenic megakaryocyte progenitors. Proc Natl Acad Sci USA 2003; 100: 205-210.
10. Ng AP, Kauppi M, Metcalf D, et al., Characterization of thrombopoietin (TPO)-responsive progenitor cells in adult mouse bone marrow with in vivo megakaryocyte and erythroid potential. Proc Natl Acad Sci USA 2012; 109: 2364-2369.
11. Ferkowicz MJ, Starr M, Xie X, et al., CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo. Development 2003; 130: 4393-4403.
12. Deutsch VR, Tomer A,. Advances in megakaryocytopoiesis and thrombopoiesis: From bench to bedside. Br J Haematol 2013; 161: 778-793.
13. Kaushansky K, Lok S, Holly RD, et al., Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature 1994; 369: 568-571.
14. Kimura S, Roberts AW, Metcalf D, et al., Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin. Proc Natl Acad Sci USA 1998; 95: 1195-1200.
15. Bersenev A, Wu C, Balcerek J, et al., Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2. J Clin Invest 2008; 118: 2832-2844.
16. Yoshihara H, Arai F, Hosokawa K, et al., Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell Stem Cell 2007; 1: 685-697.
17. Hitchcock IS, Kaushansky K,. Thrombopoietin from beginning to end. Br J Haematol 2014; 165: 259-268.
18. Ghosn EE, Yamamoto R, Hamanaka S, et al., Distinct B-cell lineage commitment distinguishes adult bone marrow hematopoietic stem cells. Proc Natl Acad Sci USA 2012; 109: 5394-5398.
19. Canobbio I, Balduini C, Torti M,. Signalling through the platelet glycoprotein Ib-V-IX complex. Cell Signal 2004; 16: 1329-1344.
20. Nishikii H, Eto K, Tamura N, et al., Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells. J Exp Med 2008; 205: 1917-1927.
21. Wilson A, Laurenti E, Oser G, et al., Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell 2008; 135: 1118-1129.
22. Osawa M, Hanada K, Hamada H, et al., Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 1996; 273: 242-245.
23. Gekas C, Graf T,. CD41 expression marks myeloid-biased adult hematopoietic stem cells and increases with age. Blood 2013; 121: 4463-4472.
24. Kiel MJ, Yilmaz OH, Iwashita T, et al., SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 2005; 121: 1109-1121.
25. Adolfsson J, Mansson R, Buza-Vidas N, et al., Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment. Cell 2005; 121: 295-306.
26. Morita Y, Ema H, Nakauchi H,. Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment. J Exp Med. 207: 1173-1182.
27. Miyawaki K, Arinobu Y, Iwasaki H, et al., CD41 marks the initial myelo-erythroid lineage specification in adult mouse hematopoiesis: Redefinition of murine common myeloid progenitor. Stem Cells 2014; 33: 976-987.
28. Seita J, Ema H, Ooehara J, et al., Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction. Proc Natl Acad Sci USA 2007; 104: 2349-2354.
29. Kozuma Y, Ninomiya H, Murata S, et al., The pro-apoptotic BH3-only protein Bim regulates cell cycle progression of hematopoietic progenitors during megakaryopoiesis. J Thromb Haemost 2010; 8: 1088-1097.
30. Sudo T, Yokota T, Oritani K, et al., The endothelial antigen ESAM monitors hematopoietic stem cell status between quiescence and self-renewal. J Immunol 2012; 189: 200-210.
31. Gurney AL, Carver-Moore K, de Sauvage FJ, et al., Thrombocytopenia in c-mpl-deficient mice. Science 1994; 265: 1445-1447.